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A 5-year analysis of endothelial vs penetrating keratoplasty graft survival in Chinese patients

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International Journal of Ophthalmology(English edition) 2020年第9期13卷 1374-1377页

作者： Anita Lai Wah Li Rachel Pui Wai Kwok ka Wai kam Alvin Lerrmann Young Department of Ophthalmology and Visual sciences Prince of Wales Hospital&Alice Ho Miu Ling Nethersole HospitalNew Territories East ClusterHospital Authoritythe Chinese University of Hong KongHong Kong SARChina

AIM:To determine if there is any difference in longterm graft survival between Descemet’s stripping endothelial keratoplasty(DsEK)and penetrating keratoplasty(PK).METHODs:A retrospective 5-year cases analysis of bullous keratopathy secondary to Fuchs’endothelial dystrophy or pseudophakic bullous keratopathy,receiving either DsEK or PK.A total of 42 DsEK cases and 25 PK cases were included in the ***:In the 5-year analysis,graft survival rates were very similar in the two groups(DsEK 77.1%vs PK76.0%.P=0.918.95%CI:-6.3 to 33.4).sub-analyses at 1y(DsEK 81%vs PK 95%.P=0.085.95%CI:-29 to 3.6)and 2y(DsEK 81%vs PK 88%.P=0.381.95%CI:-25.9 to 11.8)show a trend towards lower survival rates of DsEK vs PK,but the results were not statistically ***:Longterm 5-year graft survival is similar between the DsEK and PK methods of corneal transplant in Chinese patients with bullous keratopathy.

关键词： cornea endothelial keratoplasty corneal graft

MONITORING POLYNUCLEAR AROMATIC HYDROCARBONs IN sEDIMENT POREWATER BY sPMD

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Chinese Journal of Oceanology and Limnology 2001年第4期19卷 382-388页

作者：朱亚先张勇张杰庄一廷 ka-Fai Poon Michael H.W.Lam 洪华生 Rudolf s.s.Wu Department of Chemistry Xiamen University Environmental science Research Center the Key Laboratory for Marine Environmental Science of MOE of ChinaXiamen University Environmental Monitoring Center of Fuzhuo City Dept. Bio. Chem. Center for Coastal Pollution and Conservation City Univ. of Hong Kong

A new mimic biological semi permeable Membrane Device (sPMD) introduced for sampling organic pollutants yielded satisfactory results when it was first used as a passive sampler to concentrate and determine 16 kinds of polynuclear aromatic hydrocarbons (PAHs) by means of capillary GC on an HP 5890 GC FID in coastal sediment porewater. The concentration of PAHs in sediment porewater for naphthalene(N), acenaphthlene(AL), acenaphthene(AE), fluorene(F), phenaphthene(P), anthracene(A), fluoranthene(FA), pyrene(Py), benzoanthracene(BA), chrysene(Chr), benzofluor anthene(BF), benzofluoranthene(BF), benzopyrene(BP),indeno[1,2,3, cd] Pyrene(IP), dibenzanthracene(DA) and benzo perylene(BP) were: 50.36, under detection limits(UD), 18.19, 8.41, 8.40, 1.44, UD, 8.01, 524.15, 168.47, 50.13, 123.66, 63.48, 27.40, 82.04 and 58,81 ng/L, respectively.

关键词： sPMD monitoring PAHs porewater

Correlation of effective hepatic blood flow with liver pathology in patients with hepatitis B virus

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Liver Research 2021年第4期5卷 243-250页

作者： Xin shu Haixia sun Xiaoan Yang Yifan Jia Peiyan Xu Hong Cao ka Zhang Department of Infectious Diseases The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina Department of Infectious Diseases Huadu District People's Hospital of GuangzhouGuangzhouChina

Background and aims:Effective hepatic blood flow(EHBF)decreases with liver disease progression,and identifying liver pathology is critical for patients with liver *** study was designed to elucidate the correlation between EHBF and liver pathology and explore the potential of EHBF for predicting the degree of liver ***:In this study,207 patients with hepatitis B virus(HBV)who underwent liver biopsy and indocyanine green(ICG)clearance tests were *** was measured using the ICG clearance test,and liver tissue was histologically analyzed to determine the pathological stage according to the scheuer scoring *** data,biochemical indexes,and Fibroscan data were collected for statistical ***:EHBF levels decreased as the liver histological stages of inflammation and fibrosis increased(Ps significantly negatively associated with the levels of alanine aminotransferase,aspartate aminotransferase,gamma-glutamyl transpeptidase,alkaline phosphatase,aspartate aminotransferase-to-platelet ratio index,fibrosis index based on the four factors,and liver stiffness measurement(Ps of patients without liver inflammation(G0)were significantly higher than those of patients with liver inflammation(G1e4)(Pstic curve(AUROC)value for discriminating patients without liver inflammation was 0.827,and the optimal cutoff value was 0.936 L/*** EHBF levels of patients with severe liver inflammation(G4)were significantly lower than those of patients with G0e3 liver inflammation(Pscriminating patients with severe liver inflammation was 0.792,and the optimal cutoff value was 0.552 L/*** EHBF levels of patients without liver fibrosis(s0)were significantly higher than those of patients with liver fibrosis(s1e4)(Pscriminating patients without liver fibrosis was 0.633,and the optimal cutoff val

关键词： Hepatitis B virus(HBV) Liver inflammation Liver fibrosis Effective hepatic blood flow(EHBF) Liver disease

Chinese medicine practitioner turnover rate and the development of Chinese medicine in Hong Kong,China

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Journal of Traditional Chinese Medical sciences 2021年第2期8卷 145-149页

作者： ka-Kit Chua Vivien Lau Wing-Yan Lee Chun-Pong Lam school of Chinese Medicine Hong Kong Baptist UniversityHong KongChina sin-Hua Herbalist's&Herb Dealer's Promotion society Limited Hong KongChina Alumni Association of Full-time Chinese Medicine Undergraduate Hong Kong Baptist UniversityHong KongChina

Objective:To establish that the Hong Kong special Administrative Region(HKsAR)government is actively promoting Chinese medicine(CM)and to examine turnover rate of Chinese medicine practitioners(CMPs)in Hong Kong,China in light of this governmental ***:This study covered two major areas:reviewing CM development in Hong Kong,and assessing the turnover rate of CMPs in Hong *** first part of the paper is a historical *** investigation of turnover rate had two *** 1,quantitative method,involved online questionnaires;section 2,qualitative method comprised interviews with CMPs from different types of CM clinics to ascertain the reasons for the turnover among ***:A total of 123 online questionnaires were received in section 1(55 from male CMPs;66 from female CMPs;2 respondents were unwilling to disclose their sex).The proportion of CMPs who had resigned in 2018e19 was 22.8%(28),of whom 5.7%(7)had resigned twice in one *** rates of resignation in 3 years and 5 years were up to 40.7%(50)and 56.9%(70),*** CMPs were interviewed in section *** CMPs were more likely to resign than *** large gap between actual salary and expectations appeared to be the main reason for the high rate of ***:HKsAR government keenly desires to promote CM in Hong Kong,however,high turnover rate of CMPs was detected even under this positive governmental *** is an urgent need to conduct a more representative study of the reasons for the inclination of CMPs in Hong *** study highlights an important issue in CM development,and these results should remind different stakeholders in the CM industry and the government that CMPs need better career prospects and support in various areas.

关键词： Chinese medicine development Chinese Medicine Turnover rate Hong Kong sAR Career prospect salary

Modified Zhibai Dihuang pill,a traditional Chinese medicine formula,on steroid withdrawal in systemic lupus erythematosus:A systematic review and meta-analysis

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Journal of Integrative Medicine 2020年第6期18卷 478-491页

作者： Liang Dai ka Kei Chan Jian-chun Mao Yu Tianc Jun-hua Gu Jun Zhou Linda L.D.Zhong Institute of Digestive Diseases Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Hong Kong Chinese Medicine Clinical study Centre School of Chinese MedicineHong Kong Baptist UniversityHong KongChina Department of Rheumatology.Longhua Hospital Shanghai University of Traditional Chinese MedicineShanghai 200032China

Background:Zhibai Dihuang pill(ZBDH),a Chinese herbal formula,has been widely used as an adjunctive therapy to help reduce the patient’s steroid dose and maintain low disease activity in systemic lupus erythematosus(sLE).Objective:This systematic review evaluates the therapeutic effect of modified ZBDH in reducing steroid use in patients with *** strategy:A systematic literature search was carried out using seven databases,including PubMed,Embase,Cochrane Central Register of Controlled Trials,Chinese Biomedical Literature Database,Chinese National Knowledge Infrastructure,Chinese VIP Information and Wanfang Database,from their inception to June 1 st,*** search terms included‘‘systemic lupus erythematosus,"‘‘Chinese medicine"and‘‘clinical trial,"and their *** headings matching the above terms were also *** criteria:This meta-analysis included randomized controlled trials that evaluated the reduction of steroid dose in patients with *** Chinese medicine(TCM)formulas in experimental group should be prescribed based on ZBDH and used as adjunctive therapy and the comparator should contain *** extraction and analysis:Two authors independently conducted database search,study selection,data extraction and quality *** extracted information contained study design,sample size,recruitment mode,diagnostic criteria,inclusion and exclusion criteria,participant characteristics,TCM patterns,TCM formulas and treatment *** primary outcome was the change of steroid *** outcomes included sLE Disease Activity Index(sLEDAI),biomarkers of disease activity and clinical response *** 15.0 was used to analyze the pooled effects reported as weighted mean difference(WMD)or odds ratio,with a 95%confidence interval(CI).Results:In total,20 trials involving 1470 sLE patients were *** pooled result showed that modified ZBDH taken in combination with standard care led to a larger reduction in stero

关键词： systemic lupus erythematosus steroid Traditional Chinese medicine systematic review Meta-analysis

Epidemiology and natural history of Wilson's disease in the Chinese: A territory-based study in Hong Kong between 2000 and 2016

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World Journal of Gastroenterology 2017年第43期23卷 7716-7726页

作者： ka-shing Cheung Wai-kay seto James Fung Lung-Yi Mak Ching-Lung Lai Man-Fung Yuen Department of Medicine The University of Hong KongQueen Mary Hospital state Key Laboratory for Liver Research The University of Hong Kong

AIM To investigate the epidemiology and natural history of Wilson's disease in the *** Data were retrieved via electronic search of hospital medical registry of the Hong Kong Hospital Authority,which covers all the public healthcare services. We identified cases of Wilson's disease between 2000 and 2016 by the International Classification of Diseases(ICD)-9 code. We analyzed the incidence rate,prevalence and adverse outcomes of Wilson's *** We identified 211 patients(male cases 104; female cases 107; median age 27.2 years,IQR: 17.1-38.6 years; duration of follow-up 8.0 years,IQR: 5.0-14.0 years). The average annual incidence rate was 1.44 per million person-years while the prevalence was 17.93 per million. Between 2000 and 2016,there was a decrease in the annual incidence rate from 1.65 to 1.23 per million person-years(P = 0.010),whereas there was an increase in the annual prevalence from 7.80 to 25.20 per million(P ses with hepatic involvement,38(21.6%) had cirrhosis,three(1.7%) developed hepatocellular carcinoma,24(13.6%) underwent liver transplantations,and 26(14.8%) died. seven patients had concomitant chronic viral hepatitis B or C. The 5-year and 10-years rates of overall survival were 92.6% and 89.5%,and for transplant-free survival rates 91.8% and 87.4%,respectively. Cirrhosis and possibly chronic viral hepatitis were associated with poorer overall survival. CONCLUsION There was a significant increase in the prevalence of Wilson's disease in Hong Kong. The prognosis was favorable except for those with cirrhosis or concomitant viral hepatitis.

关键词： Hepaticolenticular degeneration Cirrhosis Hepatocellular carcinoma Transplantation

Down-conversion materials for organic solar cells:Progress,challenges,and perspectives

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Aggregate

Aggregate 2022年第3期3卷 59-79页

作者： Ram Datt swati Bishnoi Harrison ka Hin Lee sandeep Arya sonal Gupta Vinay Gupta Wing Chung Tsoi Faculty of science and Engineering Sustainable Product Engineering Centre for Innovative Functional Industrial CoatingsSwansea UniversityBay CampusFabian WaySwansea SA18ENUK Advanced Materials and Metrology Division Council of Scientific And Industrial Research-National Physical LaboratoryDr.K.S.Krishnan MargNew Delhi 110012India Department of Physics University of JammuJammuJammu and Kashmir 180006India Department of Conducting Polymers Institute of Macromolecular ChemistryCzech Academy of SciencesPrague 616206Czech Republic Department of Physics Khalifa University of Science and TechnologyP.O.Box 127788Abu DhabiUnited Arab Emirates

Organic solar cells(OsCs)in terms of power conversion efficiency(PCE)and operational lifetime have made remarkable progress during the last decade by improving the active layer materials and introducing new *** newly developed wide bandgap organic donor and low bandgap acceptor molecules covered the absorption from the visible to the near-infrared *** the incident high energy region(UV)is not in favor of *** absorption causes thermalization losses and photoinduced degradation,which hinders the PCE and lifetime of ***,lanthanide and non-lanthanide-based down-conversion(DC)materials have been introduced,which can effectively convert the high-energy photons(UV)to low-energy photons(visible)and resolve the spectral mismatch losses that limit the absorption of OsCs in high energy incident ***,the DC materials also protect the OsCs from UV-induced *** DC materials were also proposed to cross the shockley-Queisser efficiency limit of the solar *** this review,the need for DC materials and their processing method for OsCs have been thoroughly ***,the main emphasis has been given to developing lanthanides and non-lanthanides-based DC materials for OsCs,their applications,and their impact on photovoltaic device performance,stability,and future perspectives.

关键词： down-conversion down-shifting lanthanides organic solar cells photostability

Role of C11-FDG dual-tracer PET-CT scan in metastatic screening of hepatocellular carcinoma-a cost-effectiveness analysis

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Hepatobiliary surgery and Nutrition 2021年第3期10卷 301-307页

作者： Kevin K.W.Chu Albert C.Y.Chan ka Wing Ma Wong Hoi she Wing Chiu Dai Kenneth s.H.Chok Tan To Cheung Chung Mau Lo Department of surgery The University of Hong KongHong KongChina

Background:We aimed to identify predictive factors for positron emission tomography(PET)-detected hepatocellular carcinoma(HCC)metastasis and a cost-effective approach to preoperative PET-computed tomography(CT)for detecting ***:Clinicopathological and survival data of HCC patients having PET-CT with 18F-fludeoxyglucose(FDG)and 11C-acetate(ACT)following contrast-enhanced CT/magnetic resonance imaging(MRI)for preoperative tumor staging were *** logistic regression was performed to identify predictive factors for PET-detected metastasis.A cost-benefit analysis model was built for the incurred costs and the impact of PET-CT findings on treatment strategy was ***:Totally 152 patients were ***-tracer PET-CT detected metastasis in 17 patients(11%).By multivariate analysis,alpha-fetoprotein(AFP)≥400 ng/mL[relative risk(RR):4.30,95%confidence interval(CI):1.41-13.15,P=0.011]and bilobar disease(RR:3.94,95%CI:1.24-12.52,P=0.014)were independent predictive factors for PET-detected ***-CT findings altered the treatment strategy for 12 patients(7.9%);three partial hepatectomies,eight episodes of transarterial chemoembolization(TACE)and one episode of ablation were avoided,with an estimated cost-saving of Us$91,000,$150,000 and$10,600 *** the PET-CT been performed only for patients with AFP≥400 ng/mL or bilobar disease(n=74),metastasis would have been confirmed in 14 patients(18.9%),and the cost-saving per patient was estimated at Us$1,***:Dual-tracer PET-CT is cost-effective and useful for preoperative HCC staging in patients with AFP≥400 ng/mL or bilobar *** routine use in preoperative workup for all HCC patients is not *** disease with AFPs with either factor can avoid unnecessary procedures and is thus cost-effective for preoperative HCC workup.

关键词： Cost-effectiveness study dual-tracer positron emission tomography-computed tomography(dual-tracer PET-CT) hepatocellular carcinoma(HCC) metastatic screening preoperative investigation

Integrative Medicine,a New Model for the World

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China Today 2005年第2期54卷 34-35页

作者： ka-KIT HUI is a professor and direc-tor of the Center for East-West Medi-cine

ANITA De Franz has dedicated her life to sports and to the Olympics. she was team captain and won a bronze medal for rowing at the Montreal Olympic Games in 1976. In 1986 she was elected member of the International Olympic Committee and in 1996 she became the IOC's first female vice president. she is currently president of the Amateur Athletic Foundation in Los Angeles,California, the site of the 1984 Olympics in which China first participated after many years of absence from the Games.

关键词：安尼塔中国医药行业药品开发