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Effects of length alteration of OPE-containing mono- and dinuclear alkynylplatinum(II) terpyridine complexes on photophysical, structural and morphological properties

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Nano Research 2024年第10期17卷 8893-8903页

作者： Jason Koon-Lam Poon Sammual Yu-Lut Leung Eric ka-Ho wong Vivian wing-Wah Yam Institute of Molecular Functional Materials State Key Laboratory of Synthetic Chemistry and Department of ChemistryThe University of Hong KongHong Kong 999077China

A series of mononuclear complexes and unsymmetric dinuclear alkynylplatinum(II)terpyridine complexes with oligo(paraphenylene ethynylene)(OPE)-derived backbone with a variation of the lengths of alkoxy chains and OPE backbones was *** morphological properties,packing lattice and gelation behaviors of the mononuclear complexes were systematically studied,and the thermodynamic parameters and packing lattices of the dinuclear complexes were also investigated,providing further insights into the roles of the non-covalent interactions and their delicate balance in constructing sophisticated supramolecular *** and nanotube formation have been observed upon a delicate control of the intermolecular interactions by altering the lengths and structural dimensions of the complexes.

关键词： supramolecular chemistry self-assembled nanostructures platinum(II)complexes metallogel

Association of time to prostate-specific antigen nadir and logarithm of prostate-specific antigen velocity after progression in metastatic prostate cancer with prior primary androgen deprivation therapy

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Asian Journal of Andrology 2017年第1期19卷 98-102页

作者： Jeremy YC Teoh James HL Tsu Steffi KK Yuen Peter KF Chiu Samson YS Chan ka-wing wong Kwan-Lun Ho Simon SM Hou Chi-Fai Ng Ming-Kwong Yiu Division of Urology Department of Surgery The Chinese University of Hong Kong Prince of Wales Hospital Shatin Hong Kong China Division of Urology Department of Surgery Queen Mary Hospital University of Hong Kong Hong Kong China.

We investigated the association of time to prostate-specific antigen nadir （TTPN） and logarithm of prostate-specific antigen velocity after progression Log（PSAVAP） in metastatic prostate cancer with prior primary androgen deprivation therapy （ADT）. All metastatic prostate cancer patients treated with primary ADT from 2000 to 2009 were reviewed. Patients who developed disease progression were included in the subsequent analyses. Patients were categorized into three groups according to their TTPN： TTPN of 〈3 months, 3-17 months, and 〉17 months. We compared the Log（PSAVAP） between the different TTPN groups using Mann-Whitney U-test and Kruskal-Wallis test. Further multiple linear regression analyses on Log（PSAVAP） were performed to adjust for other potential confounding factors. Among 419 patients who were treated with primary ADT, 306 patients developed disease progression with a median follow-up of 28 months, Longer TTPN was associated with lower Log（PSAVAP）（P = 0.008） within all subgroup analyses （TTPN of 〈3 vs 3-17 months, P = 0.020; TTPN of 3-17 vs 〉17 months, P = 0.009; and TTPN of 〈3 vs 〉17 months, P = 0.001）. Upon multiple linear regression analyses, baseline PSA （regression coefficient 0.001, P = 0.045）, PSA nadir （regression coefficient 0.002, P = 0.040）, and TTPN （regression coefficient -0.030, P = 0.001） were the three factors that were significantly associated with Log（PSAVAP）. In conclusion, a longer TTPN was associated with lower Log（PSAVAP） in metastatic prostate cancer patients following primary ADT. TTPN cut-offs at 3 months and 17 months appeared to have prognostic significance in predicting Log（PSAVAP）. TTPN may serve as a good prognostic indicator in deciding the treatment strategy in patients with disease progression.

关键词： androgen deprivation therapy prostate cancer prostate-specific antigen velocity after progression ti me to prostate-specific antigen nadir

Anterior perineal hernia after anterior exenteration

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Asian Journal of Urology 2017年第4期4卷 253-255页

作者： ka wing wong Terence Chun-ting Lai Ada Tsui-lin Ng Brian Sze-ho Ho James Hok-leung Tsu Chiu Fung Tsang W.K.Ma Ming Kwong Yiu Division of Urology Department of SurgeryQueen Mary HospitalUniversity of Hong KongHong KongChina

Perineal hernia is a rare complication of anterior *** reported this complication after an anterior exenteration for bladder cancer with bleeding complication requiring packing and second-look *** approach is a simple... 详细信息

关键词： Perineal hernia Anterior exenteration Bladder cancer Mesh repair

Oxidative stress mediates glycidol-induced endothelial injury and its protection by 6-C-(E-2-fluorostyryl)naringenin

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Food Science and Human Wellness 2024年第5期13卷 2584-2594页

作者： Yue Zhou Hui Xu ka-wing Cheng Feng Chen Qian Zhou Mingfu Wang College of Civil and Transportation Engineering/College of Chemistry and Environmental Engineering Shenzhen UniversityShenzhen 518060China

Glycidol is a common lipid-derived foodborne toxicant mainly presents in refined oils and related *** endothelial cells may be potential targets of the deleterious effects associated with glycidol *** human umbilical vein endothelial cells(HUVECs),we found that glycidol treatment promoted endothelialto-mesenchymal transition(EndMT)at a lower concentration(0.5 mmol/L),while induced apoptosis and inflammation at a higher concentration(1 mmol/L).These harmful effects were achieved by the activation of NF-κB/MAPK signaling pathway and were mediated by reactive oxygen species(ROS).In addition,the protective potential of 6-C-(E-2-fluorostyryl)naringenin(6-CEFN)against glycidol was evaluated and compared with *** pre-treated with 6-CEFN,but not naringenin,displayed resistance to endothelial dysfunction caused by glycidol.

关键词： Glycidol Endothelial cells 6-C-(E-2-fluorostyryl)naringenin Oxidative stress Endothelial-to-mesenchymal transition

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Functionalized selenium nanoparticles ameliorated acetaminophen-induced hepatotoxicity through synergistically triggering PKCδ/Nrf2 signaling pathway and inhibiting CYP 2E1

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Food Science and Human Wellness 2024年第2期13卷 932-945页

作者： Si Zou Yetao Gong Xiujie Li Yanbin Wu Jinzhong Wu Jianguo Wu ka-Hing wong College of Pharmacy Fujian University of Traditional Chinese MedicineFuzhou 350122China Research Institute for Future Food The Hong Kong Polytechnic UniversityHong Kong 999077China Department of Food Science and Nutrition The Hong Kong Polytechnic UniversityHong Kong 999077China

Selenium nanoparticles(SeNPs)have been demonstrated potential for use in diseases associated with oxidative *** SeNPs with lower toxicity and higher biocompatibility could bring better therapeutic activity and clinical application ***,this work was conducted to investigate the protective effect of Pleurotus tuber-regium polysaccharide-protein complex funtionnalized SeNPs(PTR-SeNPs)against acetaminophen(APAP)-induced oxidative injure in HepG2 cells and C57BL/6J mouse *** elucidation of the underlying molecular mechanism,in particular their modulation of Nrf2 signaling pathway was also *** results showed that PTR-SeNPs could significantly ameliorate APAP-induced oxidative injury as evidenced by a range of biochemical analysis,histopathological examination and immunoblotting ***-SeNPs could hosphorylate and activate PKCδ,depress Keap1,and increase nuclear accumulation of Nrf2,resulting in upregulation of GCLC,GCLM,HO-1 and NQO-1 ***,PTR-SeNPs suppressed the biotransformation of APAP to generate intracellular ROS through CYP 2E1 inhibition,restoring the mitochondrial ***,the protective effect of PTR-SeNPs against APAP induced hepatotoxicity was weakened as Nrf2 was depleted in vivo,indicating the pivotal role of Nrf2 signaling pathway in PTR-SeNPs mediated hepatoprotective *** a potential hepatic protectant,PTR-SeNPs could serve as a new source of selenium supplement for health-promoting and biomedical applications.

关键词： PTR-SeNPs(polysaccharide-proteincomplex functionalized selenium nanoparticles) Acetaminophen-induced hepatotoxicity Nuclear factor erythroid 2-related factor 2 Cytochrome P450 enzyme 2E1 Mitochondria

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Modulation doping of p-type Cu_(12)Sb_(4)S_(13)toward improving thermoelectric performance

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Journal of Materials Science & Technology 2024年第4期171卷 71-79页

作者： Khak Ho Lim Mingquan Li Yu Zhang Yue Wu Qimin Zhou Qingyue Wang Xuan Yang Pingwei Liu Wen-Jun Wang ka Wai wong ka Ming Ng Yu Liu Andreu Cabot Institute of Zhejiang University-Quzhou Quzhou 324000China College of Chemical and Biological Engineering Zhejiang UniversityHangzhou 310007China School of Chemistry and Chemical Engineering Hefei University of TechnologyHefei 230009China Materials Research Institute The Pennsylvania State UniversityUniversity ParkPA 16802USA Ostia Technologies Limited United Kingdom Department of Chemical and Biological Engineering The Hong Kong University of Science and TechnologyClear Water BayHong KongChina ICREA Pg.Lluis Companys 23Barcelona 08010Spain Catalonia Energy Research Institute-IREC Sant Adria del BesosBarcelona 08930Spain

The commercial viability of thermoelectric(TE)devices relies heavily on two factors:cost reduction and efficiency *** this study,we first produce p-type Cu_(12)Sb_(4)S_(16-x)(x=0,3,4)using a low-temperature bottom-up approach and demonstrate Cu_(12)Sb_(4)S_(13)to show the best TE performance among the three tested ***,the TE energy conversion efficiency of Cu_(12)Sb_(4)S_(13)is further enhanced by optimizing its electronic band structure through the incorporation of small amounts of *** an optimal Te content of 5 mol%,more than a twofold increase in the TE figure of merit(zT)is *** gain insight into the mechanism of improvement on the transport properties of the mate-rial,we compare the interphase transport mechanism by incorporating nanodomains of different metals(Ag and Cu)into the Cu_(12)Sb_(4)S_(13)*** improved electrical conductivity obtained with Cu_(12)Sb_(4)S_(13)-Te nanocomposites is attributed to a charge flooding of the Cu_(12)Sb_(4)S_(13)*** contrast,excessive down-ward band-bending at the interphases of Ag/Cu metal-semiconductor drastically reduces the electrical ***,a weighted mobility(μw)analysis shows a dominant thermal activation of carri-ers in Cu_(12)Sb_(4)S_(13)-Te *** this material,a strong decrease in lattice thermal conductivity is also found,which is associated with a phonon-carrier scattering *** work shows the impor-tance of proper band-engineering in TE nanocomposites to decouple electrical and thermal transport to enhance TE performance,and the efficacy ofμw for electrical and thermal transport analysis.

关键词： Modulation doping Thermoelectric Interphase transport Charge flooding Phonon-carrier scattering

Applications and advancements in animal models for antiviral research on mosquito-borne arboviruses

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Animal Models and Experimental Medicine 2024年第5期 673-684页

作者： Megan Caifeng Tang ka Heng wong Adzzie Shazleen Azman Rafidah Lani School of Science Monash University Malaysia Department of Medical Microbiology Faculty of Medicine Universiti Malaya

Vector-borne diseases caused by arthropod-borne viruses(arboviruses) are a considerable challenge to public health globally. Mosquito-borne arboviruses, such as Chikungunya, Dengue, and Zika viruses, cause a range of human illnesses and may be fatal. Currently, efforts to control these diseases still face challenges due to growing vector resistance towards insecticides, urbanization, and limited effective antiviral treatments and vaccines. Animal models are crucial in antiviral research on mosquito-borne arboviruses, playing a role in understanding disease mechanisms,vaccine development, and toxicity testing, but the application of animal models still faces the challenges of ethical considerations and animal-to-human translational success. Genetically engineered mouse models, hamster models and non-human primate(NHP) are currently used in arbovirus research, but new models such as tree shrews and novel humanized mice are emerging. In the context of Malaysian research, the use of long-tailed macaques as potential NHP models for arbovirus research is possible;however, it faces the ethical dilemma of using an endangered species for scientific purposes. Overall, animal models play a crucial role in advancing infectious disease research, but a balance between medical research and species conservation must be upheld.

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Chemical biology investigation of a triple-action,smart-decomposition antimicrobial booster based-combination therapy against“ESkaPE”pathogens

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Science China Chemistry 2024年第9期67卷 3071-3082页

作者： Min Wang Huangsheng Pu Yangfan Xu Chenxuan Wu Yuanxin Gu Qingyun Cai Guoxing Yin Peng Yin Chunhui Zhang wing-Leung wong Muyang Wan Yugang Bai Xinxin Feng State Key Laboratory of Chem-/Bio-Sensing and Chemometrics Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biologyand School of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China College of Biology Hunan UniversityChangsha 410082China College of Advanced Interdisciplinary Studies&Hunan Provincial Key Laboratory of Novel Nano Optoelectronic Information Materials and Devices National University of Defense TechnologyChangsha 410073China Nanhu Laser Laboratory National University of Defense TechnologyChangsha 410073China Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research(Ministry of Education) College of Chemistry and Chemical EngineeringHunan Normal UniversityChangsha 410081China State Key Laboratory of Chemical Biology and Drug Discovery Department of Applied Biology and Chemical TechnologyThe Hong Kong Polytechnic UniversityHong Kong SAR 999077China Hunan Provincial Key Laboratory of Anti-Resistance Microbial Drugs The Third Hospital of Changsha(The Affiliated Changsha Hospital of Hunan University)Changsha 410015China

The global antibiotic resistance crisis necessitates urgent *** innovative approach involves potentiating antibiotics and non-antibiotic drugs with adjuvants or boosters.A major drawback of these membrane-active boosters is their limited biocompatibility,as they struggle to differentiate between prokaryotic and eukaryotic *** study reports the chemical biology investigation of a dual-action oligoamidine(OA1)booster with a glutathione-triggered decomposition ***1,when combined with other antimicrobial molecules,exhibits a triple-targeting mechanism including cell membrane disruption,DNA targeting,and intracellular enzyme *** multi-targeting mechanism not only enhances the in vitro and in vivo eradication of antibiotic-resistant“ESkaPE”pathogens,but also suppresses the development of bacterial ***,OA1 maintains its activity in bacterial cells by creating an oxidative environment,while it quickly decomposes in mammalian cells due to high glutathione *** mechanistic insights and design principles may provide a feasible approach to develop novel antimicrobial agents and effective anti-resistance combination therapies.

关键词： antimicrobial booster oligoamidine membrane disruption DNA targeting triggered degradation anti-resistance

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Tracking Source Variations of Inhalation Cancer Risks and Ozone Formation Potential in Hong Kong over Two Decades(2000−2020)Using Toxic Air Pollutant Monitoring Data

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Environment & Health 2024年第6期2卷 411-421页

作者： Yee ka wong Wai Wai Chan Dasa Gu Jian Zhen Yu Alexis K.H.Lau Division of Environment and Sustainability The Hong Kong University of Science and TechnologyKowloonHong Kong 000000China Institute for the Environment The Hong Kong University of Science and TechnologyKowloonHong Kong 000000China Institute for the Environment and Department of Chemistry The Hong Kong University of Science and TechnologyKowloonHong Kong 000000China Institute for the Environment and Department of Civil and Environmental Engineering The Hong Kong University of Science and TechnologyKowloonHong Kong 000000China

Toxic air pollutants(TAPs)are a class of airborne chemicals known or suspected to cause serious health *** study,applying positive matrix factorization and inhalation unit risk estimates of TAPs,quantifies the changes in significant sources contributing to inhalation cancer risks(ICRs)from 2000 to 2020 in Hong Kong,*** ICR decreased from 1701 to 451 cases per million between 2000−2004 and 2016−2020,largely attributed to the reduction in diesel particulate matter(DPM),gasoline and solvent use-related volatile organic compounds(VOCs),and coal/biomass combustion-related polycyclic aromatic hydrocarbons and metal(loid)*** regional contribution of VOCs associated with industrial and halogenated solvent sources increased substantially,representing the largest non-DPM ICR contributor(37%)in 2016−2020,stressing the need for a more comprehensive risk evaluation across the fast-growing and densely populated Greater Bay Area(GBA).ICRs in Hong Kong and the GBA will likely remain over 100 cases per million by *** contributions to ozone formation potential of VOC/carbonyl sources were quantified,which show a notable shift from being solvent/gasoline-dominant in 2000−2004 to being more evenly shared by various sources in 2016−*** a similar TAP monitoring network in the GBA is anticipated to provide the monitoring data needed to facilitate the development of more informed air quality management strategies.

关键词： toxic air pollutant hazardous air pollutant health risk assessment source apportionment ozone formation potential air quality management