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Combining acellular nerve allografts with brainderived neurotrophic factor transfected bone marrow mesenchymal stem cells restores sciatic nerve injury better than either intervention alone

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Neural Regeneration Research 2014年第20期9卷 1814-1819页

作者： Yanru Zhang Hui Zhang Gechen Zhang ka ka Wenhua Huang School of International Education Zhengzhou University Institute of Clinical Anatomy Southern Medical University Department of Orthopedic Surgery First Affiliated Hospital of Zhengzhou University

In this study, we chemically extracted acellular nerve allografts from bilateral sciatic nerves, and repaired 10-mm sciatic nerve defects in rats using these grafts and brain-derived neurotrophic factor transfected bone marrow mesenchymal stem cells. Experiments were performed in three groups： the acellular nerve allograft bridging group, acellular nerve allograft ＋ bone marrow mesenchymal stem cells group, and the acellular nerve allograft ＋ brain-derived neurotrophic factor transfected bone marrow mesenchyrnal stem cells group. Results showed that at 8 weeks after bridging, sciatic functional index, triceps wet weight recovery rate, myelin thickness, and number of myelinated nerve fibers were significantly changed in the three groups. Variations were the largest in the acellular nerve allograft ＋ brain-derived neurotrophic factor transfected bone marrow mesenchymal stem cells group compared with the other two groups. Experimental findings suggest that chemically extracted acellular nerve allograft combined nerve factor and mesenchymal stem cells can promote the restoration of sciatic nerve defects. The repair effect seen is better than the single application of acellular nerve allograft or acellular nerve allograft combined mesenchymal stem cell transplantation.

关键词： nerve regeneration peripheral nerve regeneration peripheral nerve injury chemicallyextracted acellular nerve brain-derived neurotrophic factor bone marrow mesenchymal stem cells nerve tissue engineering neural regeneration

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Repair of peripheral nerve defects with chemically extracted acellular nerve allografts loaded with neurotrophic factors-transfected bone marrow mesenchymal stem cells

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Neural Regeneration Research 2015年第9期10卷 1498-1506页

作者： Yan-ru Zhang ka ka Ge-chen Zhang Hui Zhang Yan Shang Guo-qiang Zhao Wen-hua Huang Medical College Henan Polytechnic University Institute of Clinical Anatomy Southern Medical University Department of Orthopedics First Affiliated Hospital of Zhengzhou University Department of Laboratory Medicine Children’s Hospital of Zhengzhou School of Basic Medical Sciences Zhengzhou University

Chemically extracted acellular nerve allografts loaded with brain-derived neurotrophic fac- tor-transfected or ciliary neurotrophic factor-transfected bone marrow mesenchymal stem cells have been shown to repair sciatic nerve injury better than chemically extracted acellular nerve allografts alone, or chemically extracted acellular nerve allografts loaded with bone marrow mesenchymal stem cells. We hypothesized that these allografts compounded with both brain-derived neurotrophic factor- and ciliary neurotrophic factor-transfected bone marrow mesenchymal stem cells may demonstrate even better effects in the repair of peripheral nerve injury. We cultured bone marrow mesenchymal stem cells expressing brain-derived neuro- trophic factor and/or ciliary neurotrophic factor and used them to treat sciatic nerve injury in rats. We observed an increase in sciatic functional index, triceps wet weight recovery rate, myelin thickness, number of myelinated nerve fibers, amplitude of motor-evoked potentials and nerve conduction velocity, and a shortened latency of motor-evoked potentials when al- lografts loaded with both neurotrophic factors were used, compared with allografts loaded with just one factor. Thus, the combination of both brain-derived neurotrophic factor and cili- ary neurotrophic factor-transfected bone marrow mesenchymal stem cells can greatly improve nerve injury.

关键词： nerve regeneration peripheral nerve injury brain-derived neurotrophic factor ciliaryneurotrophic factor chemically extracted acellular nerve allografis bone marrow mesenchymal stemcells peripheral nerve neural regeneration

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Assessing impact of land use and climate change on regulating ecosystem services in the Czech Republic

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Ecosystem Health and Sustainability 2016年第3期2卷 1-13页

作者： Eliška Krkoška Lorencová Zuzana V.Harmáčková Lucie Landová Adam Pártl David Vačkář Global Change Research Institute The Czech Academy of SciencesBělidla 986/4a60300BrnoCzech Republic Faculty of Humanities Charles University in PragueU Kříže 815000Prague 5-JinoniceCzech Republic Environment Center Charles University in PragueJ.Martího 2/40716200Prague 6Czech Republic

Ecosystem services,defined as benefits provided by ecosystem functioning to society,are essential to human *** to global environmental change and related anthropogenic drivers,ecosystems are often degraded,which hinders the delivery of ecosystem *** study aims to quantify the impacts of land use and climate change on two regulating ecosystem services-carbon sequestration and water purification in terms of nitrogen retention in the Czech *** employing approaches of scenarios and modeling,we illustrate current and potential future status of these ecosystem *** results show that among the ecosystem change drivers,one of the dominant domestic land-use change of ALARM BAMBU(Business-As Might Be Usual)scenario is change of arable land and grassland to forest area that increases by 4.5%in 2080 compared to *** results of ecosystem service modeling based on BAMBU scenario for the years 2050 and 2080 indicate that the highest yearly carbon sequestration rate occurred in 2000-2050,reaching 640 GgC·yr^(−1),2000-2080 shows decline in this regulating service by 16%.Average nitro-gen leaching to water streams reached 0.75 kgN·ha^(−1)·yr^(−1)for BAMBU in 2050 scenario and 0.80 kgN·ha^(−1)·yr^(−1)for BAMBU in 2080 scenario as a result of decreasing nitrogen load,which suggested a decrease in nitrogen pollution compared to *** ecosystem services have not been extensively mainstreamed into research and policies in eastern European countries,we aim to contribute to improvement of knowledge on current status and potential future pathways of the provision of regulating ecosystem services in the Czech Republic.

关键词： Czech Republic drivers ecosystem services InVEST modeling scenarios Special Feature:Ecosystem Management in Transition in Central and Eastern Europe

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工人阶级状况、资本主义制度与社会主义运动——恩格斯健康观探赜

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毛泽东邓小平理论研究 2021年第3期 78-84,108页

作者：郭咔咔河南大学马克思主义学院

在当前中国和世界进行抗疫斗争的实践中,恩格斯健康观无疑对审视资本主义造成的健康问题和指导健康中国建设具有重要意义。恩格斯健康观主要包括三个层面:一是以工人阶级生存状况为核心的主体向度;二是以批判资本主义制度为核心的客体向... 详细信息

在当前中国和世界进行抗疫斗争的实践中,恩格斯健康观无疑对审视资本主义造成的健康问题和指导健康中国建设具有重要意义。恩格斯健康观主要包括三个层面:一是以工人阶级生存状况为核心的主体向度;二是以批判资本主义制度为核心的客体向度;三是以社会主义运动为核心的对资本主义的超越向度。资本主义社会制度必然造成人的体力智力低下从而导致"所有的人退化"的结果,无法真正解决健康问题。因此,需要在批判资本主义的过程中使工人阶级走向"政治健康",工人阶级政党的"健康"发展是超越资本主义社会的关键,社会主义社会必然是真正健康的社会。

关键词：工人阶级资本主义制度社会主义健康观

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De novo synthesis of atropisomeric benzofurans via Cu/SPDO complex catalyzed asymmetric formal [3 + 2] annulation

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Science China Chemistry 2025年第1期68卷 174-180页

作者： Fan-Xiao Meng Xing-Yu Wang ka Lu Ju-Song Yang Fu-Min Zhang Ai-Jun Ma Bao Du Yong-Qiang Tu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University School of Chemistry and Chemical Engineering Shanghai Jiao Tong University School of Biotechnology and Health Sciences Wuyi University

Herein, the de novo synthesis of atropisomeric benzofurans through the Cu/spirocyclic-pyrrolidine-oxazoline(SPDO) complex catalyze asymmetric formal [3 + 2] cycloaddition between quinones and ynamides is explored, producing a range of structurally diverse axially chiral benzofurans in satisfactory yields with good to excellent enantioselectivities. Furthermore, density functional theory calculations were applied to explain the possible reaction mechanism.

关键词： benzofuran atropisomers novel de novo synthetic strategy asymmetric formal [3 + 2] cycladdition Cu/SPDO complex DFT calculations

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阿尔都塞对马克思的政治哲学式解读——以《保卫马克思》为例

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西南科技大学学报（哲学社会科学版） 2014年第3期31卷 82-86,108页

作者：郭咔咔中国政法大学马克思主义学院北京100088

阿尔都塞在《保卫马克思》中以对马克思著作的源泉论解读批判为出发点,独树一帜地确立了其结构主义的马克思哲学解读方法和原则,其目的就是为了凸显马克思思想中的总问题及其变化,"认识论断裂"表明了马克思思想中的意识形态阶段和科学... 详细信息

阿尔都塞在《保卫马克思》中以对马克思著作的源泉论解读批判为出发点,独树一帜地确立了其结构主义的马克思哲学解读方法和原则,其目的就是为了凸显马克思思想中的总问题及其变化,"认识论断裂"表明了马克思思想中的意识形态阶段和科学阶段的转换,阿尔都塞对马克思思想和著作的如此解读,目的在于保证成熟时期的马克思思想的科学性和纯正性,从而将其与意识形态划分界限,进而在实践中回应社会主义人道主义问题;"保卫马克思的哲学"同时具有了保卫马克思的事业的内涵,使得阿尔都塞的这种解读具有理论和实践的双重向度。

关键词：保卫马克思源泉论意识形态人道主义

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西方马克思主义意识形态论的四维向度

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井冈山大学学报（社会科学版） 2019年第1期40卷 92-97页

作者：郭咔咔河南大学马克思主义学院河南开封475001

西方马克思主义意识形态论的发展逻辑可以通过四维向度来把握,即意识形态的政治学维度(早期西方马克思主义)、意识形态的社会学维度(法兰克福学派和结构主义马克思主义)、意识形态的文化学维度(文化马克思主义)和意识形态的心理学维度(... 详细信息

西方马克思主义意识形态论的发展逻辑可以通过四维向度来把握,即意识形态的政治学维度(早期西方马克思主义)、意识形态的社会学维度(法兰克福学派和结构主义马克思主义)、意识形态的文化学维度(文化马克思主义)和意识形态的心理学维度(后马克思主义)。在西方马克思主义意识形态论的演变中,既有西方马克思主义对于当代资本主义的批判,也有马克思的"在场",马克思深刻影响了西方马克思主义的意识形态论。

关键词：西方马克思主义意识形态论四维向度

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论詹姆逊的后现代主义文化批判理论

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喀什大学学报 2021年第2期42卷 59-65页

作者：郭咔咔河南大学马克思主义学院河南开封475001

詹姆逊的后现代主义文化批判理论,是以总体性的方法为理论工具,以生产方式为主符码,通过对资本主义的历史分期来确立其文化分期理论的,这使得詹姆逊认为,后现代主义是晚期资本主义的文化主导。这种后现代主义文化,渗透着资本的逻辑,从... 详细信息

詹姆逊的后现代主义文化批判理论,是以总体性的方法为理论工具,以生产方式为主符码,通过对资本主义的历史分期来确立其文化分期理论的,这使得詹姆逊认为,后现代主义是晚期资本主义的文化主导。这种后现代主义文化,渗透着资本的逻辑,从而呈现出文化和经济的交互作用,因此,其本质上的深度的消逝、其风格中的历史感的退却、其情感体验中的表意链断裂以及其空间维度的“崇高”成为后现代主义区别于现代主义的主要特征。这种后现代主义文化逻辑下的人们,丧失了反思性和批判力,呈现出主体的零散化和破碎性。为破解这种后现代主义的困境,詹姆逊倡导了以认知测绘美学为主要内容的文化政治解放图式。

关键词：后现代主义文化批判文化政治学认知测绘

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Hyperuricemia in Patients with Chronic Renal Failure in the General Hospital of National Reference of N’Djamena (Chad)

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Open Journal of Nephrology 2017年第1期7卷 9-18页

作者： Guillaume Mahamat Abderraman Ibrahim Hamat Zeinabou Maiga Moussa Tondi Ahmed Tall Lemrabott Maria Faye Cisse Mouhamadou Moustapha Kossi Akomola Sabi ka Elhaj Fary ka Niang Abdou Diouf Boucar Hemodialysis Unit H&#244pital Général de Référence Nationale (HGRN) N’Djamena Tchad Medical Department FSS/ Université Abdou Moumouni de Niamey Service de Néphrologie et Hémodialyse H&#244pital National Lamordé de Niamey Niamey Niger Nephrology service H&#244pital Aristide Le Dantec de Dakar Dakar Sénégal Nephrology and Hemodialysis Service CHU SO Lomé Lomé Togo

Introduction: Hyperuricemia is defined as a level of serum uric acid greater than or equal to 70 mg/l (420 μmol/l) in men and 60 mg/l (360 μmol/l) in women. Several studies have shown that it is a risk factor or a factor of progression of chronic kidney disease. Recent experimental and epidemiological data correlate the association of hyperuricemia with chronic kidney disease (CKD), arterial hypertension and cardiovascular diseases, thus raising the question of the usefulness of therapeutics in the prevention of renal diseases. The objective of this study is to seek a link between chronic kidney disease and hyperuricemia. Materials and Methods: This is a descriptive and analytical study conducted at hemodialysis unit and cardiology service of General Hospital of National reference of N’Djamena (Chad) from 1th January to 1th October 2013 (10 months). We included all chronic kidney disease patients hospitalized in hemodialysis unit and cardiology service who presented associated hyperuricemia. Results: There were 712 CKD patients who were hospitalized. Among them, there were 108 patients who were included in the study and who had hyperuricemia as a prevalence of 15.20%. The average age of patients was 35.5 years and the sex ratio was 3/1. The age group between 40 to 60 years represented 54.6%. There were 41.7% of traders. Hypertensive patients accounted for 49.1%;association of diabetes and hypertension was noted in 12.90%. Renal insufficiency was moderate in 43.5% of patients. Hyperuricemia was present in more than 90% of patients. Profession, age, hematuria, proteinuria and hypertension were statistically positively related to hyperuricemia. Treatment consisted of prescribing allopurinol in 84% of patients. In more than 11% of patients the progression was unfavorable. Conclusion: The implication of hyperuricemia in chronic kidney disease has been proved in several recent studies. However, randomized studies at very long scales have to be carried out to conclude from

关键词： Component Formatting Style Styling

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以人为本视域下的思想政治教育探析

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无锡商业职业技术学院学报 2014年第3期14卷 71-74页

作者：郭咔咔中国政法大学马克思主义学院北京100088

以人为本是思想政治教育的内在价值和客观要求,坚持以人为本的思想政治教育是社会主义市场经济发展的需要,是社会主义和谐社会建设的需要,是思想政治教育发展的内在趋势。以人为本的思想政治教育要明确人的内涵,在传统思想政治教育的社... 详细信息

以人为本是思想政治教育的内在价值和客观要求,坚持以人为本的思想政治教育是社会主义市场经济发展的需要,是社会主义和谐社会建设的需要,是思想政治教育发展的内在趋势。以人为本的思想政治教育要明确人的内涵,在传统思想政治教育的社会价值向现代思想政治教育的个体价值转变中实现二者的有机结合,将思想政治教育放在主体间性的视域下,树立服务型意识,进行人性向善教育。

关键词：思想政治教育以人为本实现途径

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