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Augmenting osteoporotic bone regeneration through a hydrogel-based rejuvenating microenvironment

Bioactive Materials 2024年第11期41卷 440-454页

作者： Xiaoting Zhang Boguang Yang lu Feng Xiayi Xu Chenmin Wang Yuk-wai Lee Ming Wang Xuan lu Ling Qin Sien Lin Liming Bian Gang Li Musculoskeletal Research Laboratory Department of Orthopaedics&TraumatologyThe Chinese University of Hong KongPrince of Wales HospitalHong KongChina Stem Cells and Regenerative Medicine Laboratory Li Ka Shing Institute of Health SciencesThe Chinese University of Hong KongPrince of Wales HospitalHong KongChina The CUHK-ACC Space Medicine Centre on Health Maintenance of Musculoskeletal System The Chinese University of Hong Kong Shenzhen Research InstituteShenzhenPR China SH Ho Scoliosis Research Laboratory Department of Orthopaedics and TraumatologyThe Chinese University of Hong KongHong KongChina Joint Scoliosis Research Center of the Chinese University of Hong Kong and Nanjing University The Chinese University of Hong KongHong KongChina Li ka Shing Institute of Health Sciences The Chinese University of Hong KongChina School of Biomedical Sciences and Engineering Guangzhou International CampusSouth China University of TechnologyGuangzhou511442PR China Department of Orthopaedics and Traumatology The University of Hong KongHong KongChina

Osteoporotic bone defects pose a significant challenge for bone regeneration as they exhibit impaired healing capacity and delayed healing *** address this issue,this study introduces a hydrogel that creates a rejuvenating microenvironment,thereby facilitating efficient bone repair during the initial two weeks following bone defect *** hydrogel,named GelHFS,was created through host-guest polymerization of gelatin and acrylatedβ-*** of the human fetal mesenchymal stem cell secretome(HFS)formed GelHFS hydrogel aimed at mimicking a rejuvenated stem cell *** results demonstrated that GelHFS hydrogel promotes cell stellate spreading and osteogenic differentiation via integrinβ1-induced focal adhesion *** of GelHFS hydrogel in an osteoporotic bone defect rat model recruited endogenous integrinβ1-expressing cells and enhanced new bone formation and bone *** findings reveal that GelHFS hydrogel provides a rejuvenating niche for endogenous MSCs and enhances bone regeneration in osteoporotic bone *** findings highlight the potential of GelHFS hydrogel as an effective therapeutic strategy for addressing challenging bone healing such as osteoporotic bone regeneration.

关键词： Osteoporotic bone defects Bone regeneration Rejuvenating microenvironment Secretome Focal adhesion pathway

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长壁开采老采空区注浆充填范围确定方法

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采矿与安全工程学报 2008年第4期25卷 499-501页

作者：卢正邓喀中靳永强四川德阳建筑职业技术学院四川德阳618000 中国矿业大学环境与测绘学院江苏徐州221116

浅部老采空区注浆充填是保证老采空区建筑物地基稳定的有效措施,在确定充填治理范围时,目前大多采用正在开采的地表移动角确定注浆充填范围,这将导致充填范围过大,造成不必要的浪费,为此,基于国内开采沉陷资料,首先建立了正在开采的地... 详细信息

浅部老采空区注浆充填是保证老采空区建筑物地基稳定的有效措施,在确定充填治理范围时,目前大多采用正在开采的地表移动角确定注浆充填范围,这将导致充填范围过大,造成不必要的浪费,为此,基于国内开采沉陷资料,首先建立了正在开采的地表移动角与深厚比的关系,然后在分析老采空区变形机理基础上,提出了残余移动角的思想,根据残余移动与正在开采的地表移动相似性,建立了残余移动角与老采空区开采深度、等效开采厚度之间的关系,给出了老采空区充填注浆范围的确定方法,为老采空区充填治理范围的确定,提供了可靠的理论和方法.

关键词：老采空区注浆充填残余移动角

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Analysis of a Mesoscale Convective System that Produced a Single Sprite

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Advances in Atmospheric Sciences 2017年第2期34卷 258-271页

作者： Jing YANG Gaopeng lu Ningyu LIU Haihua CU Yu WANG Morris COHEN Key Laboratory of Middle Atmosphere and Global Environment Observation Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science and TechnologyNanjing 210044China Geospace Physics Laboratory Physics and Space Sciences DepartmentFlorida Institute of TechnologyMelbourneFL 32901USA Hebei Province meteorological Bureau Shijiazhuang 050000China State Grid Electric Power Research Institute Wuhan 430074China School of Electrical and Computer Engineering Georgia Institute of TechnologyAtlantaGA 30332USA

Sprites are brief optical emissions occurring above thunderstorms. Features of sprites and their parent thunderstorms and lightning activities have been studied by many researchers. Here, we report a single sprite recorded over a mesoscale convective system during its life cycle in Northeast China. The results show that the sprite might have been a dancing one, with a 20 km horizontal displacement from its parent cloud-to-ground flash （CG） and a 38 ms time delay; all the sprite elements occurred during the continuing current process of the parent flash. The peak current of the parent CG was the largest during the almost one-hour time window containing the sprite, and the absolute values of all the negative flashes were smaller than 100 ka during the same time period and did not produce sprite. The sprite did not occur during the time period in which the maximum area of the thunderstorm reached. The occurrence of sprite corresponded well with the decay of the thunderstorm convection, and no significant relationship between the occurrence of sprite and the increase in the 30-35 dBZ and 35-40 dBZ interval was found. The large wind gradient in the 8-12 km region of the thunderstorm may have played an important role in the sprite production.

关键词： sprite mesoscale convective system Doppler radar lightning magnetic field

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High-precision Dating and Geological Significance of Chang 7 Tuff Zircon of the Triassic Yanchang Formation, Ordos Basin in Central China

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Acta Geologica Sinica(English Edition) 2019年第6期93卷 1823-1834页

作者： ZHU Rukai CUI Jingwei DENG Shenghui luO Zhong lu Yuanzheng QIU Zhen Research Institute of Petroleum Exploration and Development

The Ordos Basin, as the second largest petroliferous basin of China, contains abundant oil and gas resources, oil shale, and sandstone-type uranium mineral resources. Chang 7 shale is not only the major source rock of the Mesozoic petroliferous system of the Basin, but is also crucial in determining the space-time distribution relationship of the shale section for the effective exploration and development of the Basin's oil and gas resources. To obtain a highly precise age of the shale development section, we collected tuff samples from the top and bottom profile of the Chang 7 Member, Yishi Village, Yaoqu Town, Tongchuan District, on the southern margin of the Ordos Basin and performed high-precision chemical abrasion(CA)–isotope dilution(ID)–thermal ionization mass spectrometry(TIMS) zircon U-Pb dating on the basis of extensive laser ablation inductively coupled plasma mass spectrometry(LA-ICP-MS) zircon U-Pb dating data. Our results show the precise ages of the top and bottom zircon in the Chang 7 shale to be 241.06±0.12 Ma and 241.558±0.093 Ma, respectively. We first obtained Chang 7 age data with Grade 0.1-Ma precision and then determined the age of the shale development in the Chang 7 Member to be the early-Middle Triassic Ladinian. This result is supported by paleontological evidence. The deposition duration of the Chang 7 shale is 0.5 Ma with an average deposition rate of the shale section being 5.3 cm/ka. Our research results provide time scale and basic data for further investigation of the basin–mountain coupling relation of the shale section, the sedimentary environment and volcanic ash and organic-matter-rich shale development relation, and the organism break-out and organic-matter enrichment mechanism.

关键词： Ordos Basin Chang 7 Member tuff zircon U-Pb dating

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Nonparametric Regression Combining Linear Structure

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Wuhan University Journal of Natural Sciences 2019年第4期24卷 277-282页

作者： ZHANG Yanli SONG Yunquan LIN lu WANG Xiuli School of Statistics Shandong University of Finance and Economics Jinan 250014 Shandong China College of Science China University of Petroleum Qingdao 266580 Shandong China Zhongtai Securities Institute for Financial Studies Shandong University Jinan 250100 Shandong China School of Mathematics and Statistics Shandong Normal University Jinan 250014 Shandong China

Nonparametric models are popular owing to their flexibility in model building and optimality in estimation. However nonparametric models have the curse of dimensionality and do not use any of the prior information. How to sufficiently mine structure information hidden in the data is still a challenging issue in model building. In this paper, we propose a parametric family of estimators which allows for penalizing deviation from linear structure. The new estimator can automatically capture the linear information underlying regressions function to avoid the curse of dimensionality and offers a smooth choice between the full nonparametric models and parametric models. Besides, the new estimator is the linear estimator when the model has linear structure,and it is the local linear estimator when the model has no linear structure. Compared with the complete nonparametric models, our estimator has smaller bias due to using linear structure information of the data. The new estimator is useful in higher dimensions;the usual nonparametric methods have the curse of *** on the projection framework, the theoretical results give the structure of the new estimator and simulation studies demonstrate the advantages of the new approach.

关键词： nonparametric full model nonlinear

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皮肤组织的热力学行为表征：Ⅱ．黏弹性行为

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西安交通大学学报（医学版） 2008年第4期29卷 365-369页

作者：徐峰卢天健 Seffen K A 剑桥大学工程系英国剑桥CB2 1PZ 西安交通大学强度与振动教育部重点实验室陕西西安710049

目的检验关于胶原蛋白是皮肤黏弹性主要决定因素的假设,重点考察皮肤组织在动态载荷下的热力学性能。方法采用不同的热加载实现皮肤组织中胶原质不同程度的热变性;使用差示扫描量热仪检测胶原质的热变性及其热稳定性,并通过热损伤积分... 详细信息

目的检验关于胶原蛋白是皮肤黏弹性主要决定因素的假设,重点考察皮肤组织在动态载荷下的热力学性能。方法采用不同的热加载实现皮肤组织中胶原质不同程度的热变性;使用差示扫描量热仪检测胶原质的热变性及其热稳定性,并通过热损伤积分方程分析了胶原质的热稳定性;采用动态热力学分析仪表征了温度和皮肤胶原质损伤对皮肤黏弹性特性的影响。结果由于水份的流失,储存模量随温度的升高而显著增大;与此相反,功耗因子却呈现出明显的温度不敏感性。结论热损伤和热变性程度对皮肤黏弹性性能的影响与温度的影响相类似,表明在恒定的频率下胶原蛋白分子的热变性对皮肤的黏弹性行为影响很大。

关键词：皮肤组织热力学行为热变性黏弹性

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Rapid quantification of semen hepatitis B virus DNA by real-time polymerase chain reaction

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World Journal of Gastroenterology 2005年第34期11卷 5385-5389页

作者： Wei-Ping Qian Yue-Qiu Tan Ying Chen Ying Peng Zhi Li Guang-Xiu lu Made C. Liu Hsiang-Fu Kung Ming-Ling He Li-ka Shing luofu Hospital Shenzhen 518033 Guangdong Province China Institute of Reproduction and Stem Cell Engineering Xiangya School of Medicine Central South University Changsha 410008 Hunan Province China The Institute of Molecular Biology The University of Hong Kong Hong Kong Special AdministrativeRegion China Department of Neurology The Second AffiliatedHospital Sun Yat-Sen University Guangzhou 510120 Guangdong Province China The Center for Emerging Infectious Diseases The Chinese University ofHong Kong Hong Kong Special Administrative Region China

AIM： To examine the sensitivity and accuracy of real-time polymerase chain reaction （PCR） for the quantification of hepatitis B virus （HBV） DNA in semen. METHODS： Hepatitis B viral DNA was isolated from HBV carriers＇ semen and sera using phenol extraction method and QIAamp DNA blood mini kit （Qiagen, Germany）. HBV DNA was detected by conventional PCR and quantified by TaqMan technology-based real-time PCR （quantitative polymerase chain reaction （qPCR））. The detection threshold was 200 copies of HBV DNA for conventional PCR and 10 copies of HBV DNA for real time PCR per reaction. RESULTS： Both methods of phenol extraction and QIAamp DNA blood mini kit were suitable for isolating HBV DNA from semen. The value of the detection thresholds was 500 copies of HBV DNA per mL in the semen. The viral loads were 7.5×10^7 and 1.67×10^7 copies of HBV DNA per mL in two HBV infected patients＇ sera, while 2.14×10^5 and 3.02×10^5 copies of HBV DNA per mL in the semen. CONCluSION： Real-time PCR is a more sensitive and accurate method to detect and quantify HBV DNA in the semen.

关键词： Hepatitis B virus Semen Real-time polymerase chain reaction Viral load

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落新妇苷在自身免疫性疾病中作用机制的研究进展

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中药药理与临床 2023年第2期39卷 120-125页

作者：陆玉双陈柳尹胡凯广西医科大学第一附属医院南宁530021

自身免疫性疾病是一类因机体免疫功能紊乱对自身抗原产生免疫应答导致自身损害而引发的疾病,目前针对这类疾病最常见的治疗药物主要包括免疫抑制剂、糖皮质激素、细胞毒性化疗药物、等,但这些广谱药物由于缺乏选择性且一般需长期用药,... 详细信息

自身免疫性疾病是一类因机体免疫功能紊乱对自身抗原产生免疫应答导致自身损害而引发的疾病,目前针对这类疾病最常见的治疗药物主要包括免疫抑制剂、糖皮质激素、细胞毒性化疗药物、等,但这些广谱药物由于缺乏选择性且一般需长期用药,故均具有明显的毒副作用,因此研发一种高效、低毒、适合长期使用的新型免疫抑制剂尤为重要。落新妇苷是广泛存在于多种中药和食物中的一类二氢黄酮醇化合物,具有“药食同源性”,已有大量文献报道落新妇苷在治疗自身免疫性疾病方面具有独特、高效的选择性免疫抑制作用,本文就其在各种自身免疫性疾病中作用机制的研究进展作一综述,为未来进一步开发利用和正式申报新药提供科学依据。

关键词：落新妇苷自身免疫性疾病选择性免疫抑制研究进展

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Coercivity Enhancement of Nd-Fe-B Thin Film Magnets through Dy Surface Diffusion Process

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Journal of Materials Science & Technology 2011年第9期27卷 826-830页

作者： C.Y. You J. Zhu N. Tian Z.X. lu State Key Laboratory for Advanced Metals and Materials University of Science and Technology Beijing Beijing 100083 China School of Materials Science and Engineering Xi＇an University of Technology Xi＇an 710048 China

The Dy capping layer was deposited at different temperatures on the Nd-Fe-B thin films to investigate the mechanism of the coercivity enhancement through the Dy surface diffusion. The highest coercivity of 2005 ka/m （25.2 kOe） was obtained at the Dy deposition temperature of 460℃, which was significantly higher than the value of 1297 ka/m （16.3 kOe） without Dy capping layer. By performing the transmission electron microscopy （TEM） analysis, it was found that some of the grain boundaries were enriched with Nd element, which could be partly ascribed to the promotion by the Dy surface diffusion. In comparison to the evolution of the spin reorientation temperature of Nd2Fe14B phase after the deposition of the Dy capping layer, it is concluded that structural modification plays a significant role in the coercivity enhancement due to the Dy surface diffusion.

关键词： Nd-Fe-B thin film Coercivity enhancement Dy layer Microstructure

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luminescence Chronology and Radiocarbon Reservoir Age Determination of Lacustrine Sediments from the Heihai Lake,NE Qinghai-Tibetan Plateau and Its Paleoclimate Implications

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Journal of Earth Science 2018年第3期29卷 695-706页

作者： Fuyuan An Zhongping Lai Xiangjun Liu Yixuan Wang Qiufang Chang Baoliang lu Xiaoyun Yang Key Laboratory of Comprehensive and Highly Efficient Utilization of Salt Lake Resources Qinghai Institute of Salt Lakes Chinese Academy of SciencesXining 810008China Qinghai Provincial Key Laboratory of Geology and Environment of Salt Lakes Qinghai Institute of Salt LakesChinese Academy of SciencesXining 810008China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Cryosphere Sciences Cold and Arid Regions Environmental and Engineering Research InstituteChinese Academy of SciencesLanzhou 730000China School of Earth Sciences China University of GeoscieneesWuhan 430074China Department of Geology Baylor UniversityWaco 76798USA

The accurately determining the lake ^14C reservoir age has a crucial significance for climatic reconstruction. In this study, the optically stimulated luminescence （OSL） dating method is employed to date samples from highstand lacustrine sediments, palaeoshoreline, fluvial terrace, and the alluvial fan of the Heihai Lake catchment. Accelerator mass spectrometry （AMS） 14C dating was also used to date fossil plants from highstand lacustrine sediments. Based on the calculations of linear regression with OSL against radiocarbon ages for same layers of two sections, the quantitative ^14C reservoir ages were estimated to lie between 3 353 and 3 464 yr during the 1.8 to 2.4 ka, which showed temporal variation. The sources of old carbon are the dissolution of carbonate bedrocks distributed along the Kunlun Mountain. The OSL ages of the different members of the hydatogen sedimentary system at Heihai Lake catchment indicate that a stronger hydrologic condition occurred from 3.0±0.2 to 1.8±0.2 ka, with a maximum lake level of 9 m higher than present. This humid stage was widely recorded in different sediments on the QTP and Chinese Loess Plateau （CLP）, indicating its broad synchronicity across the Asian Summer Monsoon region. The enhanced East Asian Summer Monsoon （EASM） and the Indian Summer Monsoon （ISM） resulted in the increase of moisture availability for the Heihai Lake area during this stage.

关键词： luminescence and radiocarbon dating 14C reservoir age Heihai Lake Qinghai-Tibetan Plateau(QTP) palaeoclimate implications.

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