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基于DTI-ALPS指数评价AICI患者的脑胶质淋巴系统功能

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中国医学计算机成像杂志 2024年第2期30卷 129-133页

作者：韦敏姜乔继沙静云严卉姜粲然张超徐州医科大学附属医院放射科徐州221000 徐州医科大学盐城临床学院盐城市第一人民医院神经外科

目的:利用沿血管周围间隙弥散张量成像(DTI-ALPS)评估急性缺血性脑梗死(AICI)患者的脑胶质淋巴系统功能变化。方法:回顾性搜集徐州医科大学附属医院2021年9月至2023年6月收治的33例AICI患者(AICI组)和33例健康志愿者(健康对照组)的临床... 详细信息

目的:利用沿血管周围间隙弥散张量成像(DTI-ALPS)评估急性缺血性脑梗死(AICI)患者的脑胶质淋巴系统功能变化。方法:回顾性搜集徐州医科大学附属医院2021年9月至2023年6月收治的33例AICI患者(AICI组)和33例健康志愿者(健康对照组)的临床及影像学资料,采集所有被试者的DTI参数以计算DTI-ALPS指数,用于评价AICI患者脑胶质淋巴系统功能的变化。结果:AICI组患者病灶侧大脑半球DTI-ALPS指数显著低于健侧(t=-3.11,P<0.01),也显著低于健康对照组(t=-5.20,P<0.01),AICI病灶的体积、病灶至测量层面的距离与病灶侧大脑半球DTI-ALPS指数均无显著相关性(P=0.38;P=0.24)。结论:利用DTI-ALPS指数能够评估AICI患者脑胶质淋巴系统功能变化,且AICI患者脑胶质淋巴系统功能的损害在病灶同侧大脑半球。

关键词：脑胶质淋巴系统急性缺血性脑梗死弥散张量成像血管周围间隙

应用DTI-ALPS指数观察胶质瘤的脑胶质淋巴系统功能变化

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临床放射学杂志 2024年第3期43卷 332-336页

作者：姜粲然李若涵沙静云蔡璐璐赵厚亮孟冲张超徐凯徐州医科大学附属医院影像科 221000

目的利用沿血管周围间隙扩散张量成像(DTI-ALPS)指数评估脑胶质瘤患者的胶质淋巴系统(GS)功能变化,探索影响脑胶质瘤GS功能的因素。方法回顾性纳入37例经手术病理证实为脑胶质瘤的住院患者和34名健康对照(HCs)。评估脑胶质瘤患者肿瘤... 详细信息

目的利用沿血管周围间隙扩散张量成像(DTI-ALPS)指数评估脑胶质瘤患者的胶质淋巴系统(GS)功能变化,探索影响脑胶质瘤GS功能的因素。方法回顾性纳入37例经手术病理证实为脑胶质瘤的住院患者和34名健康对照(HCs)。评估脑胶质瘤患者肿瘤的部位、大小、信号等常规影像特征后,经ITK-SNAP软件手动勾画胶质瘤瘤体与瘤周水肿(PTBE)并计算体积,测量所有受试者DTI参数值并计算出DTI-ALPS指数。利用t检验观察DTI-ALPS指数的组间差异,用Pearson相关分析观察DTI-ALPS指数与肿瘤体积、PTBE的相关性。结果单因素方差分析显示,肿瘤同侧大脑半球的DTI-ALPS指数(1.23±0.16)显著低于对侧大脑半球(1.34±0.17)(P=0.014)与HCs (1.43±0.15)(P<0.001)。肿瘤对侧大脑半球与HCs的DTI-ALPS指数无显著差异(P=0.075)。肿瘤同侧大脑半球DTI-ALPS指数与PTBE体积呈显著负相关(P=0.008,r=-0.432)。结论利用DTI-ALPS指数能够无创性评估脑胶质瘤GS的功能,且肿瘤同侧GS功能显著减低。PTBE是影响胶质瘤患者GS功能减低的重要因素。

关键词：胶质淋巴系统脑胶质瘤瘤周水肿血管周围间隙扩散张量成像

Variations of Raindrop Size Distribution and Radar Retrieval in Outer Rainbands of Typhoon Mangkhut(2018)

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Journal of Meteorological Research 2022年第3期36卷 500-519页

作者： Jingjing LYU Huiwen XIAO Yuchun DU Lina sha Yuqing DENG Weikai JIA Shengjie NIU Yue ZHOU Guqian PANG Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters(CIC-FEMD) Key Laboratory for Aerosol-Cloud-Precipitation of China Meteorological AdministrationNanjing University of Information Science&TechnologyNanjing 210044 Hubei Key Laboratory for Heavy Rain Monitoring and Warning Research Institute of Heavy RainChina Meteorological AdministrationWuhan 430205 Climate Center of Guangdong Province Guangzhou 510080 College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049

The evolution of the microphysical properties of raindrops from Typhoon Mangkhut’s outer rainbands as the storm made landfall in South China in September 2018 was *** observations by three two-dimensional video disdrometers deployed in central Guangdong Province were analyzed *** was found that the radial distribution of the median volume diameter(D_(0))and normalized intercept parameter(N_(w))varied in different stages,and that raindrops smaller than 3.0 mm contributed more than 99%of the total *** the characteristics of precipitation in the typhoon outer rainband,a modified stratiform rain(SR)-convective rain(CR)separator line is proposed based on D_(0) and N_(w) ***,an“S-C likelihood index”is introduced,which was used to classify three rain types(SR,CR,and mixed rain).The CR results were highly consistent with those of the improved typhoon precipitation classification method based on rain *** calculating effectively the radar reflectivity factor(Ze)in the Ku and ka bands,D0-Ze and N_(w)-D_(0) empirical relations were thereby derived for improving the accuracy of rainfall *** the four quantitative precipitation estimators using S-band dual-polarimetric radar parameters simulated by the T-matrix method,the estimator that adopted the specific differential phase and differential reflectivity was found to be the most effective for both SR and CR.

关键词： typhoon two-dimensional video disdrometer drop size distribution axis ratio quantitative precipitation estimation

Long-term clinical outcomes of drug-eluting stents ***-metal stents in Chinese geriatric patients

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Journal of Geriatric Cardiology 2013年第4期10卷 330-335页

作者： Pak-Hei Chan sha-sha Liu Hung-Fat Tse Wing-Hing Chow Man-Hong Jim Hee-Hwa HO Chung Wah Siu Department of Medicine Li Ka Shing Faculty of Medicine The University of Hong Kong 102 Pokfulam Rd Hong Kong China Cardiac Medical Unit Grantham Hospital 125 Wong Chuk Hang Rd Aberdeen Hong Kong China

BACKGROUND & OBJECTIVE: Little is known about the relative efficacies of percutaneous coronary intervention (PCI) with drug-eluting stents (DES) and bare-metal stents (BMS) in elderly patients。 The objective of this study was to evaluate the clinical outcome for geriatric patients who received either DES or BMS。 METHODS: From January 2002 to October 2005, 199 consecutive Chinese geriatric patients (≥ 75 years old) underwent PCI with coronary DES or BMS implantation at our institution。 We analyzed the major clinical end points that included all-cause mortality, cardiovascular death, myocardial infarction, target lesion revascularization (TLR), stent thrombosis, and bleeding complications。 RESULTS: The three-year cumulative rates of all-cause mortality, cardiovascular death, and myocardial infarction were significantly lower in the DES group (6.3%,3.6%,5.4%) compared with the BMS group (16.2%,11.5%,14.9%; P <0.05)。 No significant differences were found in the three-year cumulative rate for target lesion revascularization (6.3% vs4.6%, P =0.61) or stent thrombosis (3.6% vs2.3%, P =0.70)。 Likewise, there were no statistically significant differences in the cumulative rate for intracranial hemorrhage, or major and minor hemorrhage at three years。 CONCLUSIONS: DES-based PCI was associated with a significant reduction in the three-year cumulative rate of all-cause mortality, cardiovascular death, and myocardial infarction compared with BMS, without increased risk of TLR, stent thrombosis, or bleeding complications at three years in this group of Chinese geriatric patients。

关键词： Bare-metal stents Drug-eluting stents Geriatric patients Percutaneous coronary intervention

Clinical efficacies,underlying mechanisms and molecular targets of Chinese medicines for diabetic nephropathy treatment and management

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Acta Pharmaceutica Sinica B 2021年第9期11卷 2749-2767页

作者： Guoyi Tang sha Li Cheng Zhang Haiyong Chen Ning Wang Yibin Feng School of Chinese Medicine Li Ka Shing Faculty of Medicinethe University of Hong KongHong Kong SAR 999077China

Diabetic nephropathy(DN) has been recognized as a severe complication of diabetes mellitus and a dominant pathogeny of end-stage kidney disease,which causes serious health problems and great financial burden to human society *** strategies,such as renin-angiotensinaldosterone system blockade,blood glucose level control,and bodyweight reduction,may not achieve satisfactory outcomes in many clinical practices for DN ***,due to the multi-target function,Chinese medicine possesses promising clinical benefits as primary or alternative therapies for DN *** studies have emphasized identifying bioactive compounds and molecular mechanisms of reno-protective effects of Chinese *** pathways involved in glucose/lipid metabolism regulation,antioxidation,anti-inflammation,anti-fibrosis,and podocyte protection have been identified as crucial mechanisms of ***,we summarize the clinical efficacies of Chinese medicines and their bioactive components in treating and managing DN after reviewing the results demonstrated in clinical trials,systematic reviews,and meta-analyses,with a thorough discussion on the relative underlying mechanisms and molecular targets reported in animal and cellular *** aim to provide comprehensive insights into the protective effects of Chinese medicines against DN.

关键词： Chinese medicine Herbal medicine Diabetic nephropathy Diabetic kidney disease Signaling pathway Molecular target

Complete mitochondrial genome of the Japanese snapping shrimp Alpheus japonicus(Crustacea:Decapoda:Caridea):Gene rearrangement and phylogeny within Caridea

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Science China(Life Sciences) 2012年第7期55卷 591-598页

作者： SHEN Xin LI Xiao sha ZhongLi YAN BinLun XU QiHua Jiangsu Key Laboratory of Marine Biotechnology Huaihai Institute of Technology Lianyungang 222005 China Institute of Oceanology Chinese Academy of Sciences Qingdao 266071 China shandong Peanut Research Institute Qingdao 266100 China

The complete sequence of the mitochondrial genome of the Japanese snapping shrimp Alpheus japonicus Miers(Crustacea:Decapoda:Caridea) is presented here.A comparative analysis based on the currently available mitochondrial genomic data revealed many previously unknown characteristics of the mitochondrial genomes of caridean *** *** mitochondrial genome is 16487 bp long and contains the typical set of 37 metazoan *** gene arrangements in the mitochondrial genomes of four previously studied carideans(Macrobrachium rosenbergii,***,*** and Halocaridina rubra) were found to be identical to the pancrustacean ground pattern;thus,it was considered that gene rearrangements probably did not occur in the suborder *** the present study,a translocation of the trnE gene involving inversion was found in Alpheus mitochondrial *** phenomenon has not been reported in any other crustacean mitochondrial genome that has been studied so far;however,the translocation of one transfer RNA gene(trnP or trnT) was reported in the mitochondrial genome of Exopalaemon *** the ratios of the nonsynonymous and synonymous substitutions rates(ka/Ks) for the 13 protein coding genes from two Alpheus species(*** and ***) and three Macrobrachium species(***,***,***) were calculated,the ka/Ks values for all the protein coding genes in Alpheus and Macrobrachium mitochondrial genomes were found to be less than 1(between 0.0048 and 0.2057),indicating that a strong purification selection had *** phylogenetic tree that was constructed based on the mitochondrial protein coding genes in the genomes of nine related species indicated that Palaemonidae and Alpheidae formed a monophyly and shared a statistically significant relationship,(Palaemonidae+Alpheidae)+Atyidae,at the family level.

关键词：线粒体基因组甲壳纲十足目罗氏沼虾系统发育树基因重排日本人刺参蛋白编码基因

2016—2021年新疆生产建设兵团接种含麻疹成分疫苗AEFI病例的监测分析

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微生物学免疫学进展 2022年第4期50卷 47-52页

作者：韦性晶米莎莎李凡卡新疆医科大学公共卫生学院新疆乌鲁木齐830011 新疆生产建设兵团疾病预防控制中心新疆乌鲁木齐830002

目的分析新疆生产建设兵团(简称新疆兵团)接种含麻疹成分疫苗(measles-containing vaccines,MCV)疑似预防接种异常反应(adverse events following immunization,AEFI)的监测分析。方法通过收集新疆兵团2016—2021年中国免疫规划信息管... 详细信息

目的分析新疆生产建设兵团(简称新疆兵团)接种含麻疹成分疫苗(measles-containing vaccines,MCV)疑似预防接种异常反应(adverse events following immunization,AEFI)的监测分析。方法通过收集新疆兵团2016—2021年中国免疫规划信息管理系统接种MCV AEFI病例,采用描述性流行病学方法对AEFI病例进行分析。结果6年间新疆兵团共报告接种MCV AEFI病例276例,年均报告发生率91.52/10万。AEFI监测系统运行符合国家食品药品监督管理局《全国疑似预防接种异常反应监测方案》的规定。全年均有AEFI病例报告,主要集中在5—8月。新疆兵团14个师均有报告病例,各师接种MCV AEFI病例差异有统计学意义(χ^(2)=187.181,P7~8月龄人群最多;职业分布以散居儿童为主,占85.87%。不良反应以一般反应为主,占81.75%,各年一般反应、异常反应和偶合症病例数发生差异无统计学意义(χ^(2)=11.506、P=0.203,P>0.05);一般反应主要是发热,占86.61%。结论2016—2021年新疆兵团AEFI监测信息系统运转正常,敏感性和及时性均较高。MCV安全性较好,接种MCV AEFI发生率呈现先升后降的趋势但发生率较高。

关键词：含麻疹成分疫苗疑似预防接种异常反应安全性监测

α-ZrP/Fe_(3)O_(4)的制备及其对敌草快分离分析的研究

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现代化工 2022年第9期42卷 235-238,244页

作者：沙鸥朱雨情胡卡利姚佳伟周全陈丽江苏海洋大学环境与化学工程学院江苏连云港222005 江苏海洋大学药学院江苏连云港222005 连云港市第一人民医院检验科江苏连云港222002 江苏海洋大学江苏省海洋资源开发研究院江苏连云港222005

采用溶剂热法制备α-ZrP纳米粒子,在此基础上利用机械化学法制备了α-ZrP/Fe_(3)O_(4)并用作磁固相萃取剂与紫外分光光法联用对环境水样中的敌草快进行快速检测。结果表明,在最佳实验条件下,敌草快在0.025~1.0μg/mL范围内线性关系良好... 详细信息

采用溶剂热法制备α-ZrP纳米粒子,在此基础上利用机械化学法制备了α-ZrP/Fe_(3)O_(4)并用作磁固相萃取剂与紫外分光光法联用对环境水样中的敌草快进行快速检测。结果表明,在最佳实验条件下,敌草快在0.025~1.0μg/mL范围内线性关系良好,相关系数R=0.9993,检出限为0.015μg/mL。对该方法进行加标回收验证,河水的加标回收率为83.5%~103.6%,相对标准偏差为3.29%~4.22%。该方法操作简单、现象直观,为环境水体中敌草快的快速测定提供了一种新方法。

关键词：磁分散固相萃取机械化学法敌草快紫外-可见分光光度法

新疆生产建设兵团人群乙肝血清学流行状况及影响因素分析

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疾病预防控制通报 2022年第3期37卷 28-31,66页

作者：米莎莎郝启迪鲁梦婷李凡卡新疆生产建设兵团疾病预防控制中心乌鲁木齐830002 陕西中医药大学第二附属医院西安712000

目的了解新疆生产建设兵团(简称兵团)人群乙型病毒性肝炎(简称乙肝)的感染及疫苗接种情况,并分析影响因素,为控制当地乙肝流行提供依据。方法采用多阶段分层随机抽样方法,于2018年抽取新疆兵团6个师的常住人口入户调查并抽取静脉血,采... 详细信息

目的了解新疆生产建设兵团(简称兵团)人群乙型病毒性肝炎(简称乙肝)的感染及疫苗接种情况,并分析影响因素,为控制当地乙肝流行提供依据。方法采用多阶段分层随机抽样方法,于2018年抽取新疆兵团6个师的常住人口入户调查并抽取静脉血,采用酶联免疫吸附试验(ELISA)进行血清学检测,以单因素和多因素Logistic回归分析影响因素。结果共调查2420人,乙肝病毒表面抗原(HBsAg)阳性率、抗乙肝病毒表面抗原抗体(抗-HBs)阳性率和抗乙肝病毒核心抗原抗体(抗-HBc)阳性率分别为1.98%,67.31%,32.93%。HBsAg阳性率随年龄增加呈升高趋势(趋势χ^(2)=16.730,P<0.05),南疆、北疆和东疆分别为2.82%,1.36%,1.21%,差异有统计学意义(χ^(2)=6.891,P<0.05);抗-HBc阳性率随年龄增加呈升高趋势(趋势χ^(2)=207.118,P<0.05)。乙肝疫苗接种率随年龄增加呈下降趋势(趋势χ^(2)=349.918,P<0.05),1岁~组儿童最高(99.60%),29岁及以上组最低(57.01%)。共用牙刷、有输血史是HBsAg阳性的危险因素,接种疫苗是感染乙肝的保护因素。结论新疆兵团的儿童乙肝防控工作已取得明显成效,应进一步加强成人乙肝防控工作。

关键词：乙型肝炎血清流行病学疫苗