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Ku波段全腔提取相对论磁控管仿真设计

强激光与粒子束 2024年第10期36卷 133-136页

作者：秦奋徐莎张勇崔悦张玉涵王冬中国工程物理研究院应用电子学研究所先进激光与高功率微波全国重点实验室四川绵阳621900

为了拓展相对论磁控管工作频段,设计了一个Ku波段高效率全腔提取相对论磁控管。该器件采用20腔阳极结构,冷腔模拟结果表明其π模工作频率约为13.5 GHz。结合全腔轴向提取技术,在电压150 kV、电流0.41 ka、工作磁场0.4 T的条件下,PIC仿... 详细信息

为了拓展相对论磁控管工作频段,设计了一个Ku波段高效率全腔提取相对论磁控管。该器件采用20腔阳极结构,冷腔模拟结果表明其π模工作频率约为13.5 GHz。结合全腔轴向提取技术,在电压150 kV、电流0.41 ka、工作磁场0.4 T的条件下,PIC仿真得到38 MW的仿真功率,工作频率13.47 GHz;仿真得到的功率转换效率约61.6%。仿真结果表明该器件转换效率高,结构紧凑,具有实现轻小型永磁包装的潜质。

关键词：高功率微波相对论磁控管全腔提取 Ku波段轻小型化

基于DTI-ALPS指数评价AICI患者的脑胶质淋巴系统功能

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中国医学计算机成像杂志 2024年第2期30卷 129-133页

作者：韦敏姜乔继沙静云严卉姜粲然张超徐州医科大学附属医院放射科徐州221000 徐州医科大学盐城临床学院盐城市第一人民医院神经外科

目的:利用沿血管周围间隙弥散张量成像(DTI-ALPS)评估急性缺血性脑梗死(AICI)患者的脑胶质淋巴系统功能变化。方法:回顾性搜集徐州医科大学附属医院2021年9月至2023年6月收治的33例AICI患者(AICI组)和33例健康志愿者(健康对照组)的临床... 详细信息

目的:利用沿血管周围间隙弥散张量成像(DTI-ALPS)评估急性缺血性脑梗死(AICI)患者的脑胶质淋巴系统功能变化。方法:回顾性搜集徐州医科大学附属医院2021年9月至2023年6月收治的33例AICI患者(AICI组)和33例健康志愿者(健康对照组)的临床及影像学资料,采集所有被试者的DTI参数以计算DTI-ALPS指数,用于评价AICI患者脑胶质淋巴系统功能的变化。结果:AICI组患者病灶侧大脑半球DTI-ALPS指数显著低于健侧(t=-3.11,P<0.01),也显著低于健康对照组(t=-5.20,P<0.01),AICI病灶的体积、病灶至测量层面的距离与病灶侧大脑半球DTI-ALPS指数均无显著相关性(P=0.38;P=0.24)。结论:利用DTI-ALPS指数能够评估AICI患者脑胶质淋巴系统功能变化,且AICI患者脑胶质淋巴系统功能的损害在病灶同侧大脑半球。

关键词：脑胶质淋巴系统急性缺血性脑梗死弥散张量成像血管周围间隙

Long-term clinical outcomes of drug-eluting stents ***-metal stents in Chinese geriatric patients

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Journal of Geriatric Cardiology 2013年第4期10卷 330-335页

作者： Pak-Hei Chan sha-sha Liu Hung-Fat Tse Wing-Hing Chow Man-Hong Jim Hee-Hwa HO Chung Wah Siu Department of Medicine Li Ka Shing Faculty of Medicine The University of Hong Kong 102 Pokfulam Rd Hong Kong China Cardiac Medical Unit Grantham Hospital 125 Wong Chuk Hang Rd Aberdeen Hong Kong China

BACKGROUND & OBJECTIVE: Little is known about the relative efficacies of percutaneous coronary intervention (PCI) with drug-eluting stents (DES) and bare-metal stents (BMS) in elderly patients。 The objective of this study was to evaluate the clinical outcome for geriatric patients who received either DES or BMS。 METHODS: From January 2002 to October 2005, 199 consecutive Chinese geriatric patients (≥ 75 years old) underwent PCI with coronary DES or BMS implantation at our institution。 We analyzed the major clinical end points that included all-cause mortality, cardiovascular death, myocardial infarction, target lesion revascularization (TLR), stent thrombosis, and bleeding complications。 RESULTS: The three-year cumulative rates of all-cause mortality, cardiovascular death, and myocardial infarction were significantly lower in the DES group (6.3%,3.6%,5.4%) compared with the BMS group (16.2%,11.5%,14.9%; P hage, or major and minor hemorrhage at three years。 CONCLUSIONS: DES-based PCI was associated with a significant reduction in the three-year cumulative rate of all-cause mortality, cardiovascular death, and myocardial infarction compared with BMS, without increased risk of TLR, stent thrombosis, or bleeding complications at three years in this group of Chinese geriatric patients。

关键词： Bare-metal stents Drug-eluting stents Geriatric patients Percutaneous coronary intervention

Clinical efficacies,underlying mechanisms and molecular targets of Chinese medicines for diabetic nephropathy treatment and management

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Acta Pharmaceutica Sinica B 2021年第9期11卷 2749-2767页

作者： Guoyi Tang sha Li Cheng Zhang haiyong Chen Ning Wang Yibin Feng School of Chinese Medicine Li Ka Shing Faculty of Medicinethe University of Hong KongHong Kong SAR 999077China

Diabetic nephropathy(DN) has been recognized as a severe complication of diabetes mellitus and a dominant pathogeny of end-stage kidney disease,which causes serious health problems and great financial burden to human society *** strategies,such as renin-angiotensinaldosterone system blockade,blood glucose level control,and bodyweight reduction,may not achieve satisfactory outcomes in many clinical practices for DN ***,due to the multi-target function,Chinese medicine possesses promising clinical benefits as primary or alternative therapies for DN *** studies have emphasized identifying bioactive compounds and molecular mechanisms of reno-protective effects of Chinese *** pathways involved in glucose/lipid metabolism regulation,antioxidation,anti-inflammation,anti-fibrosis,and podocyte protection have been identified as crucial mechanisms of ***,we summarize the clinical efficacies of Chinese medicines and their bioactive components in treating and managing DN after reviewing the results demonstrated in clinical trials,systematic reviews,and meta-analyses,with a thorough discussion on the relative underlying mechanisms and molecular targets reported in animal and cellular *** aim to provide comprehensive insights into the protective effects of Chinese medicines against DN.

关键词： Chinese medicine Herbal medicine Diabetic nephropathy Diabetic kidney disease Signaling pathway Molecular target

应用DTI-ALPS指数观察胶质瘤的脑胶质淋巴系统功能变化

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临床放射学杂志 2024年第3期43卷 332-336页

作者：姜粲然李若涵沙静云蔡璐璐赵厚亮孟冲张超徐凯徐州医科大学附属医院影像科 221000

目的利用沿血管周围间隙扩散张量成像(DTI-ALPS)指数评估脑胶质瘤患者的胶质淋巴系统(GS)功能变化,探索影响脑胶质瘤GS功能的因素。方法回顾性纳入37例经手术病理证实为脑胶质瘤的住院患者和34名健康对照(HCs)。评估脑胶质瘤患者肿瘤... 详细信息

目的利用沿血管周围间隙扩散张量成像(DTI-ALPS)指数评估脑胶质瘤患者的胶质淋巴系统(GS)功能变化,探索影响脑胶质瘤GS功能的因素。方法回顾性纳入37例经手术病理证实为脑胶质瘤的住院患者和34名健康对照(HCs)。评估脑胶质瘤患者肿瘤的部位、大小、信号等常规影像特征后,经ITK-SNAP软件手动勾画胶质瘤瘤体与瘤周水肿(PTBE)并计算体积,测量所有受试者DTI参数值并计算出DTI-ALPS指数。利用t检验观察DTI-ALPS指数的组间差异,用Pearson相关分析观察DTI-ALPS指数与肿瘤体积、PTBE的相关性。结果单因素方差分析显示,肿瘤同侧大脑半球的DTI-ALPS指数(1.23±0.16)显著低于对侧大脑半球(1.34±0.17)(P=0.014)与HCs (1.43±0.15)(P<0.001)。肿瘤对侧大脑半球与HCs的DTI-ALPS指数无显著差异(P=0.075)。肿瘤同侧大脑半球DTI-ALPS指数与PTBE体积呈显著负相关(P=0.008,r=-0.432)。结论利用DTI-ALPS指数能够无创性评估脑胶质瘤GS的功能,且肿瘤同侧GS功能显著减低。PTBE是影响胶质瘤患者GS功能减低的重要因素。

关键词：胶质淋巴系统脑胶质瘤瘤周水肿血管周围间隙扩散张量成像

Complete mitochondrial genome of the Japanese snapping shrimp Alpheus japonicus(Crustacea:Decapoda:Caridea):Gene rearrangement and phylogeny within Caridea

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Science China(Life Sciences) 2012年第7期55卷 591-598页

作者： SHEN Xin LI Xiao sha ZhongLi yaN BinLun XU QiHua Jiangsu Key Laboratory of Marine Biotechnology Huaihai Institute of Technology Lianyungang 222005 China Institute of Oceanology Chinese Academy of Sciences Qingdao 266071 China shandong Peanut Research Institute Qingdao 266100 China

The complete sequence of the mitochondrial genome of the Japanese snapping shrimp Alpheus japonicus Miers （Crustacea： Decapoda： Caridea） is presented here. A comparative analysis based on the currently available mitochondrial genomic data re- vealed many previously unknown characteristics of the mitochondrial genomes of caridean shrimps. The A. japonicus mito- chondrial genome is 16487 bp long and contains the typical set of 37 metazoan genes. The gene arrangements in the mito- chondrial genomes of four previously studied carideans （Macrobrachium rosenbergii, M. nipponense, M. lanchesteri and halocaridina rubra） were found to be identical to the pancrustacean ground pattern; thus, it was considered that gene rear- rangements probably did not occur in the suborder Caridea. In the present study, a translocation of the trnE gene involving in- version was found in Alpheus mitochondrial genomes. This phenomenon has not been reported in any other crustacean mito- chondrial genome that has been studied so far; however, the translocation of one transfer RNA gene （trnP or trnT） was report- ed in the mitochondrial genome of Exopalaemon carinicauda. When the ratios of the nonsynonymous and synonymous sub- stitutions rates （ka/Ks） for the 13 protein coding genes from two Alpheus species （A. japonicus and A. distinguendus） and three Macrobrachium species （M. rosenbergii, M. nipponense, M. lanchesteri） were calculated, the kaIKs values for all the protein coding genes in Alpheus and Macrobrachium mitochondrial genomes were found to be less than 1 （between 0.0048 and 0.2057）, indicating that a strong purification selection had occurred. The phylogenetic tree that was constructed based on the mitochondrial protein coding genes in the genomes of nine related species indicated that Palaemonidae and Alpheidae formed a monophyly and shared a statistically significant relationship, （Palaemonidae＋Alpheidae）＋Atyidae, at the family level.

关键词： Decapoda Caridea mitochondrial genome gene order phylogeny

Variations of Raindrop Size Distribution and Radar Retrieval in Outer Rainbands of Typhoon Mangkhut(2018)

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Journal of Meteorological Research 2022年第3期36卷 500-519页

作者： Jingjing LYU Huiwen XIAO Yuchun DU Lina sha Yuqing DENG Weikai JIA Shengjie NIU Yue ZHOU Guqian PANG Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters(CIC-FEMD) Key Laboratory for Aerosol-Cloud-Precipitation of China Meteorological AdministrationNanjing University of Information Science&TechnologyNanjing 210044 Hubei Key Laboratory for Heavy Rain Monitoring and Warning Research Institute of Heavy RainChina Meteorological AdministrationWuhan 430205 Climate Center of Guangdong Province Guangzhou 510080 College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049

The evolution of the microphysical properties of raindrops from Typhoon Mangkhut’s outer rainbands as the storm made landfall in South China in September 2018 was *** observations by three two-dimensional video disdrometers deployed in central Guangdong Province were analyzed *** was found that the radial distribution of the median volume diameter(D_(0))and normalized intercept parameter(N_(w))varied in different stages,and that raindrops smaller than 3.0 mm contributed more than 99%of the total *** the characteristics of precipitation in the typhoon outer rainband,a modified stratiform rain(SR)-convective rain(CR)separator line is proposed based on D_(0) and N_(w) ***,an“S-C likelihood index”is introduced,which was used to classify three rain types(SR,CR,and mixed rain).The CR results were highly consistent with those of the improved typhoon precipitation classification method based on rain *** calculating effectively the radar reflectivity factor(Ze)in the Ku and ka bands,D0-Ze and N_(w)-D_(0) empirical relations were thereby derived for improving the accuracy of rainfall *** the four quantitative precipitation estimators using S-band dual-polarimetric radar parameters simulated by the T-matrix method,the estimator that adopted the specific differential phase and differential reflectivity was found to be the most effective for both SR and CR.

关键词： typhoon two-dimensional video disdrometer drop size distribution axis ratio quantitative precipitation estimation

Acoustic radiation force on a multilayered sphere in a Gaussian standing field

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Chinese Physics B 2018年第3期27卷 299-305页

作者： haibin Wang Xiaozhou Liu sha Gao Jun Cui Jiehui Liu Aijun He Gutian Zhang Key Laboratory of Modern Acoustics Institute of AcousticsNanjing UniversityNanjing 210093China State Key Laboratory of Acoustics Institute of AcousticsChinese Academy of SciencesBeijing 100190China School of Electronic Science and Engineering Nanjing UniversityNanjing 210023China Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical SchoolNanjing 210093China

We develop a model for calculating the radiation force on spherically symmetric multilayered particles based on the acoustic scattering *** expression is derived for the radiation force on a multilayered sphere centered on the axis of a Gaussian standing wave propagating in an ideal fluid,The effects of the sound absorption of the materials and sound wave on acoustic radiation force of a multilayered sphere immersed in water are analyzed,with particular emphasis on the shell thickness of every layer,and the width of the Gaussian *** results reveal that the existence of particle trapping behavior depends on the choice of the non-dimensional frequency ka,as well as the shell thickness of each *** study provides a theoretical basis for the development of acoustical tweezers in a Gaussian standing wave,which may benefit the improvement and development of acoustic control technology,such as trapping,sorting,and assembling a cell,and drug delivery applications.

关键词： acoustic radiation force Gaussian standing field multilayered sphere model sound scattering

利用ARIMA和BP神经网络模型分析新疆生产建设兵团乙肝流行特征

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现代预防医学 2021年第18期48卷 3265-3269+3284页

作者：郝启迪米莎莎李凡卡石河子大学医学院新疆生产建设兵团疾控中心

目的通过分析2009-2019年新疆生产建设兵团乙肝发病数据,了解乙肝发病特征及规律。同时构建ARIMA模型和BP神经网络对2020年新疆生产建设兵团乙肝发病率进行预测,选取合适模型为乙肝及时防控调整做参考依据。方法收集新疆生产建设兵团疾... 详细信息

目的通过分析2009-2019年新疆生产建设兵团乙肝发病数据,了解乙肝发病特征及规律。同时构建ARIMA模型和BP神经网络对2020年新疆生产建设兵团乙肝发病率进行预测,选取合适模型为乙肝及时防控调整做参考依据。方法收集新疆生产建设兵团疾病预防控制中心网站公布的法定传染病月疫情统计数据和中国统计年鉴数据,利用SPSS 20.0进行流行病学统计分析。利用R(forecast包、tseries包)建立ARIMA模型,利用MATLAB构建BP神经网络对新疆生产建设兵团2009年1月-2019年12月的乙肝月发病率进行拟合预测。结果 2009-2019年新疆生产建设兵团乙肝病毒性肝炎年平均发病率为95.76/10万(29 476/3 078.05万,95%CI:94.67～96.86),乙肝发病率处于逐年下降中;各年报告男性发病率均高于女性,男女发病数比为1.676∶1;BP神经网络预测精度指标(MAE,MAPE,RMSE)均优于ARIMA模型。结论 2009-2019年新疆生产建设兵团乙肝发病率趋势逐年下降。BP神经网络是短期预测新疆生产建设兵团乙肝月发病趋势的较为理想的模型。

关键词：乙型病毒性肝炎流行病学 ARIMA模型 BP神经网络预测