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A prospective cohort of men with localized prostate cancer on active surveillance protocol in Hong Kong,China:what did we learn?

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Asian Journal of Andrology 2024年第3期26卷 245-249页

作者： Xiaobo Wu Ivan Ching-Ho Ko Cindy Yeuk-lam Hong Samuel Chi-Hang Yee Jeremy Yuen-Chun Teoh Samson Yun-Sang Chan Ho-Man Tam Chi-Kwok Chan Chi-Fai Ng Peter ka-Fung Chiu SH Ho Urology Centre Department of SurgeryFaculty of MedicineThe Chinese University of Hong KongHong KongChina

This study aimed to report the outcomes of active surveillance(AS)in the management of low-risk prostate cancer(PCa).It recruited87 men who were prospectively followed up according to the Prostate Cancer Research International Active Surveillance(PRIAS)protocol with local adaptation at SH Ho Urology Centre,Prince of Wales Hospital,Hong Kong,*** investigated the predictorsof disease progression and found that baseline prostate-specific antigen density(PSAD)and the presence of the highest ProstateImaging-Reporting and Data System(PI-RADS)score 5 lesion on magnetic resonance imaging(MRI)are significantly correlatedwith disease ***,men with PSAD>0.2 ng ml^(−2)or PI-RADS 4 or 5 lesions had significantly worse upgradingfree survival compared to those with PSAD≤0.2 ng ml−2 and PI-RADS 2 or 3 *** study concludes that AS is a safe andeffective management strategy for selected patients to defer radical treatment and that most disease progression can be detectedafter the first repeated *** combination of PSAD>0.2 ng ml^(−2)and PI-RADS 4 or 5 lesions may serve as a useful predictorof early disease progression and provide a guide to optimize follow-up protocols for men in different risk groups.

关键词： active surveillance cohort localized prostate cancer

Comparing 11 early warning scores and three shock indices in early sepsis prediction in the emergency department

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World Journal of Emergency Medicine 2024年第4期15卷 273-282页

作者： Rex Pui Kin lam Zonglin Dai Eric Ho Yin Lau Carrie Yuen Ting Ip Ho Ching Chan Lingyun Zhao Tat ChiTsang Matthew Sik Hon Tsui Timothy Hudson Rainer Department of Emergency Medicine School of Clinical MedicineLi Ka Shing Faculty of Medicinethe University of Hong KongHong KongChina School of Public Health Li Ka Shing Faculty of Medicinethe University of Hong KongHong KongChina Accident and Emergency Department Queen Mary HospitalHong KongChina

BACKGROUND:This study aimed to evaluate the discriminatory performance of 11 vital sign-based early warning scores(EWSs)and three shock indices in early sepsis prediction in the emergency department(ED).METHODS:We performed a retrospective study on consecutive adult patients with an infection over 3 months in a public ED in Hong *** primary outcome was sepsis(Sepsis-3 definition)within 48 h of ED *** c-statistics and the DeLong test,we compared 11 EWSs,including the National Early Warning Score 2(NEWS2),Modified Early Warning Score,and Worthing Physiological Scoring System(WPS),etc.,and three shock indices(the shock index[SI],modified shock index[MSI],and diastolic shock index[DSI]),with Systemic Inflammatory Response Syndrome(SIRS)and quick Sequential Organ Failure Assessment(qSOFA)in predicting the primary outcome,intensive care unit admission,and mortality at different time ***:We analyzed 601 patients,of whom 166(27.6%)developed ***2 had the highest point estimate(area under the receiver operating characteristic curve[AUROC]0.75,95%CI 0.70-0.79)and was significantly better than SIRS,qSOFA,other EWSs and shock indices,except WPS,at predicting the primary ***,the pooled sensitivity and specificity of NEWS2≥5 for the prediction of sepsis were 0.45(95%CI 0.37-0.52)and 0.88(95%CI 0.85-0.91),*** discriminatory performance of all EWSs and shock indices declined when used to predict mortality at a more remote time ***:NEWS2 compared favorably with other EWSs and shock indices in early sepsis prediction but its low sensitivity at the usual cut-off point requires further modification for sepsis screening.

关键词： Sepsis Emergency department Clinical prediction rule Early warning score Shock index

Toward Carbon-Neutral Water Systems:Insights from Global Cities

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Engineering 2022年第7期8卷 77-85页

作者： ka Leung lam Gang Liu Anne Marieke Motelica-Wagenaar Jan Peter van der Hoek Division of Natural and Applied Sciences Duke Kunshan UniversityKunshan 215316China Research Center for Eco-Environmental Sciences Chinese Academy of SciencesBeijing 100085China Waternet Amsterdam 1096 ACNetherlands Department of Water Management Delft University of TechnologyDelft 2628 CNNetherlands

Many cities have pledged to achieve carbon *** urban water industry can also contribute its share to a carbon-neutral *** a multi-city time-series analysis approach,this study aims to assess the progress and lessons learned from the greenhouse gas(GHG)emissions management of urban water systems in four global cities:Amsterdam,Melbourne,New York City,and *** cities are advanced in setting GHG emissions reduction targets and reporting GHG emissions in their water *** four cities have reduced the GHG emissions in their water industries,compared with those from more than a decade ago(i.e.,the latest three-year moving averages are 13%–32%lower),although the emissions have“rebounded”multiple times over the *** emissions reductions were mainly due to various engineering opportunities such as solar and mini-hydro power generation,biogas valorization,sludge digestion and incineration optimization,and aeration system *** cities have recognized the many challenges in reaching carbon-neutrality goals,which include fluctuating water demand and rainfall,more carbon-intensive flood-prevention and water-supply strategies,meeting new air and water quality standards,and revising GHG emissions accounting *** study has also shown that it is difficult for the water industry to achieve carbon neutrality on its own.A collaborative approach with other sectors is needed when aiming toward the city’s carbon-neutrality *** an approach involves expanding the usual system boundary of the water industry to externally tap into both engineering and non-engineering opportunities.

关键词： Urban water Greenhouse gas emissions Cities Climate change mitigation Carbon neutrality

The development of roadside green swales in the Chinese Sponge City Program:Challenges and opportunities

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Frontiers of Engineering Management 2023年第4期10卷 566-581页

作者： Lingwen Lu Faith ka shun Chan Matthew Johnson Fangfang Zhu Yaoyang Xu Key Laboratory of Urban Environment and Health Ningbo Observation and Research StationInstitute of Urban EnvironmentChinese Academy of Sciences(CAS)Xiamen361021China School of Geographical Sciences Faculty of Science and EngineeringUniversity of Nottingham Ningbo ChinaNingbo315100China CAS Haixi Industrial Technology Innovation Center in Beilun Zhejiang Key Laboratory of Urban Environmental Processes and Pollution ControlNingbo315830China Water@Leeds Research Institute University of LeedsLeeds LS29JTUK School of Geography University of NottinghamNottinghamshireNG72RDUK Department of Civil Engineering Faculty of Science and EngineeringUniversity of Nottingham Ningbo ChinaNingbo 315100China Zhejiang Key Laboratory of Urban Environmental Processes and Pollution Control CAS Haixi Industrial Technology Innovation Center in BeilunNingbo 315830China

Roadside green swales have emerged as popular stormwater management infrastructure in urban areas,serving to mitigate stormwater pollution and reduce urban surface water ***,there is a limited understanding of the various types,structures,and functions of swales,as well as the potential challenges they may face in the *** recent years,China has witnessed a surge in the adoption of roadside green swales,especially as part of the prestigious Sponge City Program(SCP).These green swales play a crucial role in controlling stormwater pollution and conserving urban water resources by effectively removing runoff pollutants,including suspended solids,nitrogen,and *** review critically examines recent research findings,identifies key knowledge gaps,and presents future recommendations for designing green swales for effective stormwater management,with a particular emphasis on ongoing major Chinese infrastructure *** the growing global interest in bioswales and their significance in urban development,China's current classification of such features lacks a clear definition or specific consideration of ***,policymakers have often underestimated the adverse environmental effects of road networks,as reflected in existing laws and planning *** review argues that the construction and maintenance of roadside green swales should be primarily based on three critical factors:Wellthought-out road planning,suitable construction conditions,and sustainable long-term *** integration of quantitative environmental standards into road planning is essential to effectively address the challenge of pollution from rainfall *** combat pollution associated with roads,a comprehensive assessment of potential pollution loadings should be carried out,guiding the appropriate design and construction of green swales,with a particular focus on addressing the phenomenon of first *** of the major challenges faced in su

关键词： grass swale infiltration swale bioswale wet swale spongecity

Carvedilol Versus Other Nonselective Beta Blockers for Variceal Bleeding Prophylaxis and Death: A Network Meta-analysis

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Journal of Clinical and Translational Hepatology 2023年第5期11卷 1143-1149页

作者： ka-Shing Cheung Chiu-Hang Mok Lok-ka lam Xian-Hua Mao Lung-Yi Mak Wai-kay Seto Man-Fung Yuen Department of Medicine School of Clinical MedicineThe University of Hong KongQueen Mary HospitalHong KongChina Department of Medicine The University of Hong Kong-Shenzhen HospitalShenzhenGuangdongChina School of Clinical Medicine The University of Hong KongHong KongChina State Key Laboratory of Liver Research The University of Hong KongHong KongChina

Background and Aims:We aimed to perform a network meta-analysis(NWM)to examine comparative effectiveness of non-selective beta blockers(NSBBs)on prophylaxis of gastroesophageal variceal bleeding(GVB)and mortality ***:MEDLINE(OVID)and EMBASE databases were searched for eligible randomized clinical trials(RCTs)from inception to July 3,*** of interest included primary/secondary prophylaxis of GVB,failure to achieve hepatic venous pressure gradient(HVPG)decremental response,liver-related and all-cause mortality.A Bayesian NWM was performed to derive relative risk(RR)with 95%credible intervals(CrIs).The ranking probability of each NSBB was assessed by surface under cumulative ranking curve(SUCRA).Results:Thirty-three RCTs including 3,188 cirrhosis patients with gastroesophageal varices were *** with placebo,nadolol ranked first for reducing variceal bleeding[RR:0.25,(95%CrI:0.11–0.51);SUCRA:0.898],followed by carvedilol[RR:0.33,(95%CrI:0.11–0.88);SUCRA:0.692]and propranolol[RR:0.52,(95%CrI:0.37–0.75);SUCRA:0.405].Carvedilol was more effective than propranolol in achieving HVPG decremental response[RR:0.43,(95%CrI:0.26–0.69)].Carvedilol ranked first for reducing all-cause mortality[RR:0.32,(95%CrI:0.17–0.57);SUCRA:0.963],followed by nadolol[RR:0.48,(95%CI:0.29–0.77);SUCRA:0.688],and propranolol[RR:0.77,(95%CI:0.58–1.02);SUCRA:0.337].Similar findings were observed for liver-related *** ranked the *** RR of adverse events was 4.38,(95%CrI:0.33–161.4);SUCRA:0.530,followed by propranolol[RR:7.54,(95%CrI:1.90–47.89);SUCRA:0.360],and nadolol[RR:18.24,(95%CrI:91.51–390.90);SUCRA:0.158].Conclusions:Carvedilol is the preferred NSBB with better survival benefit and lower occurrence of adverse events among patients with gastroesophageal varices.

关键词： NSBB Carvedilol Nadolol Propranolol Varices Cirrhosis CPSH

Percutaneous closure of gastrorenal shunt as adjunctive therapy for esophageal carcinoma

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Journal of Interventional Medicine 2023年第1期6卷 46-48页

作者： Yanlin Li Simon Ying-Kit Law ka-On lam Anthony Wing-Ip Lo Department of Diagnostic Radiology School of Clinical MedicineThe University of Hong KongHong KongChina Department of Surgery School of Clinical MedicineThe University of Hong KongHong KongChina Department of Clinical Oncology School of Clinical MedicineThe University of Hong KongHong KongChina Department of Pathology School of Clinical MedicineThe University of Hong KongHong KongChina

The embolization of gastric varices is an established technique for acute bleeding in patients with portal hypertension. Here, we report an attempt to embolize a gastrorenal shunt to facilitate esophagectomy in a patient with an esophageal malignancy. To our knowledge, this is the first case in the literature to highlight the role of interventional medicine in the treatment of patients with esophageal malignancy.

关键词： Intervention Radiology Oesophageal cancer Gastrointestinal surgery Oncology

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基于肠道菌群多模态信息融合的疾病检测方法

青岛大学学报（自然科学版） 2024年第2期37卷 47-54页

作者：刘畅吴舜尧青岛大学计算机科学技术学院青岛266071

利用可操作分类单元(Operational Taxonomical Units, OTU)或扩增子序列变体(Amplicon Sequence Variants, ASV)推断下游信息时,现有扩增子测序数据分析可能丢失不同物种谱构建法的多模态信息,为此,详细分析了4种疾病的OTU和ASV数据集... 详细信息

利用可操作分类单元(Operational Taxonomical Units, OTU)或扩增子序列变体(Amplicon Sequence Variants, ASV)推断下游信息时,现有扩增子测序数据分析可能丢失不同物种谱构建法的多模态信息,为此,详细分析了4种疾病的OTU和ASV数据集在肠道群落多样性和群落结构方面的差异,提出了一种有效整合OTU与ASV用于疾病表征预测的方法:MDDMI(Microbiome-based Disease Detection with Multimodal Information)。实验结果表明,MDDMI优于单模态数据分析法。

关键词：图卷积神经网络疾病预测多模态肠道菌群

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甘蓝型油菜转录因子SRS基因家族的全基因组鉴定及表达分析

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中国油料作物学报 2024年第4期46卷 795-807页

作者：王龙张永顺王红艳肖麓青海大学农林科学院青海省春油菜遗传改良重点实验室国家油菜改良中心青海分中心农业农村部春油菜科学观测实验站青海省春油菜工程技术研究中心青海西宁810016 辽宁大学生命科学院植物表观遗传与进化实验室辽宁沈阳110036

SRS(shi-related sequence)是植物特异的转录因子家族,在植物生长发育、激素信号转导和应对胁迫响应过程中发挥着重要的作用。为了研究SRS基因家族在甘蓝型油菜(Brassica napus L.)中潜在的生物学功能以及该基因家族在甘蓝型油菜形成过... 详细信息

SRS(shi-related sequence)是植物特异的转录因子家族,在植物生长发育、激素信号转导和应对胁迫响应过程中发挥着重要的作用。为了研究SRS基因家族在甘蓝型油菜(Brassica napus L.)中潜在的生物学功能以及该基因家族在甘蓝型油菜形成过程中的进化,利用比较基因组学的方法,在甘蓝型油菜及二倍体祖先种白菜(*** L.)和甘蓝(*** L.)中分别鉴定到38、16和20个SRS基因,并对其理化性质、系统发育关系、基因结构、基因共线性、顺式作用元件和表达模式进行分析。结果表明,所有鉴定的SRS蛋白被分为9个分支,且甘蓝型油菜SRS基因家族的进化过程中发生了内含子/外显子的丢失事件。ka/Ks分析发现,SRS基因在重复事件后经历了纯化选择。在多数的SRS基因启动子中发现了分别与光响应、厌氧诱导和脱落酸响应相关的顺式作用元件,且甘蓝型油菜SRS基因启动子比二倍体祖先启动子含有更多的胚乳基因表达和光响应顺式作用元件。转录组分析发现,甘蓝型油菜SRS基因在不同处理下以不同的表达模式响应并表现出根部的优势表达。综上,本研究为了解甘蓝型油菜SRS基因家族功能和作用提供初步的理论依据,为甘蓝型油菜及其二倍体祖先之间基因进化的分子机制提供参考。

关键词： SRS 基因家族进化转录组甘蓝型油菜

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基于图数据增强的疾病与基因关联挖掘

青岛大学学报（自然科学版） 2024年第1期37卷 20-26页

作者：贾祥虎吴舜尧青岛大学计算机科学技术学院青岛266071

针对现有关联数据不完整和利用多源组学数据不充分等问题,设计基于三跳局部拓扑相似性的计算指标,识别具有生物学意义但尚未映射的蛋白质相互作用(Protein-Protein Interactions,PPI),提出了一种基于图数据增强的新型图神经网络方法(GDa... 详细信息

针对现有关联数据不完整和利用多源组学数据不充分等问题,设计基于三跳局部拓扑相似性的计算指标,识别具有生物学意义但尚未映射的蛋白质相互作用(Protein-Protein Interactions,PPI),提出了一种基于图数据增强的新型图神经网络方法(GDaEPred)用于疾病与基因关联挖掘。实验结果表明,GDaEPred的平均精确率提升了4.1%,精确率、召回率和F1score也均有提升。

关键词：图神经网络图数据增强致病基因预测