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Microplastic exposure disturbs sleep structure,reduces lifespan,and decreases ovary size in Drosophila melanogaster

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Zoological Research 2024年第4期45卷 805-820页

作者： Wei Yan Zi-Jie li Zi-Yi lin Shu-Qin Ji William ka Fai Tse Zhi-Qiang Meng Chang liu lei li Shenzhen-Hong Kong Institute of Brain Science Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518000China CAS Key laboratory of Brain Connectome and Manipulation the Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518000China laboratory of Developmental Disorders and Toxicology Center for Promotion of International Education and ResearchFaculty of AgricultureKyushu UniversityFukuokaFukuoka 819-0395Japan Shenzhen Key laboratory of Drug Addiction the Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518000China Guangdong Provincial Key laboratory of Brain Connectome and Behavior Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518000China

The organ-specific toxicity resulting from microplastic(MP)exposure has been extensively explored,particularly concerning the gut,liver,testis,and ***,under natural conditions,these effects are not restricted to specific organs or *** whether MP exposure presents a systemic threat to an entire organism,impacting factors such as lifespan,sleep,and fecundity,is *** this study,we investigated the effects of dietary exposure to two different doses of MPs(1–5μm)using the terrestrial model organism Drosophila *** indicated that the particles caused gut damage and remained within the digestive *** MP exposure significantly shortened the lifespan of adult *** short-term exposure disrupted sleep patterns,increasing the length of daytime sleep ***,one week of MP exposure reduced ovary size,with a trend towards decreased egg-laying in mated *** MPs did not penetrate the brain or ovaries,transcriptome analysis revealed altered gene expression in these *** the ovary,Gene Ontology(GO)analysis indicated genotoxic effects impacting inflammation,circadian regulation,and metabolic processes,with significant impacts on extracellular structure-related *** the brain,GO analysis identified changes in pathways associated with proteolysis and carbohydrate ***,this study provides compelling evidence of the systemic negative effects of MP exposure,highlighting the urgent need to address and mitigate environmental MP pollution.

关键词： Microplastics Sleep lifespan Reproduction Risk assessment Drosophila melanogaster

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工匠精神融入工科高校学风建设路径探究

大学（研究与管理） 2024年第4期 34-37页

作者：樊玉华任伟健靳凯山东科技大学机械电子工程学院山东青岛266590

当前,我国正处于实现中华民族伟大复兴的关键时期,对高质量人才的需求更加迫切。高校作为人才培养的重要场所,肩负着“为党育人、为国育才”的重要使命,学风建设作为大学精神的集中体现,是立德树人的本质要求,更是高校培养高素质人才、... 详细信息

当前,我国正处于实现中华民族伟大复兴的关键时期,对高质量人才的需求更加迫切。高校作为人才培养的重要场所,肩负着“为党育人、为国育才”的重要使命,学风建设作为大学精神的集中体现,是立德树人的本质要求,更是高校培养高素质人才、实现高质量科技创新的坚实基础和强力保障。文章立足工科高校专业和学生特点,分析工匠精神内涵意蕴,提出将其融入工科高校学风建设的对策建议,旨在帮助高校落实立德树人根本任务,提高人才培养质量,促进大学生全面成长成。

关键词：工匠精神工科高校学风建设

The role of lIN28B in tumor progression and metastasis in solid tumor entities

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Oncology Research 2023年第2期31卷 101-115页

作者： TABEA GEWAlT ka-WON NOH lYDIA MEDER Department I of Internal Medicine Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Center for Molecular Medicine Cologne University of CologneCologneGermany Institute for Pathology Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Mildred Scheel School of Oncology Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany

lIN28B is an RNA-binding protein that targets a broad range of microRNAs and modulates their maturation and *** normal conditions,lIN28B is exclusively expressed in embryogenic stem cells,blocking differentiation and promoting *** addition,it can play a role in epithelial-to-mesenchymal transition by repressing the biogenesis of let-7 *** malignancies,lIN28B is frequently overexpressed,which is associated with increased tumor aggressiveness and metastatic *** this review,we discuss the molecular mechanisms of lIN28B in promoting tumor progression and metastasis in solid tumor entities and its potential use as a clinical therapeutic target and biomarker.

关键词： Cancer Metastasis lIN28B let-7 Stemness EMT Resistance

集束化护理联合护理路径对重症肺炎并发呼吸衰竭患者的血气指标、炎症因子及生活质量的影响

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海南医学 2024年第13期35卷 1968-1972页

作者：陈卡佳袁爱枝樊聪智马兰开封市中心医院呼吸内科重症监护病房河南开封475000 开封市中心医院呼吸与危重症医学科河南开封475000

目的探讨集束化护理联合护理路径对重症肺炎并发呼吸衰竭患者的血气指标、炎症因子及生活质量的影响。方法选择2020年1月至2023年1月开封市中心医院收治的100例重症肺炎并发呼吸衰竭患者进行研究,按随机数表法分为观察组和对照组各50... 详细信息

目的探讨集束化护理联合护理路径对重症肺炎并发呼吸衰竭患者的血气指标、炎症因子及生活质量的影响。方法选择2020年1月至2023年1月开封市中心医院收治的100例重症肺炎并发呼吸衰竭患者进行研究,按随机数表法分为观察组和对照组各50例。对照组患者给予常规护理,观察组患者在对照组护理基础上给予集束化护理联合护理路径护理,两组患者均护理至出院。比较两组患者的预后情况,以及护理前后的血气指标[动脉血氧分压(PaO_(2))、动脉血氧饱和度(SaO_(2))/动脉血二氧化碳分压(PaCO_(2))]、炎症因子[C反应蛋白(CRP)、降钙素原(PCT)、白细胞介素-6 (Il-6)]及简明生活质量简表(SF-36)评分,并比较两组患者的并发症发生情况。结果观察组患者的气促缓解时间、机械通气时间、住IUC时间及住院时间分别为(2.78±0.72) d、(23.09±3.10) d、(4.28±0.74) d、(10.21±2.17) d,明显短于对照组的(3.98±0.81) d、(27.98±2.98) d、(7.09±1.27) d、(14.28±2.37) d,差异均有统计学意义(Pl-6、PCT、CRP水平均降低,且观察组患者的上述指标分别为(51.28±6.20) ng/l、(1.28±0.23)μg/l、(12.09±3.18) mg/l,明显低于对照组的(62.18±5.98) ng/l、(1.98±0.31)μg/l、(17.29±3.09) mg/l,差异均有统计学意义(P<0.05);护理后,两组患者的生活质量各项评分均升高,且观察组患者的生理功能、物质生活、社会功能、情感职能评分分别为(67.21±5.11)分、(70.28±5.09)分、(72.38±5.21)分、(72.19±5.01)分,明显高于对照组的(60.93±4.921)分、(63.28±4.99)分、(65.82±4.90)分、(64.29±4.93)分,差异均有统计学意义(P<0.05);观察组患者的并发症总发生率为6.00%,明显低于对照组的20.00%,差异有统计学意义(P<0.05)。结论集束化护理联合护理路径应用于重症肺炎所致的呼吸衰竭效果良好,可促进患者血气指标恢复,降低炎症反应,提高患者生活质量,安全性高,可在临床推广运用。

关键词：重症肺炎呼吸衰竭护理路径集束化护理炎症因子生活质量并发症

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Advantageous mechanochemical synthesis of copper(Ⅰ)selenide semiconductor,characterization,and properties

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Frontiers of Chemical Science and Engineering 2022年第3期16卷 433-442页

作者： katarína Gáborová Marcela Achimovičová Michal Hegedüs Vladimír Girman Mária kaňuchová Erika Dutková Institute of Geotechnics Slovak Academy of SciencesKošice04001Slovakia Institute of Metallurgy Faculty of MaterialsMetallurgy and RecyclingTechnical UniversityKošice04201Slovakia Synthon s.r.o.Blansko67801Czech Republic Faculty of Science Pavol JozefŠafárik UniversityKošice04154Slovakia Institute of Earth Resources Faculty of MiningEcologyProcess Control and GeotechnologiesTechnical UniversityKošice04200Slovakia

Copper(I)selenide-nanocrystalline semiconductor was synthesized via one-step mechanochemical synthesis after 5 min milling in a planetary ball *** kinetics of synthesis was followed by X-ray powder diffraction analysis and specific surface area measurements of milled 2Cu/Se *** X-ray diffraction confirmed the orthorhombic crystal structure of Cu_(2)Se with the crystallite size∼25 *** surface chemical structure was studied by X-ray photoelectron spectroscopy,whereby the binding energy of the Cu 2p and Se 3d signals corresponded to Cu^(+)and Se^(2−)oxidation *** electron microscopy revealed agglomerated nanocrystals and confirmed their orthorhombic structure,as *** optical properties were studied utilizing ultraviolet-visible spectroscopy and photoluminescence *** direct bandgap energy 3.7 eV indicated a blue-shift phenomenon due to the quantum size *** type of Cu_(2)Se synthesis can be easily adapted to production dimensions using an industrial vibratory *** advantages of mechanochemical synthesis represent the potential for inexpensive,environmentally-friendly,and waste-free manufacturing of Cu_(2)Se.

关键词： Cu_(2)Se berzelianite nanocrystalline semiconductor mechanochemical synthesis planetary ball mill

基于网络药理学和体内实验探讨茯苓多糖抗对乙酰氨基酚致肝损伤的作用机制

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右江民族医学院学报 2024年第4期46卷 451-457,473页

作者：秦丽秀吴咖刘慧裕陈庆婷莫洁杨斌广西医科大学药学院广西南宁530021 广西南宁市第二人民医院广西南宁530031

目的利用网络药理学和体内实验,探讨茯苓多糖(PCP)抗对乙酰氨基酚(APAP)致肝损伤的作用靶点。方法通过SwissTargetPrediction数据库、SuperPred数据库和Pharmmapper数据库获取PCP的作用靶点,利用OMIM数据库、GeneCards数据库查找APAP致... 详细信息

目的利用网络药理学和体内实验,探讨茯苓多糖(PCP)抗对乙酰氨基酚(APAP)致肝损伤的作用靶点。方法通过SwissTargetPrediction数据库、SuperPred数据库和Pharmmapper数据库获取PCP的作用靶点,利用OMIM数据库、GeneCards数据库查找APAP致肝损伤相关作用靶点,使用String数据库构建蛋白互作网络(PPI)并筛选核心靶点。利用R软件进行基因本体(GO)和京都基因与基因组百科全书(KEGG)通路分析,通过AutoDuck vina软件对茯苓多糖和核心靶点进行分子对接。最后,用HE染色评估小鼠肝组织损伤情况,并且通过RT-PCR和免疫组化染色法(IHC)检测核心靶点的表达情况。结果共获得26个核心靶点,GO富集分析显示细胞凋亡、细胞周期、免疫等生物过程可能参与PCP抗APAP致肝损伤的进程。KEGG富集分析显示茯苓多糖抗APAP致肝损伤的信号通路主要集中在p53信号通路(p53 signaling pathway)、NOD样受体信号通路(NOD-like receptor signaling pathway)、TNF信号通路(TNF signaling pathway)等。分子对接结果显示,PCP与等核心靶点具有较好的结合能力。HE染色显示,APAP组小鼠肝组织形态结构出现异常,表现为细胞大面积坏死,而PCP干预后可以减轻肝组织损伤。RT-PCR和IHC结果表明,PCP通过逆转APAP暴露引起的CDK2、TNF、BCl2l1及MAOA水平升高来缓解小鼠肝损伤。结论通过网络药理学和体内实验找到了PCP抗APAP致肝损伤的可能潜在靶点,其作用机制可能与调节细胞周期、免疫反应、凋亡和药物代谢有关。

关键词：酰氨酚化学性与药物性肝损伤茯苓多糖保护作用

Corneal blindness and current major treatment concerngraft scarcity

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International Journal of Ophthalmology(English edition) 2017年第7期10卷 1154-1162页

作者： kah Hie Wong ka Wai kam li Jia Chen Alvin l.Young Department of Ophthalmology and Visual Sciences Chinese University of Hong Kong Department of Ophthalmology and Visual Sciences Prince of Wales Hospital

According to World Health Organization, the global prevalence of blindness in 2010 was 39 million people, among which 4% were due to corneal opacities. Often, the sole resort for visual restoration of patients with damaged corneas is corneal transplantation. However, despite rapid developments of surgical techniques, instrumentations and immunosuppressive agents, corneal blindness remains a prevalent global health issue. This is largely due to the scarcity of good quality corneal grafts. In this review, the causes of corneal blindness, its major treatment options, and the major contributory factors of corneal graft scarcity with potential solutions are discussed.

关键词： corneal blindness keratoplasty corneal graft corneal donation eye banking

苯丁酸甘油酯治疗儿童鸟氨酸氨甲酰基转移酶缺乏症1例

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中国当代儿科杂志 2024年第5期26卷 512-517页

作者：杨帆王立瑞李辛胡佳悦应令雯冯碧云李芸芸林卡娜佘佳笑李浩常国营王秀敏上海交通大学医学院附属上海儿童医学中心临床研究病区上海200127 上海交通大学医学院附属上海儿童医学中心内分泌遗传代谢科上海200127 云南省德宏州陇川县人民医院儿科云南德宏678700

苯丁酸甘油酯(glyceryl phenylbutyrate,GPB)是治疗鸟氨酸氨甲酰基转移酶缺乏症(ornithine transcarbamylase deficiency,OTCD)的长期管理药物,可有效控制高氨血症,但国内使用该药的经验匮乏。该文回顾性分析上海交通大学医学院附属上... 详细信息

苯丁酸甘油酯(glyceryl phenylbutyrate,GPB)是治疗鸟氨酸氨甲酰基转移酶缺乏症(ornithine transcarbamylase deficiency,OTCD)的长期管理药物,可有效控制高氨血症,但国内使用该药的经验匮乏。该文回顾性分析上海交通大学医学院附属上海儿童医学中心1例诊断为OTCD的患儿资料,并进行相关文献复习。该患儿确诊后使用GPB治疗,随后进行疗效随访和药学监测。患儿,男,6岁6个月,语言发育差,不听指令,脾气暴躁并伴有攻击性行为。监测血氨最高327μmol/l;尿有机酸分析提示尿嘧啶水平升高;头颅磁共振成像示双侧大脑半球广泛异常信号;基因检测发现OTC基因新生突变(c.241T>C,p.S81P)。予以GPB治疗后1、2、3个月左右的血氨分别为43、80、56μmol/l。患儿治疗期间血氨控制良好,未见与药物相关的不良反应,发育落后情况较前改善,可听指令,脾气好转,无攻击性行为。

关键词：苯丁酸甘油酯鸟氨酸氨甲酰基转移酶缺乏症尿素循环障碍高氨血症药学监测儿童

Correct Interpretation of Creep Rates: A Case Study of Cu

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Journal of Materials Science & Technology 2015年第11期31卷 1065-1068页

作者： W.Blum J.Dvoák P.Král P.Eisenlohr V.Sklenika Institut für Werkstoffwissenschaften University of Erlangen-Nürnberg Institute of Physics of Materials Academy of Sciences of the Czech Republic Department of Chemical Engineering and Materials Science Michigan State University

Traditionally the deformation resistance in creep is characterized by the minimum creep rate εmin and its sensitivity to stress （stress exponent n） and temperature （activation energy Q）. Various values of constant n have been reported in the literature and interpreted in terms of specific mechanisms. The present case study of coarse-grained Cu at 573 K yields a stress exponent n = 9 for εmin. in tension and a relatively low activation energy. The evolution of the deformation resistance with strain at constant tensile creep load and comparison with creep in compression without fracture indicates that the tensile εmin. result from transition from uniform deformation to strain localization during fracture. This is confirmed by the results of creep in compression where fracture is suppressed. Both the tensile εmin, and the compressive creep rate at strains around 0.3 can be described using existing equations for quasi-stationary deformation containing the subgrain boundary misorientation θ as structure parameter. While in the latter case constant θ leads to monotonic increase of n with stress, the tensile nine-power-law results from variable θ, and has no simple meaning. The result of this case study means that uncritical interpretation of minimum tensile creep rates as stationary ones bears a high risk of systematic errors in the determination of creep parameters and identification of creep mechanisms.

关键词： Cu Creep Minimum creep rate Activation energy Stress exponent