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Virtual reality based multiple life skill training for intellectual disability:A multicenter randomized controlled trial

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Engineered Regeneration 2022年第2期3卷 121-130页

作者： James chung-Wai Cheung Ming Ni Andy Yiu-Chau Tam Tim Tin-chun Chan Alyssa ka-Yan Cheung Ocean Yu-Hong Tsang Chi-Bun Yip Wing-kai Lam Duo Wai-Chi Wong Department of Biomedical Engineering Faculty of EngineeringThe Hong Kong Polytechnic UniversityHong Kong 999077China Research Institute for Smart Ageing The Hong Kong Polytechnic UniversityHong Kong 999077China Jockey Club Smart Ageing Hub Department of Biomedical EngineeringFaculty of EngineeringThe Hong Kong Polytechnic UniversityHong Kong 999077China Department of Orthopaedics Pudong New Area People’s Hospital Affiliated to Shanghai Jiaotong UniversityShanghai 201299China Social Service Department Yan Chai HospitalHong Kong 999077China C2 Innovations and Research Limited Hong Kong 999077China Department of Kinesiology Shenyang Sport UniversityShenyang 110102China Sports Information and External Affairs Centre Hong Kong Sports InstituteHong Kong 999077China

Life skill-based training is essential for intellectual disabled individuals to regain autonomy and social *** reality(VR)could deliver a nascent application that is more engaging and *** objective of this study was to evaluate the training effects of the VR-based multiple life skill training program on life skill perfor-mance,self-efficacy,memory,cognitive and behavioral functions via a multicenter randomized controlled trial.A total of 145 intellectual disabled participants were recruited for a randomized controlled trial with three in-tervention arms:VR(n=42);traditional(n=53);and control(n=50).The life skill tasks for the interventions included 1)grocery shopping,2)cooking,and 3)kitchen *** measures were performance scores for the three tasks,self-efficacy scale,digit span score,and Frontal Assessment Battery score,graded by blinded ***-after effects of each group were evaluated using separated Wilcoxon Signed-rank *** sig-nificantly improved cooking,cleaning performance,and memory span,while traditional training significantly improved shopping,cooking,and cleaning *** generalized estimating equation evaluated effects between groups adjusted for age,gender and intelligence quotient(IQ).VR had significantly larger improvement effects in cooking and cleaning than the control group and memory span compared to traditional training and controls *** appeared to be a significant confounder on the training *** work may consider developing artificial intelligence to customize programs depending on IQ level.

关键词： Mental retardation Intellectual development X-reality Immersive rehabilitation Metaverse

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Transurethral resection of prostate for acute urinary retention is linked to shorter survival in younger men

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Asian Journal of Andrology 2019年第5期21卷 468-472页

作者： Jeremy Yuen-chun Teoh Chi-Kwok Chan Maggie Haitian Wang Chi-Ho Leung Eddie Shu-Yin Chan Peter ka-Fung Chiu Chi-Hang Yee Hon-Ming Wong Simon See-Ming Hou Chi-Fai Ng S.H.Ho Urology Centre Department of SurgeryPrince of Wales HospitalThe Chinese University of Hong KongHong KongChina Division of Biostatistics JC School of Public Health and Primary CareThe Chinese University of Hong KongHong KongChina Division of Urology Department of SurgeryNorth District HospitalHong KongChina Division of Urology Department of SurgeryAlice Ho Miu Ling Nethersole HospitalHong KongChina

It is largely unknown whether lower urinary tract symptoms(LUTS)or acute retention of urine(AROU)is linked to shorter life expectancy in *** conducted a multicenter,retrospective database analysis of patients undergoing transurethral resection of prostate(TURP)to study their *** Cox regression analysis and kaplan-Meier analysis with stratification to age and indication of TURP were *** further performed an age-and sex-matched survival analysis with the general population using data from the Census and Statistics Department of the Hong Kong Special Administrative Region(Hong Kong,China).From January 2002 to December 2012,3496 patients undergoing TURP were included in our study,with 1764 patients in the LUTS group and 1732 patients in the AROU *** age,ischemic heart disease,cerebrovascular accident,and AROU were risk factors of *** aged80 *** to the general population,younger patients in the LUTS group appeared to have better survival(80 years,survival was similar with the general population in both the LUTS and AROU *** conclusion,AROU at young age was associated with mortality,while early detection and management of LUTS may improve survival.

关键词： acute retention of urine lower urinary tract symptoms mortality transurethral resection of prostate

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Changes of marine productivity and sedimentary environment recorded by biogenic components in the Antarctica Ross Sea since the last deglaciation

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Journal of Oceanology and Limnology 2020年第6期38卷 1746-1754页

作者： XIU chun DU Ming ZHANG Xu HUO Suxia North China Sea Environmental Monitoring Center of Ministry of Natural Resources Qingdao 266033China East Sea Marine Environmental Investigating and Surveying Center of Ministry of Natural Resources Shanghai 200137China

Changes in the marine productivity and sedimentary environment since the last deglaciation in the Ross Sea are presented in this *** has replaced calcium carbonate as the major biogenic component and has a significantly positive correlation with total organic carbon(TOC),which indicates that siliceous phytoplankton controlled the absorption and release of carbon by the biological pump and was the main producer of marine organic *** the AMS 14C age framework,foraminiferal fossils and redox sensitive elements(RSEs),we found that both the sedimentary environment and marine productivity changed clearly in^11 cal ka BP,which is more likely related with the melting and retreat of the Ross Ice *** addition,the increase of marine productivity promoted the sinking of more organic-matter to the seabed.A large proportion of oxygen in the bottom water body was consumed and more carbon dioxide was produced during the decomposition of organic matter,making the bottom water body more soluble to calcium carbonate.

关键词： biogenic components marine productivity redox environment ice shelf retreat the Ross Sea

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Inflammatory reaction versus endogenous peroxisome proliferator- activated receptors expression, re-exploring secondary organ complications of spontaneously hypertensive rats

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Chinese Medical Journal 2008年第22期121卷 2305-2311页

作者： SUN Li KE Yan ZHU chun-yun TANG Ning TIAN Deng-ke GAO Yue-hong ZHENG Jian-pu BIAN ka Murad Research Institute for Modernized Chinese Medicine Shanghai University of Traditional Chinese Medicine Shanghai 201203 China Tianjin Medical University General Hospital Tianjin 300052 China Division of Nitric Oxide and Inflammatory Medicine E-Institute of Shanghai Universities Shanghai 201203 China Department of Integrative Biology and Pharmacology Institute of Molecular Medicine University of Texas Medical School 6431 Fannin Houston TX 77030 USA

Background The chronic pathological changes in vascular walls of hypertension may exert destructive effects on multiple organ systems. Accumulating evidence indicates that inflammatory reactions are involved in the pathological changes of hypertension. Three peroxisome proliferator-activated receptors （PPARs） have been identified： PPARa, PPARβ/δ, and PPARγ, all of which have multiple biological effects, especially the inhibition of inflammation. The aim of this study was to evaluate PPAR isoforms expression profile in important organs of spontaneously hypertensive rats （SHR） and to understand the modulation of endogenous PPAR isoforms under inflammatory condition. Methods l]ssues （kidney, liver, heart, and brain） were dissected from SHR and age-matched control Wistar-Kyoto rats （WKY） to investigate the abundance of PPAR isoforms and PPAR-responsive genes （acyI-CoA oxidase and CD36）. The expression of CCAAT/enhancer-binding protein 6 （C/EBP6）, which can trans-activate PPARγ expression, was also observed. The inflammatory response was analyzed by the expression of inflammatory mediators inducible nitric oxide synthase （iNOS）, intercellular adhesion molecule-1 （ICAM-1）, vascular cell adhesion molecule-1 （VCAM-1）, E-selectin, interleukin-1 beta （IL-1β）, and tumor necrosis factor alpha （TNFα）, and formation of carbonyl and nitrated proteins. Results The expressions of 3 PPAR isoforms and PPAR-responsive genes were markedly upregulated in SHR compared with those of WKY. Specifically, the expression of PPARa protein in the kidney, liver, heart and brain increased by 130.76 %, 91.48%, 306.24%, and 90.70%; PPARβ/δ upregulated by 109.34%, 161.98%, 137.04%, and 131.66%; PPARγ increased by 393.76%, 193.17%, 559.29%, and 591.18%. In consistent with the changes in PPARy, the expression of C/EBPδ was also dramatically elevated in SHR. Inflammatory mediators expressions were significantly increased in the most organs of SHR than WKY. As a consequence, increased formation of carbony

关键词： spontaneously hypertensive rats inflammation peroxisome proliferator-activated receptors

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车载三维数据采集系统的绝对标定及精度分析

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武汉大学学报（信息科学版） 2008年第1期33卷 55-59页

作者：张卡盛业华叶春梁诚南京师范大学虚拟地理环境教育部重点实验室南京市文苑路1号210046

针对GPS/INS/CCD相机集成的车载三维数据采集系统,给出了系统精确的直接定位方程,并将罗德里格矩阵用到系统的绝对标定中,推导了定位方程中所需的相机坐标系和惯导载体坐标系之间的平移与旋转参数的求解公式。然后,根据误差传播定律,推... 详细信息

针对GPS/INS/CCD相机集成的车载三维数据采集系统,给出了系统精确的直接定位方程,并将罗德里格矩阵用到系统的绝对标定中,推导了定位方程中所需的相机坐标系和惯导载体坐标系之间的平移与旋转参数的求解公式。然后,根据误差传播定律,推导了X、Y、Z三个方向上的坐标误差公式及点位误差公式。实验结果表明,本标定方法意义明确,计算过程简单,具有较高的标定精度,对实际应用具有重要的价值。

关键词： GPS 惯性导航系统车载三维数据采集系统绝对标定罗德里格矩阵精度分析

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Targeted prebiotics alter the obese gut microbiome in humans

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Signal Transduction and Targeted Therapy 2021年第11期6卷 3163-3164页

作者： Junjun She Chi chun Wong Jun Yu Department of General Surgery The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxiChina Center for Gut Microbiome Research Med-X InstituteThe First Affiliated Hospital of Xi’an Jiao tong UniversityXi’anShaanxiChina Institute of Digestive Disease and Department of Medicine and Therapeutics State Key Laboratory of Digestive DiseaseLi Ka Shing Institute of Health SciencesThe Chinese University of Hong KongHong Kong SARChina

A recent study published in Nature by Delannoy-Bruno et al.1 described the role of formulated fibre snacks on the obese gut microbiome utilizing mouse-human co-clinical trial,and demonstrated that precise dietary fibre intervention directed at the obese gut microbiome modulates the host’s physiological *** and observational studies2 have long linked a diet rich in fibre to protection against chronic *** fibre functions as a prebiotic that can be utilized by gut *** accumulating evidence showing roles of gut microbes in health and disease,there is renewed interest in harnessing fibre as a prebiotic to promote a healthy gut *** fibres are safe,inexpensive,and readily incorporated into our ***,the development of evidenced-based fibre preparations that selectively induce the abundance of desirable gut microbes pose a huge challenge,as fibre and the gut microbiome are complex identities that remain poorly *** is confounded by their dynamic interactions and inter-and intra-personal variations.

关键词： Bruno fibre utilizing

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The paradox of immunotherapy in NASH-HCC

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Signal Transduction and Targeted Therapy 2021年第7期6卷 1942-1943页

作者： Yao Peng Chi chun Wong Jun Yu Department of Gastroenterology Guangzhou First Peopled HospitalSouth China University of TechnologyGuangzhouChina Institute of Digestive Disease and Department of Medicine and Therapeutics State Key Laboratory of Digestive DiseaseLi Ka Shing Institute of Health SciencesCUHK-Shenzhen research InstituteThe Chinese University of Hong KongHong KongChina

A recent study published in Nature by Dominik Pfister et al.1 unveiled a darker side of immune checkpoint blockade(ICB)immunotherapy in the context of nonalcoholic steatohepatitis-associated hepatocellular carcinoma(N... 详细信息

关键词： PD1 immunotherapy

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Anterior perineal hernia after anterior exenteration

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Asian Journal of Urology 2017年第4期4卷 253-255页

作者： ka Wing Wong Terence chun-ting Lai Ada Tsui-lin Ng Brian Sze-ho Ho James Hok-leung Tsu Chiu Fung Tsang W.K.Ma Ming Kwong Yiu Division of Urology Department of SurgeryQueen Mary HospitalUniversity of Hong KongHong KongChina

Perineal hernia is a rare complication of anterior *** reported this complication after an anterior exenteration for bladder cancer with bleeding complication requiring packing and second-look *** approach is a simple... 详细信息

关键词： Perineal hernia Anterior exenteration Bladder cancer Mesh repair

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Metacognitive Knowledge of Tertiar yLevel EFL Reading: Case Studies in an Acquisition-Poor Context

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Chinese Journal of Applied Linguistics 2015年第2期38卷 166-187,246页

作者：李洁 Cecilia ka Wai chun 中南财经政法大学外国语学院香港中文大学教育学院

This paper describes how a group of Chinese tertiary-level EFL readers utilized metacognitive knowledge in their academic reading process by contrasting the possible metacognitive differences between two less successful and two successful Chinese EFL readers. Data were collected through think-alouds, interviews and observations. It was found that although vocabulary posed difficulties for both successful and less successful readers, the deployment of strategic knowledge of tackling the unknown words made a difference between successful and less successful readers. The participants＇ person knowledge about motivation such as reader interest, goal of reading and reader role could exert influences on their reading. Implications of the findings for tertiary EFL reading pedagogy in China are discussed.

关键词： metacognitive knowledge tertiary EFL reading think-alouds interview case study

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断裂带方解石脉ESR定年研究及其对龙蟠-乔后断裂剑川段活动性的指示

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地震地质 2024年第1期46卷 81-100页

作者：姬昊刘春茹魏传义杨会丽尹功明常祖峰中国地震局地质研究所地震动力学国家重点实验室北京100029 云南省地震局昆明650216

龙蟠-乔后断裂带作为川滇菱形块体的一条大型边界断裂,构造运动强烈,地震活动频繁,发生多次5级以上地震,造成了重大的财产损失和人员伤亡,因此十分有必要加强对该断裂带的活动性研究,并评估其地震危险性。龙蟠-乔后断裂剑川段河南村断... 详细信息

龙蟠-乔后断裂带作为川滇菱形块体的一条大型边界断裂,构造运动强烈,地震活动频繁,发生多次5级以上地震,造成了重大的财产损失和人员伤亡,因此十分有必要加强对该断裂带的活动性研究,并评估其地震危险性。龙蟠-乔后断裂剑川段河南村断层剖面发育厚层方解石脉,为断层定年提供了十分宝贵的材料。文中利用ESR法对该剖面的方解石脉开展了测年研究,得到4件方解石脉样品(HNC-ESR01、HNC-ESR02、HNC-ESR03、HNC-ESR04)的年龄分别为(7.1±0.8)ka、(7.1±0.9)ka、(7.3±1.7)ka、(6.9±1.5)ka,年龄数据集中,平均年龄为(7.1±1.3)ka,指示该断层在不晚于距今(7.1±1.3)ka的时间段内发生过活动。年龄结果与该地区探槽工作揭示的古地震事件发生时间((6130±30)~(6320±40)a BP)在误差范围内吻合,表明断裂带方解石脉ESR定年是活动断裂和古地震研究的一种有效的年代学方法。但需要注意的是,ESR年龄仍存在误差较大的问题,在后续工作中需要进一步完善。另外,文中采用了5种拟合函数(LIN、SSE、DSE、EXP+LIN、D_(gamma))计算方解石脉样品的等效剂量值,结果表明,SSE函数提供了最佳的拟合效果。

关键词：川滇菱形块体龙蟠-乔后断裂方解石脉 ESR定年古地震

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