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Dietary Lipid Intervention in the Prevention of Brain Aging

Engineering 2024年第6期37卷 128-137页

作者： Wei Xiong Bing Fang Xiaoyu wa.g Ming Zhang Min Du Jiazeng Sun juan Chen Yixuan Li Changhao Sun Xingen Lei Xue Zhang Fazheng Ren Key Laboratory of Precision Nutrition and Food Quality Department of Nutrition and HealthChina Agricultural UniversityBeijing 100083China Key Laboratory of Functional Dairy Co-Constructed by the Ministry of Education and Beijing MunicipalityCollege of Food Science and Nutritional EngineeringChina Agricultural UniversityBeijing 100083China School of Food Science and Chemical Engineering Beijing Technology and Business UniversityBeijing 100048China Department of Animal Science Washington State UniversityPullmanWA 99164USA Department of Nutrition and Food Hygiene School of Public HealthHarbin Medical UniversityHarbin 150028China Department of Animal Science Cornell UniversityIthacaNY 14853USA National Health Commission(NHC)and Chinese Academy of Medical Sciences(CAMS)Key Laboratory of Molecular Probe and Targeted Theranostics Harbin Medical UniversityHarbin 150028China

As people live longer,the burden of aging-related brain diseases,especially dementia,is *** aging increases the risk of cognitive impairment,which manifests as a progressive loss of neuron function caused by the impairment of synaptic plasticity via disrupting lipid ***,supplemental dietary lipids have the potential to prevent brain *** review summarizes the important roles of dietary lipids in brain function from both structure and mechanism *** and animal studies have provided evidence of the functions of polyunsaturated fatty acids(PUFAs)in brain *** results of interventions indicate that phospholipids—including phosphatidylcholine,phosphatidylserine,and plasmalogen—are efficient in alleviating cognitive impairment during aging,with plasmalogen exhibiting higher efficacy than *** is a recognized nutrient used in clinical trials due to its special vinyl ether bonds and abundance in the postsynaptic membrane of *** research should determine the dose-dependent effects of plasmalogen in alleviating brain-aging diseases and should develop extraction and storage procedures for its clinical application.

关键词： Brain aging Nutritional intervention Phospholipids Phosphatidylcholine Phosphatidylserine Plasmalogen

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Effects of Qingre Huoxue Jiedu Formula on Nerve growth Factor-Induced Psoriasis

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Chinese Journal of Integrative Medicine 2022年第3期28卷 236-242页

作者： wa.g Jun-hui JIANg Ying-juan LI Min wa.g Ning CUI Bing-nan LIU wa-li Dermatology Department Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijing(100053)China Dermatology Department Dongfang HospitalBeijing University of Chinese MedicineBeijing(100078)China Laboratory of Molecular Biology Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijing(100053)China

Objective:To elucidate the mechanisms of 4 effective components from a Chinese medicine formula,namely Qingre Huoxue Jiedu Formula(QHJ heat-and toxin-clearing and blood-activating formula),in the treatment of nerve growth factor(NgF)-induced ***:Keratinocyte proliferation and T cell proliferation models were developed using *** NgF solution(NgF+DMEM,100 ng/mL)was added to all induced groups and treated groups and were cultured for 24 h,while a solution with NTRK1 antagonist(K252 a+DEME,300 nmol/L)was added and cultured for 1 *** models were used to evaluate the effects of the treatment with each of the 4 components of QHJ,namely shikonin,paeonol,astilbin and ursolic *** apoptosis and proliferation were measured by flow cytometry analysis and CCK8 assay,*** mRNA expression levels of Bax,Bcl-xl,and NgF receptor(NgFR)were assessed by quantitative real-time PCR(qRT-PCR)and Western blot analysis,***:(1)All QHJ-treated groups showed significantly increased cell apoptosis and inhibition of cell proliferation compared with the NgF-induced groups(Pgnificantly enhanced cell apoptosis and inhibition of cell proliferation compared with cells treated with QHJ only(Pgroups showed higher protein expression levels of Bax,Bcl-xl compared with other groups(Pgnificantly increased the protein expression levels of Bax,Bcl-xl and NgFR compared with those treated with QHJ only(all Pght be through enhancing cell apoptosis and inhibition of cell proliferation,and upregulating the expression level of Bax,Bcl-xl and NgFR.

关键词： psoriasis inflammatory dermatosis nerve growth factor keratinocyte Chinese medicine formula

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The HIF-1α/PLOD2 axis integrates extracellular matrix organization and cell metabolism leading to aberrant musculoskeletal repair

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Bone Research 2024年第2期12卷 289-301页

作者： Heeseog ka.g Amy L.Strong Yuxiao Sun Lei guo Conan juan Alec C.Bancroft Ji Hae Choi Chase A.Pagani Aysel A.Fernandes Michael Woodard Juhoon Lee Sowmya Ramesh Aaron W.James David Hudson Kevin N.Dalby Lin Xu Robert J.Tower Benjamin Levi Center for Organogenesis Regeneration and TraumaDepartment of SurgeryUniversity of Texas SouthwesternDallasTX 75390USA Section of Plastic Surgery Department of SurgeryUniversity of MichiganAnn ArborMI 48109USA Quantitative Biomedical Research Center Peter O’Donnell Jr.School of Public HealthUniversity of Texas SouthwesternDallasTX 75390USA Department of Orthopedics and Sports Medicine University of WashingtonSeattleWA 98195USA Division of Chemical Biology and Medicinal Chemistry College of PharmacyUniversity of Texas at AustinAustinTX 78712USA Department of Pathology Johns Hopkins UniversityBaltimoreMD 21218USA

While hypoxic signaling has been shown to play a role in many cellular processes,its role in metabolism-linked extracellular matrix(ECM)organization and downstream processes of cell fate after musculoskeletal injury remains to be ***(HO)is a debilitating condition where abnormal bone formation occurs within extra-skeletal *** andhypoxia-inducible factor 1α(HIF-1α)activation have been shown to promote ***,the underlying molecular mechanisms bywhich the HIF-1αpathway in mesenchymal progenitor cells(MPCs)contributes to pathologic bone formation remain to ***,we used a proven mouse injury-induced HO model to investigate the role of HIF-1αon aberrant cell ***-cell RNA sequencing(scRNA-seq)and spatial transcriptomics analyses of the HO site,we found that collagen ECM organizationis the most highly up-regulated biological process in *** mesenchymal cell-specific deletion of Hif1α(Hoxa11-CreER^(T2);Hif1a^(fl/fl))significantly mitigated HO in ***-seq analysis of these Hoxa11-CreER^(T2);Hif1a^(fl/fl)mice identified the PLOD2/LOXpathway for collagen cross-linking as downstream of the HIF-1αregulation of ***,our scRNA-seq data and mechanisticstudies further uncovered that glucose metabolism in MPCs is most highly impacted by HIF-1α*** a translational aspect,a pan-LOX inhibitor significantly decreased HO.A newly screened compound revealed that the inhibition of PLOD2 activity in MPCssignificantly decreased osteogenic differentiation and glycolytic *** suggests that the HIF-1α/PLOD2/LOX axis linked tometabolism regulates HO-forming MPC *** results suggest that the HIF-1α/PLOD2/LOX pathway represents a promisingstrategy to mitigate HO formation.

关键词： metabolism skeletal aberrant

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三频雷达遥感云参数能力的模拟与初步分析

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大气科学 2024年第5期48卷 2004-2014页

作者：霍娟段民征韩瑽琤毕永恒中国科学院大气物理研究所中层大气和全球环境探测重点实验室(LAgEO) 北京100029

短波雷达在观测云内粒子微物理属性方面具有优势,是探测全球水循环重要环节——云的强有力探测工具。本文简要回顾了云雷达探测的理论基础,从雷达探测基本原理出发,借助小粒子电磁波散射理论和方法,建立了一套多波长雷达观测正演(前向)... 详细信息

短波雷达在观测云内粒子微物理属性方面具有优势,是探测全球水循环重要环节——云的强有力探测工具。本文简要回顾了云雷达探测的理论基础,从雷达探测基本原理出发,借助小粒子电磁波散射理论和方法,建立了一套多波长雷达观测正演(前向)模型(Radar Simulation Packa.e,简称RSP),并利用RSP对当前主流的三种典型波长X波段(9.5 gHz、3 cm)、ka.段(35 gHz、8 mm)和W波段(94 gHz、3 mm)短波雷达的遥感探测能力开展了模拟分析。通过与瑞利法计算结果相比较,证实RSP法的计算精度可靠准确。基于RSP法模拟结果,建立了液水含量(LWC)与雷达反射率因子(Ze)、有效粒子半径(re)与Ze之间幂指数形式的反演关系;建立了利用不同云层高度处两波长的反射率因子差值,反演云层平均LWC的反演关系等。本文工作对如何利用雷达探测参数提取液态云滴的微物理参数方法进行了探讨,一方面为多波长雷达探测云特征获得更准确的理论认识,另一方面为云微物理参数的反演提供理论依据和分析手段。

关键词：雷达毫米波微物理反演云模拟

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Selective separation of pyrene from mixed polycyclic aromatic hydrocarbons by a hexahedral metal-organic cage

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Chinese Chemical Letters 2024年第1期35卷 523-527页

作者： Ya-Liang Lai juan Su Le-Xiong Wu Dong Luo Xue-Zhi wa.g Xian-Chao Zhou Chuang-Wei Zhou Xiao-Ping Zhou Dan Li College of Chemistry and Materials Science Guangdong Provincial Key Laboratory of Functional Supramolecular Coordination Materials and ApplicationsJinan UniversityGuangzhou 510632China

Polycyclic aromatic hydrocarbons(PAHs)play an important role in the industry,and the development of new materials for the selective separation of PAHs is of great *** this work,we report a hexahedral metal-organic cage with low symmetry by subcomponent *** this cage,the eight ZnII centers adopt an interestin∧∧/△△△△△△or∧∧∧∧∧∧/△△*** cage with a cavity volume of 520˚A3 can bind anthracene,phenanthrene,and pyrene to form 1:1 host-guest complexes,while the bigger triphenylene,chrysene,perylene,and coronene cannot be *** binding constant ka.of pyrene is about 1.110×10^(3)(mol/L)^(−1),which is more than an order of magnitude larger than that of anthracene and phenanthrene(111(mol/L)^(−1),277(mol/L)^(−1),respectively).X-ray structure studies reveal that the pyrene is located in the cavity and stabilized by multiple C–H…π*** separation from a mixture of PAHs,pyrene with>96.1%purity can be *** work provides a useful method for the first time for the selective separation of pyrene from PAHs mixture by utilizing a metal-organic cage as the material,making it a useful tool for purifying and separating specific compounds from complex mixtures.

关键词： Polycyclic aromatic hydrocarbons Metal-organic cage Host-guest chemistry Selective separation

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Rasch validation of the Chinese parent-child interaction scale (CPCIS)

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World Journal of Pediatrics 2018年第3期14卷 238-246页

作者： Patrick Ip Winnie Tso Nirmala Rao Frederick ka.Wing Ho Ko Ling Chan King wa Fu Sophia Ling Li Winnie goh Wilfred Hing-sang Wong Chun Bong Chow Department of Pediatrics and Adolescent Medicine University of Hong KongHong KongPeople's Republic of China Faculty of Education University of Hong KongRoom 510Meng Wah ComplexHong KongPeople's Republic of China Department of Applied Social Sciences The Hong Kong Polytechnic UniversityHong KongPeople's Republic of China Journalism and Media Studies Center The University of Hong KongHong KongPeople's Republic of China KK Women's and Children's Hospital SingaporeSingapore

Background Proper parent-child interaction is crucial for child development, but an assessment tool in Chinese is currently lacking. This study aimed to develop and validate a parent-reported parent-child interaction scale for Chinese preschool children. Methods The Chinese parent-child interaction scale (CPCIS) was designed by an expert panel based on the literature and clinical observations in the Chinese context. The initial CPCIS had 14 parent-child interactive activity items. Psychometric properties of the CPCIS were examined using the Rasch model and confirmatory factor analysis (CFA). Convergent validity was investigated by the associations between CPCIS and family income, maternal education level, and children's school readiness. Results The study recruited 567 Chinese parent-child pairs from diverse socioeconomic backgrounds, who completed the CPCIS. Six out of the 14 items in the initial CPCIS were dropped due to suboptimal fi t values. The refined 8-item CPCIS was shown to be valid and reliable by Rasch models and CFA. The person separation reliability and Cronbach's α of the CPCIS were 0.81 and 0.82, respectively. The CPCIS scores were positively associated with family's socioeconomic status (η2 = 0.05,P < 0.001), maternal education level (η2 = 0.08,P < 0.001), and children's school readiness (η2 = 0.01,P < 0.01). Conclusion CPCIS is an easily administered, valid, and reliable tool for the assessment of parent-child interactions in Chinese families.

关键词： Chinese Early childhood Home learning environment Parent-child interaction Validation

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The Tianma 65 m radio telescope at Shanghai

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Astronomical Techniques and Instruments 2024年第5期1卷 239-246页

作者： Qinghui Liu Zhiqiang Shen Xiaoyu Hong Qian Ye Bin Li Jinqing wa.g Rongbing Zhao Li Fu Weiye Zhong Lingling wa.g juan Li Zhen Yan Wu Jiang Bo Xia Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China

The Shanghai Tianma 65 m radio telescope(TMRT)is a large,fully rotatable radio telescope with multiple scientific *** main body of the telescope and four low-frequency receiving systems,including L,C,and S/X bands,were completed between 2008 and *** 2013 to 2017,four high-frequency receiving systems,including Ku,K,ka.and Q bands,were constructed and their performance was comprehensively *** are three main innovations.(1)A fully movable large radio telescope system with advanced performance and complete functions has been built.(2)An advanced,reliable main reflector adjustment system has been completed,overcoming gravity deformation and creating a large antenna with a main reflective surface accuracy of 0.28 mm(root mean square)for any elevation.(3)Five innovative technologies have been developed to achieve high-precision pointing in any direction within 3″.The TMRT has made a crucial contribution to the orbital measurement and positioning of China’s lunar and deep space *** enhancing China's ability to participate in international VLBI observations and radio astronomy,this has facilitated a series of achievements in observational radio astronomical research,in areas such as VLBI,spectral lines,and pulsars.

关键词： Radio telescope Tianma Large antenna Receiving system Surface accuracy

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不同血压控制目标和用药方案对老年心衰合并高血压患者预后的影响研究

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中国现代药物应用 2024年第13期18卷 23-27页

作者：单秀娟袁培徐州市康复医院内科 221000

目的分析不同血压控制目标和用药方案对老年心力衰竭(心衰)合并高血压患者预后的影响。方法选取150例老年心衰合并高血压患者,其中118例获得有效随访,按照入院时血压控制目标将118例患者分别纳入强化降压组[入院1 h内降压目标:收缩压0.0... 详细信息

目的分析不同血压控制目标和用药方案对老年心力衰竭(心衰)合并高血压患者预后的影响。方法选取150例老年心衰合并高血压患者,其中118例获得有效随访,按照入院时血压控制目标将118例患者分别纳入强化降压组[入院1 h内降压目标:收缩压g(1 mm Hg=0.133 kPa);74例]、非强化降压组(入院1 h内降压目标:收缩压130~150 mm Hg;44例);另外按照出院时口服降压药物不同将其分别纳入A组(22例)、B组(27例)、C组(24例)、D组(25例)、E组(20例)。A组接受钙离子拮抗剂(CCB)联合血管紧张素转化酶抑制剂(ACEI)治疗,B组接受CCB联合血管紧张素Ⅱ受体拮抗剂(ARB)治疗,C组接受ACEI联合利尿剂治疗,D组接受ARB联合利尿剂治疗,E组接受CCB联合β受体阻滞剂(β-B)治疗。分析不同血压控制目标对患者预后的影响,以及不同用药方案对患者预后的影响。结果强化降压组与非强化降压组入组时左室射血分数(LVEF)、左室舒张末期内径(LVEDd)、左室收缩末期内径(LVESd)、氨基末端脑钠肽前体(NT-proBNP)、收缩压、舒张压、日间收缩压标准差(dSSD)、日间舒张压标准差(dDSD)、夜间收缩压标准差(nSSD)及夜间舒张压标准差(nDSD)比较,差异无统计学意义(P>0.05);随访6个月时,两组LVEF均较入组时升高,LVEDd、LVESd、NT-proBNP、收缩压、舒张压、dSSD、dDSD、nSSD、nDSD均较入组时下降,强化降压组LVEF(45.41±2.53)%高于非强化降压组的(42.08±2.96)%,LVEDd(46.51±2.44)mm、LVESd(32.98±1.89)mm、NT-proBNP(360.15±33.14)pg/ml、收缩压(133.28±16.47)mm Hg、舒张压(82.93±6.95)mm Hg、dSSD(8.67±1.62)mm Hg、dDSD(8.14±0.29)mm Hg、nSSD(7.28±2.03)mm Hg、nDSD(8.09±1.46)mm Hg均低于非强化降压组的(51.44±4.07)mm、(38.03±1.49)mm、(577.14±35.60)pg/ml、(145.23±12.39)mm Hg、(87.71±7.16)mm Hg、(10.62±2.45)mm Hg、(8.27±0.33)mm Hg、(9.51±1.37)mm Hg、(8.79±1.35)mm Hg,差异有统计学意义(P0.05)。随访6个月时,A组、B组、C组、D组的LVEF均高于E组,LVEDd、LVESd、NT-proBNP及收缩压、舒张压、dSSD、dDSD、nSSD、nDSD均低于E组,差异有统计学意义(P0.05)。结论老年心衰合并高血压患者接受早期强化降压治疗后,其心功能恢复及血压控制效果更为理想;除CCB联合β-B外,根据患者个体情况选择CCB、ACEI、ARB、利尿剂药物联合应用均可实现良好的血压控制效果,降低心衰再住院风险。

关键词：血压控制目标用药方案心力衰竭合并高血压预后老年

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基于等效水量法的城市内涝模型实时订正技术研究

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中国农村水利水电 2024年第7期 19-25页

作者：魏军陈笑娟李婷徐艺芙河北省气象与生态环境重点实验室河北石家庄050021 中国气象局雄安大气边界层重点开放实验室河北雄安新区071800 河北省气象灾害防御和环境气象中心河北石家庄050021

为解决现有城市内涝模型在模拟计算时的输入场通常仅考虑降雨量及先期预先设定的相关参数,无法将实况积水数据代入模型对模拟结果进行实时订正,使得模型计算结果与实际存在偏差较大的问题,采用模型计算结果与积水监测数据实时同化确定... 详细信息

为解决现有城市内涝模型在模拟计算时的输入场通常仅考虑降雨量及先期预先设定的相关参数,无法将实况积水数据代入模型对模拟结果进行实时订正,使得模型计算结果与实际存在偏差较大的问题,采用模型计算结果与积水监测数据实时同化确定模型中产汇流系数和排水系数,提出一种基于等效水量法的城市内涝模型实时订正方法。以石家庄市城市内涝仿真数学模型为应用案例,选取典型暴雨个例进行效果验证,结果表明实时订正后的模拟积水值更能较好反映出实际积水情况,模拟值与实况值的一致性指数从订正前的0.72提升到了订正后的0.96,通过订正技术显著提升了模型的计算精度。

关键词：内涝模型实时订正等效水量法石家庄市

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Identification of differential gene expressions in colorectal cancer and polyp by cDNA microarray

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World Journal of gastroenterology 2012年第6期18卷 570-575页

作者： Yi-Chen Dai Xiao-San Zhu Qing-Zhen Nan Zhang-Xin Chen Jun-Pei Xie Yu-ka.Fu Yuan-Yuan Lin Qing-Na Lian Qiao-Fang Sang Xiao-juan Zhan Department of gastroenterology Chenggong HospitalXiamen UniversityXiamen 361003Fujian ProvinceChina Department of gastroenterology The 174th Hospital of the Chinese PLAWenyuan RoadXiamen 361003Fujian ProvinceChina Department of gastroenterology Nanfang HospitalSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina

AIM： TO screen the differential expressed genes in colorectal cancer and polyp tissue samples. METHODS： Tissue specimens containing 16 cases of colorectal adenocarcinoma and colorectal polyp vs nor- mal mucosae were collected and subjected to cDNA microarray and bioinformatical analyses. Quantitative reverse transcription-polymerase chain reaction （qRT- PCR） was used to confirm some of the cDNA microarray ***： The experimental data showed that eight genes were differentially expressed, most of which were upregulated in adenomatous polyp lesions. Forty-six genes expressions were altered in colorectal cancers, of which 29 were upregulated and 17 downregulated, as compared to the normal mucosae. In addition, 18 genes were similarly altered in both adenomatous polyps and colorectal cancer, qRT-PCR analyses confirmed the cDNA microarray data for four of those 18 genes： MTA1, PDCD4, TSC1 and PDgFRA. CONCLUSION： These differentially expressed genes likely represent biomarkers for early detection of co- Iorectal cancer and may be potential therapeutic targets after confirmed by further studies.

关键词： Colorectal polyp Colorectal cancer cDNA mi-croarray Quantitative reverse transcription-polymerasechain reaction

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