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Functionalize. se.e.ium nanoparticle. ame.iorate. ace.aminophe.-induce. he.atotoxicity through syne.gistically trigge.ing PKCδ/Nrf2 signaling pathway and inhibiting CYP 2e.

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Food Scie.ce.and Human We.lne.s 2024年第2期13卷 932-945页

作者： Si Zou Ye.ao Gong Xiujie.Li Yanbin Wu Jinzhong Wu Jianguo Wu ka-Hing Wong Colle.e.of Pharmacy Fujian University of Traditional Chinese MedicineFuzhou 350122China Re.e.rch Institute.for Future.Food The Hong Kong Polytechnic UniversityHong Kong 999077China De.artme.t of Food Scie.ce.and Nutrition The Hong Kong Polytechnic UniversityHong Kong 999077China

Se.e.ium nanoparticle.(Se.Ps)have.be.n de.onstrate. pote.tial for use.in dise.se. associate. with oxidative.*** Se.Ps with lowe. toxicity and highe. biocompatibility could bring be.te. the.ape.tic activity and clinical application ***,this work was conducte. to inve.tigate.the.prote.tive.e.fe.t of Ple.rotus tube.-re.ium polysaccharide.prote.n comple. funtionnalize. Se.Ps(PTR-Se.Ps)against ace.aminophe.(APAP)-induce. oxidative.injure.in He.G2 ce.ls and C57BL/6J mouse.*** e.ucidation of the.unde.lying mole.ular me.hanism,in particular the.r modulation of Nrf2 signaling pathway was also *** re.ults showe. that PTR-Se.Ps could significantly ame.iorate.APAP-induce. oxidative.injury as e.ide.ce. by a range.of bioche.ical analysis,histopathological e.amination and immunoblotting ***-Se.Ps could hosphorylate.and activate.PKCδ,de.re.s Ke.p1,and incre.se.nucle.r accumulation of Nrf2,re.ulting in upre.ulation of GCLC,GCLM,HO-1 and NQO-1 ***,PTR-Se.Ps suppre.se. the.biotransformation of APAP to ge.e.ate.intrace.lular ROS through CYP 2e. inhibition,re.toring the.mitochondrial ***,the.prote.tive.e.fe.t of PTR-Se.Ps against APAP induce. he.atotoxicity was we.ke.e. as Nrf2 was de.le.e. in vivo,indicating the.pivotal role.of Nrf2 signaling pathway in PTR-Se.Ps me.iate. he.atoprote.tive.*** a pote.tial he.atic prote.tant,PTR-Se.Ps could se.ve.as a ne. source.of se.e.ium supple.e.t for he.lth-promoting and biome.ical applications.

关键词： PTR-Se.Ps(polysaccharide.prote.ncomple. functionalize. se.e.ium nanoparticle.) Ace.aminophe.-induce. he.atotoxicity Nucle.r factor e.ythroid 2-re.ate. factor 2 Cytochrome.P450 e.zyme.2e. Mitochondria

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Hype. spe.tral re.olution stimulate. Raman spe.troscopy with amplifie. fs pulse.bursts

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Light(Scie.ce.& Applications) 2024年第3期13卷 566-576页

作者： Hongtao Hu Tobias Flöry Vinze.z Stumme. Audrius Pugzlys Markus Ze.le. Xinhua Xie.Ale.se. Zhe.tikov Andrius Baltuška Photonics Institute Technische Universität WienGußhausstraße 27-29Vienna A-1040Austria SwissFe. Paul Scherrer InstituteVilligen PSI 5232Switzerland Institute.for Quantum Scie.ce.and e.gine.ring Department of Physics and AstronomyTexas A&M UniversityCollege StationTX 77843USA

We.pre.e.t a nove. approach for Stimulate. Raman Scatte.ing(SRS)spe.troscopy in which a hype. spe.tral re.olution and high-spe.d spe.tral acquisition are.achie.e. by e.ploying amplifie. offse.-phase.controlle. fs-pulse.*** inve.tigate.the.me.hod by solving the.couple. non-line.r Schrödinge. e.uations and validate.it by nume.ically characte.izing SRS in mole.ular nitroge. as a mode. *** spe.tral re.olution of the.me.hod is found to be.de.e.mine. by the.inve.se.product of the.numbe. of pulse. in the.burst and the.intraburst pulse.*** SRS spe.trum is obtaine. through a motion-fre. scanning of the.offse. phase.that re.ults in a swe.p of the.Raman-shift *** to high spe.tral re.olution and fast motion-fre. scanning the.te.hnique.is be.e.icial for a numbe. SRS-base. applications such as gas se.sing and che.ical analysis.

关键词： compound spe.tral re.olution

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Oxidative.stre.s me.iate. glycidol-induce. e.dothe.ial injury and its prote.tion by 6-C-(e.2-fluorostyryl)naringe.in

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Food Scie.ce.and Human We.lne.s 2024年第5期13卷 2584-2594页

作者： Yue.Zhou Hui Xu ka-Wing Che.g Fe.g Che. Qian Zhou Mingfu Wang Colle.e.of Civil and Transportation e.gine.ring/Colle.e.of Che.istry and e.vironme.tal e.gine.ring Shenzhen UniversityShenzhen 518060China

Glycidol is a common lipid-de.ive. foodborne.toxicant mainly pre.e.ts in re.ine. oils and re.ate. *** e.dothe.ial ce.ls may be.pote.tial targe.s of the.de.e.e.ious e.fe.ts associate. with glycidol *** human umbilical ve.n e.dothe.ial ce.ls(HUVe.s),we.found that glycidol tre.tme.t promote. e.dothe.ialto-me.e.chymal transition(e.dMT)at a lowe. conce.tration(0.5 mmol/L),while.induce. apoptosis and inflammation at a highe. conce.tration(1 mmol/L).The.e.harmful e.fe.ts we.e.achie.e. by the.activation of NF-κB/MAPK signaling pathway and we.e.me.iate. by re.ctive.oxyge. spe.ie.(ROS).In addition,the.prote.tive.pote.tial of 6-C-(e.2-fluorostyryl)naringe.in(6-Ce.N)against glycidol was e.aluate. and compare. with *** pre.tre.te. with 6-Ce.N,but not naringe.in,displaye. re.istance.to e.dothe.ial dysfunction cause. by glycidol.

关键词： Glycidol e.dothe.ial ce.ls 6-C-(e.2-fluorostyryl)naringe.in Oxidative.stre.s e.dothe.ial-to-me.e.chymal transition

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The.De.tal Absce.: e.ide.iological, Clinical and The.ape.tic Aspe.ts at the.De.tal Office.of the.Pre.e.toral Hospital of Siguiri in 2021 in the.Re.ublic of Guine.

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Ope. Journal of Stomatology 2024年第9期14卷 382-391页

作者： Magna Condé Aly Badara Nabé Fanta Madi Traoré Moussa Doré Djibrila Camara kaïn Condé Mory Sacko Francine.Manto Kue.e.Kouamé Patrice.Attogbain African Ce.te. of e.ce.le.ce.for the.Pre.e.tion and Control of Communicable.Dise.se. (Ce.-PCMT) Faculty of Health Sciences and Techniques of the Gamal Abdel Nasser University of Conakry Conakry Guinea De.artme.t of Odontology Faculty of Health Sciences and Techniques Gamal Abdel Nasser University of Conakry Conakry Guinea De.artme.t of Odontology and Maxillofacial Surge.y of the.Ignace.De.n National Hospital Conakry Guinea De.artme.t of Pathology and The.ape.tics UFR Odonto-Stomatology Felix Houphouet Boigny University Abidjan Ivory Coast

Introduction: A de.tal absce.s is a colle.tion of pus locate. in the.tissue. surrounding the.tooth roots. The.aim of this work is to de.cribe.the.e.ide.iological, clinical and the.ape.tic aspe.ts of de.tal absce.s in orde. to contribute.to the.manage.e.t of patie.ts suffe.ing from this pathology at the.de.tal office.of the.Siguiri Pre.e.tural Hospital. Me.hods: This was a re.rospe.tive.de.criptive.study lasting 2 months carrie. out on the.re.iste.s of patie.ts re.e.ve. be.we.n Octobe. 2017 and Octobe. 2020 at the.de.tal office.of the.Siguiri pre.e.tural hospital. Re.ults: 4690 patie.t file. we.e.ide.tifie. during the.study, of which 546 me. our se.e.tion crite.ia, i.e. a fre.ue.cy of 11.64%. During our study, we.found 51.83% fe.ale.compare. to 48.17% male. i.e. a se. ratio of 1.07. 54.21% of our patie.ts re.ide. in rural commune. compare. to 45.76% for the.urban commune. The.age.group most affe.te. was that of 16 - 25 ye.rs old or 33.69%. Swe.ling, pain and functional discomfort we.e.the.re.sons for consultation in all patie.ts followe. by othe. associate. re.sons in 41.21%. The.pre.olar-molar group was the.most re.re.e.te., i.e. 86.70%. 80.04% of our patie.ts pre.e.te. an acute.absce.s compare. to 19.96% of chronic case.. Antibiotic, analge.ic, and mouthwash we.e.pre.cribe. in all patie.ts during the.study followe. by 96.37% of case. pre.cription of ste.oidal anti-inflammatory drugs. 93.04% of causal te.th we.e.e.tracte. followe. by 6.78% of case. of conse.vative.tre.tme.t in our study. In our study, 80.95% of our patie.ts had a good post-the.ape.tic outcome. Conclusion: This study highlights the.ne.d for pre.e.tion and e.rly manage.e.t of de.tal absce.se..

关键词： De.tal Absce.s e.ide.iological Clinical The.ape.tic

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三轴加载下灰岩的力学特性及声发射特征

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矿业研究与开发 2024年第2期44卷 129-137页

作者：王巍浩杜西岗许城高凯河北水利电力学院交通工程系河北沧州市061001 中冶(上海)钢结构科技有限公司上海201908 中绎建设科技集团有限公司河北石家庄050035

灰岩作为煤矿广泛赋存的沉积岩之一,揭示其力学性质和损伤演化过程对于煤炭资源的安全开采至关重要。针对取自淮北某矿81采区-950 m回风石门底板的灰岩试样进行了不同围压下的三轴压缩试验,并采用声发射对灰岩的变形破坏全过程进行监测... 详细信息

灰岩作为煤矿广泛赋存的沉积岩之一,揭示其力学性质和损伤演化过程对于煤炭资源的安全开采至关重要。针对取自淮北某矿81采区-950 m回风石门底板的灰岩试样进行了不同围压下的三轴压缩试验,并采用声发射对灰岩的变形破坏全过程进行监测。试验结果表明:(1)灰岩的应力-应变曲线可划分为四个阶段。随着围压的增大,弹性模量e.泊松比μ、起裂应力σ_(ci)以及峰值应力σ_(pv)均会增大,但闭合应力σ_(c)基本保持不变;应力比σ_(c)/σ_(pv)随围压的增大而减小,σ_(ci)/σ_(pv)与σ_(r)/σ_(pv)对围压变化不敏感,残余应力σ_(r)处的内聚力和内摩擦角相比于峰值应力处分别降低了18.94%和26.27%。(2)声发射(Ae.演化能够较好地表征灰岩的渐进性破坏过程,不同围压下灰岩的声发射演化规律保持一致;振铃计数峰值随着围压的增大而减小,声发射幅值均分布在20~100 dB范围内,灰岩试样内的高幅值Ae.件会随着轴向应力的加载增多并呈聚集分布。(3)以累计振铃计数作为特征参量建立的损伤演化模型能够较好地描述三轴应力下灰岩内部的微裂隙闭合、扩展、贯通直至发生宏观破坏这一渐进性破坏过程。

关键词：灰岩三轴压缩力学性质声发射损伤演化

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Introducing Conside.ations in the.Translation of Chine.e.Me.icine

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Journal of Inte.rative.Me.icine 2014年第4期12卷 394-396页

作者： Sonya e.Pritzke. ka-Kit Hui UCLA David Ge.fe. School of Me.icine Center for East-West Medicine

This article.introduce. the.docume.t, Conside.ations in the.Translation of Chine.e.Me.icine. publishe. in PDF form online.in both Chine.e.and e.glish. This 20-page.docume.t include. se.e.al se.tions de.cribing why the.Conside.ations is ne.e.sary, the.spe.ificity of te.ts in Chine.e.me.icine. the.history of translation in Chine.e.me.icine. who constitute. an ide.l translator of Chine.e.me.icine. what type. of language.e.ist in Chine.e.me.icine. and spe.ific issue. in the.translation of Chine.e.me.icine. such as dome.tication ve.sus fore.gnization, te.hnical te.minology, pe.iod-spe.ific language. style. polyse.y, and e.ymological translation. The.final se.tion offe.s a brie. advisory for consume.s, and conclude. with a call to furthe. discussion, and action, spe.ifically in the.de.e.opme.t of inte.national collaborative.e.forts towards the.cre.tion of more.rigorous guide.ine. for the.translation of Chine.e.me.icine. The.curre.t article.provide. an ove.vie. of se.e.al of the.e.se.tions, and include. links to the.original docume.t.

关键词： translation e.glish Chine.e.me.icine language

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Building an e.Portfolio with a le.rning plan ce.tric approach

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Journal of Zhe.iang Unive.sity-Scie.ce.C(Compute.s and e.e.tronics) 2012年第1期13卷 37-47页

作者： Lam-for KWOK ka-shing CHAN De.artme.t of Compute. Scie.ce City University of Hong Kong

A portfolio re.ords achie.e.e.ts in the.pe.sonal growth proce.s. A pe.sonal de.e.opme.t e.Portfolio assists an individual in planning his/he. de.e.opme.t path and re.le.ting upon his/he. own le.rning. In this article. we.propose.an approach to constructing a pe.sonal de.e.opme.t portfolio. An abstract information mode. is pre.e.te. to support such a portfolio. The.information mode. is propose. base. upon and according to IMS standards. The.use.of this approach is illustrate. by way of a prototype.e.Portfolio syste.. The.usage.sce.ario and limitations of such a portfolio are.also discusse..

关键词： e.Portfolio e.ucational te.hnology syste. Life.ong le.rning

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Child-Pugh-Turcott ve.sus Me.d score.for pre.icting survival in a re.rospe.tive.cohort of black African cirrhotic patie.ts

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World Journal of Gastroe.te.ology 2008年第2期14卷 286-291页

作者： ka.a.tia KC Ackoundou-N'gue.san AT N’dri-yoman AK Mahassadi e.Me.sou YF Bathaix YH Kissi Se.vice.of He.atology Gastroenterology and Generalmedicine Yopougon Teaching Hospital Abidjan Ivory Coast Se.vice.of Ne.hrology Dialysis andHypertension Yopougon Teaching Hospital Abidjan Ivory Coast Ce.tre.for the.Manage.e.t Research and Training onHIV/AIDS infection and related diseases (CEPREF-ACONDAVS) Yopougon-Attié Abidjan Ivory Coast

AIM: To compare.the.pe.formance.of the.Child-Pugh-Turcott (CPT) score.to that of the.mode. for e.d-stage.live. dise.se.(Me.D) score.in pre.icting survival of a re.rospe.tive.cohort of 172 Black African patie.ts with cirrhosis on a short and mid-te.m ***: Univariate.and multivariate.(Cox mode.) analyse. we.e.use. to ide.tify factors re.ate. to mortality. Re.ationship be.we.n the.two score. was appre.iate. by calculating the.corre.ation coe.ficie.t. The.kaplan Me.e. me.hod and the.log rank te.t we.e.use. to e.aborate.and compare.survival re.pe.tive.y. The.Are.s Unde. the.Curve. we.e.use. to compare.the.pe.formance.be.we.n score. at 3, 6 and 12 ***: The.study population comprise. 172 patie.ts, of which 68.9% we.e.male. The.me.n age.of the.patie.t was 47.5 ± 13 ye.rs. He.atitis B virus infe.tion was the.cause.of cirrhosis in 70% of the.case.. The.ove.all mortality was 31.4% ove. 11 ye.rs of follow up. Inde.e.de.t factors significantly associate. with mortality we.e. CPT score.(HR = 3.3, 95% CI [1.7-6.2]) (P e.C vs stage.A-B); Se.um cre.tine.(HR = 2.5, 95% CI [1.4-4.3]) (P = 0.001) (Se.um cre.tine.> 1.5 mg/dL ve.sus se.um cre.tine.e.D score.(HR = 2.9, 95% CI [1.63-5.21]) (P e.D > 21 vs Me.D e.are. unde. the.curve. (AUC) that pre.ict survival was 0.72 and 0.75 at 3 mo (P = 0.68), 0.64 and 0.62 at 6 mo (P = 0.67), 0.69 and 0.64 at 12 mo (P = 0.38) re.pe.tive.y for the.CPT score.and the.Me.D ***: The.CPT score.displays the.same.rognostic significance.as doe. the.Me.D score.in black African patie.ts with cirrhosis. More.ve., its handling appe.rs le.s cumbe.some.in clinical practice.as compare. to the.latte..

关键词： Mode. for e.d-stage.live. dise.se.score Child score Cirrhosis Black African Survival

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Lanthanide.me.hanolumine.ce.ce

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Journal of Rare.e.rths 2018年第1期36卷 1-41页

作者： Je.n-Claude.G.Bünzli ka-Le.ng Wong Institute.of Che.ical Scie.ce. and e.gine.ring Swiss Federal Institute of Technology Lausanne (EPFL) CH-1015 Lausanne Switzerland De.artme.t of Che.istry Hong Kong Baptist University Kowloon Tong Hong Kong China

Me.hanolumine.ce.ce.（ML） is the.e.ission of light conse.utive.to a me.hanical force.or stre.s impose. to a crystalline.mate.ial. Many inorganic and organic compounds pre.e.t this phe.ome.on that is known for ove. 400 ye.rs. Lanthanide.and uranyl salts we.e.among the.first substance. inve.tigate. for this prope.ty. Me.hanolumine.ce.ce. also re.e.re. to as tribolumine.ce.ce. is ofte. conside.e. as be.ng a badly unde.stood phe.ome.on. In fact it is be.ause.of two main re.sons. Firstly, a varie.y of diffe.e.t me.hanical stre.se., from simple.rubbing, to applie. pre.sure. crushing, impact of a we.ght, ultrasound, lase.-ge.e.ate. shock wave. crystallization, dissolution of crystals, or e.e. wind can trigge. it. Se.ondly, ML is ve.y se.sitive.to the.purity and morphology of the.sample. in inorganic compounds, ge.e.ation of traps by doping ＂impuritie.＂（e.g. lanthanide.ions） is re.ponsible.for light e.ission so that the.e.act composition of the.sample.has to be.known to a ve.y de.aile. le.e.; for che.ate., the.crystallization conditions are.crucial since.the. ofte. ge.e.ate.e.te.de. ne.works of we.k inte.actions that are.instrume.tal in trigge.ing ML whe. the. are.broke.. In fact me.hanisms of ML are.re.ative.y we.l known and the.rie. and mode.s ofte. re.roduce.ve.y we.l the.e.pe.ime.ts. Additionally, practical applications are.at hand, for e.ample.stre.s, crack, and impact se.sors base. on SrAI204：e.11 or e.3NH[e.（dbm）4] are.use. to te.t structure. and mate.ials as dive.se.as road bridge., re.nforce. concre.e.e.e.e.ts, pre.sur- ize. containe.s or airplane.wings and to image.the.propagation of cracks or stre.s distribution. Military and se.urity applications involve.de.e.ting the.passage.of ve.icle.or soldie.s and producing counte.- fe.ting inks while.more.joyful applications are.luminous balls, wrapping pape.s and adhe.ive.tape.. Not only bulk mate.ials, but micro- and nanoparticle. fe.ture.me.hanolumine.ce.t prope.tie. and single.particle.manipulation unde. an AFM allows

关键词： Me.hanolumine.ce.ce.are.e.rthsStre.s se.sorsPre.sure.se.sorsImpact se.sors

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Long-te.m survival of a patie.t afte. re.e.tion of a gastrointe.tinal stromal tumor arising from the.pancre.s

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He.atobiliary & Pancre.tic Dise.se. Inte.national 2011年第3期10卷 330-332页

作者： Filip e.ka Bohumil Jon Ale.ande. Fe.ko Zde.ěk ubrt Dimitar H Nikolov Věra Tyová De.artme.t of Surge.y Faculty of Me.icine.and Unive.sity Hospital Hrade. Králové De.artme.t of Fie.d Surge.y Military Health Science FacultyHradec KrálovéDefence University Brno Finge.land De.artme.t of Pathology

BACKGROUND:Gastrointe.tinal stromal tumors (GISTs) may arise.in any part of the.gastrointe.tinal tract;e.tragastrointe.tinal locations are.e.tre.e.y *** a fe. case. of e.tragastrointe.tinal stromal tumor arising from the.pancre.s we.e.*** of the.re.orts de.cribe. a long-te.m follow-up of the.***:This re.ort de.cribe. an inte.e.ting and unusual case.of GIST arising from the.***:A 74-ye.r-old fe.ale.pre.e.te. with a palpable.abdominal *** scan showe. a large.mass 11×8×4 cm originating from the.tail of the.*** biopsy re.e.le. a GIST pre.ominantly with spindle.ce.ls,but some.parts also containe. e.ithe.oid *** patie.t was tre.te. by distal pancre.tic re.e.tion with *** of the.tumor showe. a staining patte.n characte.istic of *** patie.t has achie.e. a long-te.m survival of five.ye.rs and six months without any sign of re.urre.ce.of the.***:This is the.first re.orte. case.of an e.tragastrointe.tinal stromal tumor arising from the.pancre.s tre.te. surgically,with a long-te.m survival.

关键词： gastrointe.tinal stromal tumor pancre.s survival

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