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Journal of the Operations Research Society of China 2024年第3期12卷 757-771页

作者： Shan Jiang ka-meng nip School of Management Xiamen UniversityXiamen361005FujianChina School of Mathematical Sciences Xiamen UniversityXiamen361005FujianChina

In this work,we study the conic quadratic mixed-integer formulation for assortment optimization problem under the mixture of multinomial logit(MMNL)*** MMNL model generalizes the widely studied multinomial logit choice model and can approximate any random utility model with an arbitrary additive *** important operational decision problem in revenue management is assortment optimization problem,which aims to find a subset of products to make available to customers that maximizes the expected revenue of the *** is known that assortment optimization problem under the MMNL model is NP-hard and inapproximable within any constant performance *** used methods for solving such problem are heuristical approaches or customized combinatorial optimization *** the meanwhile,studies related to global optimization approaches are relatively *** propose an enhanced conic quadratic mixed-integer formulation for solving assortment optimization problem under the MMNL model with a higher computational ***,we conduct extensive numerical experiments to demonstrate that the proposed reformulation significantly outperforms the existing conic reformulations for assortment optimization under the MMNL model.

关键词： Assortment optimization MMNL model Conic reformulation Capacitated constrained

内镜下低温等离子射频消融切除Krouse T2和T3期鼻内翻性乳头状瘤的临床疗效分析(附手术视频)

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南京医科大学学报（自然科学版） 2024年第8期44卷 1069-1075页

作者：张丙文孟玲韩陈荣荣赵真南京医科大学附属南京医院(南京市第一医院)耳鼻咽喉-头颈外科江苏南京210006

目的:分析内镜下低温等离子切除Krouse T2和T3期鼻内翻性乳头状瘤(nasal inverted papilloma,nip)的临床疗效。方法:回顾性分析南京医科大学附属南京医院(南京市第一医院)耳鼻咽喉-头颈外科于2012年10月—2022年10月收治并行内镜下手术... 详细信息

目的:分析内镜下低温等离子切除Krouse T2和T3期鼻内翻性乳头状瘤(nasal inverted papilloma,nip)的临床疗效。方法:回顾性分析南京医科大学附属南京医院(南京市第一医院)耳鼻咽喉-头颈外科于2012年10月—2022年10月收治并行内镜下手术的141例Krouse T2和T3期nip患者的临床病例资料,并根据术中是否使用低温等离子射频消融切除肿瘤及处理肿瘤根基,分为使用低温等离子射频消融的观察组和不使用低温等离子射频消融的对照组。对比分析两组患者的手术时间、术中出血量、平均住院时间、术后疼痛视觉模拟评分(visual analogue scale,VAS)、术后并发症和术后复发率。结果:观察组T2+T3期和T3期nip患者平均手术时间短于相应对照组,但差异无统计学意义(P>0.05);观察组T2期nip患者平均手术时间短于相应对照组,差异有统计学意义(Pnip患者平均术中出血量更少,平均住院时间更短,术后疼痛VAS评分更低,差异有统计学意义(Pnip患者的术后并发症发生情况与相应的对照组比较,差异无统计学意义(P>0.05)。观察组T2+T3和T3期nip患者术后复发率低于对照组,差异有统计学意义(Pnip复发率低于对照组,但差异无统计学意义(P>0.05)。结论:内镜下低温等离子射频消融术可在清晰的手术视野下处理Krouse T2和T3期nip及其基底,具有术中出血量少、住院时间短、疼痛轻、复发率低等优势,临床疗效满意,值得推广应用。

关键词：鼻内翻性乳头状瘤鼻内镜低温等离子射频消融

尿蛋白陽性孕婦血清sFlt-1/PlGF比值的實用價值

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镜湖医学 2024年第1期24卷 81-84页

作者：馮婉珊聶珠容吳健欣陳倩碧陳浩雲澳門鏡湖醫院檢驗科中国

目的檢測尿蛋白陽性孕婦血清可溶性血管内皮生長因子受體-1(sFlt-1)、胎盤生長因子(PlGF)水平,探討sFlt-1/PlGF比值預測子癇前期及其他不良妊娠結局的實用價值。方法收集2019年10月~2022年11月尿蛋白陽性孕婦80例為觀察組,同期尿蛋白陰... 详细信息

目的檢測尿蛋白陽性孕婦血清可溶性血管内皮生長因子受體-1(sFlt-1)、胎盤生長因子(PlGF)水平,探討sFlt-1/PlGF比值預測子癇前期及其他不良妊娠結局的實用價值。方法收集2019年10月~2022年11月尿蛋白陽性孕婦80例為觀察組,同期尿蛋白陰性的孕婦40例為對照組,檢測兩組孕婦血清中sFlt-1及PlGF水平,統計分析兩組sFlt-1/PlGF比值>38的差異性,受試者工作特徵曲線(Receiver Operating Characteristic curve,ROC)評估sFlt-1/PlGF比值預測不良妊娠結局及子癇前期的診斷價值。結果觀察組及對照組血清sFlt-1/PlGF比值中位數分别為14.66、5.06,觀察組高於對照組,兩組間差異有統計學意義(P<0.05);用sFlt-1/PlGF比值與不良妊娠結局及子癇前期作ROC曲線分析,曲線下面積(Area Under the Curve,AUC)分别為0.90、0.77。結論尿蛋白陽性孕婦血清sFlt-1/PlGF比值,能為子癎前期及其他不良妊娠結局的預測提供參考價值。

关键词： sFlt-1/PlGF比值尿蛋白不良妊娠結局子癇前期

Nanofiber matrix formulations for the delivery of Exendin-4 for tendon regeneration: In vitro and in vivo assessment

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Bioactive Materials 2023年第7期25卷 42-60页

作者： Sama Abdulmalik Jack Gallo Jonathan nip Sara katebifar Michael Arul Amir Lebaschi Lucas N.Munch Jenna M.Bartly Shilpa Choudhary Ivo kalajzic Yeshavanth Kumar Banasavadi-Siddegowdae Syam P.Nukavarapu Sangamesh G.Kumbar Department of Orthopedic Surgery University of Connecticut HealthFarmingtonCTUSA Department of Biomedical Engineering University of ConnecticutStorrsCTUSA Department of Materials Science and Engineering University of ConnecticutStorrsCTUSA Department of Physiology and Neurobiology University of ConnecticutStorrsCTUSA Department of Immunology Center on AgingUniversity of Connecticut HealthFarmingtonCTUSA Department of Reconstructive Sciences University of Connecticut HealthFarmingtonCTUSA Surgical Neurology Branch National Institute of Neurological Disorders and StrokeNational Institutes of HealthBethesdaMDUSA

Tendon and ligament injuries are the most common musculoskeletal injuries,which not only impact the quality of life but result in a massive economic *** interventions for tendon/ligament injuries utilize biological and/or engineered grafts to reconstruct damaged tissue,but these have *** matrices confer superior physicochemical properties over biological grafts but lack desirable bioactivity to promote tissue *** incorporating drugs can enhance bioactivity,large matrix surface areas and hydrophobicity can lead to uncontrolled burst release and/or incomplete release due to *** overcome these limitations,we evaluated the delivery of a peptide growth factor(exendin-4;Ex-4)using an enhanced nanofiber matrix in a tendon injury *** overcome drug surface binding due to matrix hydrophobicity of poly(caprolactone)(PCL)-which would be expected to enhance cell-material interactions-we blended PCL and cellulose acetate(CA)and electrospun nanofiber matrices with fiber diameters ranging from 600 to 1000 *** avoid burst release and protect the drug,we encapsulated Ex-4 in the open lumen of halloysite nanotubes(HNTs),sealed the HNT tube endings with a polymer blend,and mixed Ex-4-loaded HNTs into the polymer mixture before *** reduced burst release from~75%to~40%,but did not alter matrix morphology,fiber diameter,or tensile *** evaluated the bioactivity of the Ex-4 nanofiber formulation by culturing human mesenchymal stem cells(hMSCs)on matrix surfaces for 21 days and measuring tenogenic differentiation,compared with nanofiber matrices in basal media ***,we observed that Ex-4 nanofiber matrices accelerated the hMSC proliferation rate and elevated levels of sulfated glycosaminoglycan,tendon-related genes(Scx,Mkx,and Tnmd),and ECM-related genes(Col-Ⅰ,Col-Ⅲ,and Dcn),compared to *** then assessed the safety and efficacy of Ex-4 nanofiber matrices in a full-thickness rat Achilles tendon

关键词： Nanofiber matrix formulation Protein delivery Soft tissue regeneration Halloysite nanotubes

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若干车间排序问题和最短路问题的组合问题

若干车间排序问题和最短路问题的组合问题

作者：聂嘉明（nip kameng）清华大学

学位级别：硕士

本文研究了一些由三个经典的车间排序问题,和最短路问题各自组合而成的组合问题。问题的目的是在一个工件集中选取一个子集,使其构成一个最短路问题的可行解,然后把工件安排到一个车间进行排序,使所得排序的最大完工时间最小。本文先... 详细信息

本文研究了一些由三个经典的车间排序问题,和最短路问题各自组合而成的组合问题。问题的目的是在一个工件集中选取一个子集,使其构成一个最短路问题的可行解,然后把工件安排到一个车间进行排序,使所得排序的最大完工时间最小。本文先对这些问题的计算复杂性进行研究。第一个结果是即使在只有两台机器的情况下,这些问题仍是NP难的。第二个结果是当机器数目作为问题的输入时,除非P=NP,这些问题不存在近似比小于2的多项式近似算法。随后根据每一个问题的特点设计相应的近似算法,并对这些算法的时间复杂性和近似比进行分析。最后讨论把问题的结果推广到车间排序和最小支撐树,或和一个更广泛的covering问题的组合问题上。本文表明前面的研究结果基本都可以推广到车间排序和这两个问题各自的组合问题上。本文主要的创新点如下: 1.通过结合车间排序问题和最短路(最小支撐树、covering)问题,提出一系列新的组合优化问题,并证明了这些问题的计算复杂性和提出了相应的近似算法。 2.针对车间排序问题的特点,提出了一个比covering问题更广泛的问题,把它应用到车间排序问题和它的组合问题的定义上,并得到一个对组合优化问题的组合问题适用性更广泛的定义。 3.对于这些组合问题,根据车间排序问题的已有算法返回的解的特点,通过重复迭代算法和修正权重的思想,设计出一系列有效求解的近似算法,同时进一步扩展了这个思想的应用。

关键词：车间排序最短路组合优化的组合问题计算复杂性近似算法

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荔枝的采后处理及贮藏

世界热带农业信息 1989年第2期 34-36页

作者： Wai-kit nip 唐树良

本文综述报道了侧重于保持荔枝色泽的采后处理和贮藏的各种方法。

关键词：荔枝肉贮藏温度采后处理贮存期限多酚氧化酶荔枝干果皮色泽无色花青素荔枝果皮褐变反应

Serum insulin, insulin resistance, p-cell dysfunction, and gallstone disease among type 2 diabetics in Chinese population: A community-based study in Kinmen, Taiwan

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World Journal of Gastroenterology 2005年第45期11卷 7159-7164页

作者： Chi-Ming Liu Tao-Hsin Tung Shih-Tzer Tsai Jorn-Hon Liu Yeh-Kuang Tsai Victor Tze-kai Chen Tseng-nip Tam Hsu-Feng Lu Kuang-Kuo Wang Chung-Te Hsu Hui-Chuan Shih De-Chuan Chan Pesus Chou Community Medicine Research Center and Institute of Public Health National Yang-MingUniversity Cheng Hsin General Hospital Taipei Taiwan China Department of medicine Veterans GeneralHospital Taipei Taiwan China Cheng Hsin General Hospital Faculty ofMedicine School of Medicine National Yang-Ming UniversityTaipei Taiwan China University of California San Francisco SanFrancisco CA United States Cardinal Tien Hospital College ofMedicine Fu-Jen Catholic University National Defence MedicineCenter Taipei Taiwan China Cheng Hsin General Hospital Taipei Taiwan China Department of Nursing Kaohsiung MilitaryGeneral Hospital Kaohsing Taipei Taiwan China Division of General Surgery Tri-ServiceGeneral Hospital National Defence Medical Center TaipeiTaiwan China Community Medicine Research Center and Instituteof Public Health National Yang-Ming University Taipei TaiwanChina

AIM: To explore the association of serum insulin, insulin resistance, and β-cell dysfunction with gallstone disease (GSD) in type 2 diabetics. METHODS: We used a community-based study conducted between 1991 and 1993 in Kinmen, Taiwan to identify type 2 diabetics. A screening program for GSD was performed in 2001 by a panel of specialists who employed real-time ultrasound sonography to examine the abdominal region after the patient had fasted for at least 8 h. Screening was conducted in 2001 on 848 patients diagnosed with type 2 diabetes. The HOMA method was used to compare the profile differences for insulin resistance (HOMA IR) and β-cell dysfunction (HOMA β-cell). RESULTS: We studied 440 type 2 diabetics who attended sonography check-ups. After excluding eight insulin-treated diabetics, the prevalence of GSD among the remaining 432 was 13.9% (26/187) among males and 14.7% (36/245) among females. After adjustment for other GSD-associated risk factors in addition to age and obesity, GSD risk increased among females with levels of serum insulin [4th vs 1st quartile odds ratios (OR) = 4.46 (95%CI: 1.71-11.66)] and HOMA IR [4th vs 1st quartile OR = 4.46 (95%CI: 1.71-11.66)]. Better HOMA β-cell function was significantly related to decreased risk of GSD [4th vs 1st quartile OR = 0.16 (95%CI: 0.03-1.70)]. Among males, age and central obesity were the most significant risk factors for GSD. No association of GSD with serum insulin, HOMA IR, and HOMA β-cell was observed among males. CONCLUSION: Serum insulin, insulin resistance, and β-cell dysfunction are risk factors for GSD in females, but not males with type 2 diabetes.

关键词： Type 2 diabetes Gallstone disease Insulinresistance β-cell dysfunction Community-based study

A new phosphidation route for the synthesis of nipx and their cocatalytic performances for photocatalytic hydrogen evolution over g-C3N4

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Journal of Energy Chemistry 2020年第9期29卷 241-249,I0008页

作者： Ziqun Wang Longfeng Li Mingzhu Liu Tifang Miao Xiangju Ye Sugang meng Shifu Chen Xianliang Fu College of Chemistry and Material Science Huaibei Normal UniversityHuaibei 235000AnhuiChina Department of Chemistry Anhui Science and Technology UniversityFengyang 233100AnhuiChina

Ni-based phosphides(nipx)composed of earth-abundant elements are promising cocatalysts to replace noble metals for photocatalytic H2 evolution reaction(HER).A safe,energy-saving,and compositioncontrollable synthesis of nipx is still highly desired.A facile and mild solvothermal process was developed for the first time for selective synthesis of a series of nipx,including Ni,Ni12P5,Ni2P/Ni12P5,Ni/Ni2P and Ni2P,through controlling the dosage of NaBH4 and *** phosphidation process was mainly composed of(1)a sequential reduction of Ni2+to Nj0 and(H2PO2)-to P(around the formed Ni0)triggered by NaBH4,and(2)a final phosphidation between Nj0 and the in situ generated P *** photocatalytic HER performance of g-C3N4 can be substantially improved with the decoration of nipx(3 wt%)as the separation of photoinduced charge carriers can be promoted and some active sites with low over-potential for HER can be *** cocatalytic efficiency of nipx is mainly determined by P ***2P with a high ratio of P consequently exhibits the highest HER performance(215.1 umol g-1 h-1),which is almost six times higher than that of the pristine g-C3N4(35.6 umol g-1 h-1).Thus,as for the cocatalyst based on Ni phosphides,Ni2P is the preferable crystal phase and more efforts should be devoted to Ni2P to further optimize its structure,texture,and morphology in future works.

关键词： Ni-phosphides Carbon nitrides Photocatalysis Hydrogen production Solvothermal synthesis

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蒙特利尔城市活动

建筑与文化 2007年第4期 60-61页

作者： L’équipe de nip Paysage

公共场所的生活构成了蒙特利尔的特色，体现了这个城市勃勃的生机。

关键词：城市活动蒙特利尔公共场所

Engineering of Co_(3O)_(4)@Ni_(2)P heterostructure as trifunctional electrocatalysts for rechargeable zinc-air battery and self-powered overall water splitting

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Journal of Materials Science & Technology 2022年第20期115卷 19-28页

作者： Xiaolin Hu Tongxin Yang Zuguang Yang Zongyang Li Ronghua Wang meng Li Guangsheng Huang Bin Jiang Chaohe Xu Fusheng Pan College of Aerospace Engineering Chongqing UniversityChongqing 400044China College of Materials Science and Engineering Chongqing UniversityChongqing 400044China National Engineering Research Center for Magnesium Alloys Chongqing UniversityChongqing 400044China MOE Key Laboratory of Low-grade Energy Utilization Technologies and Systems CQU-NUS Renewable Energy Materials&Devices Joint LaboratorySchool of Energy&Power EngineeringChongqing UniversityChongqing 400044China

Rational design of highly efficient,robust and nonprecious electrocatalysts for the oxygen reduction reaction(ORR),oxygen evolution reaction(OER)and hydrogen evolution reaction(HER)is highly demanded and ***,heterostructural Co_(3O)_(4)@Ni_(2)P arrays with numerous reaction sites,unique interfacial electronic structure and fast charge transfer kinetics are developed as electrocatalysts for rechargeable Zn-air batteries and overall water *** density functional theory calculation and X-ray absorption fine structure analysis manifest that the synergistic structural and abundant electronic modulations interfaces are formed,thus simultaneously promoting the electrocatalytic kinetics,activities and ***,it can achieve an ultralow overpotential of 270 m V and 28 m V at 10 m A cm^(-2) for OER and HER,*** water electrolyzer delivers a current density of 10 m A cm^(-2) at 1.563 V;furthermore,rechargeable Zn-air batteries triggered by this heterostructure can achieve excellent cyclic stability of 177 h(2 h per cycle)at 10 m A cm^(-2);both devices are superior to the Pt/C+Ir/*** work not only designs an efficient trifunctional electrocatalyst but also paves an avenue to understand the heterostructure engineering for catalysts development and disclose the underlying relationship of interfacial electronic structures and catalytic properties.

关键词： Density functional theory Trifunctional electrocatalysts Heterostructure Zn–air batteries Overall water splitting