检索结果-南通市图书馆

在线全文

学校读者我要写书评

暂无评论

设计民主化背景下合作设计方法的使用与辨析

装饰 2021年第12期 89-93页

作者：娄明张凌浩邵健伟江南大学设计学院香港理工大学设计学院

参与式设计与协同设计由于概念相似度高,在设计操作中常常容易混淆。文章借助溯源探究、模型比较与案例说明的分析方法,在说明两者都是体现集体智力的设计合作基础上,从合作对象、核心思想、权利分配等维度分析两者的区别。通过全面分析... 详细信息

参与式设计与协同设计由于概念相似度高,在设计操作中常常容易混淆。文章借助溯源探究、模型比较与案例说明的分析方法,在说明两者都是体现集体智力的设计合作基础上,从合作对象、核心思想、权利分配等维度分析两者的区别。通过全面分析,帮助设计师厘清两者概念与使用方面的异同,使其在未来设计中更有效地使用两种方法。

关键词：参与式设计协同设计设计民主集体智力比较分析

N, N-dimethyltryptamine, a natural psychedelic, rapidly improves spatial memory and hippocampal longterm potentiation: a potential rapid-acting therapy for dementia-associated wandering

在线全文

学校读者我要写书评

暂无评论

中国药理学与毒理学杂志 2023年第7期37卷 489-490页

作者： CHENG Dan LEI Zhuogui Benjamin Chun-Kit TONG Catherine kin CHIU LI Ying king-Ho CHEUNG ZHANG Zhangjin School of Chinese Medicine the University of HongKong Department of Neuroscience City University of HongKong School of Chinses Medicine and Mr. and Mrs. Ko Chi ming Centre for Parkinson’s Disease Research HongKong Baptist University Department of Psychology LKS Faculty of Medicine the University of HongKong Department of Chinese Medicine the University of Hong Kong-Shenzhen Hospital

There is no fast-acting treatment strategies against Alzheimer′s disease(AD), in particular dementia-related wandering. N, N-dimethyltryptamine(DMT) is a natural psychedelic that may have rapid-onset nootropic effects. In this study, 5 × FAD transgenic mice which recapitulated amyloid neuropathological features of AD received one single injection of 6 or 12 mg · kg-1DMT and tested at 0.5, 1, and 2 h thereafter in Y-maze for spatial memory. 5×FAD transgenic mice exhibited pronounced decreases in time spent, number entered, and distance travelled in the novel arm of Y-maze. DMT at 12 mg · kg-1partially or completely reversed the three behavioral indices at multiple time points, up to 2 h post injection. The rapid-onset behavioral improvement was consistent with pharmacokinetic analysis of DMT, showing approximately 30 min to reach the maximum concentration in the brain tissue. The transgenic mice also displayed dramatically impaired hippocampal long-term potentiation(LTP), an electrophysiological feature of memory formation and consolidation. DMT potently enhanced LTP and restored intracellular calcium activity, expression and phosphorylation of calcium/calmodulin-dependent protein kinase Ⅱ(CaMKⅡ) and AMPA-type glutamate receptor1(GluR1), the two key calcium-activated mediators involved in LTP induction. Adenosine triphosphate(ATP)is purinergic signalling molecules that are involved in LTP induction and maintenance. DMT rapidly increased mitochondrial ATP dynamics in in vivo and in vitro *** results suggest that DMT rapidly improve spatial memory and hippocampal LTP by restoring the CaMKⅡ-GluR1 signaling pathway and mitochondrial ATP production. It may be served as a fast-acting nootropic agent for the treatment of AD in particular wandering.

关键词：

A Potential Anti-metastatic Chinese Herb Andrographis paniculata—Its In Vitro Activities in Esophageal Cancer Cells and Endothelial Cells

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

A Potential Anti-metastatic Chinese Herb Andrographis panicu...

Transvenous Embolization of Carotid Cavernous Fistula by Sequential Occlusion of the Cavernous Sinus

第十四届全国中药和天然药物学术研讨会

作者： Grace Gar-Lee Yue Julia kin-ming Lee Kar-Man Chan Kwok-Pui Fung Philip Wai-Yan Chiu Clara Bik-San Lau The Chinese University of Hong Kong

＜正＞Esophageal cancer is associated with high postoperative recurrence and systemic *** adjuvant chemotherapy and concurrent radiation have shown favourable efficacies,searching for alternative treatments for metast...

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

介入放射学杂志 2004年第S1期13卷 136-136页

作者： Cheng kin ming Department of Neurosurgery of Queen Elizabeth Hospital

Objective Introduction When we perform transvenous embolization of carotid cavernous fistula, we selectively occluded the venous outflow to the retrograde cortical venous drainage and retrograde ophthalmic venous drainage as the initial steps before the rest of the cavernous sinus. The rationale is to prevent re-diversion of flow into the ophthalmic veins and cortical veins in a subtotally occluded carotid cavernous *** From 1997 to 2004, a total of 46 patients with carotid cavernous fistula were treated by transvenous embolization using the proposed selective occlusion strategy. There were 6 direct and 40 dural cartoid cavernous fistulae. The embolic agents were Guglielmi detachable coils and fibered platinum coils. Transvenous embolization routes included inferior petrosal sinus (IPS) alone (32 patients), IPS and intercavernous sinus (9 patients), and superior ophthalmic vein (5 patients).Result The follow-up period ranged from 4 months to 7 years. One patient developed retinal hemorrhage due to ophthalic vein thrombosis one week after the embolization procedure. Two patients had transient ophthalmoplegia and 2 patients had symptomatic recurrence of the carotid cavernous fistula during the follow-up. Clinical cure was achieved in 44 patients (96%).Conclusion The sequential occlusion strategy offers a safe and effective method in the transvenous embolization of carotid cavernous fistula.

关键词： Transvenous Embolization of Carotid Cavernous Fistula by Sequential Occlusion of the Cavernous Sinus

Hepatic arterial infusion chemotherapy for hepatocellular carcinoma with portal vein tumor thrombosis

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2003年第12期9卷 2666-2670页

作者： Yung-Chih Lai Cheng-Yen Shih Chin-ming Jeng Sien-Sing Yang Jui-Ting Hu Yung-Chuan Sung Han-Ting Liu Shaw-Min Hou Chi-Hwa Wu Tzen-kwan Chen Department of Internal Medicine Cathay General HospitalTaipeiTaiwanChina Department of Radiology Cathay General HospitalTaipeiTaiwanChina Department of Surgery Cathay General HospitalTaipeiTaiwanChina

AIM: Hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT) is associated with poor prognosis. The aim of this prospective study was to evaluate the efficacy of hepatic arterial infusion chemotherapy (HAIC) for patients with this ***: Eighteen HCC patients with PVTT were treated with HAIC via a subcutaneously implanted injection port. A course of chemotherapy consisted of daily cisplatin (10 mg for one hour) followed by 5-fiuorouracil (250 mg for five hours) zfor five continuous days within a given week. The patients were scheduled to receive four consecutive courses of *** were defined in whom either a complete or partial response was achieved, while non-responders were defined based on stable or progressive disease status. The prognostic factors associated with survival after treatment were ***: Six patients exhibited partial response to this form of HAIC (response rate = 33 %). The 3, 6, 9, 12 and 18-month cumulative survival rates for the 18 patients were 83 %, 72 %, 50 %, 28 %, and 7 %, respectively. Median survival times for the six responders and 12 non-responders were 15.0 (range, 11-18) and 7.5 (range, 1-13) months,respectively, It was demonstrated by both univariate and multivariate analyses that the therapeutic response and hepatic reserve function were significant prognostic ***: HAIC using low-dose cisplatin and 5-fluorouracil may be a useful alternative for the treatment of patients with advanced HCC complicated with PVTT. There may also be survival-related benefits associated with HAIC.

关键词：肝动脉灌注化疗门静脉肿瘤栓塞肝细胞癌影像学检查临床研究

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

鎢单晶体中位錯蝕斑的研究

南京大学学报(自然科学版) 1964年第1期 54-68页

作者：閔乃本吉光民馮端

本文指出了在钨单晶体{100}面产生金字塔形浸蚀斑,{111}面产生三角锥形浸蚀斑的浸蚀剂和浸蚀条件。通过浸蚀——抛光——再浸蚀的方法及亚晶界的分析,初步建立了位错和浸蚀斑间一一对应的关系。进一步运用这一技术研究了钨单晶中的亚晶... 详细信息

本文指出了在钨单晶体{100}面产生金字塔形浸蚀斑,{111}面产生三角锥形浸蚀斑的浸蚀剂和浸蚀条件。通过浸蚀——抛光——再浸蚀的方法及亚晶界的分析,初步建立了位错和浸蚀斑间一一对应的关系。进一步运用这一技术研究了钨单晶中的亚晶界,通过倾侧性亚晶界的交结点的分析,指出钨单晶体中存有二组〈100〉柏格斯矢量的刃位错组成的不对称倾侧亚晶界,二组1/2〈111〉柏格斯矢量的刃位错组成的不对称倾侧亚晶界。文章还提出了分析二组非正交的异柏格斯矢量的刃位错所构成倾侧晶界(且观察面不与位错线正交)的较为一般的极图分析法。

关键词：对应关系单晶体倾侧晶界金字塔形图象刃型位错非正交亚晶界面缺陷刃位错散斑不对称均匀成核

Ace2, rather than ace1, is the major acetylcholinesterase in the silkworm, Bombyx moil

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Insect Science 2009年第4期16卷 297-303页

作者： Hui-Juan Chen Zhen Liao Xiao-ming Hui Guo-Qing Li Fei Li Zhao-Jun Han Department of Entomology Nanjing Agricultural University Nanjing China

Two acetylcholinesterase （ace） genes have been reported in many insect species. In pests such as Helicoverpa assulta and Plutella xylostellas, acel gene encodes the predominant synaptic enzyme that is the main target of organophosphorus （OP） and carbamate pesticides. It has been reported that pesticide selection has an impact on the ace gene evolution. The domesticated silkworm, Bombyx mori, also has two ace genes. We studied ace gene expression and enzyme activities in silkworm as this has not faced pesticide selection over the past decades. The expression levels of two ace genes, Bm-acel and Bm-ace2, were estimated by quantitative real-time polymerase chain reaction. Bin-ace2 was expressed more highly than Bm-acel in all tested samples of different developmental stages or tissues, suggesting ace2, rather than acel, is the major type ofacetylcholinesterase （ACHE） in Bombyx mori. This is inconsistent with the aforementioned lepidopterons agricultural pests, partly be due to the widespread use of pesticides that may induce high expression of the acel gene in these pests. Besides high expression in the head, Bm-acel also expresses highly in the silk glands and Bm-ace2 is abundant in the germline, implying both ace genes may have potential non-hydrolytic roles in development. Furthermore, we found that the mRNA levels of two ace genes and their ratios （ace2/acel） change day to day in the first and third instars. This challenges the conventional method of estimating enzymatic activity using crude extract as an enzyme solution, as it is a mixture of ACHE 1 and ACHE2. An efficient and simple method for separating different ACHEs is necessary for reliable toxicological analyses.

关键词： acetylcholinesterase Bombyx mori expression kin quantitative real-time polymerase chain reaction (qRT-PCR)

Effect of Initiation of Basal Insulin Glargine on Glycemic Control in Patients with Diabetes: Real Life Experience from Hong Kong

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Diabetes Mellitus 2017年第3期7卷 108-120页

作者： Chi-kin Yeung Fhkcp Fhkam Wilson Wai-man Ngai Ip-tim Lau Department of Medicine Tseung Kwan O Hospital Hong Kong China Sanofi (Hong Kong) Ltd. Hong Kong China

Introduction: To assess the changes in glycemic control after initiating or switching to a basal insulin analogue in patients with diabetes mellitus. Methods: A retrospective, observational analysis was conducted using electronic data from a Hong Kong regional hospital. Data from adult patients with type 1 and 2 diabetes mellitus (T1DM and T2DM, respectively) who had been prescribed with basal insulin glargine in 2008-2010, with recorded HbA1c levels at the time of initiation, at 6 and 12 months thereafter, were analysed. Results: Data from 106 eligible patients were analysed. Substantial reduction in HbA1c and fasting sugar levels were reported in both T1DM (Δ HbA1c = 1.5%, Δ FBG = 1.3 mmol/L p < 0.05) and T2DM (Δ HbA1c = 1.2%, Δ FBG = 2.9 mmol/L p < 0.05) patients after 12 months of therapy. A total of 42% of T1DM and 26% of T2DM patients achieved HbA1c levels < 7.0%. After adjustment, T2DM patients who were insulin naive achieved a statistically greater HbA1c reduction (Δ = 1.7%) than those who previous treated with premixed or basal bolus insulin (Δ = 0.3%) (p < 0.05). Percentage of patients experiencing hypoglycaemia reduced from 69% to 62% in T1DM but increased from 26% to 36% in T2DM patients. All hypoglycaemic episodes recorded were either asymptomatic or mild and self-limiting. Only 4% of the patients discontinued treatment at the end of 12 months. Conclusions: In real life clinical practice, a single daily basal insulin analogue therapy provided effective glycemic control with an acceptable risk of mild hypoglycaemia.

关键词： Glycemic Control Insulin Initiation Insulin Glargine Type 1 Diabetes Mellitus Type 2 Diabetes Mellitus Hong Kong

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

略论《二十四孝》演变及其对东亚之影响

中国文化研究 2019年第2期 42-60页

作者： [日]金文京日本京都大学北京语言大学

《二十四孝》自产生之时起就对百姓的日常生活产生了巨大的影响,因而在后世得到了广泛的流传。本文详细梳理了《二十四孝》在五代、宋代、金代、元末、明代后期的流传演变及版本问题,并在此基础之上探究《二十四孝》在东亚各国尤其是在... 详细信息

《二十四孝》自产生之时起就对百姓的日常生活产生了巨大的影响,因而在后世得到了广泛的流传。本文详细梳理了《二十四孝》在五代、宋代、金代、元末、明代后期的流传演变及版本问题,并在此基础之上探究《二十四孝》在东亚各国尤其是在日本的流传情况。

关键词：《二十四孝》《孝行录》东亚比较文化日本文学