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Functionalized selenium nanoparticles ameliorated acetaminophen-induced hepatotoxicity through synergistically triggering PKCδ/Nrf2 signaling pathway and inhibiting CYP 2e1

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Food Science and Human Wellness 2024年第2期13卷 932-945页

作者： Si Zou Yetao Gong Xiujie Li Yanbin Wu Jinzhong Wu Jianguo Wu ka-Hing Wong College of Pharmacy Fujian University of Traditional Chinese MedicineFuzhou 350122China Research Institute for Future Food The Hong Kong Polytechnic UniversityHong Kong 999077China Department of Food Science and Nutrition The Hong Kong Polytechnic UniversityHong Kong 999077China

Selenium nanoparticles(SeNPs)have been demonstrated potential for use in diseases associated with oxidative *** SeNPs with lower toxicity and higher biocompatibility could bring better therapeutic activity and clinical application ***,this work was conducted to investigate the protective effect of Pleurotus tuber-regium polysaccharide-protein complex funtionnalized SeNPs(PTR-SeNPs)against acetaminophen(APAP)-induced oxidative injure in HepG2 cells and C57BL/6J mouse *** elucidation of the underlying molecular mechanism,in particular their modulation of Nrf2 signaling pathway was also *** results showed that PTR-SeNPs could significantly ameliorate APAP-induced oxidative injury as evidenced by a range of biochemical analysis,histopathological examination and immunoblotting ***-SeNPs could hosphorylate and activate PKCδ,depress Keap1,and increase nuclear accumulation of Nrf2,resulting in upregulation of GCLC,GCLM,HO-1 and NQO-1 ***,PTR-SeNPs suppressed the biotransformation of APAP to generate intracellular ROS through CYP 2e1 inhibition,restoring the mitochondrial ***,the protective effect of PTR-SeNPs against APAP induced hepatotoxicity was weakened as Nrf2 was depleted in vivo,indicating the pivotal role of Nrf2 signaling pathway in PTR-SeNPs mediated hepatoprotective *** a potential hepatic protectant,PTR-SeNPs could serve as a new source of selenium supplement for health-promoting and biomedical applications.

关键词： PTR-SeNPs(polysaccharide-proteincomplex functionalized selenium nanoparticles) Acetaminophen-induced hepatotoxicity Nuclear factor erythroid 2-related factor 2 Cytochrome P450 enzyme 2e1 Mitochondria

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Hyper spectral resolution stimulated Raman spectroscopy with amplified fs pulse bursts

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Light(Science & Applications) 2024年第3期13卷 566-576页

作者： Hongtao Hu Tobias Flöry Vinzenz Stummer Audrius Pugzlys Markus Zeiler Xinhua Xie Aleksei Zheltikov Andrius Baltuška Photonics Institute Technische Universität WienGußhausstraße 27-29Vienna A-1040Austria SwissFeL Paul Scherrer InstituteVilligen PSI 5232Switzerland Institute for Quantum Science and engineering Department of Physics and AstronomyTexas A&M UniversityCollege StationTX 77843USA

We present a novel approach for Stimulated Raman Scattering(SRS)spectroscopy in which a hyper spectral resolution and high-speed spectral acquisition are achieved by employing amplified offset-phase controlled fs-pulse *** investigate the method by solving the coupled non-linear Schrödinger equations and validate it by numerically characterizing SRS in molecular nitrogen as a model *** spectral resolution of the method is found to be determined by the inverse product of the number of pulses in the burst and the intraburst pulse *** SRS spectrum is obtained through a motion-free scanning of the offset phase that results in a sweep of the Raman-shift *** to high spectral resolution and fast motion-free scanning the technique is beneficial for a number SRS-based applications such as gas sensing and chemical analysis.

关键词： compound spectral resolution

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三轴加载下灰岩的力学特性及声发射特征

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矿业研究与开发 2024年第2期44卷 129-137页

作者：王巍浩杜西岗许城高凯河北水利电力学院交通工程系河北沧州市061001 中冶(上海)钢结构科技有限公司上海201908 中绎建设科技集团有限公司河北石家庄050035

灰岩作为煤矿广泛赋存的沉积岩之一,揭示其力学性质和损伤演化过程对于煤炭资源的安全开采至关重要。针对取自淮北某矿81采区-950 m回风石门底板的灰岩试样进行了不同围压下的三轴压缩试验,并采用声发射对灰岩的变形破坏全过程进行监测... 详细信息

灰岩作为煤矿广泛赋存的沉积岩之一,揭示其力学性质和损伤演化过程对于煤炭资源的安全开采至关重要。针对取自淮北某矿81采区-950 m回风石门底板的灰岩试样进行了不同围压下的三轴压缩试验,并采用声发射对灰岩的变形破坏全过程进行监测。试验结果表明:(1)灰岩的应力-应变曲线可划分为四个阶段。随着围压的增大,弹性模量e、泊松比μ、起裂应力σ_(ci)以及峰值应力σ_(pv)均会增大,但闭合应力σ_(c)基本保持不变;应力比σ_(c)/σ_(pv)随围压的增大而减小,σ_(ci)/σ_(pv)与σ_(r)/σ_(pv)对围压变化不敏感,残余应力σ_(r)处的内聚力和内摩擦角相比于峰值应力处分别降低了18.94%和26.27%。(2)声发射(Ae)演化能够较好地表征灰岩的渐进性破坏过程,不同围压下灰岩的声发射演化规律保持一致;振铃计数峰值随着围压的增大而减小,声发射幅值均分布在20~100 dB范围内,灰岩试样内的高幅值Ae事件会随着轴向应力的加载增多并呈聚集分布。(3)以累计振铃计数作为特征参量建立的损伤演化模型能够较好地描述三轴应力下灰岩内部的微裂隙闭合、扩展、贯通直至发生宏观破坏这一渐进性破坏过程。

关键词：灰岩三轴压缩力学性质声发射损伤演化

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Analysis of the Level of Pollutants in the ICS Location Area

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Open Journal of Air Pollution 2023年第3期12卷 92-101页

作者： Sokhna Die ka Dia Issa Samb Ousmane Niass Thaddée Adiouma Seck Gorgui ka Natural Justice Hub de Dakar Senegal Organic and Therapeutic Chemistry Research Team (eCOT) Department of Chemistry University Alioune Diop Bambey Senegal

The present study deals with the analysis of the level of pollution found in the area where the Chemical Industries of Senegal (ICS) is located. The results of various field surveys and physicochemical analyses show a high exposure of sulphur and phosphate. This study aims to define abatement strategies to reduce the effects of pollution in the area where ICS is located and mitigate the harmful impacts to the health of the population by creating a system to inform the population of the level of concentration of pollutants in the environment. This will allow the different targets to understand pollution, its manifestations and its effects on health and the environment, prevention, participation in the limitation of pollutant emissions and the formation of eco-citizens sensitive to the issue of environmental pollution of ICS.

关键词： environment Pollutants Physicochemical Analysis

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Toward Carbon-Neutral Water Systems:Insights from Global Cities

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engineering 2022年第7期8卷 77-85页

作者： ka Leung Lam Gang Liu Anne Marieke Motelica-Wagenaar Jan Peter van der Hoek Division of Natural and Applied Sciences Duke Kunshan UniversityKunshan 215316China Research Center for eco-environmental Sciences Chinese Academy of SciencesBeijing 100085China Waternet Amsterdam 1096 ACNetherlands Department of Water Management Delft University of TechnologyDelft 2628 CNNetherlands

Many cities have pledged to achieve carbon *** urban water industry can also contribute its share to a carbon-neutral *** a multi-city time-series analysis approach,this study aims to assess the progress and lessons learned from the greenhouse gas(GHG)emissions management of urban water systems in four global cities:Amsterdam,Melbourne,New York City,and *** cities are advanced in setting GHG emissions reduction targets and reporting GHG emissions in their water *** four cities have reduced the GHG emissions in their water industries,compared with those from more than a decade ago(i.e.,the latest three-year moving averages are 13%–32%lower),although the emissions have“rebounded”multiple times over the *** emissions reductions were mainly due to various engineering opportunities such as solar and mini-hydro power generation,biogas valorization,sludge digestion and incineration optimization,and aeration system *** cities have recognized the many challenges in reaching carbon-neutrality goals,which include fluctuating water demand and rainfall,more carbon-intensive flood-prevention and water-supply strategies,meeting new air and water quality standards,and revising GHG emissions accounting *** study has also shown that it is difficult for the water industry to achieve carbon neutrality on its own.A collaborative approach with other sectors is needed when aiming toward the city’s carbon-neutrality *** an approach involves expanding the usual system boundary of the water industry to externally tap into both engineering and non-engineering opportunities.

关键词： Urban water Greenhouse gas emissions Cities Climate change mitigation Carbon neutrality

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Transfusion-transmitted hepatitis e:What we know so far?

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World Journal of Gastroenterology 2022年第1期28卷 47-75页

作者： Carmen ka Man Cheung Sunny Hei Wong Alvin Wing Hin Law Man Fai Law Medicine and Therapeutics Prince of Wales HospitalHong Kong 852China Institute of Digestive Disease and Department of Medicine and Therapeutics the Chinese University of Hong KongHong Kong 852China Lee Kong Chian School of Medicine Nanyang Technological UniversitySingapore 639798Singapore West Island School Hong Kong 852China

Hepatitis e virus(HeV)is a major cause of viral hepatitis *** is growing concern about transfusion-transmitted HeV(TT-HeV)as an emerging global health *** can potentially result in chronic infection in immunocompromised patients,leading to a higher risk of liver cirrhosis and even *** 0.0013%and 0.281%of asymptomatic blood donors around the world have HeV viremia,and 0.27%to 60.5%have anti-HeV immunoglobulin *** is infectious even at very low blood concentrations of the *** patients who develop persistent hepatitis e infection should have their immunosuppressant regimen reduced;ribavirin may be considered as *** interferon can be considered in those who are refractory or intolerant to ***,a nucleotide analog,showed modest antiviral activity in some clinical studies but sustained viral response was not ***,rescue treatment remains an unmet *** need for HeV screening of all blood donations remains *** screening has been adopted in some countries after consideration of risk and resource *** pathogen reduction methods have also been proposed to reduce the risk of *** studies are needed to define the incidence of transmission through transfusion,their clinical features,outcomes and prognosis.

关键词： Hepatitis e virus Acute and chronic hepatitis Immunosuppression Blood transfusion Transplantation

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基于凹槽结构的导管螺旋桨梢部流动研究

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船舶力学 2024年第6期28卷 866-876页

作者：金志辉王鹏董华超温志文丁永乐西安精密机械研究所西安710077 西北工业大学航海学院西安710072

针对导管螺旋桨的梢部流动,受压气机中“机匣处理”的启发,将矩形凹槽结构应用于导管内壁,用于降低导管螺旋桨梢涡强度和抑制梢涡空化,进而有望改善导管螺旋桨的水动力和空泡性能。采用计算流体力学方法,针对19A导管和ka4-70螺旋桨有无... 详细信息

针对导管螺旋桨的梢部流动,受压气机中“机匣处理”的启发,将矩形凹槽结构应用于导管内壁,用于降低导管螺旋桨梢涡强度和抑制梢涡空化,进而有望改善导管螺旋桨的水动力和空泡性能。采用计算流体力学方法,针对19A导管和ka4-70螺旋桨有无凹槽/不同凹槽结构进行非定常数值计算,研究凹槽结构对桨叶叶梢压力、梢涡强度、梢涡结构以及水动力性能的影响。结果表明:凹槽结构会明显改变导管螺旋桨梢部流场涡的形成,减弱梢涡强度,提高叶片梢部最小压力,并且对推进性能几乎没有影响。研究结果可为导管螺旋桨的梢涡控制以及减振降噪提供一种新的解决途径。

关键词：导管螺旋桨凹槽结构梢涡结构空泡机匣处理

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Introducing Considerations in the Translation of Chinese Medicine

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Journal of Integrative Medicine 2014年第4期12卷 394-396页

作者： Sonya e.Pritzker ka-Kit Hui UCLA David Geffen School of Medicine Center for East-West Medicine

This article introduces the document, Considerations in the Translation of Chinese Medicine, published in PDF form online in both Chinese and english. This 20-page document includes several sections describing why the Considerations is necessary, the specificity of texts in Chinese medicine; the history of translation in Chinese medicine; who constitutes an ideal translator of Chinese medicine; what types of language exist in Chinese medicine; and specific issues in the translation of Chinese medicine, such as domestication versus foreignization, technical terminology, period-specific language, style, polysemy, and etymological translation. The final section offers a brief advisory for consumers, and concludes with a call to further discussion, and action, specifically in the development of international collaborative efforts towards the creation of more rigorous guidelines for the translation of Chinese medicine. The current article provides an overview of several of these sections, and includes links to the original document.

关键词： translation english Chinese medicine language

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Vibrational resonance in a multistable system with position-dependent mass

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Communications in Theoretical Physics 2023年第11期75卷 115-134页

作者： T O Roy-Layinde K A Omoteso O T Kolebaje F O Ogunmefun R A Fasasi J A Laoye U e Vincent Department of Physics Olabisi Onabanjo UniversityAgo-IwoyeOgun StateNigeria Department of Physics Adeyemi Federal University of EducationOndoNigeria Department of Physical Sciences Redeemer’s UniversityP.M.B.230EdeNigeria Department of Physics Lancaster UniversityLancaster LA14 YBUnited Kingdom

The occurrence of vibrational resonance(VR)in a dual-frequency-driven multistable system with a spatially varying mass modelling particle with position-dependent mass(PDM)and evolving in a one-dimensional symmetric periodic potential has been investigated and reported in this *** numerically compute and analyze the response amplitude,the effects of the PDM parameters(m0,a)on the potential structure,the occurrence of VR and the bifurcation of the equilibrium *** is shown that the PDM parameters,besides controlling VR,can induce unconventional resonance patterns through the variation of the potential well *** resonant states can be influenced through the cooperation of the PDM parameters and the external forcing leading the system from multiresonance state into single and double resonance *** contributions of the fixed rest mass m0 on the VR and the PDM-induced resonance are determined by threshold conditions imposed by the magnitude of the mass nonlinear strength a.

关键词： vibrations resonance position-dependent mass multistable oscillator dualfrequency force nonlinear systems

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TRPC5 is essential in endothelium-dependent contraction of aorta from diet-induced obese mice

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Fundamental Research 2022年第3期2卷 429-436页

作者： Yifei Zhu Sheng Wang Yuan Chu ka Zhang Xin Wen Lei Feng Fan Yu Xin Ma Wuxi School of Medicine Jiangnan UniversityWuxi 214000China

The role of the Ca^(2+)-permeable ion channel TRPC5 in regulating vasocontraction in obesity is poorly ***,we investigated whether TRPC5 contributes to vascular dysfunction in obesity by promoting endothelium-dependent contraction via activation of cytosolic phospholipase A2(cPLA_(2))in the aortic endothelial cells of obese ***-induced endothelium-dependent relaxation and contraction in the aorta were measured us-ing wire ***_(2)activity was measured by the fluorogenic PLA_(2)substrate Bis-BODIPY^(TM)FL C_(11)-*** intracellular Ca^(2+)level in response to acetylcholine was measured by Fluo-4 ***-derived contracting factors were assessed by enzyme ***-induced obesity(DIO)attenuated endothelium-dependent vasodilation,enhanced endothelium-dependent contraction(eDC),and increased the expression of TRPC5 in the mouse *** of TRPC5 promoted eDC in the wild-type mouse aorta,whereas pharma-cological inhibition and genetic knockout of TRPC5 decreased eDC in the DIO mouse ***,cPLA_(2)phosphorylation and activity were higher in aortic endothelial cells from DIO mice,and this was attenuated by inhibition and knockout of *** 2(COX-2)expression was increased in DIO mouse endothe-lium and was decreased by a TRPC5 inhibitor and knockout of *** of prostaglandins F_(2α(PGF_(2α)and e 2(PGe 2)was involved in TRPC5-regulated eDC in DIO *** study demonstrated that TRPC5 contributes to endothelial and vascular dysfunction and is involved in eDC through activation of cPLA_(2)and enhanced COX-2-PGF_(2α)/PGe_(2)levels in DIO mice.

关键词： Transient receptor potential channel canonical family member 5(TRPC5) endothelium-dependent contraction Vascular function Diet-induced obesity

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