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Computational design of structured chemical products

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Frontiers of Chemical Science and Engineering 2021年第5期15卷 1033-1049页

作者： Faheem Mushtaq Xiang Zhang ka Y.Fung ka M.ng Department of Chemical and Biological Engineering The Hong Kong University of Science and TechnologyHong KongChina

In chemical product design,the aim is to formulate a product with desired *** and internal product structure are two key drivers of product performance with direct impact on the mechanical,electrical,and thermal ***,there is a keen interest in elucidating the dependence of product performance on ingredients,structure,and the manufacturing process to form the *** of product structure,particularly microstructure,is an intrinsically complex problem that involves different phases of different physicochemical properties,mass fraction,morphology,size distribution,and ***,computational methods have emerged that assist systematic microstructure quantification and *** objective of this paper is to review these computational methods and to show how these methods as well as other developments in product design can work seamlessly in a proposed performance,ingredients,structure,and manufacturing process framework for the design of structured chemical *** begins with the desired target properties and key *** is followed by computation for microstructure and then selection of processing steps to realize this *** framework is illustrated with the design of nanodielectric and die attach adhesive products.

关键词： product design performance ingredients structure manufacturing process framework structured chemical products microstructure design

Late retroperitoneal recurrence of hepatocellular carcinoma 12 years after initial diagnosis

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World Journal of Gastroenterology 2010年第17期16卷 2187-2189页

作者： Tiffany Cho-Lam Wong ka-Fai To Simon See-Ming hou Sidney kam-Hung Yip Chi-Fai ng Department of Surgery Prince of Wales HospitalThe Chinese University of Hong Kong Department of Anatomical and Cellular Pathology The Chinese University of Hong Kong

Hepatocellular carcinoma (HCC) is an aggressive tumor with poor long-term ***,we present an unusual patient with a solitary recurrence of HCC in the right kidney 12 years after the initial *** illustrates the importan... 详细信息

关键词： Hepatocellular carcinoma Late recurrence Metastasis Retroperitoneal

Probabilistic characterization of cyclic shear modulus reduction for normally to moderately over-consolidated clays

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Earthquake Engineering and Engineering Vibration 2016年第3期15卷 495-508页

作者： Iok-Tong ng ka-Veng Yuen ngai-Kuan Lao Dept.of Civil and Environmental Engineering Faculty of Science and Technology University of Macao

Evaluation of the cyclic shear modulus of soils is a crucial but challenging task for many geotechnical earthquake engineering and soil dynamic issues. Improper determination of this property unnecessarily drives up design and maintenance costs or even leads to the construction of unsafe structures. Due to the complexities involved in the direct measurement, empirical curves for estimating the cyclic shear modulus have been commonly adopted in practice for simplicity and economical considerations. However, a systematic and robust approach for formulating a reliable model and empirical curve for cyclic shear modulus prediction for clayey soils is still lacking. In this study, the Bayesian model class selection approach is utilized to identify the most significant soil parameters affecting the normalized cyclic shear modulus and a reliable predictive model for normally to moderately over-consolidated clays is proposed. Results show that the predictability and reliability of the proposed model out performs the well-known empirical models. Finally, a new design chart is established for practical usage.

关键词： Bayesian analysis cyclic shear modulus empirical model geotechnical earthquake engineering normally tomoderately over-consolidated clays

Study of the attenuation relationship for the Wenchuan M_s 8.0 earthquake

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Earthquake Engineering and Engineering Vibration 2015年第1期14卷 1-11页

作者： Sin-Chi Kuok Iok-Tong ng ka-Veng Yuen Faculty of Science and Technology University of Macao

Prediction of peak ground acceleration is an essential element in engineering seismology and it has received great attention in last few decades. In this paper, a comprehensive database of the strong-motion records of the 2008 great Wenchuan Ms 8.0 earthquake is analyzed to investigate the seismic attenuation relationship and the directivity effects. In contrast to most existing seismic attenuation models, the proposed model considers explicitly the directivity effect which has primary influence on the magnitude of ground motion. Bayesian model updating is used to obtain the model parameters and the associated uncertainty. Comparative study is performed with the well-known Boore-Joyner-Fumal empirical formula. Results show that consideration of the directivity effect is vital in modeling the seismic attenuation relationship.

关键词： Bayesian inference Boore-Joyner-Fumal attenuation relationship directivity peak ground acceleration seismic attenuation model

Structure and sequence analysis of influenza A virus nucleoprotein

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Science China(Life Sciences) 2009年第5期52卷 439-449页

作者： ng Andy ka-Leung SHAW Pang-Chui Molecular Biotechnology Programme Department of Biochemistry and Centre for Protein Science and Crystallography The Chi-nese University of Hong Kong

Influenza A virus nucleoprotein (NP) forms homo-oligomers and multiple copies of NP wrap around genomic RNA, along with a trimeric polymerase making up ribonucleoprotein (RNP) complex. Sequence comparison of more than 2500 influenza A NP showed that this protein contains 30.1 % of polymorphic residues. NP is composed of a head and a body domain and a tail loop/ linker region. The head domain is more conserved than the body domain, as revealed from the structure-based sequence alignment. NP oligomerization is mediated by the insertion of the non-polymorphic and structurally conserved tail loop of one NP molecule to a groove of another NP. The different form of NP oligomers is due to the flexibility of the polymorphic linkers that join the tail loop to the rest of the protein. The RNA binding property of NP is known to involve the protruding element and the flexible basic loop between the head and body domains, both having high degree of primary sequence conservation. To bind RNA, NP may first capture the RNA by the flexible basic loop and then the RNA is clamped by the protruding element.

关键词： Influenza H5N1 nucleoprotein oligomerization RNA binding

Economic analysis in product design——A case study of a TCM dietary supplement

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Chinese Journal of Chemical Engineering 2016年第1期24卷 202-214页

作者： Yuen Shan Cheng ka Yip Fung ka Ming ng Christianto Wibowo Department of Chemical and Biomolecular Engineering The Hong Kong University of Science and Technology ClearWaterBay Technology Inc.

An approach for the economic analysis of chemical product design is proposed. It takes into account of customers' preference on product quality and economic considerations such as pricing, profit, market share, capital investment, and operating cost. The activities needed to support business decision making – identifying product quality, estimating product cost, calculating financial metrics, and performing make–buy analysis – are *** design of a Ganoderma lucidum dietary supplement, a traditional Chinese medicinal(TCM) product, is used to illustrate all the activities in this approach.

关键词： Product design Product conceptualization TCM dietary supplement Economic analysis Make–buy analysis

TCGA whole-transcriptome sequencing data reveals significantly dysregulated genes and signaling pathways in hepatocellular carcinoma

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Frontiers of Medicine 2015年第3期9卷 322-330页

作者： Daniel Wai-Hung Ho Alan ka-Lun kai Irene Oi-Lin ng Department of Pathology and State Key Laboratory for Liver Research The University of Hong Kong ttong Kong SAR China

This study systematically evaluates the TCGA whole-transcriptome sequencing data of hepatocellular carcinoma （HCC） by comparing the global gene expression profiles between tumors and their corresponding non- tumorous liver tissue. Based on the differential gene expression analysis, we identified a number of novel dysregulated genes, in addition to those previously reported. Top-listing upregulated （CENPF and FOXM1） and downregulated （CLEC4G, CRHBP, and CLEC1B） genes were successfully validated using qPCR on our cohort of 65 pairs of human HCCs. Further examination for the mechanistic overview by subjecting significantly upregulated and downregulated genes to gene set enrichment analysis showed that different cellular pathways were involved. This study provides useful information on the transcriptomic landscape and molecular mechanism of hepatocarcinogenesis for development of new biomarkers and further in-depth characterization.

关键词： TCGA whole-transcriptome sequencing HCC liver cancer

The impact of hypoxia in hepatocellular carcinoma metastasis

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Frontiers of Medicine 2014年第1期8卷 33-41页

作者： Carmen Chak-Lui Wong Alan ka-Lun kai Irene Oi-Lin ng The State Key Laboratory for Liver Research and Department of Pathology The Universi(v of Hong Kong Hong Kong China

Hypoxia is a common phenomenon in hepatocellular carcinoma （HCC）. Hypoxia stabilizes transcription factor, hypoxia-inducible factor （HIF）, to activate gene transcription. Expression of HIF is closely associated with metastasis and poor prognosis in HCC. HIF mediates expression of genes that are involved in every step of HCC metastasis including epithelial-mesenchymal transition, invasion of the extracellular matrix, intravasation, extravasation, and secondary growth of the metastases. Because HIF is the central regulator of HCC metastasis, HIF inhibitors are attractive tools when used alone or as combined treatment to curb HCC metastasis. This review will summarize the current findings on the impact of hypoxia/HIF in HCC, with a particular focus on cancer metastasis.

关键词： hypoxia hepatocellular carcinoma (HCC) metastasis hypoxia-inducible factor (HIF)

Exacerbated VEGF up-regulation accompanies diabetes-aggravated hemorrhage in mice after experimental cerebral ischemia and delayed reperfusion

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Neural Regeneration Research 2022年第7期17卷 1566-1575页

作者： Angela ka Wai Lai Tsz Chung ng Victor ka Lok Hung ka Cheung Tam Chi Wai Cheung Sookja Kim Chung Amy Cheuk Yin Lo Department of Ophthalmology Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administration RegionChina Department of Anesthesiology Laboratory and Clinical Research Institute for PainThe University of Hong KongHong Kong Special Administration RegionChina Macao University of Science and Technology TaipaMacao Special Administration RegionChinaSchool of Biomedical SciencesThe State Key Laboratory of Pharmaceutical BiotechnologyThe University of Hong KongHong Kong Special Administration RegionChina

Reperfusion therapy is the preferred treatment for ischemic stroke,but is hindered by its short treatment window,especially in patients with diabetes whose reperfusion after prolonged ischemia is often accompanied by exacerbated *** mechanisms underlying exacerbated hemorrhage are not fully *** study aimed to identify this mechanism by inducing prolonged 2-hour transient intraluminal middle cerebral artery occlusion in diabetic Ins2Akita/+mice to mimic patients with diabetes undergoing delayed mechanical *** results showed that at as early as 2 hours after reperfusion,Ins2Akita/+mice exhibited rapid development of neurological deficits,increased infarct and hemorrhagic transformation,together with exacerbated down-regulation of tight-junction protein ZO-1 and upregulation of blood-brain barrier-disrupting matrix metallopeptidase 2 and matrix metallopeptidase 9 when compared with normoglycemic Ins2+/+*** indicated that diabetes led to the rapid compromise of vessel integrity immediately after reperfusion,and consequently earlier death and further aggravation of hemorrhagic transformation 22 hours after *** observation was associated with earlier and stronger up-regulation of pro-angiogenic vascular endothelial growth factor(VEGF)and its downstream phospho-Erk1/2 at 2 hours after reperfusion,which was suggestive of premature angiogenesis induced by early VEGF up-regulation,resulting in rapid vessel disintegration in diabetic *** reticulum stress-related pro-apoptotic C/EBP homologous protein was overexpressed in challenged Ins2Akita/+mice,which suggests that the exacerbated VEGF up-regulation may be caused by overwhelming endoplasmic reticulum stress under diabetic *** conclusion,the results mimicked complications in patients with diabetes undergoing delayed mechanical thrombectomy,and diabetes-induced accelerated VEGF up-regulation is likely to underlie exacerbated hemorrhagic transformat

关键词： blood-brain barrier brain injury diabetes mellitus hemorrhagic transformation infarct ischemia/reperfusion injury middle cerebral artery occlusion mouse model stroke vascular endothelial growth factor