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Ethanolic extract of cashew apple inhibits lipid metabolism and ameliorates obesity in atherogenic diet-induced obese rats

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Asian Pacific Journal of Tropical Biomedicine 2019年第10期9卷 405-414页

作者： Thatiparthi Jhansyrani Dodoala Sujatha Koganti Bharathi kvsrg prasad Department of Pharmacology Institute of Pharmaceutical TechnologySri Padmavati Mahila VisvavidyalayamTirupati-517502Andhra PradeshIndia

Objective:To evaluate the anti-obesity activity of ethanolic extract of cashew apple using various in vitro and in vivo ***:Phytochemical screening was carried out in ethanolic extract of cashew apple,followed by quantification of phenol and *** potential was evaluated using 2,2-diphenyl-1-picrylhydrazyl and 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid)scavenging *** inhibitory effect of ethanolic extract of cashew apple on atic lipase was also *** addition,anti-obesity activity was determα-amylase and pancreined in two in vivo models,lipid emulsion model and atherogenic diet-induced obese rat *** of postprandial plasma triglycerides were assessed in lipid emulsion model,whereas serum lipid profile,in vivo antioxidants and histopathological studies of the carotid artery and liver were performed in an atherogenic diet-induced obese ***:Phytochemical screening revealed the presence of carbohydrates,alkaloids,polyphenols,terpenoids,and *** in vitro assays showed inhibition of *** extract of cashew appα-amylase and pancreatic lipase and strong antioxidant ple showed significant and timedependent inhibitory activity on postprandial triglycerides after administration of lipid emulsion for 5 *** extract of cashew apple at 200 and 400 mg/kg on day 60 showed a significant reduction in body weight,body mass index and atherogenic index,whereas lipid profile and liver function marker levels in the serum were decreased in a dose-dependent manner at time intervals(day 0,20,40,and 60)compared to the atherogenic diet-induced obese *** observations showed reduced non-alcoholic fatty liver deposits and decreased atherosclerotic fatty streak plaques(carotid artery)after treatment with ethanolic extract of cashew ***:Ethanolic extract of cashew apple ameliorates obesity,which may be partly mediated by its delayed absorption of cholesterol and carbohydrates

关键词： Anacardium occidentale Atherogenic diet Lipid emulsion Lipid profile Obesity

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