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Red Yeast Rice Increases Excretion of Bile Acids in Hamsters

Biomedical and Environmental Sciences 2009年第4期22卷 269-277页

作者： ka-YING MA ZE-SHENG ZHANG SHU-XIN ZHAO QI CHANG YIN-MEI wong SAI YING VENUS YEUNG Yu HUANG AND ZHEN-YU CHEN Food and Nutritional Sciences Program Department of Biochemistry The Chinese University of Hong Kong Shatin New Territories Hong Kong China Faeulty of Food Engineering & Biotechnology Tianjin University of Science and Technology Tianjin 300457 China Institute of Medicinal Plant Development Chinese Academy of Medical Science & Peking Union Medical College Beijing 100193 China Department of Physiology The Chinese University of Hong Kong Shatin New Territories Hong Kong China

Objective To investigate the hypocholesterolemic activity of red yeast rice （RYR） and its underlying mechanism. Methods Three groups of hamsters were fed either the control diet or one of the two experimental diets containing by weight 0.1% RYR （0.1RYR） or 0.3% RYR （0.3RYR）. Blood （0.5 mL） was collected from the retro-orbital sinus into a heparinized capillary tube at the end of week 0, 3, and 6. Plasma lipoproteins were measured using enzymatic kits, while fecal neutral and acidic sterols were quantified using a gas-liquid chromatography. Results Plasma total cholesterol was reduced by 12% in 0.1RYR group and by 18% in 0.3RYR group compared with the control value. Similarly, plasma triacylglycerol was decreased by 11% in 0.1RYR group and by 24% in 0.3RYR group. Western blotting analysis demonstrated that RYR had no effect on sterol regulatory element binding protein 2, fiver X receptor, 3-hydroxy-3-methylglutary-CoA reductase, LDL receptor, and cholesterol-7α-hydroxylase. HPLC analysis confirmed that RYR contained 0.88% monacolin K. It was recently found that RYR supplementation increased excretion of fecal acidic sterols by 34 folds compared with the conlrol value. Conclusion Hypocholesterolemic activity of RYR is mediated at least partially by enhancement of acidic sterol excretion.

关键词： Bile acid Cholesterol Monacolin Red yeast rice Triacylglcerols

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Efficacy of Vaccine Protection Against COVID-19 Virus Infection in Patients with Chronic Liver Diseases

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Journal of Clinical and Translational Hepatology 2023年第3期11卷 718-735页

作者： Carmen ka Man Cheung Kimmy Wan Tung Law Alvin Wing Hin Law Man Fai Law Rita Ho Sunny Hei wong Department of Medicine and Therapeutics Prince of Wales HospitalHong KongChina West Island School Hong KongChina Department of Medicine North District HospitalHong KongChina Institute of Digestive Disease and Department of Medicine and Therapeutics State Key Laboratory of Digestive DiseaseLi Ka Shing Institute of Health SciencesThe Chinese University of Hong KongHong KongChinaLee Kong Chian School of MedicineNanyang Technological UniversitySingapore

The outbreak of coronavirus disease 2019 (COVID-19) has resulted in significant morbidity and mortality worldwide. Vaccination against coronavirus disease 2019 is a use-ful weapon to combat the virus. Patients with chronic liver diseases (CLDs), including compensated or decompensated liver cirrhosis and noncirrhotic diseases, have a decreased immunologic response to coronavirus disease 2019 vaccines. At the same time, they have increased mortality if infected. Current data show a reduction in mortality when patients with chronic liver diseases are vaccinated. A suboptimal vac-cine response has been observed in liver transplant recipi-ents, especially those receiving immunosuppressive therapy, so an early booster dose is recommended to achieve a better protective effect. Currently, there are no clinical data com-paring the protective efficacy of different vaccines in patients with chronic liver diseases. Patient preference, availability of the vaccine in the country or area, and adverse effect profiles are factors to consider when choosing a vaccine. There have been reports of immune-mediated hepatitis after coronavi-rus disease 2019 vaccination, and clinicians should be aware of that potential side effect. Most patients who developed hepatitis after vaccination responded well to treatment with prednisolone, but an alternative type of vaccine should be considered for subsequent booster doses. Further prospec-tive studies are required to investigate the duration of immu-nity and protection against different viral variants in patients with chronic liver diseases or liver transplant recipients, as well as the effect of heterologous vaccination.

关键词： COVID-19 SARS-CoV-2 Chronic liver disease Liver transplanta-tion Vaccine mRNA.

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Guidelines for evaluation and management of cerebral collateral circulation in ischaemic stroke 2017

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Stroke & Vascular Neurology 2018年第3期3卷 117-130页

作者： Liping Liu Jing Ding Xinyi Leng Yuehua Pu Li-An Huang Anding Xu ka Sing Lawrence wong Xin Wang Yongjun Wang 无 Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Neurology Zhongshan HospitalFudan UniversityShanghaiChina Department of Medicine and Therapeutics The Chinese University of Hong KongPrince of Wales HospitalHong KongChina Department of Neurology The First Affiliated HospitalJinan UniversityGuangzhouChina on behalf of the Chinese Society of Cerebral Blood Flow and Metabolism the Chinese Stroke Association

Collateral circulation plays a vital role in sustaining blood flow to the ischaemic areas in acute,subacute or chronic phases after an ischaemic stroke or transient ischaemic *** collateral circulation has shown protective effects towards a favourable functional outcome and a lower risk of recurrence in stroke attributed to different aetiologies or undergoing medical or endovascular *** the past decade,the importance of collateral circulation has attracted more attention and is becoming a hot spot for ***,the diversity in imaging methods and criteria to evaluate collateral circulation has hindered comparisons of findings from different cohorts and further studies in exploring the clinical relevance of collateral circulation and possible methods to enhance collateral *** statement is aimed to update currently available evidence and provide evidence-based recommendations regarding grading methods for collateral circulation,its significance in patients with stroke and methods under investigation to improve collateral flow.

关键词： collateral protective statement

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Spontaneous type 1 pattern, ventricular arrhythmias and sudden cardiac death in Brugada Syndrome： an updated systematic review and meta-analysis

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Journal of Geriatric Cardiology 2017年第10期14卷 639-643页

作者： Ahmed Bayoumy Meng-Qi GONG ka Hou Christien Li Sunny Hei wong William KK Wu Guang-Ping LI George Bazoukis Konstantinos P Letsas Wing Tak wong Yun-Long XIA Tong LIU Gary Tse Department of Medicine and Therapeutics Faculty of Medicine Chinese University of Hong Kong Hong Kong China Li ka Shing Institute of Health Sciences Faculty of Medicine Chinese University of Hong Kong Hong Kong China Faculty of Medicine University of Amsterdam The Netherlands Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease Department of Cardiology Tianjin Institute of Cardiology Second Hospitalof Tianjin Medical University Tianjin China Faculty of Medicine Newcastle University United Kingdom Department of Anaesthesia and Intensive Care Faculty of Medicine Chinese University of Hong Kong Hong Kong China Second Department of Cardiology Evangelismos General Hospital of Athens Athens Greece School of Life Sciences Chinese University of Hong Kong Hong Kong China Department of Cardiology First Affiliated Hospital of Dalian Medical University Dalian China

Brugada syndrome （BrS） is primary electrical disorder characterized by ST segment elevation with right bundle branch block morphology in patients with apparent structurally normal hearts, It predisposes affected individuals to ventricular tachycardia/fibrillation （VT/VF） and sudden cardiac death （SCD）.A number of studies have identified risk factors that are associated with a more malignant course of disease. These include male gender, syncope, a spontaneous type 1 ECG pattern, family history of SCD, family history of Brugada syndrome,

关键词： Brugada syndrome Risk stratification Spontaneous type 1 Sudden cardiac death Ventricular arrhythmia

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Impact of small-for-size liver grafts on medium-term and long-term graft survival in living donor liver transplantation: A meta-analysis

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World Journal of Gastroenterology 2019年第36期25卷 5559-5568页

作者： ka Wing Ma Kelly Hiu Ching wong Albert Chi Yan Chan Tan To Cheung Wing Chiu Dai James Yan Yue Fung wong Hoi She Chung Mau Lo Kenneth Siu Ho Chok Department of Surgery Queen Mary Hospital Hong Kong China Li ka Shing Faculty of Medicine The University of Hong Kong Hong Kong China Department of Surgery The University of Hong Kong Hong Kong China Department of Medicine Queen Mary Hospital Hong Kong China

BACKGROUND Small-for-size grafts (SFSGs) in living donor liver transplantation (LDLT) could optimize donor postoperative outcomes and also expand the potential donor pool. Evidence on whether SFSGs would affect medium-term and long-term recipient graft survival is lacking. AIM To evaluate the impact of small-for-size liver grafts on medium-term and longterm graft survival in adult to adult LDLT. METHODS A systematic review and meta-analysis were performed by searching eligible studies published before January 24, 2019 on PubMed, EMBASE, and Web of Science databases. The primary outcomes were 3-year and 5-year graft survival. Incidence of small-for-size syndrome and short term mortality were also extracted. RESULTS This meta-analysis is reported according to the guidelines of the PRISMA 2009 Statement. Seven retrospective observational studies with a total of 1821 LDLT recipients were included in the meta-analysis. SFSG is associated with significantly poorer medium-term graft survival. The pooled odds ratio for 3-year graft survival was 1.58 [95% confidence interval 1.10-2.29, P = 0.014]. On the other hand, pooled results of the studies showed that SFSG had no significant discriminatory effect on 5-year graft survival with an odds ratio of 1.31 (95% confidence interval 0.87-1.97, P = 0.199). Furthermore, incidence of small-for-size syndrome detected in recipients of SFSG ranged from 0-11.4% in the included studies. CONCLUSION SFSG is associated with inferior medium-term but not long-term graft survival. Comparable long-term graft survival based on liver graft size shows that smaller grafts could be accepted for LDLT with appropriate flow modulatory measures. Close follow-up for graft function is warranted within 3 years after liver transplantation.

关键词： Living donor liver transplantation Small-for-size grafts Small-for-size syndrome Graft survival

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99Tc^m-二膦酸盐及18F-NaF动态骨显像的机制及临床应用

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中华核医学与分子影像杂志 2019年第1期39卷 53-61页

作者：孟庆龙(译) 宋少莉(审校) 复旦大学附属肿瘤医院核医学科上海200032 中国医学科学院阜外医院超声影像中心北京100037

利用99Tcm-二膦酸盐及18F-NaF进行的动态骨显像可以非常灵敏地获得细微的骨灌注及骨转化改变的功能信息,从而帮助临床医师处理各种骨病。该文总结了99Tcm-二膦酸盐及18F-NaF的摄取机制,并对比二者用于动态骨显像、多时间点骨显像以及骨... 详细信息

利用99Tcm-二膦酸盐及18F-NaF进行的动态骨显像可以非常灵敏地获得细微的骨灌注及骨转化改变的功能信息,从而帮助临床医师处理各种骨病。该文总结了99Tcm-二膦酸盐及18F-NaF的摄取机制,并对比二者用于动态骨显像、多时间点骨显像以及骨显像定量评价的临床、基础研究中的表现。

关键词： 99Tcm-甲基二膦酸盐 18F-NaF 动态显像

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Responsive lanthanide materials for tumors targeting imaging and inhibition

Responsive lanthanide materials for tumors targeting imaging...

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第二届海峡两岸功能材料科技与产业峰会（2015）

作者： ka-Leung wong Department of Chemistry Hong Kong Baptist University

One of the major drawbacks of the existing anticancer agents is the differentiation of cancer cells and normal ***,some studies in the literatures suggest several overexpressed cancer cell cycle regulated proteins(***(s),Plk1 and EBNA1)can be the target for particular *** small molecules as their inhibitors have been reported;however,those reported inhibitors are not emissive and somehow can’t directly

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Atrophy of the left dorsolateral prefrontal cortex is associated with poor performance in verbal fluency in elderly poststroke women

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Neural Regeneration Research 2013年第4期8卷 346-356页

作者： Yang-Kun Chen Wei-Min Xiao Defeng Wang Lin Shi Winnie CW Chu Vincent CT Mok ka Sing wong Gabor S Ungvari Wai Kwong Tang Department of Neurology Dongguan People's Hospital Department of Diagnostic Radiology and Organ Imaging the Chinese University of Hong Kong Department of Medicine and Therapeutics the Chinese University of Hong Kong Graylands Hospital School of Psychiatry & Clinical NeurosciencesUniversity of Western AustraliaPerth 6005Australia Department of Psychiatry the Chinese University of Hong Kong

This study aimed to investigate the association between atrophy in the prefrontal cortex with executive function and verbal fluency in elderly male and female patients poststroke. Thirty elderly female patients with non-aphasic ischemic stroke aged -〉 60 years and 30 age-matched non-aphasic male patients with ischemic stroke were recruited. Automatic magnetic resonance imaging segmentation was used to assess the volume of the whole prefrontal cortex, along with its subdivisions： anterior cingulate cortex, orbitofrontal cortex and dorsolateral prefrontal cortex. The Semantic Verbal Fluency Test was administered at 3 and 15 months poststroke. At 3 months poststroke, left dorsolateral prefrontal cortex volume was significantly correlated with Verbal Fluency Test score in female patients only （partial coefficient = 0.453, P = 0.045）, after controlling for age, education, diabetes, neurological deficit, white matter lesions volume, as well as the location and volume of infarcts. At 15 months poststroke, there remained a significant association between the left dorsolateral prefrontal cortex volume and Verbal Fluency Test （partial coefficient = 0.661, P = 0.001） and between the left prefrontal cortex volume and Verbal Fluency Test （partial coefficient = 0.573, P = 0.004） in female patients after the same adjustments. These findings indicate that atrophy of the left dorsolateral prefrontal cortex contributes to the impairment of verbal fluency in elderly female patients with stroke. Sex differences may be present in the neuropsychological mechanisms of verbal fluency impairment in patients with stroke.

关键词： neural regeneration neuroimaging brain atrophy verbal fluency executive function stroke sex differences prefrontal cortex dorsolateral prefrontal cortex magnetic resonance imaging grants-supported paper photographs-containing paper neuroregeneration

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Serum Mac-2 binding protein glycosylation isomer level predicts hepatocellular carcinoma development in E-negative chronic hepatitis B patients

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World Journal of Gastroenterology 2019年第11期25卷 1398-1408页

作者： Lung-Yi Mak Wai-Pan To Danny ka-Ho wong James Fung Fen Liu Wai-kay Seto Ching-Lung Lai Man-Fung Yuen Department of Medicine Queen Mary Hospital Department of Medicine The University of Hong Kong State Key Laboratory for Liver Research The University of Hong Kong

BACKGROUND Liver cirrhosis is a major risk factor for hepatocellular carcinoma(HCC)development in chronic hepatitis B(CHB). Serum Mac-2 binding protein glycosylation isomer(M2 BPGi) is a novel serological marker for fibrosis. The role of M2 BPGi in prediction of HCC is *** To examine the role of serum M2 BPGi in predicting HCC development in hepatitis B e antigen(HBeAg)-negative *** Treatment-naive CHB patients with documented spontaneous HBeAg seroconversion were recruited. Serum M2 BPGi was measured at baseline(within3 years from HBeAg seroconversion), at 5 years and 10 years after HBeAg seroconversion and expressed as cut-off index(COI). Multivariate cox regression was performed to identify predictors for HCC development. ROC analysis was used to determine the cut-off value of M2 *** Among 207 patients(57% male, median age at HBeAg seroconversion 40 years old) with median follow-up of 13.1(11.8-15.5) years, the cumulative incidence of HCC at 15 years was 7%. Median M2 BPGi levels were significantly higher in patients with HCC compared to those without HCC(baseline: 1.39 COI vs 0.38 COI, P < 0.001; 5-year: 1.45 COI vs 0.47 COI, P < 0.001; 10-year: 1.20 COI vs 0.55 COI, P = 0.001). Multivariate analysis revealed age at HBeAg seroconversion[odds ratio(OR) = 1.196, 95% confidence interval(CI): 1.034-1.382, P = 0.016] and baseline M2 BPGi(OR = 4.666, 95%CI: 1.296-16.802, P = 0.018) were significant factors predictive of HCC. Using a cut-off value of 0.68 COI, baseline M2 BPGi yielded AUROC of 0.883 with 91.7% sensitivity and 80.8% *** High serum M2 BPGi within 3 years after HBeAg seroconversion was a strong predictor for subsequent HCC development in treatment-naive HBeAg-negative CHB patients.

关键词： Hepatocellular carcinoma Hepatitis B Liver fibrosis Mac-2 binding protein glycosylation isomer Biomarker

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Profiles and removal efficiency of polycyclic aromatic hydrocarbons by two different types of sewage treatment plants in Hong Kong

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Journal of Environmental Sciences 2017年第3期29卷 196-206页

作者： Yu Bon Man ka Lai Chow Zhang Cheng Wing Yin Mo Yung Hau Chan James Chung Wah Lam Frankie Tat Kwong Lau Wing Cheong Fung Ming Hung wong Consortium on Health EnvironmentEducation and Research(CHEER)and Department of Science and Environmental StudiesThe Education University of Hong KongTai PoHong KongChina Department of Environmental Engineering Jinan UniversityGuangzhou 510630China State Key Laboratory in Marine Pollution Croucher Institute for Environmental SciencesHong Kong Baptist University and City University of Hong KongKowloon TongHong KongChina Department of Geography Hong Kong Baptist UniversityKowloon TongHong KongChina College of Environment Sichuan Agricultural UniversityChengdu 611130China State Key Laboratory in Marine Pollution and Research Centre for the Oceans and Human Health City University of Hong KongKowioon TongHong KongChina The Drainage Services Department The Government of the Hong Kong Special Administrative RegionHong KongChina

Sewage discharge could be a major source of polycyclic aromatic hydrocarbons （PAHs） in the coastal waters. Stonecutters Island and Shatin Sewage Treatment Works （SCISTW and STSTW） in Hong Kong, adopted chemically enhanced primary treatment and biological treatment, respectively. This study aimed at （1） determining the removal efficiencies of PAHs, （2） comparing the capabilities in removing PAHs, and （3） characterizing the profile of each individual PAHs, in the two sewage treatment plants （STPs）. Quantification of 16 PAHs was conducted by a Gas Chromatography. The concentrations of total PAHs decreased gradually along the treatment processes （from 301 ± 255 and 307 ± 217 ns/L to 14.9 ± 12.1 and 63.3 ± 54.1 ng/L in STSTW and SCISTW, respectively）. It was noted that STSTW was more capable in removing total PAHs than SCISTW with average total removal effidency 94.4% ± 4.12% us. 79.2% ± 7.48% （p 〈 0.05）. The removal of PAHs was probably due to sorption in particular matter, confirmed by the higher distribution coefficient of individual and total PAHs in solid samples （dewatered sludge contained 92.5% and 74.7% of total PAHs in SCISTW and STSTW, respectively） than liquid samples （final efffluent-total contained 7.53% and 25.3% of total PAHs in STSTW and SCISTW, respectively）. Despite the impressive capability of STSTW and SCISTW in removing PAHs, there was still a considerable amount of total PAHs （1.85 and 39.3 ks/year, respectively for the two STPs） being discharged into Hone Kon coastal waters, which would be an environmental concern.

关键词： Sewage treatment plantsPAHsRemoval efficiencySludgeSewage

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