检索结果-南通市图书馆

Percutaneous closure of gastrorenal shunt as adjunctive therapy for esophageal carcinoma

在线全文

学校读者我要写书评

暂无评论

Journal of Interventional Medicine 2023年第1期6卷 46-48页

作者： Yanlin Li Simon Ying-Kit Law ka-On lam Anthony Wing-Ip Lo Department of Diagnostic Radiology School of Clinical MedicineThe University of Hong KongHong KongChina Department of Surgery School of Clinical MedicineThe University of Hong KongHong KongChina Department of Clinical Oncology School of Clinical MedicineThe University of Hong KongHong KongChina Department of Pathology School of Clinical MedicineThe University of Hong KongHong KongChina

The embolization of gastric varices is an established technique for acute bleeding in patients with portal hypertension. Here, we report an attempt to embolize a gastrorenal shunt to facilitate esophagectomy in a patient with an esophageal malignancy. To our knowledge, this is the first case in the literature to highlight the role of interventional medicine in the treatment of patients with esophageal malignancy.

关键词： Intervention Radiology Oesophageal cancer Gastrointestinal surgery Oncology

Picosecond Laser Surface Texturing of a Stavax Steel Substrate for Wettability Control

在线全文

学校读者我要写书评

暂无评论

Engineering 2018年第6期4卷 816-821页

作者： Xincai Wang Hongyu Zheng Yinchi Wan Wenhe Feng Yee cheong lam Singapore Institute of Manufacturing Technology(SIMTech) A*STARSingapore 138634Singapore SIMTech-NTU Joint Laboratory(Precision Machining) Nanyang Technological UniversitySingapore 639798Singapore School of Mechanical Engineering Shandong University of TechnologyZibo 255000China

In this investigation,a picosecond laser was employed to fabricate surface textures on a Stavax steel substrate,which is a key material for mold fabrication in the manufacturing of various polymer *** main types of surface textures were fabricated on a Stavax steel substrate:periodic ripples,a two-scale hierarchical two-dimensional array of micro-bumps,and a micro-pits array with *** wettability of the laser-textured Stavax steel surface was converted from its original hydrophilicity into hydrophobicity and even super-hydrophobicity after exposure to *** results clearly show that this super-hydrophobicity is mainly due to the surface *** ultrafast laserinduced catalytic effect may play a secondary role in modifying the surface chemistry so as to lower the surface *** laser-induced surface textures on the metal mold substrates were then replicated onto polypropylene substrates via the polymer injection molding *** surface wettability of the molded polypropylene was found to be changed from the original hydrophilicity to *** developed process holds the potential to improve the performance of fabricated plastic products in terms of wettability control and easy cleaning.

关键词： Picosecond laser Surface texturing Stavax steel Polymer Hydrophobicity

Inhibition of lysine methyltransferase G9a/GLP reinstates long-term synaptic plasticityand synaptic tagging/capture by facilitatingprotein synthesis in the hippocampal CA1area of APP/PS1 mouse model ofAlzheimer’s disease

在线全文

学校读者我要写书评

暂无评论

Translational Neurodegeneration 2021年第2期10卷 294-296页

作者： Javan Lee Tze Han karen ka lam Pang Sheila Rui Xia Ang Mahima Sharma Sreedharan Sajikumar Department of Physiology Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117597Singapore Neurobiology Programme Life Sciences InstituteNational University of SingaporeSingapore 117456Singapore Healthy Longevity Translational Research Programme Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117456Singapore

Histone H3 lysine 9 di-methylation(H3K9me2)is an epigenetic repressive histone modification that was found at aberrant states in Alzheimer’s disease(AD)patient samples[1].The addition of H3K9me2/3 is mainly catalyzed by lysine methyltransferase G9a,which functions as a heteromeric complex with G9a-like protein(GLP).G9a/GLP has other non-histone substrates,including itself.G9a/GLP is implicated in regulating synaptic plasticity,learning and memory[2,3].

关键词： Alzheimer GLP plasticity

Metastatic Colorectal Cancer: Optimizing Treatment with Anti-EGFR Monoclonal Antibody

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Cancer Therapy 2012年第6期3卷 902-911页

作者： ka-On lam Victor Ho-Fun Lee Department of Clinical Oncology Li Ka Shing Faculty of Medicine The University of Hong Kong Hong Kong China.

Colorectal cancer remains a major cause of morbidity and mortality worldwide despite substantial improvement in the standard of care. Although surgical resection in selected patients may potentially be curative, systemic therapy is the only choice of treatment for most patients with metastatic colorectal cancer. Anti-epidermal growth factor receptor (anti-EGFR) monoclonal antibody has established its role in the systemic therapy of metastatic colorectal cancer through multiple well-designed clinical trials and yet, the optimal use of anti-EGFR monoclonal antibody is undefined. This article serves to review the available evidence for anti-EGFR monoclonal antibodies and to speculate optimal strategy for their uses.

关键词： Colorectal Cancer Epidermal Growth Factor Receptor Cetuximab Panitumumab Strategy

Utilization of microwave steam pyrolysis to produce biochar for thermal energy storage

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Waste Disposal and Sustainable Energy 2022年第4期4卷 335-341页

作者： Wahap bin Abu Bakar Peter Nai Yuh Yek kah Yein cheong Augustine Chioma Affam Chee Chung Wong Rock Keey Liew Yie Hua Tan Su Shiung lam Centre for Research of Innovation and Sustainable Development University of Technology SarawakNo.1Jalan University96000SibuMalaysia Centre on Technological Readiness and Innovation in Business Technopreneurship(CONTRIBUTE) University of Technology Sarawak96000SibuSarawakMalaysia NV Western PLT No.208BSecond FloorMacalister Road10400GeorgetownPenangMalaysia Department of Chemical and Energy Engineering Faculty of Engineering and ScienceCurtin University MalaysiaCDT 25098009MiriSarawakMalaysia Higher Institution Centre of Excellence(HICoE) Institute of Tropical Aquaculture and Fisheries(AKUATROP)Universiti Malaysia Terengganu21030 Kuala NerusTerengganuMalaysia

Microwave steam pyrolysis(MSP)is an innovative thermochemical approach to converting biomass into high-quality biochar using steam to improve the dielectric heating of microwave *** shows high fixed carbon and carbon contents at a maximum temperature of 550℃in 10 *** MSP achieved a heating rate of 112℃/min from 200℃to 400℃to produce biochar ***,the thermal properties of biochar in microwave heating were investigated in this study to explore its potential as a microwave heat-absorbent *** is able to perform volumetric and controllable heating to the ***,biochar shows good microwave heat absorbency,storing and transferring heat *** temperature profile of three different sizes of biochar was investigated to examine the efficiency of biochar in heat absorption from microwave *** was found that the powder form of biochar showed a higher heat transfer rate of 40℃/min and a low cooling rate of 7.5℃/*** presented results are useful for evaluating the application of biochar as a promising medium for heat storage systems.

关键词： Microwave Steam Pyrolysis Biochar Thermal Storage

Perfluorooctane sulfonate(PFOS) and related fluorochemicals in chicken egg in China

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Science Bulletin 2008年第4期53卷 501-507页

作者： WANG Yuan YEUNG Leo Wai Yin YAMASHITA Nobuyoshi TANIYASU Sachi SO Man ka Margaret B. MURPHY lam Paul Kwan Sing Centre for Coastal Pollution and Conservation Department of Biology and Chemistry City University of Hong Kong 83 Tat Chee Avenue Kowloon Tong HKSAR China National Institute of Advanced Industrial Science and Technology (AIST) 16-10nogawa Tsukuba Ibaraki 305-8569 Japan

The ubiquitous occurrence of perfluorinated compounds(PFCs) in environmental samples has drawn much *** human exposure studies found relatively high perfluorooctane sulfonate(PFOS) concentrations in blood samples from several cities in China when compared with other *** objectives of the present study were:(1) to measure PFC concentrations and compositions in chicken egg samples from local markets in China;and(2) to conduct a preliminary human health risk assessment of egg *** pooled egg samples from eight locations were analyzed for 11 *** results showed that close to 100% of the PFOS in the egg was distributed in egg yolk and PFOS was not detected in egg white(<0.08 ng/g wet weight,w/w).Of the perfluoroalkylsulfonates,only PFOS was detected in all egg samples,while of the perfluoroalkylcarboxylates,perfluoroundecanoic acid(PFUnDA) was detected in all samples,followed by perfluorooctanoate(PFOA)(75% occurrence) and perfluorodecanoic acid(PFDA)(50% occurrence).PFOS concentrations in egg ranged from 45.0 to 86.9 ng/g w/*** results suggested that current concentrations of PFOS in domestic chicken eggs are unlikely to cause immediate harm to Chinese populations.

关键词：中国鸡蛋人体健康风险评估污染物含氟化合物全氟辛烷磺酸

Screening and identification of mimotopes of the major shrimp allergen tropomyosin using one-bead-one- compound peptide libraries

在线全文

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2017年第3期14卷 308-318页

作者： Nicki YH Leung Christine YY Wai Marco HK Ho Ruiwu Liu Kit S lam Jin Jun Wang Shang An Shu ka Hou Chu Patrick SC Leung School of Life Sciences The Chinese University of Hong Kong Shatin N.T. Hong Kong SAR China Department of Pediatrics and Adolescent Medicine Queen Mary Hospital The University of Heng Kong Pokfulam Hong Kong SAR China Department of Biochemistry and Molecular Medicine University of California Davis CA 95616 USA Division of Rheumatology/Allergy School of Medicine University of California Davis CA 95616 USA

The one-bead-one-compound （OBOC） combinatorial peptide library is a powerful tool to identify ligand and receptor interactions. Here, we applied the OBOC library technology to identify mimotopes specific to the immunoglobulin E （IgE） epitopes of the major shellfish allergen tropomyosin. OBOC peptide libraries with 8-12 amino acid residues were screened with serum samples from patients with shellfish allergy for IgE mimotopes of tropomyosin. Twenty-five mimotopes were identified from the screening and their binding reactivity to tropomyosin-specific IgE was confirmed by peptide ELISA. These mimotopes could be divided into seven clusters based on sequence homology, and epitope mapping by EpiSearch of the clustered mimotopes was performed to characterize and confirm the validity of mimotopes. Five out of six of the predicted epitopes were found to overlap with previously identified epitopes of tropomyosin. To further confirm the mimicry potential of mimotopes, BALB/c mice were immunized with mimotopes conjugated to keyhole limpet hemocyanin and assayed for their capacity to induce tropomyosin-specific antibodies. BALB/c mice that received mimotope immunization were found to have an elevated level of tropomyosin-specific immunoglobulin G, but not mice that received an irrelevant mimotope. This study pioneers the successful application of the OBOC libraries using whole sera to screen and identify multiple shrimp allergen mimotopes and validates their mimicry potential using in vitro, in vivo, and in silico methods.

关键词： epitope mimotope OBOC peptide library tropomyosin

Multiomics approaches to uncover endometrial receptivity in embryo implantation:a mini-review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Reproductive and Developmental Medicine 2024年第3期8卷 178-185页

作者： Sudini R.Fernando Yang Yan Manish Kumar Hoi-lam Lai Yin-Lau Lee Ernest H.Y.Ng William S.B.Yeung kai-Fai Lee Department of Obstetrics and Gynaecology Li Ka Shing Faculty of MedicineThe University of Hong KongPokfulamHong Kong SAR 999077China Department of Animal Science Faculty of Animal Science and Export AgricultureUva Wellassa UniversityBadullaSri Lanka Shenzhen Key Laboratory of Fertility Regulation The University of Hong Kong-Shenzhen HospitalFutian DistrictShenzhen 518053China

Successful implantation requires concerted interactions during the apposition,adhesion,and invasion of the embryo into a receptive ***,the embryo implantation rate for assisted reproduction remains low despite the transfer of good quality *** in endometrial transcriptomics,proteomics,lipidomics,and even microbiota all play important roles in embryo ***,the expression of steroid hormone-regulated adhesive and anti-adhesive molecules during the embryo implantation window is becoming an area of increasingly intense *** review(a)summarizes the different molecules expressed in the receptive endometrium and(b)proposes the use of surface protein markers to predict pregnancy outcomes from assisted reproduction.

关键词： Cell surface proteins Steroid regulation Endometrial receptivity Receptivity marker Infertility

The impact of post-operative atrial fibrillation on outcomes in coronary artery bypass graft and combined procedures

在线全文

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2021年第5期18卷 319-326页

作者： Yau-lam Alex Chau Ji Won Yoo Ho Chuen Yuen Khalid Bin Waleed Dong Chang Tong Liu Fang Zhou Liu Gary Tse Sharen Lee ka Hou Christien Li Faculty of Pharmaceutical Sciences University of British ColumbiaBritish ColumbiaCanada Department of Medicine and Geriatrics Princess Margaret HospitalHong KongChina Department of Cardiology Fuwai Hospital Chinese Academy of Medical Sciences ShenzhenShenzhenChina Institute of Biomedicine and Biotechnology Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhenChina Xiamen Cardiovascular Hospital Xiamen UniversityXiamenChina Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease Department of CardiologyTianjin Institute of CardiologyThe Second Hospital of Tianjin Medical UniversityTianjinChina Department of Cardiology Guangdong Cardiovascular InstituteGuangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhouChina Faculty of Health and Medical Sciences University of SurreyGU27ALGuildfordUnited Kingdom Cardiovascular Analytics Group Laboratory of Cardiovascular PhysiologyHong KongChina Arrowe Park Acute Stroke Unit Wirral University Teaching Hospital NHS Foundation TrustWirralUK

BACKGROUND Postoperative atrial fibrillation(POAF)is a common yet understudied clinical issue after coronary artery bypass graft(CABG)leading to higher mortality rates and *** systematic review and metaanalysis evaluated the rates of adverse outcomes between patients with and without POAF in patients treated with CABG or combined *** The search period was from the beginning of PubMed and Embase to May 18th,2020 with no language *** inclusion criteria were:(1)studies comparing new onset atrial fibrillation before or after revascularization *** new onset AF before or after *** outcomes assessed included allcause mortality,cardiac death,cerebral vascular accident(CVA),myocardial infarction(MI),repeated revascularization,major adverse cardiac event(MACE),and major adverse cardiac and cerebrovascular events(MACCEs).RESULTS Of the 7,279 entries screened,11 studies comprising of 57,384 patients were *** to nonPOAF,POAF was significantly associated with higher risk of allcause mortality(Risk Ratio(RR)=1.58;95%Confidence Interval(CI):1.42−1.76,P<0.00001)with accompanying high level of heterogeneity(I^(2)=62%).Conclusions Patients with POAF after CABG or combined procedures are at an increased risk of allcause mortality or ***,POAF after such procedures should be closely monitored and treated judiciously to minimize risk of further *** there are studies on POAF versus no POAF on outcomes,the heterogeneity suggests that further studies are needed.

关键词： bypass fibrillation mortality