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Application of quantitative estimates of fecal hemoglobin concentration for risk prediction of colorectal neoplasia

World Journal of Gastroenterology 2013年第45期19卷 8366-8372页

作者： Chao-sheng Liao Yu-Min Lin Hung-Chuen Chang Yu-Hung Chen Lee-Won Chong Chun-Hao Chen Yueh-Shih Lin kuo-Ching Yang Chia-Hui Shih Division of Gastroenterology Department of Internal Medicine Shin Kong Wu Ho-Su Memorial Hospital Taipei 111 Taiwan School of Medicine Fu Jen Catholic University New Taipei City 24205 Taiwan Department of Family Medicine Shin Kong Wu Ho-Su Memorial Hospital Taipei 111 Taiwan Health Management Center Shin Kong Wu HoSu Memorial Hospital Taipei 111 Taiwan Chang Gung Institute of Technology School of Nursing Tao-Yuan 333 Taiwan

AIM:To determine the role of the fecal immunochemical test(FIT),used to evaluate fecal hemoglobin concentration,in the prediction of histological grade and risk of colorectal ***:We enrolled 17881 individuals who attended the two-step colorectal cancer screening program in a single hospital between January 2010 and October *** was recommended to the participants with an FIT of≥12 ngHb/mL *** classified colorectal lesions as cancer(C),advanced adenoma(AA),adenoma(A),and others(O)by their colonoscopic and histological *** linear regression analysis adjusted for age and gender was used to determine the association between the FIT results and colorectal tumor *** risk of adenomatous neoplasia was estimated by calculating the positive predictive values for different FIT ***:The positive rate of the FIT was 10.9%(1948/17881).The attendance rate for colonoscopy was 63.1%(1229/1948).The number of false positive results was *** these 1229 cases,the numbers of O,A,AA,and C were 759,221,201,and 48,*** analysis revealed a positive association between histological grade and FIT concentration(β=0.088,P0.95,P<0.001).CONCLUSION:Higher FIT concentrations are associated with more advanced histological *** prediction for colorectal neoplasia based on individual FIT concentrations is significant and may help to improve the performance of screening programs.

关键词： Colorectal cancer Fecal immunochemical test Screening Risk prediction Performance

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In-beam gamma rays of CSNS Back-n characterized by black resonance filter

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NUCLEAR SCIENCE AND TECHNIQUES 2024年第10期35卷 1-12页

作者： Wang, Jin-Cheng Ren, Jie Jiang, Wei Ruan, Xi-Chao Liu, Ying-Yi Yang, Hao-Lan Xu, kuo-Zhi Pan, Xin-Yi Sun, Qi Bao, Jie Huang, Han-Xiong Bai, Hao-Fan Bai, Jiang-Bo Cao, Ping Chen, Qi-Ping Chen, Yong-Hao Duan, Wen-Hao Fan, An-Chuan Fan, Rui-Rui Feng, Chang-Qing Gu, Min-Hao Han, Chang-Cai Han, Zi-Jie He, Guo-Zhu He, Yong-Cheng Hong, Yang Hu, Yi-Wei Jiang, Zhi-Jie Kang, Ling Lan, Chang-Lin Li, Bo Li, Feng Li, Qiang Li, Xiao Li, Yang Liu, Jie Liu, Rong Liu, Shu-Bin Liu, Yi-Na Luan, Guang-Yuan Ning, Chang-Jun Qiu, Yi-Jia Ren, Wen-Kai Ren, Zhi-Zhou Song, Zhao-Hui Sun, Kang Tan, Zhi-Xin Tang, Jing-Yu Tang, sheng-Da Wang, Li-Jiao Wang, Peng-Cheng Wang, Zhao-Hui Wen, Zhong-Wei Wu, Xiao-Guang Wu, Xuan Wu, Ze-Peng Xia, Cong Xie, Li-Kun Yi, Han Yu, Tao Yu, Yong-Ji Zhang, Guo-Hui Zhang, Hang-Chang Zhang, Qi-Wei Zhang, Xian-Peng Zhang, Yu-Liang Zhang, Zhi-Yong Zhao, Mao-Yuan Zhou, Zhi-Hao Zhu, Ke-Jun Zou, Chong China Inst Atom Energy Key Lab Nucl Data Beijing 102413 Peoples R China Chinese Acad Sci Inst High Energy Phys Beijing 100049 Peoples R China Spallat Neutron Source Sci Ctr Dongguan 523803 Peoples R China Chinese Acad Sci Inst High Energy Phys State Key Lab Particle Detect & Elect Beijing 100049 Peoples R China Univ Chinese Acad Sci Beijing 100049 Peoples R China Peking Univ Sch Phys State Key Lab Nucl Phys & Technol Beijing 100871 Peoples R China Fudan Univ Inst Modern Phys Shanghai 200433 Peoples R China Univ Sci & Technol China State Key Lab Particle Detect & Elect Hefei 230026 Peoples R China Univ Sci & Technol China Sch Nucl Sci & Technol Hefei 230026 Peoples R China Univ Sci & Technol China Dept Modern Phys Hefei 230026 Peoples R China China Acad Engn Phys Inst Nucl Phys & Chem Mianyang 621900 Peoples R China Univ Sci & Technol China USTC Archaeometry Lab Hefei 230026 Peoples R China Northwest Inst Nucl Technol Xian 710024 Peoples R China Lanzhou Univ Sch Nucl Sci & Technol Lanzhou 730000 Peoples R China Univ Sci & Technol China Inst Adv Technol Hefei 230027 Peoples R China

The back-streaming white-neutron beamline (Back-n) of the China Spallation Neutron Source is an essential neutron- research platform built for the study of nuclear data, neutron physics, and neutron applications. Many types of cross-sectional neutron-reaction measurements have been performed at Back-n since early 2018. These measurements have shown that a significant number of gamma rays can be transmitted to the experimental stations of Back-n along with the neutron beam. These gamma rays, commonly referred to as in-beam gamma rays, can induce a non-negligible experimental background in neutron-reaction measurements. Studying the characteristics of in-beam gamma rays is important for understanding the experimental background. However, measuring in-beam gamma rays is challenging because most gamma-ray detectors are sensitive to neutrons; thus, discriminating between neutron-induced signals and those from in-beam gamma rays is difficult. In this study, we propose the use of the black resonance filter method and a CeBr3 scintillation detector to measure the characteristics of the in-beam gamma rays of Back-n. Four types of black resonance filters, Ta-181, Co-59, Ag-nat, and Cd-nat, were used in this measurement. The time-of-flight (TOF) technique was used to select the detector signals remaining in the absorption region of the TOF spectra, which were mainly induced by in-beam gamma rays. The energy distribution and flux of the in-beam gamma rays of Back-n were determined by analyzing the deposited energy spectra of the CeBr3 scintillation detector and using Monte Carlo simulations. Based on the results of this study, the background contributions from in-beam gamma rays in neutron-reaction measurements at Back-n can be reasonably evaluated, which is beneficial for enhancing both the experimental methodology and data analysis.

关键词： In-beam gamma rays Back-n Black filter resonance technique In-beam gamma rays Back-n CeBr3 scintillator Black filter resonance technique C6D6 DETECTOR SYSTEM LINE

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Evaluation of the role of H pylori infection in pathogenesis of gastric cancer by immunoblot assay

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World Journal of Gastroenterology 2006年第43期12卷 7029-7032页

作者： kuo-Ching Yang Alexander Chu Chao-sheng Liao Yu-Min Lin Gen-Min Wang Division of Gastroenterology Department of Internal Medicine Shin Kong Wu Ho-Su MemorialHospitalTaipei Taiwan China Taipei Medical University Taipei TaiwanChina

AIM： To elucidate the different serological reactions to H pylori using the immunoblotting technique for further understanding of its pathogenic role in gastric cancer. METHODS： A total of 54 patients were divided into two groups after upper gastrointestinal endoscopy： normal control group （25 patients） and gastric cancer group （29 patients）. Both groups were further divided into Hpylori （＋） and H pylori （-） subgroups based on the results of CLO test, Giemsa staining and culture. Sera were further analyzed with the immunoblotting technique （HelicoBIot 2.0, Genelabs Diagnostics, Singapore）. RESULTS： The positive rate of the immunoblotting test was as high as 88.9% in the H pylori （-） gastric cancer group and only 14.3% in the H pylori （-） normal control group with a statistically significant difference. CONCLUSION： The prevalence of H pylori infection is higher in gastric cancer patients than in the normal controls, suggesting that H pylori may play a role in the pathogenesis of gastric cancer.

关键词： Western blot Immunoblotting Gastric cancer Hpylori Enzyme-linked immunosorbent assay

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应力对La_(0.83)Sr_(0.17)MnO_3薄膜输运性能的影响

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物理学报 2006年第3期55卷 1435-1440页

作者：江阔李合非宫声凯北京航空航天大学材料学院北京100083

采用溶胶-凝胶方法在Si(111)上制备了LSMO(x=0.17)薄膜.研究了块体材料和不同厚度薄膜R-T曲线、红外光谱和X射线衍射.结果表明,LSMO薄膜属于正交晶体结构,薄膜取向与膜厚度有关,当膜厚度为450nm或680nm时,主要取向〈200〉,而膜厚度为90... 详细信息

采用溶胶-凝胶方法在Si(111)上制备了LSMO(x=0.17)薄膜.研究了块体材料和不同厚度薄膜R-T曲线、红外光谱和X射线衍射.结果表明,LSMO薄膜属于正交晶体结构,薄膜取向与膜厚度有关,当膜厚度为450nm或680nm时,主要取向〈200〉,而膜厚度为900nm时取向为〈020〉:根据离子对相互作用能和谐振子模型,得到了红外吸收与Mn—O—Mn键长和键角关系式,600cm-1附近红外吸收与晶格常数b的变化有关;块体与薄膜的金属—绝缘体转变温度(TMI)存在较大差别,薄膜转变温度显著低于块体,并与厚度有一定关系.认为是LSMO薄膜中的应力诱导了晶格常数变化,引起键角改变及JT效应是转变温度变化的主要原因.

关键词：单晶硅晶格常数金属-绝缘体转变温度应力诱导

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Prediction value of radiosensitivity of hepatocarcinoma cells for apoptosis and micronucleus assay

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World Journal of Gastroenterology 2005年第44期11卷 7036-7039页

作者： Zhi-Zhong Liu Wen-Ying Huang Xiao-sheng Li Ju-sheng Lin Xiao-Kun Cai kuo-Huang Lian He-Jun Zhou Tongji Hospital Tongji Medical CollegeHuazhong University of Science and Technology Wuhan 430030Hubei Province China The People's Hospital of Chenzhou City Chenzhou 423000 Hunan Province China Xiehe Hospital Tongji Medical CollegeHuazhong University of Science and Technology Wuhan 430030Hubei Province China

AIM： To investigate the prediction value of radiosensitivity of hepatocarcinoma cells for apoptosis and rnicronucleus assay. METHODS： Clonogenic assay, flow cytometry, and CB micronuclei assay were used to survey the cell survival rate, radiation-induced apoptosis and rnicronucleus frequency of hepatocarcinorna cell lines SMMC-7721, HL-7702, and HepG2 after being irradiated by X-ray at the dosage ranging 0-8 Gy. RESULTS： After irradiation, there was a dose-effect relationship between rnicronucleus frequency and radiation dosage among the three cell lines （P〈0.05）. A positive relationship was observed between apoptosis and radiation dosage among the three cell lines. The HepG2 cells had a significant correlation （P〈0.05） but apoptosis incidence had a negative relationship with rnicronucleus frequency. There was a positive relationship between apoptosis and radiation dosage and the correlation between 5MMC-7721 and HL-7702 cell lines had a significant difference （P〈0.01）. After irradiation, a negative relationship between cell survival rate and radiation dosages was found among the three cell lines （P〈0.01）. There was a positive relationship between cell survival rate and rnicronucleus frequency （P〈0.01）. No correlation was observed between apoptosis and cell survival rate. CONCLUSION： The radiosensiUvity of hepatocarcinoma cells can be reflected by apoptosis and rnicronuclei. Detection of apoptosis and rnicronuclei could enhance the accuracy for predicting radiosensitivity.

关键词： Hepatocarcinoma cell ticronuclei Apoptosis Radiosensitivity

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Effect of oral epidermal growth factor on mucosal healing in rats with duodenal ulcer

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World Journal of Gastroenterology 2003年第10期9卷 2261-2265页

作者： Jane CJ Chao kuo-Yu Liu sheng-Hsuan Chen Chia-Lang Fang Chih-Wei Tsan School of Nutrition and Health Sciences Taipei Medical University 110 Taiwan Department of Gastroenterology Taipei Medical University Hospital 110 Taiwan Department of Pathology Taipei Medical University 110 Taiwan Department of Surgery National Defense Medical Center Tri-Service General Hospital 110 Taiwan

AIM: To investigate the effect of epidermal growth factor (EGF) on mucosal healing in rats with duodenal ***: Male Sprague-Dawley rats were randomly divided into sham operation without EGF, sham operation with EGF, duodenal ulcer without EGF, or duodenal ulcer with EGF groups. Additionally, normal rats without operation served as the control group. Duodenal ulcer was induced in rats by 300 mL/L acetic acid. Rats with EGF were orally administered at a dose of 60 μg/kg/day in drinking water on the next day of operation (day 1). Healing of duodenal ulcer was detected by haematoxylin and eosin staining. Cell growth of damaged mucosa was determined by the contents of nucleic acids and proteins. The level of EGF in duodenal mucosa was measured by ***: The pathological results showed that duodenal ulcer rats with EGF improved mucosal healing compared with those without EGF after day 5. Duodenal ulcer rats with EGF significantly increased duodenal DNA content compared with those without EGF on day 15 (6.44±0.54mg/g VS 1.45±0.52 mg/g mucosa, P＜0.05). Duodenal RNA and protein contents did not differ between duodenal ulcer rats with and without EGF during the experimental *** operation and duodenal ulcer rats with EGF significantly increased duodenal mucosal EGF content compared with those without EGF on day 5 (76.0±13.7 ng/g VS 35.7±12.9ng/g mucosa in sham operation rats, and 68.3±10.9 ng/gVS 28.3±9.2 ng/g mucosa in duodenal ulcer rats, P＜0.05).CONCLUSION: Oral EGF can promote mucosal healing of the rats with duodenal ulcer by stimulating mucosal proliferation accompanied by an increase in mucosal EGF content.

关键词：表皮生长因子十二指肠溃汤动物实验 ELISA 十二指肠粘膜

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The effect of acupuncture at Neiguan point on the vagal modulation of the heart

The effect of acupuncture at Neiguan point on the vagal modu...

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海峡两岸中西医结合学术研讨会

作者： sheng-Teng Huang, Gau-Yang Chen, Cheng-Deng kuo, Huey-ming Lo, Jaung-Geng Lin, Ying-Shiung Lee

Department of Chinese Medicine, Chang Gung Memorial Hospital, Kaohsiung (S-T Huang MD);Graduate Institute of Clinical Medicine, Chang Gung University, Tao-Yuan (Y-S Lee MD);Department ofMedicine, Tao-Yuan General Hospital, Tao-Yuan (G-Y Chen MD PhD, H-M Lo MD);Institute of BiomedicalEngineering, National Yang-ming University, Taipei (G-Y Chen);Department of Medical Research andEducation, Veterans General Hospital-Taipei, Taipei (C-D kuo MD PhD), Acupuncture Research Center,

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新的核苷类化合物β-L-D4A及其异构体体外抗HBV作用

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中国药学杂志 2005年第16期40卷 1270-1273页

作者：吴金明林菊生章金艳梁扩寰温州医学院附属第一医院消化内科浙江温州325000 华中科技大学同济医学院同济医院肝病研究所湖北武汉430030

目的探索比较β-L-D4A(L-D4A)及其异构体体外抗HBV作用,以期获得高效、高治疗指数(TI)的新一类抗HBV化合物。方法L-D4A及其异构体干预2.2.15细胞(Hep G2细胞进行HBV基因组转染后所得)培养,ELISA法检测上清HBs Ag, HBe Ag;32p标记HBV DN... 详细信息

目的探索比较β-L-D4A(L-D4A)及其异构体体外抗HBV作用,以期获得高效、高治疗指数(TI)的新一类抗HBV化合物。方法L-D4A及其异构体干预2.2.15细胞(Hep G2细胞进行HBV基因组转染后所得)培养,ELISA法检测上清HBs Ag, HBe Ag;32p标记HBV DNA为探针,Southern印迹法检测上清液及细胞内HBV DNA,再以计算机图像处理进行定量分析,求出50%抑制的药物浓度(ED50)。洗去HBV探针后,以32P标记细胞色素氧化酶ⅢDNA为探针再次进行杂交,以探索线粒体的毒性。以MTT法检测不同浓度药物的细胞毒性,求出50%细胞抑制的药物浓度(ID50)。结果上清液病毒DNA的Southern印迹结果显示,L型异构体较之D型异构体具有更强的HBV DNA抑制作用,L-D4A最为突出,并呈显明显的浓度依赖性,计算出ED50为0.2μmol·L-1;D-D4A具有明显的线粒体毒性,L-D4A则不明显;L-D4A细胞毒性实验显示ID50为200μmol·L-1;低浓度L-D4A对上清HBs Ag,HBe Ag无明显的影响,高浓度时有显著的抑制作用。结论体外实验显示L-D4A具有明显的抑制病毒DNA复制作用,且无明显的细胞毒性和线粒体毒性,TI(ID50/ED50)值为1 000,高于拉米夫定组(TI值为750),将有望进一步得到开发。

关键词：核苷类化合物 β-L-双脱氧双脱氢腺苷乙肝病毒

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Estradiol agonists inhibit human Lo Vo colorectal-cancer cell proliferation and migration through p53

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World Journal of Gastroenterology 2014年第44期20卷 16665-16673页

作者： Hsi-Hsien Hsu Wei-Wen kuo Da-Tong Ju Yu-Lan Yeh Chuan-Chou Tu Ying-Lan Tsai Chia-Yao Shen sheng-Huang Chang Li-Chin Chung Chih-Yang Huang Division of Colorectal Surgery Mackay Memorial Hospital Mackay Junior College of Medicine Nursing and Management Department of Biological Science and Technology China Medical University Department of Neurological Surgery Tri-Service General Hospital National Defense Medical Center Department of Pathology Changhua Christian Hospital Division of Chest Medicine Department of internal Medicine Armed Force Taichung General Hospital National Taiwan Sport University Athletic Training and Health Department Department of Nursing Mei Ho University Tsao-Tun Psychiatric Center Department of Health Executive Yuan Department of Hospital and Health Care Administration Chia Nan University of Pharmacy and Science Graduate Institute of Chinese Medical Science China Medical University Graduate Institute of Basic Medical Science China Medical University Department of Health and Nutrition Biotechnology Asia University

AIM: To investigate the effects of 17β-estradiol via estrogen receptors (ER) or direct administration of ER agonists on human colorectal cancer.

关键词： Estrogen Estrogen agonist Estrogen receptors Human colon cancer cell p53

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802.11无线网状网中基于时频信道的准动态信道分配算法

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电子与信息学报 2009年第6期31卷 1465-1469页

作者：李争平郭更生北京邮电大学网络和交换技术国家重点实验室北京100876

该文首次在多天线多信道802.11无线网状网中提出了时频信道的概念。时频信道是通过在时间和频率两个维度划分无线资源取得的。这种划分方法增加了信道数量,使信道划分更加精细,为提高系统的信道利用率做了准备。在时频信道的基础上,提... 详细信息

该文首次在多天线多信道802.11无线网状网中提出了时频信道的概念。时频信道是通过在时间和频率两个维度划分无线资源取得的。这种划分方法增加了信道数量,使信道划分更加精细,为提高系统的信道利用率做了准备。在时频信道的基础上,提出了准动态信道分配算法。该算法可以和现有的固定信道分配算法结合,实现准动态信道分配,根据链路上负载变化,取得最大的吞吐量。该算法先根据固定信道分配算法为各链路分配相同数量的时频信道,剩余部分当作公共信道。在通信过程中,各链路首先使用分配给自己的信道和空闲的公共信道。如果分配给一个链路的信道不够,且别的链路上的信道有空闲,该链路还可以暂时使用这些空闲信道。理论分析和仿真结果证明该算法可以有效提高系统的吞吐量。

关键词：无线网状网时频信道信道分配算法吞吐量

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