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Changes in brain activation patterns according to cross-training effect in serial reaction time task An functional MRI study

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Neural Regeneration Research 2013年第7期8卷 639-646页

作者： yong Hyun kwon Jung Won kwon ji Won Park Department of Physical Therapy Yeungnam College of Science & Technology Department of Physical Therapy College of Health Science Catholic University of Daegu

Cross-training is a phenomenon related to motor learning, where motor performance of the untrained limb shows improvement in strength and skill execution following unilateral training of the homologous contralateral limb. We used functional MRI to investigate whether motor performance of the untrained limb could be improved using a serial reaction time task according to motor sequential learning of the trained limb, and whether these skill acquisitions led to changes in brain activation patterns. We recruited 20 right-handed healthy subjects, who were randomly allocated into training and control groups. The training group was trained in performance of a serial reaction time task using their non-dominant left hand, 40 minutes per day, for 10 days, over a period of 2 weeks. The control group did not receive training. Measurements of response time and percentile of response accuracy were performed twice during pre- and post-training, while brain functional MRI was scanned during performance of the serial reaction time task using the untrained right hand. In the training group, prominent changes in response time and percentile of response accuracy were observed in both the untrained right hand and the trained left hand between pre- and post-training. The control group showed no significant changes in the untrained hand between pre- and post-training. In the training group, the activated volume of the cortical areas related to motor function （i.e., primary motor cortex, premotor area, posterior parietal cortex） showed a gradual decrease, and enhanced cerebellar activation of the vermis and the newly activated ipsilateral dentate nucleus were observed during performance of the serial reaction time task using the untrained right hand, accompanied by the cross-motor learning effect. However, no significant changes were observed in the control group. Our findings indicate that motor skills learned over the 2-week training using the trained limb were transferred to the opposi

关键词： neural regeneration neuroimaging cross-training effects motor skill learning cortical activation cerebellar activation serial reaction time task functional MRI response time response accuracy primary motor cortex dentate nucleus vermis grants-supported paper photographs-containingpaper neuroregeneration

Unraveling the mechanism of action of Shangxia Liangji formula for treating insomnia:a metabolomics and network pharmacology approach

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Traditional Medicine Research 2025年第2期10卷 16-29页

作者： Xia-jie Quan Hao Liang yong-Hong Tang Li jiang Xiong-Ying ji Feng-Ying Zhang Ping Zhang Bo Ouyang Department of Information The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Neurology The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Gastroscopy The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Traditional Chinese Medicine The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China

Background:Insomnia is a prevalent clinical condition and Shangxia Liangji formula(SXLJF)is a well-established method of ***,the specific mechanism of action of SXLJF remains ***:The mouse model of insomnia was established by intraperitoneal injection of ***-two mice were randomly divided into a negative control group,model group,SXLJF group(18.72 g/kg/day),and positive control group(diazepam,2 mg/kg)and treated with the corresponding drugs for 7 consecutive *** open field test and pentobarbital-induced sleeping test were ***-MS-based untargeted metabolomics and network pharmacology were applied to explore the potential targets of SXLJF for treating ***,key targets were validated using ***:Behavioral tests demonstrated that SXLJF reduced the total distance,average velocity,central distance,and sleep latency,and prolonged sleep *** and network pharmacology revealed potential targets,signaling pathways,metabolic pathways,and metabolites associated with the anti-insomnia effects of ***,tyrosine hydroxylase(TH)and tyrosine metabolism emerged as crucial metabolic pathways and targets,***-qPCR results supported the role of TH in the mechanism of SXLJF in treating ***:In conclusion,TH and tyrosine metabolism may represent significant targets and pathways for SXLJF in treating insomnia.

关键词： Shangxia Liangji formula insomnia metabolomics network pharmacology tyrosine hydroxylase tyrosine metabolism

Theoretical Simulation of Surface Evolution Using the Random Deposition and Surface Relaxation for Metal Oxide Film in Atomic Layer Deposition

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Journal of Materials Science & Technology 2010年第4期26卷 371-374页

作者： ji-Hoon Ahn Se-Hun kwon jin-Hyock Kim Ja-yong Kim Sang-Won Kang Department of Materials Science and Engineering Korea Advanced Institute of Science and Technology373-1Kusong-dongYusong-guTaejon 305-701Korea Hynix Semiconductor Incorporated San 136-1Ami-riBubal-eubIcheon-siKyongki-do467-701Korea

Atomic layer deposition （ALD） has become an essential deposition method for forming nanometer scale thin films in the microelectronics industry, and its applications have been extended to multi-component thin films, as well as to single metal oxide films. In order to investigate the development of the surface structure of ultra-thin film qualitatively as well as quantitatively, ALD processes are simulated with a molecular scale. For this simulation, the film materials are deposited on a imaginary substrate that consists of small lattice. The deposition behaviors are described by using random deposition （RD） model or random deposition with surface relaxation （RDSR） model as the ALD growth mode, and the proposed model was applied to the deposition of SrO-TiO2 thin films. Through this work, growth characteristics such as surface morphology, deposited film coverage can be predicted.

关键词： Atomic layer deposition Random deposition SrO-TiO2

Inhibitory Mechanisms of Water Extract of Oplopanax elatus on Lipopolysaccharide-lnduced Inflammatory Responses in RAW 264.7 Murine Macrophage Cells

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Chinese Journal of Integrative Medicine 2020年第9期26卷 670-676页

作者： Ki Sun kwon Hyun Lim yong Soo kwon Myong Jo Kim ji Hye Yoo Nam Ho Yoo Hyun Pyo Kim College of Pharmacy Kangwon National UniversityChuncheon(24341)Republic of Korea Department of Bio-Resource Sciences Kangwon National UniversityChuncheon(24341)Republic of Korea Bioherb Research Institute Kangwon National UniversityChuncheon(24341)Republic of Korea

Objective:To study the anti-inflammatory action and cellular mechanism of Oplopanax ***:A hot water extract of OE(WOE)was prepared and a major constituent,syringin,was successfully *** content in WOE was found to be 214.0 p.g/g dried plant(w/w).Their anti-inflammatory activities were examined using RAW 264.7 macrophages and a mouse model of croton oil-induced ear ***:In lipopolysaccharide(LPS)-treated RAW 264.7 cells,a mouse macrophage cell line,WOE was found to significantly and strongly inhibit cyclooxygenase-2(COX-2)-induced prostaglandin E2(PGE2)production[half maximal inhibitory concentration(IC50)=135.2μg/mL]and inducible nitric oxide synthase(iNOS)-induced NO production(IC50=242.9μg/mL).In the same condition,WOE was revealed to inhibit NO production by downregulating iNOS expression,mainly by interrupting mitogen activated protein kinases(MAPKs)/activator protein-1(AP-1)*** activation of all three major MAPKs,p38 MAPK,extracellular signal-regulated kinase(ERK),and c-Jun N-terminal kinase,was inhibited by WOE(50-300μg/mL).On the other hand,WOE reduced PGE2 production by inhibiting COX-2 enzyme activity,but did not affect COX-2 expression *** addition,WOE inhibited the production of proinflammatory cytokines such as interleukin-6 and tumor necrosis factor-α.In croton oil-induced ear edema in mice,oral administration of WOE(50-300 mg/kg)dose-dependently inhibited edematic ***:Water extract of OE exhibited multiple anti-inflammatory action mechanisms and may have potential for treating inflammatory disorders.

关键词： Oplopanax elatus Chinese medicine stem syringin anti-inflammation RAW 264.7

Analytic derivation of Monin-Obukhov similarity function for open atmospheric surface layer

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Science China(Physics,Mechanics & Astronomy) 2021年第3期64卷 73-83页

作者： yong ji Zhen-Su She State Key Laboratory for Turbulence and Complex Systems and Department of Mechanics and Engineering Science College of EngineeringPeking UniversityBeijing100871China

The Monin-Obukhov(MO)similarity functionφm of the atmospheric surface layer(ASL)describing the deviation from the log law of the canonical turbulent boundary layer because of thermal stratification has been traditionally determined *** study presents a unified analytic expression derived from a symmetry-based theory of wall turbulence,called structural ensemble dynamics(SED),which postulates a generalized dilation symmetry principle expressing the effect of the wall on turbulence,leading to an analytic multi-regimes expression for the mixing *** ASL in unstable and stable conditions(i.e.,UC and SC),a unified two-regime formula of the mixing length is proposed,leading to aφm,similar to the Businger-Dyer(BD)formula;with a simplified model energy balance equation,φm is completely specified with no free ***,the theory allows the study of the open ASL’s underlying additional physical processes such as bottom-up or top-down flux due to pressure variations *** that Tp is decomposed into shear-like and buoyancy-like components,we propose new explanations for two important features of typical ASL:a significantly smaller Karman constant of 0.36 and a varyingφm for SC mean speed *** theory is validated by the data obtained at Kansas and also at Qingtu Lake Observation Array in Northern China for a variety of heat flux *** conclusion,due to pressure variations,we assert that ASL is intrinsically open and that the current theory offers a new basis for its quantification.

关键词： Monin-Obukhov similarity theory open atmospheric surface layer boundary layer turbulence symmetry-based analysis

Photoluminescence of Nominally Undoped Heavy n-Type ZnO Nanowires

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Chinese Physics Letters 2011年第2期28卷 200-203页

作者： TANG Hai-Ping HE Hai-Ping LIU Chao kwon Bong-Jun YE Zhi-Zhen LEE Soonil PARK ji-yong Division of Energy Systems Research Ajou UniversitySuwon443-749Korea Baoji University of Arts and Sciences Baoji 721007 State Key Laboratory of Silicon Materials Department of Materials Science and EngineeringZhejiang UniversityHangzhou 310027

We report the identification of a donor band and the correlation between n-type conductivity and the green emission in ZnO ***-dependent photoluminescence is used to investigate nominally undoped ZnO nanowires with high n-type *** the whole temperature range,a dominant free-to-bound transition with a donor band of about 150meV below the conduction band minimum is *** nanowires show very strong green emission,which is quenched with activation energy of about 220 *** correlation between the high n-type conductivity and the strong green emission is discussed in detail,and we suggest that they may have different origins.

关键词： nanowires conductivity conductivity

脑血管病急性期血尿酸/血肌酐比值与脑血管事件复发及死亡的关系:一项前瞻性队列研究

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中国全科医学 2025年第2期28卷 175-182,192页

作者：任小乔王盼吴昊纪勇石志鸿天津医科大学神经内外科及神经康复临床学院天津市300070 天津市环湖医院 300350

背景脑卒中在世界各地有较高的死亡率和复发率。血尿酸(SUA)是嘌呤代谢的产物,已被认为是心脑血管病的危险因素。血尿酸/血肌酐比值(SUA/Scr)是代表肾功能标准化的SUA,目前有关SUA/Scr在急性脑血管病中的作用仍有争议。目的探讨脑血管... 详细信息

背景脑卒中在世界各地有较高的死亡率和复发率。血尿酸(SUA)是嘌呤代谢的产物,已被认为是心脑血管病的危险因素。血尿酸/血肌酐比值(SUA/Scr)是代表肾功能标准化的SUA,目前有关SUA/Scr在急性脑血管病中的作用仍有争议。目的探讨脑血管病急性期SUA/Scr与脑血管事件复发和死亡的关系。方法本研究为前瞻性队列研究,选取2006年9月—2019年9月天津市环湖医院连续收治的首次发生脑血管事件的13313例患者为研究队列,并对患者进行随访,随访截至2020年9月。随访方式为门诊及电话相结合。随访主要终点事件为全因死亡,次要终点事件为脑血管事件复发、心血管事件复发、其他血管事件发生(如下肢动静脉栓塞)。采用Cox比例风险回归模型探究SUA/Scr与脑血管事件复发与死亡的关系。结果根据脑血管病急性期SUA/Scr四分位数,将患者分为Q1组(SUA/Scr≤3.16,n=3520)、Q2组(3.164.92,n=3243)。截至随访结束,774例(5.8%)患者死亡,2064例(15.5%)患者复发脑血管事件。脑血管病急性期SUA/Scr位于Q1~Q4的患者中,男性复发脑血管病的例数依次为302、375、408、337例,女性依次为99、125、169、249例;男性复发脑梗死的例数依次为261、314、345、283例,女性依次为90、101、142、205例;男性复发大动脉粥样硬化型脑梗死的例数依次为154、191、214、183例,女性依次为58、52、45、31例;男性全因死亡的例数依次为165、128、131、88例,女性依次为57、63、62、80例;男性因脑梗死死亡的例数依次为93、72、70、46例,女性依次为31、33、36、44例;男性因大动脉粥样硬化型脑梗死死亡的例数依次为58、52、45、31例,女性依次为17、18、27、24例。调整多项混杂因素后,SUA/Scr位于Q4相较于Q1是男性急性脑梗死复发的影响因素(HR=0.690,95%CI=0.500~0.953,P=0.026);SUA/Scr位于Q4相较于Q1是男性脑梗死亚组患者大动脉粥样硬化型脑梗死复发的影响因素(HR=0.740,95%CI=0.578~0.947,P=0.017)。SUA/Scr位于Q4相较于Q1是男性全因死亡、因脑梗死死亡的影响因素(HR=0.575,95%CI=0.368~0.901,P=0.003;HR=0.610,95%CI=0.353~0.814,P=0.011)。SUA/Scr位于Q3、Q4相较于Q1是男性出院后死亡的影响因素(HR=0.656,95%CI=0.476~0.904,P=0.010;HR=0.582,95%CI=0.409~0.829,P=0.001)。SUA/Scr位于Q4相较于Q1是男性脑梗死亚组患者因大动脉粥样硬化型脑梗死死亡的影响因素(HR=0.580,95%CI=0.386~0.873,P=0.007)。结论一定范围内,脑血管病急性期SUA/Scr升高对男性患者脑血管事件复发及死亡有一定的保护作用,低SUA/Scr与男性大动脉粥样硬化型脑梗死的死亡和复发风险升高有关,但与小动脉闭塞型脑梗死和心源性卒中复发和死亡无关。在女性患者中没有观察到SUA/Scr与脑血管事件复发及死亡的关系。

关键词：脑血管障碍脑卒中血尿酸/血肌酐比值动脉粥样硬化男性复发死亡队列研究前瞻性研究 Cox比例风险回归模型

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Topological r-entropy and Measure Theoretic r-entropy of Flows

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Acta Mathematica Sinica,English Series 2022年第4期38卷 761-769页

作者： yong ji Yun Ping WANG Department of Mathematics Ningbo UniversityNingbo 315211P.R.China School of Science Ningbo University of TechnologyNingbo 315211P.R.China School of Mathematical Sciences and Institute of Mathematics Nanjing Normal UniversityNanjing 210023P.R.China

The topological r-entropy and measure theoretic r-entropy of a flow are *** a flow(X,φ),it is shown that topological(measure theoretic)r-entropy is equal to the topological(measure theoretic)entropy of the time one ... 详细信息

关键词： Topological r-entropy measure theoretic r-entropy flow

CREEP BEHAVIOR OF Zr-1.5Nb-0.4Sn-0.1Fe-0.1Cu ALLOY

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Acta Mechanica Solida Sinica 2008年第4期21卷 308-311页

作者： ji Young Kim Kwang Su Na yong Duck Kim ji Hui Kim kwon Yeong Lee Ki Nam Kim Seon jin Kim Division of Advanced Materials Science and Engineering Hanyang University133-791Korea Technical Research Center Sheet Products Design TeamHyundai Steel CompanyKodae-RiSongak-MyeonDangjin-GunChungnam167-32Korea

Creep behavior of the Zr-1.5Nb-0.4Sn-0.1Fe-0.1Cu alloy sheet is investigated from 300℃ to 400℃ in the stress range from 50 MPa to 180 MPa along the rolling direction. The measured strain rates range from 8.8 × 10^-10 s^-1 to 4.7 × 10^-7 s^-1. The activation energies are estimated to assess the creep deformation mechanisms in this alloy. The strain rate is slightly different at low stress, while it shows a distinct difference at high stresses. Stress exponents of this alloy increase with increasing applied stress at all testing temperatures. It is concluded that the creep deformation of the Zr-1.5Nb-0.4Sn-0.1Fe-0. 1 Cu alloy is controlled by the diffusion creep at low stress region and by the climbing of dislocations at high stress region.

关键词： creep zirconium alloy nuclear cladding