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Ovarian Tumors in Senegalese Women: Impact of D-Loop Mutations between Healthy and Cancerous Tissues

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Open Journal of Genetics 2024年第2期14卷 37-46页

作者： Rouguiyatou ka Fatimata Mbaye Bineta Kénéme Mbacké Sembène Genomics Laboratory Department of Animal Biology Faculty of Science and Technology Cheikh Anta Diop University Dakar Senegal

In Senegal in particular, ovarian cancer, which is one of the most common gynecological cancers, accounts for 2.8% of deaths. The most important risk factor is genetic, with 10% of cases occurring in a context of genetic predisposition. The sequencing of the human genome, which has led to the discovery of millions of sequence variations, makes it possible to study variations within sequences. These variations are limited to Single nucleotide Polymorphisms (SnPs) and this common form of polymorphism occurs approximately every 1000 bases in the human genome and 1.8 million SnPs are currently listed according to [1]. The aim of this study is to gain a better understanding of the impact of mutations in the D-loop region of mtDnA on ovarian cancer in Senegalese women. This study involved searching for mutations in our study population after DnA extraction and sequencing. Mutations were found after a comparison of our sequences with the Cambridge reference sequence (nC_012920). The mutations found in the DnA studied extend from position 7 to position 16568 and most of these mutations are located in the hypervariate zones (HV1 and HV2). Heteroplasmy with three mutant alleles was also found in certain variants. Common mutations were found in both healthy and cancerous tissues, with almost identical frequencies in both types of tissue. This enabled us to understand the spread of tumor cells throughout the ovary.

关键词： Ovarian Cancer Mutations D-Loop Heteroplasmy

The Dental Absces: Epidemiological, Clinical and Therapeutic Aspects at the Dental Office of the Prefectoral Hospital of Siguiri in 2021 in the Republic of Guinea

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Open Journal of Stomatology 2024年第9期14卷 382-391页

作者： Magna Condé Aly Badara nabé Fanta Madi Traoré Moussa Doré Djibrila Camara kaïn Condé Mory Sacko Francine Manto Kuete Kouamé Patrice Attogbain African Center of Excellence for the Prevention and Control of Communicable Diseases (CEA-PCMT) Faculty of Health Sciences and Techniques of the Gamal Abdel Nasser University of Conakry Conakry Guinea Department of Odontology Faculty of Health Sciences and Techniques Gamal Abdel Nasser University of Conakry Conakry Guinea Department of Odontology and Maxillofacial Surgery of the Ignace Deen national Hospital Conakry Guinea Department of Pathology and Therapeutics UFR Odonto-Stomatology Felix Houphouet Boigny University Abidjan Ivory Coast

Introduction: A dental abscess is a collection of pus located in the tissues surrounding the tooth roots. The aim of this work is to describe the epidemiological, clinical and therapeutic aspects of dental abscess in order to contribute to the management of patients suffering from this pathology at the dental office of the Siguiri Prefectural Hospital. Methods: This was a retrospective descriptive study lasting 2 months carried out on the registers of patients received between October 2017 and October 2020 at the dental office of the Siguiri prefectural hospital. Results: 4690 patient files were identified during the study, of which 546 met our selection criteria, i.e. a frequency of 11.64%. During our study, we found 51.83% female compared to 48.17% male, i.e. a sex ratio of 1.07. 54.21% of our patients resided in rural communes compared to 45.76% for the urban commune. The age group most affected was that of 16 - 25 years old or 33.69%. Swelling, pain and functional discomfort were the reasons for consultation in all patients followed by other associated reasons in 41.21%. The premolar-molar group was the most represented, i.e. 86.70%. 80.04% of our patients presented an acute abscess compared to 19.96% of chronic cases. Antibiotic, analgesic, and mouthwash were prescribed in all patients during the study followed by 96.37% of cases prescription of steroidal anti-inflammatory drugs. 93.04% of causal teeth were extracted followed by 6.78% of cases of conservative treatment in our study. In our study, 80.95% of our patients had a good post-therapeutic outcome. Conclusion: This study highlights the need for prevention and early management of dental abscesses.

关键词： Dental Abscess Epidemiological Clinical Therapeutic

nomogram to predict severe retinopathy of prematurity in Southeast China

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 282-288页

作者： Dan Liu Xing-Yong Li Hong-Wu He ka-Lu Jin Ling-Xia Zhang Yang Zhou Zhi-Min Zhu Chen-Chen Jiang Hai-Jian Wu Sui-Lian Zheng Department of Ophthalmology the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina Eye Hospital and School of Ophthalmology and Optometry Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina Taizhou Optometry Hospital Taizhou 318001Zhejiang ProvinceChina Department of Ophthalmology Jiaxing Maternity and Child Health Care HospitalJiaxing 314009Zhejiang ProvinceChina Department of Ophthalmology Taizhou Women and Children’s Hospital of Wenzhou Medical UniversityTaizhou 318001Zhejiang ProvinceChina Clinical Medical Research Center the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina Department of Ophthalmology Taizhou Municipal HospitalTaizhou 318099Zhejiang ProvinceChina

AIM:To define the predictive factors of severe retinopathy of prematurity(ROP)and develop a nomogram for predicting severe ROP in southeast ***:Totally 554 infants diagnosed with ROP hospitalized in the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University and hospitalized in Taizhou Women and Children’s Hospital were *** data and 43 candidate predictive factors of ROP infants were collected *** regression model was used to identify predictive factors of severe ROP and to propose a nomogram for individual risk prediction,which was compared with WInROP model and Digirop-Birth ***:Infants from the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University(n=478)were randomly allocated into training(n=402)and internal validation group(n=76).Infants from Taizhou Women and Children’s Hospital were set as external validation group(n=76).Severe ROP were found in 52 of 402 infants,12 of 76 infants,and 7 of 76 infants in training group,internal validation group,and external validation group,*** weight[odds ratio(OR),0.997;95%confidence interval(CI),0.996-0.999;Pnd non-invasive ventilation(OR,0.288;95%CI,0.146-0.570;Pntified as predictive factors for the prediction of severe ROP,by univariate analysis and multivariate *** predicting severe ROP based on the internal validation group,the areas under receiver operating characteristic curve(AUC)was 78.1(95%CI,64.2-92.0)for the nomogram,32.9(95%CI,15.3-50.5)for WInROP model,70.2(95%CI,55.8-84.6)for Digirop-Birth *** external validation group,AUC of the nomogram was also higher than that of WInROP model and Digirop-Birth model(80.2 versus 51.1 and 63.4).The decision curve analysis of the nomogram demonstrated better clinical efficacy than that of WInROP model and Digirop-Birth *** calibration curves demonst

关键词： retinopathy of prematurity nomogram predictive factor birth weight multiple births non-invasive ventilation

Evolution of Mother-to-Child HIV-1 Transmission Rate in Mali from 2009 to 2018

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Advances in Microbiology 2024年第5期14卷 256-267页

作者： Alou Sanogo Mohamed Ag Baraïka Maïga Aminata Demba Koita Mahamadou Abdou Mamadou Guindo Clémentine n’Diaye Fatoumata namoudou Traoré Abdoulaye Bagayoko Youssouf Diallo Flabou Bougoudogo Ibrehima Guindo national Institute for Public Health Bamako Mali Faculty of Pharmacy (FAPH) University of Science of Technical and Technology de Bamako Bamako Mali University Hospital Center (CHU)-Point G Bamako Mali Faculty of Medecine and Odonto-Stomatology University of Science of Technical and Technology de Bamako Bamako Mali Sector Unit for the Fight against AIDS Tuberculosis and Hepatitis Bamako Mali UnICEF (United nations Children’ s Fund) Bamako Mali

Despite enormous efforts to achieve the goal of eliminating mother-to-child transmission of HIV-1, it remains a major challenge for many countries in sub-Saharan Africa, particularly Mali. Our objective is to assess changes in the rate of mother-to-child transmission of HIV-1. We conducted a cross-sectional study between January 1, 2009 to December 31, 2018 (10 years) of early diagnosis activity in newborns and children born to HIV-1-positive mothers at the national Institute for Public Health (InSP). The samples came from health and referral centers in mali. All samples were received at the Laboratory of Molecular Biology at the InSP. Proviral DnA extraction was performed from a blood spot sample with a Roche DnA kit, Cobas AmpliPrep/Cobas TaqMan HIV-1 qualitative Test, V2.0 (Roche Molecular System, Inc, USA) following the company procedures. Molecular diagnosis was performed using the same kits using an algorithm of three identical PCRs. The Epi Info version 7 software was used for data analysis with a significance threshold of 5%. A total of 10,714 samples of infants and children born to HIV-positive mothers were analyzed by PCR. ninety-six percent of mothers were on ARV prophylaxis (AZT 3TC nVP and AZT nVP) and 60% of newborns received the same ARV prophylaxis. Of these children, 956 tested positive with an overall transmission rate of 8.92%, varying between 7.27% in 2009 and 08.01% in 2018. This rate was relatively low among children receiving prophylaxis at 2.04% and remained high for children who received breastfeeding at 5.62%. However, the transmission rate remains low for those who have benefited from mixed and artificial breastfeeding at 1.58% and 1.27% respectively. A significant proportion of children remained infected by their mothers during pregnancy, childbirth or breastfeeding. This study shows the importance of early diagnosis of HIV in children using molecular technology.

关键词： Early Diagnosis Mothers-to-Child newborns PCR DnA HIV-1

ERROR ESTIMATES FOR THE TIME DISCRETIZATIOn FOR nOnLInEAR MAXWELL'S EQUATIOnS

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Journal of Computational Mathematics 2008年第5期26卷 677-688页

作者： Mavián Slodika Ján Bua Jr. Department of Mathematical Analysis Ghent University

This paper is devoted to the study of a nonlinear evolution eddy current model of the type δtB（H）＋ △↓× （ △↓ × H） =0 subject to homogeneous Dirichlet boundary conditions H × v = 0 and a given initial datum. Here, the magnetic properties of a soft ferromagnet are linked by a nonlinear material law described by B（H）. We apply the backward Euler method for the time discretization and we derive the error estimates in suitable function spaces. The results depend on the nonlinearity of B（H）.

关键词： Electromagnetic field nonlinear eddy current problem Time discretization,Error estimate.

Identification of novel small-molecule inhibitors of SARS-CoV-2 by chemical genetics

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ACTA PHARMACEUTICA SInICA B 2024年第9期14卷 4028-4044页

作者： Chan, Chris Chun-Yiu Guo, Qian Chan, Jasper Fuk-Woo Tang, kaiming Cai, Jian-Piao Chik, ka-Heng Chik, Kenn ka-Heng Huang, Yixin Dai, Mei Qin, Bo Ong, Chon Phin Chu, Allen Wing-Ho Chan, Wan-Mui Ip, Jonathan Daniel Wen, Lei Tsang, Jessica Oi-Ling Wang, Tong-Yun Xie, Yubin Qin, Zhenzhi Cao, Jianli Ye, Zi-Wei Chu, Hin To, Kelvin kai-Wang Ge, Xing-Yi ni, Tao Jin, Dong-Yan Cui, Sheng Yuen, Kwok-Yung Yuan, Shuofeng Univ Hong Kong Li Ka Shing Fac Med Sch Clin Med State Key Lab Emerging Infect DisCarol Yu Ctr Inf Hong Kong 999077 Peoples R China Univ Hong Kong Shenzhen Hosp Dept Infect Dis & Microbiol Shenzhen 518000 Peoples R China Hong Kong Sci & Technol Pk Ctr Virol Vaccinol & Therapeut Hong Kong 999077 Peoples R China Hainan Med Univ Univ Hong Kong Joint Lab Trop Infe Academician Workstn Hainan Prov Haikou 571100 Peoples R China Univ Hong Kong Li Ka Shing Fac Med Sch Biomed Sci Pokfulam Hong Kong 999077 Peoples R China Chinese Acad Med Sci & Peking Union Med Coll NHC Key Lab Syst Biol Pathogens Inst Pathogen Biol Beijing 100730 Peoples R China Hunan Univ Coll Biol Hunan Prov Key Lab Med Virol Changsha 410082 Peoples R China

There are only eight approved small molecule antiviral drugs for treating COVID-19. Among them, four are nucleotide analogues (remdesivir, JT001, molnupiravir, and azvudine), while the other four are protease inhibitors (nirmatrelvir, ensitrelvir, leritrelvir, and simnotrelvir-ritonavir). Antiviral resistance, unfavourable drug-drug interaction, and toxicity have been reported in previous studies. Thus there is a dearth of new treatment options for SARS-CoV-2. In this work, a three-tier cell-based screening was employed to identify novel compounds with anti-SARS-CoV-2 activity. One compound, designated 172, demonstrated broad-spectrum antiviral activity against multiple human pathogenic coronaviruses and different SARS-CoV-2 variants of concern. Mechanistic studies validated by reverse genetics showed that compound 172 inhibits the 3-chymotrypsin-like protease (3CLpro) by binding to an allosteric site and reduces 3CLpro dimerization. A drug synergistic checkerboard assay demonstrated that compound 172 can achieve drug synergy with nirmatrelvir in vitro. . In vivo studies confirmed the antiviral activity of compound 172 in both Golden Syrian Hamsters and K18 humanized ACE2 mice. Overall, this study identified an alternative druggable site on the SARS-CoV-2 3CLpro, proposed a potential combination therapy with nirmatrelvir to reduce the risk of antiviral resistance and shed light on the development of allosteric protease inhibitors for treating a range of coronavirus diseases.

关键词： SARS-CoV-2 High throughput screening Broad-spectrum antiviral treatment 3CLpro inhibitor Allosteric-site inhibitor Animal models Chemical genetics Reverse genetics COROnAVIRUS DIMERIZATIOn PnEUMOnia MECHAnISM PROTEASES ACCURACY DIMER

Secrecy Outage Probability Minimization in Wireless-Powered Communications Using an Improved Biogeography-Based Optimization-Inspired Recurrent neural network

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Computers, Materials & Continua 2024年第3期78卷 3971-3991页

作者： Mohammad Mehdi Sharifi nevisi Elnaz Bashir Diego Martín Seyedkian Rezvanjou Farzaneh Shoushtari Ehsan Ghafourian Department of Industrial Engineering Iran University of Science and TechnologyNarmakTehran16846-13114Iran Department of Computer Science Iowa State UniversityAmesIowaIA50011USA ETSI de Telecomunicación Universidad Politécnica de MadridMadrid28040Spain Department of Engineering California State University East BayHaywardCalifornia94542USA Department of Industrial Engineering Bu-Ali Sina UniversityHamedan65178-38695Iran

This paper focuses on wireless-powered communication systems,which are increasingly relevant in the Internet of Things(IoT)due to their ability to extend the operational lifetime of devices with limited *** main contribution of the paper is a novel approach to minimize the secrecy outage probability(SOP)in these *** SOP is crucial for maintaining the confidentiality and integrity of data,especially in situations where the transmission of sensitive data is *** proposed method harnesses the power of an improved biogeography-based optimization(IBBO)to effectively train a recurrent neural network(Rnn).The proposed IBBO introduces an innovative migration *** core advantage of IBBO lies in its adeptness at maintaining equilibrium between exploration and *** is accomplished by integrating tactics such as advancing towards a random habitat,adopting the crossover operator from genetic algorithms(GA),and utilizing the global best(Gbest)operator from particle swarm optimization(PSO)into the IBBO *** IBBO demonstrates its efficacy by enabling the Rnn to optimize the system parameters,resulting in significant outage probability *** comprehensive simulations,we showcase the superiority of the IBBO-Rnn over existing approaches,highlighting its capability to achieve remarkable gains in SOP *** paper compares nine methods for predicting outage probability in wireless-powered *** IBBO-Rnn achieved the highest accuracy rate of 98.92%,showing a significant performance *** contrast,the standard Rnn recorded lower accuracy rates of 91.27%.The IBBO-Rnn maintains lower SOP values across the entire signal-to-noise ratio(SnR)spectrum tested,suggesting that the method is highly effective at optimizing system parameters for improved secrecy even at lower SnRs.

关键词： Wireless-powered communications secrecy outage probability improved biogeography-based optimization recurrent neural network

Environmental changes affect picoplanktonic composition in Antarctic Peninsula ponds

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Advances in Polar Science 2024年第1期35卷 108-122页

作者： Micaela DÍAZ Leonardo LAGOMARSInO Gabriela MATALOnI Marianela BELTRÁn Marcela LIBERTELLI Paulina FERMAnI Laboratorio de Ecología Acuática INTECH-UNSAM-CONICETChascomús 7130Argentina Facultad de Ciencias naturales y de la Salud UNPSJBComodoro Rivadavia 9000Argentina Laboratorio de Biodiversidad Limnología y Biología de la Conservación3IA-UNSAM-CONICETBuenos Aires 1650Argentina Departamento de Biología de Predadores Tope Instituto Antártico ArgentinoBuenos Aires 1650Argentina Laboratorio de Microbiología Ambiental IBIOMAR/CESIMAR-CENPAT-CONICETPuerto Madryn 9120Argentina

Antarctic Peninsula is experiencing one of the largest global warming events *** water bodies generated by the melting of snow in summer are numerous,and they might act as sentinels of climate change due to their rapid response and ability to integrate catchment *** in climate can influence the structure of microbial communities which dominate these freshwaters ***,we characterize three ponds at Cierva Point(Antarctic Peninsula)by examining their physico-chemical and morphological characteristics and we explored how different factors modify the structure of the microbial *** studied the abundance and biomass of heterotrophic bacteria,picocyanobacteria and picoeukaryote algae during January and February of two consecutive summers(2017 and 2018).We found that ponds had different limnological characteristics,due to their location,geomorphological features and presence of the surrounding flora and ***-chemical parameters as well as microbial community differed between ponds,months and *** 2017,most ponds were oligo to mesotrophic *** larger accumulated rainfall(as a result of environmental changes on the Antarctic Peninsula)during 2018,particularly in February,causes nutrient runoff into water *** affects those ponds with the highest seabird circulation,such as gentoo penguin,increasing *** a result,picoplanktonic abundances were higher,and the community structure shifts to a largely heterotrophic bacteria dominated *** results suggest that these communities could act as sentinels to environmental changes,anticipating a future with mostly hypertrophic ponds.

关键词： microorganisms freshwater environments climate change Cierva Point

Multi-exponential model to describe pressure-dependent P-and S-wave velocities and its use to estimate the crack aspect ratio

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Journal of Rock Mechanics and Geotechnical Engineering 2022年第2期14卷 385-395页

作者： Mihály Dobróka norbert Péter Szabó Tünde Edit Dobróka Mátyás Krisztián Baracza Department of Geophysics University of MiskolcMiskolc-Egyetemváros3515Hungary MTA-ME Geoengineering Research Group University of MiskolcMiskolc-Egyetemváros3515Hungary Research Institute of Applied Earth Sciences University of MiskolcMiskolc-Egyetemváros3515Hungary

We present new quantitative model describing the pressure dependence of acoustic P-and S-wave *** that a variety of individual mechanisms or defects(such as cracks,pore collapse and grain crushing)can contribute to the pressure-dependent change of the wave velocity,we order a characteristic pressure to all of them and allow a series of exponential terms in the description of the(Pand S-waves)velocity-pressure *** estimate the parameters of the multi-exponential rock physical model in inversion procedures using laboratory measured P-and S-wave velocity *** is known,the conventional damped least squares method gives acceptable results only when one or two individual mechanisms are *** the number of exponential terms leads to highly nonlinear ill-posed inverse *** to this reason,we develop the spectral inversion method(SIM)in which the velocity amplitudes(the spectral lines in the characteristic pressure spectrum)are only considered as *** characteristic pressures(belonging to the velocity amplitudes)are excluded from the set of inversion unknowns,instead,they are defined in a set of fixed positions equidistantly distributed in the actual interval of the independent variable(pressure).Through this novel linear inversion method,we estimate the parameters of the multi-exponential rock physical model using laboratory measured P-and S-wave velocity *** characteristic pressures are related to the closing pressures of cracks which are described by well-known rock mechanical relationships depending on the aspect ratio of elliptical *** gives the possibility to estimate the aspect ratios in terms of the characteristic pressures.

关键词： Multi-exponential rock physical model Spectral inversion method(SIM) Crack aspect ratio Characteristic pressures