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Effect of mixing structure on the hygroscopic behavior of ultrafine ammonium sulfate particles mixed with succinic acid and levoglucosan

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Particuology 2014年第2期12卷 27-34页

作者： Shila Maskey ka Yan Chong Gibaek kim Jae-Seok kim Arshad Ali Kihong Park National Leading Research Laboratory School of Environmental Science and EngineeringGwangju Institute of Science and Technology(GIST)

Understanding the interactions between water and atmospheric aerosols is critical for estimating their impact on the radiation budget and cloud formation. The hygroscopic behavior of ultrafine （〈100nm） ammonium sulfate particles internally mixed with either succinic acid （slightly soluble） or levoglucosan （soluble） in different mixing structures （core-shell vs. well-mixed} were measured using a hygroscopicity tandem differential mobility analyzer （HTDMA）. During the hydration process （6-92% relative humidity （RH））, the size of core-shell particles （ammonium sulfate and succinic acid） remained unchanged until a slow increase in particle size occurred at 79Y~ RH; however, an abrupt increase in size （i.e., a clear deliquescence） was observed at ~72% RH for well-mixed particles with a similar volume fraction to the core-shell particles （80：20 by volume）. This increase might occur because the shell hindered the complete dissolution of the core-shell particles below 92% RH. The onset RH value was lower for the ammonium sulfate/levoglucosan core-shell particles than the ammonium sulfate/succinic acid core-shell particles due to levoglucosan＇s higher solubility relative to succinic acid. The growth factor （GF） of the core-shell particles was lower than that of the well-mixed particles, while the GF of the ammonium sulfate/levoglucosan particles was higher than that of ammonium sulfate/succinic acid particles with the same volume fractions. As the volume fraction of the organic species increased, the GF decreased. The data suggest that the mixing structure is also important when determining hygroscopic behavior of the mixed particles.

关键词： Ultrafine particles Hygroscopicity Mixing structure Core-shell

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Exacerbated VEGF up-regulation accompanies diabetes-aggravated hemorrhage in mice after experimental cerebral ischemia and delayed reperfusion

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Neural Regeneration Research 2022年第7期17卷 1566-1575页

作者： Angela ka Wai Lai Tsz Chung Ng Victor ka Lok Hung ka Cheung Tam Chi Wai Cheung Sookja kim Chung Amy Cheuk Yin Lo Department of Ophthalmology Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administration RegionChina Department of Anesthesiology Laboratory and Clinical Research Institute for PainThe University of Hong KongHong Kong Special Administration RegionChina Macao University of Science and Technology TaipaMacao Special Administration RegionChinaSchool of Biomedical SciencesThe State Key Laboratory of Pharmaceutical BiotechnologyThe University of Hong KongHong Kong Special Administration RegionChina

Reperfusion therapy is the preferred treatment for ischemic stroke,but is hindered by its short treatment window,especially in patients with diabetes whose reperfusion after prolonged ischemia is often accompanied by exacerbated *** mechanisms underlying exacerbated hemorrhage are not fully *** study aimed to identify this mechanism by inducing prolonged 2-hour transient intraluminal middle cerebral artery occlusion in diabetic Ins2Akita/+mice to mimic patients with diabetes undergoing delayed mechanical *** results showed that at as early as 2 hours after reperfusion,Ins2Akita/+mice exhibited rapid development of neurological deficits,increased infarct and hemorrhagic transformation,together with exacerbated down-regulation of tight-junction protein ZO-1 and upregulation of blood-brain barrier-disrupting matrix metallopeptidase 2 and matrix metallopeptidase 9 when compared with normoglycemic Ins2+/+*** indicated that diabetes led to the rapid compromise of vessel integrity immediately after reperfusion,and consequently earlier death and further aggravation of hemorrhagic transformation 22 hours after *** observation was associated with earlier and stronger up-regulation of pro-angiogenic vascular endothelial growth factor(VEGF)and its downstream phospho-Erk1/2 at 2 hours after reperfusion,which was suggestive of premature angiogenesis induced by early VEGF up-regulation,resulting in rapid vessel disintegration in diabetic *** reticulum stress-related pro-apoptotic C/EBP homologous protein was overexpressed in challenged Ins2Akita/+mice,which suggests that the exacerbated VEGF up-regulation may be caused by overwhelming endoplasmic reticulum stress under diabetic *** conclusion,the results mimicked complications in patients with diabetes undergoing delayed mechanical thrombectomy,and diabetes-induced accelerated VEGF up-regulation is likely to underlie exacerbated hemorrhagic transformat

关键词： blood-brain barrier brain injury diabetes mellitus hemorrhagic transformation infarct ischemia/reperfusion injury middle cerebral artery occlusion mouse model stroke vascular endothelial growth factor

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中美互换摘要

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中华高血压杂志（中英文） 2024年第2期32卷 200-200页

作者： Heckel AR Arcidiacono DM Coonan ka Glasgow AC DeBlois JP Gump BB kim JY Heffernan KS 刘青练桂丽

曾患与未患新型冠状病毒成年人的24h中心血流动力学负荷。高血压虽是新型冠状病毒(corona virus disease2019,COVID-19)重症的危险因素,但COVID-19对血压的影响尚不明确。相比于与单一时间点测量肱动脉血压,24 h动态血压监测(24 hour am... 详细信息

曾患与未患新型冠状病毒成年人的24h中心血流动力学负荷。高血压虽是新型冠状病毒(corona virus disease2019,COVID-19)重症的危险因素,但COVID-19对血压的影响尚不明确。相比于与单一时间点测量肱动脉血压,24 h动态血压监测(24 hour ambulatory blood pressure monitoring,ABPM)测量的中心血压对评估心血管疾病(cardiovascular disease,CVD)风险更有预测价值。本研究采用ABPM测量24 h中心血流动力学负荷,评估曾患与未患COVID-19成年人的CVD风险。

关键词：肱动脉血压新型冠状病毒心血管疾病 ABPM 点测量危险因素

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Mitochondria-targeting self-assembled nanoparticles derived from triphenylphosphonium-conjugated cyanostilbene enable site-specific imaging and anticancer drug delivery

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Nano Research 2018年第2期11卷 1082-1098页

作者： ka Young kim Hanyong Jin Jaehyeon Park Sung Ho Jung Ji Ha Lee Hyesong Park Sung Kuk kim Jeehyeon Bae Jong Hwa Jung Department of Chemistry and Research Institute of Natural Sciences Gyeongsang National University Jinju Republic of Korea School of Pharmacy Chung-Ang University Seoul Republic of Korea

Subcellular organelle-specific nanoparticles for simultaneous tumor targeting, imaging, and drug delivery are of enormous interest in cancer therapy. Herein, we report a selective mitochondria-targeting probe 1, which was synthesized by incorporating a triphenyl phosphine with a cyanostilbene and a long alkyl chain moiety. Probe 1 was found to display fluorescence via aggregation-induced emission （AIE）. The low molecular-weight cyanostilbene-based probe 1, with and without an anticancer drug, formed a narrow homogeneous nanorod with ca. 110 nm of length or nanopartides with ca. 20 nm diameter in aqueous media. The self-assembled cyanostilbene nanoparticles （N1） selectively accumulated in the mitochondria of cancer cells and emitted fluorescence. N1 was also able to deliver an anticancer drug, doxorubicin （DOX）, to the mitochondria with high efficiency. More importantl~ N1 exhibited highly selective cytotoxicity for cancer cells over normal cells. The great potential applications of this self-assembled nanoparticle to biological systems result from its ability to aggregate in the mitochondria. This aggregation led to a significant increase in the generation of intraceUular reactive oxygen species and to a decrease in the mitochondrial membrane potential in cancer cells. Furthermore, tumor tissue uptake experiments in mice proposed that the self-assembled N1 had the ability to internalize and deliver the anticancer drug into tumor tissues effectively. Moreover, both N1 and Nl-encapsulated doxorubicin （N1-DOX） effectively suppressed tumor growth in a xenograft model in vivo. Taken together, our findings indicate that applications of N1 as a mitochondrial targeting probe, drug delivery platform, and chemotherapeutic agent provide a unique strategy for potential image-guided therapy as well as a site-specific delivery system to cancer cells.

关键词： aggregation-inducedemission,chemotherap3 drug deliver3 mitochondria-targeting,fluorescence imaging

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Epac2-deficiency leads to more severe retinal swelling, glial reactivity and oxidative stress in transient middle cerebral artery occlusion induced ischemic retinopathy

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Science China(Life Sciences) 2015年第6期58卷 521-530页

作者： LIU Jin YEUNG Patrick ka Kit CHENG Lu LO Amy Cheuk Yin CHUNG Stephen Sum Man CHUNG Sookja kim Department of Anatomy Li Ka Shing Faculty of Medicine The University of Hong Kong Department of Ophthalmology Li Ka Shing Faculty of Medicine The University of Hong Kong Research Centre of Heart Brain Hormone and Healthy Aging Li Ka Shing Faculty of Medicine The University of Hong Kong Division of Science and Technology United International College Zhuhai 519085 China State Key Laboratory of Pharmaceutical Biotechnology The University of Hong Kong

Ischemia occurs in diabetic retinopathy with neuronal loss, edema, glial cell reactivity and oxidative stress. Epacs, consisting of Epac 1 and Epac2, are cAMP mediators playing important roles in maintenance of endothelial barrier and neuronal functions To investigate the roles of Epacs in the pathogenesis of ischemic retinopathy, transient middle cerebral artery occlusion （tMCAO） was performed on Epacl-deficient （Epacl-/- ） mice, Epac2-deficient （Epac2-/-） mice, and their wild type counter-parts （Epacl＋/＋ and Epac2＋/＋）. Two-hour occlusion and 22-hour reperfusion were conducted to induce ischemia/reperfusion injury to the retina. After tMCAO, the contralateral retinae displayed similar morphology between different genotypes. Neu-ronal loss, retinal edema and increase in immunoreactivity for aquaporin 4 （AQP4）, glial fibrillary acidic protein （GFAP）, peroxiredoxin 6 （Prx6） were observed in ipsilateral retinae. Epac2 / ipsilateral retinae showed more neuronal loss in retinal ganglion cell layer, increased retinal thickness and stronger immunostaining of AQP4, GFAP, and Prx6 than those of Epac2＋/＋. However, Epacl-/- ipsilateral retinae displayed similar pathology as those in Epacl＋/＋ mice. Our observations suggest that Epac2-deficiency led to more severe ischemic retinopathy after retinal ischemia/reperfusion injury.

关键词： Epac retina ischemia retinopathy

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Cells and material-based strategies for regenerative endodontics

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Bioactive Materials 2022年第8期7卷 234-249页

作者： Zain Siddiqui Amanda M.Acevedo-Jake Alexandra Griffith Nurten kadincesme Kinga Dabek Dana Hindi ka Kyung kim Yoshifumi Kobayashi Emi Shimizu Vivek Kumar Department of Biomedical Engineering New Jersey Institute of TechnologyNewarkNJ07102USA Department of Oral Biology Rutgers School of Dental MedicineNewarkNJ07103USA Department of Endodontics Rutgers School of Dental MedicineNewarkNJ07103USA Department of Chemicals and Materials Engineering New Jersey Institute of TechnologyNewarkNJ07102USA Department of Biology New Jersey Institute of TechnologyNewarkNJ07102USA

The carious process leads to inflammation of pulp *** care options include root canal treatment or *** procedures,however,result in the loss of tooth vitality,sensitivity,and *** capping and dental pulp regeneration are continually evolving techniques to regenerate pulp tissue,avoiding necrosis and loss of *** studies have successfully employed stem/progenitor cell populations,revascularization approaches,scaffolds or material-based strategies for pulp *** we outline advantages and disadvantages of different methods and techniques which are currently being used in the field of regenerative *** also summarize recent findings on efficacious peptide-based materials which target the dental niche..

关键词： Regenerative endodontics Pulp regeneration Tissue engineering Stem cells Scaffolds

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Long-Term and Immediate Impacts of Health Emergency and Disaster Risk Management(Health-EDRM) Education Interventions in a Rural Chinese Earthquake-Prone Transitional Village

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International Journal of Disaster Risk Science 2018年第3期9卷 319-330页

作者： Emily Ying Yang Chan Janice Ying-en Ho Zhe Huang Jean Hee kim Holly Ching Yu Lam Phoebe Pui Wun Chung Carol ka Po Wong Sida Liu Sharon Chow Collaborating Centre for Oxford University and CUHK for Disaster and Medical Humanitarian Response (CCOUC) The Chinese University of Hong Kong Nuffield Department of Medicine University of Oxford The Jockey Club School of Public Health and Primary Care The Chinese University of Hong Kong Franois-Xavier Bagnoud Center for Health & Human Rights Harvard University Integrated Research on Disaster Risk (IRDR) International Centre of Excellence–CCOUC (ICoE-CCOUC) Wu Zhi Qiao (Bridge to China) Charitable Foundation

Ma'an Qiao Village, a Dai and Yi ethnic minority-based community in Sichuan Province, China sustained complete infrastructure devastation during the 2008 Panzhihua earthquake. Health emergency and disaster risk management(Health-EDRM) education intervention programs were implemented in 2010 and 2011. This serial cross-sectional survey study aimed to examine the immediate and long-term impacts of the Health-EDRM interventions in this remote rural community. The findings demonstrate knowledge improvement in areas of water and sanitation, food and nutrition, and disaster preparedness immediately after the Health-EDRM education interventions. Temporal stability of knowledge retention was observed in household hygiene and waste management and smoking beliefs in 2018, 7 years after the *** important findings include knowledge uptake pattern differences of oral rehydration solution(ORS) between earthquake-prone and flood-prone communities. Usage of Internet and mobile technology for accessing disaster-related information was found to be independent of gender and income. Overall, this study demonstrated the knowledge improvement through Health-EDRM education interventions in a remote rural community. Promoting behavioral changes through interventions to raise awareness has the potential to reduce health risks in transitional post-disaster settings. Future programs should aim to identify evidence-based practices and explore how technology can support Health-EDRM education among vulnerable subgroups.

关键词： Earthquake Transitional community Disaster preparedness kit Disaster risk reduction Health emergency and disaster risk management Rural China Sichuan

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Electron-Cyclotron Laser Using Free-Electron Two-Quantum Stark Radiation in a Strong Uniform Axial Magnetic Field and an Alternating Axial Electric Field in a Voltage-Supplied Pill-Box Cavity

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Chinese Physics Letters 2016年第3期33卷 56-59页

作者： S.H.kim Church Road 9236 Dallas Texas 75231 USA

We consider the radiation from the beam electrons traveling in a strong uniform axial magnetic field and an axial alternating electric field of wavelength Aw generated by a voltage-supplied pill-box cavity. The beam electrons emit genuine laser radiation that propagates only in the axial direction through free-electron two- quantum Stark radiation. We find that laser radiation takes place only at the expense of the axial kinetic energy when Aw 〈〈 c/（ωc/γ）, where ωc/γ is the relativistic electron--cyclotron frequency. We formulate the laser power based on quantum-wiggler electrodynamics, and envision a laser of length lore with estimated power 0.1 GW/（ka） in the 10-4 cm wavelength range.

关键词： of on in that Electron-Cyclotron Laser Using Free-Electron Two-Quantum Stark Radiation in a Strong Uniform Axial Magnetic Field and an Alternating Axial Electric Field in a Voltage-Supplied Pill-Box Cavity is Stark

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腹针治疗更年期失眠症的临床研究

腹针治疗更年期失眠症的临床研究

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作者：金佳恩（kim ka eun）南京中医药大学

学位级别：硕士

目的：通过观察腹针治疗更年期失眠症的临床研究,评价腹针治疗更年期失眠的临床疗效并探讨其作用机理。研究方法：将60例更年期失症眠患者随机分为2组,一是腹针组,二是体针组,每组各30例。10次为1疗程,共治疗2个疗程。两组在治疗前后分... 详细信息

目的：通过观察腹针治疗更年期失眠症的临床研究,评价腹针治疗更年期失眠的临床疗效并探讨其作用机理。研究方法：将60例更年期失症眠患者随机分为2组,一是腹针组,二是体针组,每组各30例。10次为1疗程,共治疗2个疗程。两组在治疗前后分别进行匹兹堡睡眠质量指数测验(PSQI)和焦虑自评量表测验(SAS),观察指数治疗前后差值作组间比较。结果：1、自身比较：腹针疗法与体针疗法均是治疗更年期失眠症的有效方法。两组治疗后匹兹堡睡眠质量指数评定量表(PSQI)中各项与治疗前比较均具有统计学意义(P<0.05);腹针组(治疗组)与体针组(对照组)治疗前后焦虑自评量表评分(SAS)均有明显的下降(P<0.05)。2、组间比较：治疗1疗程后腹针组(治疗组)和体针组(对照组)在入睡时间、实际睡眠时间、睡眠障碍项目评分差异非常显著,具有统计学意义(P<0.05);2疗程后治疗组和对照组在实际睡眠时间、睡眠效率评分差异有显著性意义(P<0.05),但两组每疗程其余各项目无明显差别;两组治疗后焦虑自评量表(SAS)评分差异非常明显,具有统计学意义(P<0.05)。3、临床疗效：治疗组(腹针组)30例,2疗程后痊愈10例,显效15例,有效4例,无效1例,总有效率97.7%;对照组(体针组)30例,2疗程后痊愈5,显效14,有效8,无效3,总有效率90%结论：腹针疗法是治疗更年期妇女失眠症非常有效,改善的状况明显优于体针疗法

关键词：腹针更年期失眠症焦虑

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Late Pleistocene spore-pollen record and climatic change at the Chongphadae Cave Site,Democratic People's Republic of Korea

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Journal of Palaeogeography 2023年第4期12卷 624-636页

作者： Se Chan kim Rye Sun Choe Il Nam kim Chol U Ryong Il kang Institute of Human Evolution and Development History Faculty of HistoryKim Il Sung UniversityTaesong DistrictPyongyangDemocratic People's Republic of Korea

We present a detailed pollen record and interpretations of late Pleistocene climatic change at the Chongphadae Cave Site, Democratic People's Republic of Korea. The mean annual paleotemperature and mean annual paleoprecipitation of the site were calculated using the temperature index and precipitation index based on ecological features and geographical distribution of each taxon. Temperature index and precipitation index range from 8.8℃ to 10.4℃ and from 805.0 mm to 963.1 mm, respectively. Four dates(radiocarbon, uranium series, fission track, and paleomagnetic excursion dating) of the deposit profile investigated yield a range of ~21.3 ka BP to ~117 ka BP, geochronologically corresponding to the late Pleistocene, and extend from the last interglacial highstand through the Last Glacial Maximum. Our results are thus consistent with the climatic shift from interglacial to glacial conditions, provide evidence that the environments of the region, which was reconstructed from the paleoclimatic index, changed from a mild and humid to a cool and dry climate during the late Pleistocene, and suggest trends similar to those of several parts of the Northern Hemisphere which lie in the same latitudinal zone as our study area.

关键词： Chongphadae cave Pollen Climatic change Late Pleistocene Mean annual temperature Mean annual precipitation

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