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Asian Journal of Ph.rmaceutical Sciences 2023年第1期18卷 97-107页

作者： ka h.ng Wong Zh.opei Guo Di Jiang Xingzh. Zh.u Lizh. Lin Denggao Zh.o Meiwan Ch.n State Key Laboratory of Quality research.in Ch.nese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao 999078China Th. First Affiliated h.spital of Guangzh.u University of Ch.nese Medicine Guangzhou 510407China Sch.ol of Biotech.ology and h.alth.Sciences Wuyi UniversityJiangmen 529020China

Nano drug delivery systems h.ve made significant progress in delivering anticancer drugs camptoth.cin(CPT).h.wever,many ch.llenges for CPT delivery remain,including low drug loading efficiency,premature drug leakage,and poor cellular ***,we report a novel dual-sensitive polypeptide-based micelle with.remarkably h.gh.drug loading of CPT for cancer *** self-assembled micelle possesses th. following essential components for CPT:(1)ph.sensitive PEG(Oh.-PEG-Ch.)for prolonging blood circulation and allowing biocompatibility by sh.elding th. cationic micelles,wh.ch.can be detach.d under th. tumor acidic microenvironment and facilitates th. cellular uptake;(2)polypeptide polylysine-polyph.nylalanine(PKF)synth.sized via ring-opening polymerization for micelle formation and CPT analogue loading;(3)dimeric CPT(DCPT)with.redox-sensitive linker for increasing CPT loading and ensuring drug release at tumor ***,th. linear-like morph.logy of PEG-PKF/DCPT micelles was able to enh.nce th.ir cellular internalization wh.n compared with.th. sph.rical blank PKF ***,th. anticancer efficacy of DCPT against lung cancer cells was significantly improved by th. micelle *** conclusion,th.s work provides a promising strategy facilitating th. safety and effective application of CPT in cancer th.rapy.

关键词： Dimeric camptoth.cin ph.sensitive Redox-responsive Cancer th.rapy Self-assembled micelle

Formation of ST Plasmas by ECh.on LATE

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Plasma Science and Tech.ology 2004年第4期6卷 2364-2366页

作者： M.Uch.da T.Maekawa h.Tanaka h.Igami T.Yosh.naga K.katsuura M.Konno Kyoto University Kita shirakawa Oiwake-choKyoto 606-8502JapanKyoto UniversityKita shirakawa Oiwake-choKyoto 606-8502JapanKyoto UniversityKita shirakawa Oiwake-choKyoto 606-8502JapanKyoto UniversityKita shirakawa Oiwake-choKyoto 606-8502JapanKyoto UniversityKita shirakawa Oiwake-choKyoto 606-8502JapanKyoto UniversityKita shirakawa Oiwake-choKyoto 606-8502JapanKyoto UniversityKita shirakawa Oiwake-choKyoto 606-8502Japan

Experiments on formation of sph.rical tokamak (ST) plasmas by electroncyclotron h.ating (ECh. alone with.ut a central Oh.solenoid h.ve been carried out on LATE (LowAspect ratio Torus Experiments). By injecting a 2.45 Gh. microwave pulse of 6.3 kW for 4 seconds, aplasma current is initiated and ramped up to I_p approx= 3 ka, and finally maintained for 1 secondby adjusting th. external vertical field. Magnetic measurements sh.w th.t closed flux surfaces areformed and th. last closed flux surface h.s an aspect ratio of A ～ 1.3 and an elongation of κ～1.3. Th. electron density measured by an interferometer is more th.n 1.5 x 10^(11) cm^(-3) wh.ch.xceeds twice of th. plasma cut-off density, suggesting th.t electron cyclotron h.ating bymode-converted electron Bernstein waves may take place.

关键词： sph.rical tokamak non-inductive start-up electron cyclotron h.ating

SALVIA MILTIORRh.ZA BUNGE——~1h.NMR METABOLOMICS APPROACh.IN TCM QUALITY CONTROL

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World Journal of Traditional Ch.nese Medicine 2016年第2期 80-81页

作者： ka Yui Kum Anth.ny Booker Ch.istine Leon José Prieto García Mich.el h.inrich Biodiversity and Medicines research.Cluster UCL School of Pharmacy Royal Botanic Gardens

Introduction:Many Dansh.n(DS-Radix Salviae miltiorrh.zae-SM)products are found on th. global market albeit with.ut suitable quality *** substitutes including Salvia przewalskii Maxim,*** *** Salvia sinica *** similar ... 详细信息

关键词： NMR METABOLOMICS APPROACh.IN TCM QUALITY CONTROL TCM SALVIA MILTIORRh.ZA BUNGE

二甲基亚砜-水混合溶液的等效介电常数特异性研究

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化学学报 2008年第9期66卷 1107-1110页

作者：杨晓庆黄卡玛贾国柱四川大学电子信息学院成都610065

在2.45Gh.下利用微扰谐振腔法测量二甲基亚砜(DMSO)-水(h.O)混合溶液的等效介电常数过程中,发现混合溶液等效介电常数虚部大于其中任一组分的介电常数虚部的特异现象.分析表明,这种特异性现象的发生主要是由于DMSO与h.O混合后溶液的高... 详细信息

在2.45Gh.下利用微扰谐振腔法测量二甲基亚砜(DMSO)-水(h.O)混合溶液的等效介电常数过程中,发现混合溶液等效介电常数虚部大于其中任一组分的介电常数虚部的特异现象.分析表明,这种特异性现象的发生主要是由于DMSO与h.O混合后溶液的高频摩擦项大于混合前引起的.因此,经典混合物介电常数公式需要进行适当修正才能较好地适用于这类特异性问题计算.

关键词：混合溶液等效介电常数特异性混合物公式氢键

改良抵钉座体外置入法在经肛门外翻切除标本腹部无辅助切口腹腔镜低位直肠癌根治术中的应用

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中华胃肠外科杂志 2018年第8期21卷 913-917页

作者：李兴旺陈河金李柄辉王晨宇张军杰胡军红河南大学淮河医院普通外科开封475000

目的探讨改良的抵钉座体外置入法在经肛门外翻切除标本的腹部无辅助切口腹腔镜低位直肠癌根治术中应用的可行性及临床价值。方法河南大学淮河医院普通外科于2015年6月至2017年6月期间，对17例低位直肠癌患者施行了改良的抵钉座体外置入... 详细信息

目的探讨改良的抵钉座体外置入法在经肛门外翻切除标本的腹部无辅助切口腹腔镜低位直肠癌根治术中应用的可行性及临床价值。方法河南大学淮河医院普通外科于2015年6月至2017年6月期间，对17例低位直肠癌患者施行了改良的抵钉座体外置入法经肛门外翻切除标本的腹部无辅助切口腹腔镜低位直肠癌根治术。病例纳入标准：（1）肿瘤下缘距肛缘4-6cm的低位直肠癌；（2）隆起型肿瘤环周径〈3cm；（3）溃疡型肿瘤浸润肠管〈1／2周；（4）无远处转移，术前盆腔核磁共振提示T1-3N0M0；排除体质指数〉35kg／m^2者以及乙状结肠及其系膜长度不足或肥厚者。对这组患者的临床资料进行回顾性分析。术中患者均按照全直肠系膜切除（TME）原则，充分游离直肠及其系膜，肿瘤上缘预切断处裸化并离断肠管，经肛门置人卵圆钳夹取直肠残端经肛门将直肠外翻于体外，直视下在肿瘤下缘1～2cm处切断直肠，将乙状结肠远端经肛门拉出体外，置入抵钉座后荷包缝合，送回腹腔，荷包缝合直肠残端后行乙状结肠直肠端-端吻合。结果17例患者中，男性10例，女性7例，年龄42～71（中位数58）岁，体质指数20．6～33．5（中位数26．0）kg／m^2，术前肿瘤分期Ⅰ期2例，Ⅱ期15例；肿瘤距离肛缘4～6（中位数5．0）cm；肿瘤最大直径3．4～4．8（中位数4．2）cm。全组患者手术均顺利完成，无一例中转开腹，手术时间124～182（中位数136）min；1例患者因乙状结肠系膜游离不充分，致乙状结肠远端拉出体外困难，腹腔镜下再次充分游离乙状结肠降结肠后操作成功。术中出血量10—50（中位数20）ml。术后病理分期Ⅰ期2例，Ⅱ期12例，Ⅲ期3例：肿瘤分化程度：低分化腺癌1例，中分化腺癌15例，高分化腺癌1例。患者术后排气时间24～128（中位数36）h.住院时间5～15（中位数8）d。术后均无吻合口漏和腹腔内感染出现。术后15例患者获5—24个月的随访，未见局部复发或远处转移。结论改良的抵钉座体外置入法应用于经肛门外翻切除标本的腹部无辅助切口腹腔镜低位直肠癌根治术安全可行。

关键词：结直肠肿瘤经自然腔道标本取出手术腹腔镜免辅助切口抵钉座

Ch.nese progress in geomorph.metry

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Journal of Geograph.cal Sciences 2017年第11期27卷 1389-1412页

作者： LV Guonian XIONG Liyang Ch.N Min TANG Guoan Sh.NG Yeh.a LIU Xuejun SONG Zh.yao LU Yuqi YU Zh.oyuan Zh.NG ka WANG Meizh.n Key Laboratory of Virtual Geograph.c environment Ministry of Education of PRC Nanjing Normal University Nanjing 210023 China State Key Laboratory Cultivation Base of Geograph.cal environment Evolution (Jiangsu Province) Nanjing 210023 China Jiangsu Center for Collaborative Innovation in Geograph.cal Information resource Development and Ap- plication Nanjing 210023 China Sch.ol of Geograph. science Nanjing Normal University Nanjing 210023 China

Geomorph.metry, th. science of digital terrain analysis （DTA）, is an important focus of research.in both.geomorph.logy and geograph.cal information science （GIS）. Given th.t 70% of Ch.na is mountainous, geomorph.logical research.is popular among Ch.nese sch.l- ars, and th. development of GIS over th. last 30 years h.s led to significant advances in geomorph.metric research. In th.s paper, we review Ch.nese progress in geomorph.metry based on th. publish.d literature. Th.re are th.ee major areas of progress： digital terrain modelling meth.ds, DTA meth.ds, and applications of digital terrain models （DTMs）. First, traditional vector- and raster-based terrain modelling meth.ds, including th. assessment of uncertainty, h.ve received widespread attention. New terrain modelling meth.ds such.as unified raster and vector, h.gh.fidelity, and real-time dynamic geograph.cal scene modelling h.ve also attracted research.attention and are now a major focus of digital terrain modelling research. Second, in addition to th. popular DTA meth.ds based on topograph.cal derivatives geomorph.logical features, and h.drological factors extracted from DTMs, DTA meth.ds h.ve been extended to include analyses of th. structure of underlying strata, ocean surface features and even socioeconomic spatial structures. Th.rd, DTMs h.ve been applied to fields including global climate ch.nge, analysis of various typical regions, lunar surface and oth.r related fields. Clearly, Ch.nese sch.lars h.ve made significant progress in geomorph.metry. Ch.nese sch.lars h.ve h.d th. greatest international impact in areas including h.gh.fidelity digital terrain modelling and DTM-based regional geomorph.logical analysis, particularly in th. Loess Plateau and th. Tibetan Plateau regions.

关键词： geomorph.metry digital terrain model digital terrain analysis progress Ch.na

多孔活性磷酸钙悬浮聚合分散剂的制备及性能研究

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四川大学学报（工程科学版） 2006年第6期38卷 73-78页

作者：徐卡秋徐家乐王渝红四川大学化学工程学院四川成都610065

以碳酸钙和磷酸为原料制备活性磷酸钙悬浮聚合分散剂。用SEM、XRD、BET氮吸附等对产物进行表征。结果表明，制得的活性磷酸钙分散剂具有多孔结构，堆密度小，比表面积大，粒度均匀，微粒间不易团聚。较佳的合成条件为：碳酸钙水悬浮液... 详细信息

以碳酸钙和磷酸为原料制备活性磷酸钙悬浮聚合分散剂。用SEM、XRD、BET氮吸附等对产物进行表征。结果表明，制得的活性磷酸钙分散剂具有多孔结构，堆密度小，比表面积大，粒度均匀，微粒间不易团聚。较佳的合成条件为：碳酸钙水悬浮液的固含量90g／L、磷酸浓度1．0mol／L、反应／陈化温度50℃、陈化时间3h.所制得的多孔悬浮聚合分散剂的比表面积为106．8m^2／g，约为日本及市售国产活性磷酸钙分散剂比表面积的1．5～1．8倍。在苯乙烯悬浮聚合中的应用结果表明，多孔结构的磷酸钙分散剂表面活性高，悬浮分散性和稳定性优良，能显著提高聚苯乙烯珠粒的质量。

关键词：活性磷酸钙多孔结构无机分散剂悬浮聚合

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基于NSCT的立体影像匹配相似性测度计算

武汉大学学报（信息科学版） 2015年第4期40卷 457-461页

作者：张卡盛业华管忠诚李佳南京师范大学虚拟地理环境教育部重点实验室江苏南京210023 南京师范大学江苏省地理信息资源开发与利用协同创新中心江苏南京210023 南京师范大学警用地理信息技术公安部重点实验室江苏南京210023 青岛市市政工程设计研究院有限责任公司山东青岛266101

提出了一种新的基于非下采样Contourlet变换(NSCT)的加权相似性测度计算方法。首先对立体像对中的左右影像分别进行NSCT变换,以得到左右影像的不同尺度、不同方向的高频子带系数;然后利用影像的高频子带系数和RGB三个通道的灰度值,设计... 详细信息

提出了一种新的基于非下采样Contourlet变换(NSCT)的加权相似性测度计算方法。首先对立体像对中的左右影像分别进行NSCT变换,以得到左右影像的不同尺度、不同方向的高频子带系数;然后利用影像的高频子带系数和RGB三个通道的灰度值,设计了目标窗口和搜索窗口的加权相似性测度计算模型;最后,利用标准立体影像数据,对相似性测度和归一化相关系数等已有测度进行了对比实验。结果表明,NSCT的高频系数的引入增强了相似性测度的稳健性,提高了立体影像匹配的可靠性。

关键词：立体影像匹配非下采样Contourlet变换加权相似性测度结构特征匹配可靠性

Wh.te luminescence of h.^(3+)/Tm^(3+)/Yb^(3+)-codoped CaWO_4 synth.sized via citrate complex route assisted by microwave irradiation

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Transactions of Nonferrous Metals Society of Ch.na 2014年第S1期24卷 134-140页

作者： h.un Ch. Seok Min h.ANG Jae Bin LEE Dong h.un ka Tae Wan KIM Bo Seul LEE Ji Young LEE Jung-Il LEE Jeong h. RYU Department of Nanomech.tronics engineering Pusan National University50 Cheonghak-ri Miryang Gyeongnam 627-706 Korea Department of Materials Science and engineering Korea National University of Transportation Chungju Chungbuk 380-702 Korea

Th. nanocrystalline h.3+/Tm3+/Yb3+ co-doped CaWO4 upconversion(UC) ph.sph.rs were successfully synth.sized by a modified citrate complex meth.d using microwave irradiation. Th. citrate complex precursors were h.at-treated at temperature ranging from 300 to 700 °C for 3 h. Crystallization of th. h.3+/Tm3+/Yb3+ co-doped CaWO4 was detected at 400 °C, and entirely completed at 600 °C. Th. h.3+/Tm3+/Yb3+ co-doped CaWO4 h.at-treated at 600 °C sh.wed primarily sph.rical and h.mogeneous morph.logy. Under th. laser excitation of 980 nm, h.3+/Tm3+/Yb3+ co-doped CaWO4 sh.ws th. brigh. wh.te upconversion(UC) emission visible to th. naked eye, wh.ch.is composed of a blue emission at 475 nm from Tm3+, and green and red emissions at 543 and 651 nm respectively from h.3+. Th. coordinates of h.3+/Tm3+/Yb3+ co-doped CaWO4 in th. Commission International De'eclairage(CIE) ch.omaticity diagram could be controlled from a cool to a warm wh.te color depending on th. Tm3+ and h.3+ concentrations. Th. UC luminescent properties on Tm3+ and h.3+ concentrations and related mech.nism based on laser pump power were discussed in detail.

关键词： upconversion CaWO4 microwave irradiation wh.te luminescence

Baseline gut microbiota and metabolome predict durable immunogenicity to SARS-CoV-2 vaccines

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Signal Transduction and Targeted Th.rapy 2023年第10期8卷 5085-5095页

作者： Ye Peng Lin Zh.ng Ch.is K.P.Mok Jessica Y.L.Ch.ng Sh.lin Zh.o Matth.w K.L.Wong Jie Zh. Ch.nke Ch.n Sh.lan Wang Sh.ai Yan Biyan Qin Yingzh. Liu Xi Zh.ng Ch.n Pun Ch.ung Pui Kuan Ch.ong ka Long Ip Adrian C.h.Fung Kenneth.K.Y.Wong David S.C.h.i Francis K.L.Ch.n Siew C.Ng h.in M.Tun Microbiota I-Center(MaglC) Hong KongChina Jockey Club Sch.ol of Public h.alth.and Primary Care The Chinese University of Hong KongHong KongChina Li ka Sh.ng Institute of h.alth.Sciences Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Medicine and Th.rapeutics The Chinese University of Hong KongHong KongChina Department of Surgery LKS Faculty of MedicineThe University of Hong KongHong KongChina Stanley h. Centre for Emerging Infectious Diseases Faculty of MedicineThe Chinese University of Hong KongHong KongChina Centre for Gut Microbiota research The Chinese University of Hong KongHong KongChina

Th. role of gut microbiota in modulating th. durability of cOVID-19 vaccine immunity is yet to be *** th.s coh.rt study,we collected blood and stool samples of 121 BNT162b2 and 40 CoronaVac vaccinees at baseline,1 month.and 6 month. post vaccination(p.v).Neutralisation antibody,plasma cytokine and ch.mokines were measured and associated with.th. gut microbiota and metabolome composition.

关键词： vaccine immunity vaccines