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肾小球足细胞裂孔膜蛋白在肾移植大鼠慢性移植肾肾病中的作用

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中华移植杂志（电子版） 2009年第4期3卷 331-331页

作者：季曙明 Pippin J kumar v Stein A 不详

进展性蛋白尿和肾小球硬化是慢性移植肾肾病(chronic allograft nephropathy, CAN)的特征性表现.足细胞是蛋白尿最主要的物理和电荷屏障,它的损伤可导致蛋白尿和肾小球硬化.尽管足细胞在局灶节段性肾小球硬化、膜性肾病、微小病变和糖... 详细信息

进展性蛋白尿和肾小球硬化是慢性移植肾肾病(chronic allograft nephropathy, CAN)的特征性表现.足细胞是蛋白尿最主要的物理和电荷屏障,它的损伤可导致蛋白尿和肾小球硬化.尽管足细胞在局灶节段性肾小球硬化、膜性肾病、微小病变和糖尿病肾病中的地位已经得到证实,但是其在CAN中的作用机制目前仍知之甚少.美国研究者利用大鼠肾移植模型试图解释足细胞损伤在CAN中的作用.

关键词：肾移植裂孔膜蛋白足细胞同种脏层上皮细胞睾丸移植肾大鼠肾病泌尿系统疾病

Novel PA encapsulated PCL hybrid coating for corrosion inhibition of biodegradable Mg alloys:A triple triggered self-healing response for synergistic multiple protection

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Journal of Magnesium and Alloys 2023年第4期11卷 1440-1460页

作者： Navdeep Singh Grewal Uma Batra Kamal kumar Anil Mahapatro Department of Metallurgical and Materials Engineering Punjab Engineering CollegeChandigarh 160012India Department of Mechanical Engineering Punjab Engineering CollegeChandigarh 160012India Department of Biomedical Engineering Wichita State UniversityWichitaKS 67260USA

Surface coatings have been extensively used to control the degradation rate of Mg alloys for bioimplant ***,these coatings only act as passive *** corrosive media,structural damage impairs their barrier properties,resulting in rapid degradation of Mg *** present study incorporates phytic acid(PA)as a healing agent in polycaprolactone(PCL)microcapsules with a unique honeycomb core matrix to obtain a self-healing PA-PCLcaps *** contact between simulated body fluid(SBF)and PA-PCLcaps coated ZM21 exhibited Cassie-Baxter interfacial states,resulting in significant hydrophobicity with a contact angle(CA)of *** corrosion potential(Ecorr)and current density(Icorr)were found to be-0.28 v and 1.1×10^(-9)A/cm^(2),respectively,for PA-PCLcaps coating,resulting in biosafe corrosion rate of 2.5×10^(-4)mm/*** mechanical scratching,rapid HA mineralization at scratched regions recovered the hydrogen evolution rate(HER,0.36 mL/cm^(2)/day)and pH change(pH 7.10)of scratched PA-PCLcaps coated ZM21 samples to corresponding unscratched samples within one day of *** coating’s self-healing ability could be attributed to PA released from punctured microcapsules,which facilitates HA *** pH-triggered(pH 10)and Mg(II)-triggered(5 mM)conditions enhanced PA release from PA-PCLcaps coating by 2.5 and 3.1 times,*** a result,dense HA mineralization occurred,which protects the coating from structural defects and ensures its durability in stimulating *** findings of present study provide new insight for design of multiple stimuli-feedback based self-healing coatings on biodegradable Mg alloys.

关键词： Self-healing coating Corrosion resistance Magnesium alloy Phytic acid Polycaprolactone microcapsules

Renewable energy based microgrid system sizing and energy management for green buildings

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Journal of Modern Power Systems and Clean Energy 2015年第1期3卷 1-13页

作者： Y.v.PAvAN kumar Ravikumar BHIMASINGU Department of Electrical Engineering Indian Institute of Technology Hyderabad(IITH)HyderabadIndia

The objective of this paper is to model a hybrid power system for buildings,which is technically feasible and economically *** a view to promote renewable energy sources,photovoltaics and wind turbines are integrated with the grid connected *** system is modeled and the optimal system configuration is estimated with the help of hybrid optimization model for electric renewables(HOMER).The logic is illustrated with a case study based on the practical data of a building located in southern *** building is associated with 3.4 MWh/day priority load(peak load as 422 kW),as well as 3.3 MWh/day deferrable load(peak load as 500 kW).Sensitivity analysis is performed to deal with uncertainties such as the increase in electricity consumption and grid tariff,environmental changes,*** the simulation result,it is observed that the designed system is cost effective and environment friendly,which leads to 6.18%annual cost savings and reduces CO_(2) emissions by 38.3%.Sensitivity results indicate that the system is optimal and adaptable in a certain range of unanticipated variances with respect to best estimated ***,an energy management strategy is developed for the optimal system to ensure reliable power during contingency and *** green and hybrid power system designed can be adaptable to any critical and large consumers of urban buildings.

关键词： Renewable energy sources(RES) Hybrid power systems(HPS) Photovoltaic(Pv) Wind turbine(WT) Low-carbon electricity Energy management Total net present cost(TNPC)

Synthesis of Co3O4 Nanoparticles Wrapped Within Full Carbon Matrix as an Anode Material for Lithium Ion Batteries

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Acta Metallurgica Sinica(English Letters) 2018年第2期31卷 164-170页

作者： Subhalaxmi Mohapatra Shantikumar v.Nair Alok kumar Rai Amrita Centre for Nanosciences and Molecular Medicine Amrita vishwa vidyapeetham Amrita University Kochi Kerala 682041 India

A facile polyol-assisted pyro-synthesis method was used to synthesize Co3O4 nanoparticles embedded into carbon matrix without using any conventional carbon source. The surface analysis by scanning electron microscopy showed that the Co3O4 nanoparticles（-20 ± 5 nm） are tightly enwrapped within the carbon matrix. CHN analysis determined the carbon content was only 0.11% in the final annealed sample. The Co3O4@carbon exhibited high capacities and excellent cycling performance as an anode at various current rates（such as 914.4 and 515.5 mAh g^-1 at 0.25 and1.0 C, respectively, after 50 cycles; 318.2 mAh g^-1 at a high current rate of 5.0 C after 25 cycles）. This superior electrochemical performance of the electrode can be attributed to the various aspects, such as,（1） the existence of carbon matrix, which acts as a flexible buffer to accommodate the volume changes during Li^＋ion insertion/deinsertion and facilitates the fast Li^＋and electron transfer and（2） the anchoring of Co3O4 nanoparticles within the carbon matrix prevents particles agglomeration.

关键词： Co3O4 Carbon matrix Pyro-synthesis Anode Lithium ion battery

Effect of Hydrodynamic Conditions on Corrosion Inhibition of Cu-Ni(90/10)Alloy in Seawater and Sulphide Containing Seawater Using 1,2,3-Benzotriazole

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Journal of Materials Science & Technology 2014年第1期30卷 65-76页

作者： B.v.Appa Rao K.Chaitanya kumar Department of Chemistry National Institute of Technology Warangal

Electrochemical studies of the effect of hydrodynamic conditions on corrosion inhibition of Cu-Ni （90/10） alloy in synthetic seawater and sulphide containing synthetic seawater by 1,2,3-benzotriazole （BTAH） are presented. Impedance, potentiodynamic polarization and cyclic voltammetric （Cv） studies are employed in the present investigation. The studies are carried out by using Cu-Ni （90/10） alloy rotating disc electrode at different rotation speeds and at different immersion periods. Reynolds numbers at each rotation speed infer that the flow of seawater is laminar. With increasing rotation speed of the electrode immersed in seawater without sulphide and BTAH, both the charge transfer resistance （Rot） and film resistance （Rf^lm） are increased. However, in the presence of sulphide ions and without BTAH, both the Rot and Rf,m are found to decrease with increasing rotation speed at identical immersion periods. Interestingly, when BTAH is added to seawater or seawater containing sulphide, both the Rot and Rf,m are increased to such a great extent that an inhibition efficiency of 99.99% is obtained. In the presence of BTAH, the phase angle Bode plots are more broadened and the maximum values of phase angle are increased to a value close to 90~ as the rotation speed is increased. The BTAH film is highly protective even under hydrodynamic condition also. Potentiodynamic polarization studies infer that BTAH functions as a mixed inhibitor under hydrodynamic conditions also. Cv studies reveal that the protective BTAH film is stable even at anodic potentials of ＋850 mv vs Ag/AgCI.

关键词： Cu-Ni (90/10) alloy Rotating disc electrode Seawater Corrosion inhibition Electrochemical studies 1,2,3-Benzotriazole

Optimal Confidential Mechanisms in Smart City Healthcare

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Computers, Materials & Continua 2022年第3期70卷 4883-4896页

作者： R.Gopi P.Muthusamy P.Suresh C.G.Gabriel Santhosh kumar Irina v.Pustokhina Denis A.Pustokhin K.Shankar Department of Computing Science and Engineering Dhanalakshmi Srinivasan Engineering CollegePerambalur621212India School of Computing Science and Engineering Galgotias UniversityNCRDelhi203201India Department of Computer Science and Engineering KPR Institute of Engineering and TechnologyCoimbatore641407India Department of Electrical and Electronics Engineering K.Ramakrishnan College of EngineeringTiruchirappalli621112India Department of Entrepreneurship and Logistics Plekhanov Russian University of EconomicsMoscow117997Russia Department of Logistics State University of ManagementMoscow109542Russia Department of Computer Applications Alagappa UniversityKaraikudi630001India

Smart City Healthcare(SHC2)system is applied in monitoring the patient at home while it is also expected to react to their needs in a timely *** system also concedes the freedom of a *** is a part of this system and it helps in providing care to the *** healthcare devices are trustworthy since it almost certainly recognizes the potential intensifications at very early stage and alerts the patients and medical experts to such an extent that they are provided with immediate *** methodologies exhibit few shortcomings in terms of computational complexity,cost and data ***,the current research article examines SHC2 security through LightWeight Cipher(LWC)with Optimal S-Box model in PRESENT *** procedure aims at changing the sub bytes in which a single function is connected with several bytes’information to upgrade the security level through Swam *** key contribution of this research article is the development of a secure healthcare model for smart city using SHC2 security via LWC and Optimal S-Box *** study used a nonlinear layer and single 4-bit S box for round configuration after verifying SHC2 information,constrained by Mutual Authentication(MA).The security challenges,in healthcare information systems,emphasize the need for a methodology that immovably concretes the *** methodology should act practically,be an effective healthcare framework that depends on solidarity and adapts to the developing *** service providers integrated the IoT applications and medical services to offer individuals,a seamless technology-supported healthcare *** proposed SHC^(2) was implemented to demonstrate its security levels in terms of time and access *** model was tested under different parameters such as encryption time,decryption time,access time and response time inminimum ***,the level of the model and throughput were analyzed by maximum value i.e.,50Mbp

关键词： Smart city healthcare security block cipher LWC

Screening of potential GCMS derived antimigraine compound from the leaves of Abrus precatorius Linn to target“calcitonin gene related peptide”receptor using in silico analysis

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Food Science and Human Wellness 2019年第1期8卷 34-39页

作者： v.Parthasarathy T.v Ajay kumar Immunology Laboratory Department of PharmacyAnnamalai UniversityAnnamalai Nagar608002TamilnaduIndia

Calcitonin receptor-like receptor(CRLR)is a human protein,that produces a calcitonin gene-related peptide receptor(CGRP)when associates with human receptor activity-modifying protein-1(HRAMP1).CGRP is believed to be involved in triggering of *** strategies were employed to design antimigraine drug using various CGRP antagonist/ligands but most of them have failed due to their inability to reach the target“CGRP receptor”as they get metabolized before conferring their pharmacological action and exhibit toxic effect to the *** present study,evaluated the binding of 13 phyto-chemical compounds of“Abrus precatorius”identified through GCMS analysis against the protein CGRP using“Discovery Studio software”.The molecular docking study and ADME/T properties prediction were performed with the compounds using C-DOCKER *** results showed that five lead compounds of *** may act as good inhibitors for migraine headache and the compounds can be re-designed and synthesized for better antimigraine activity.

关键词： Calcitonin gene-related peptide Abrus precatorius Linn Discovery studio Migraine C-DOCKER ADME properties

Coastal upwelling off the southwest coast of India:observations and simulations

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International Journal of Digital Earth 2016年第12期9卷 1256-1274页

作者： P.v.Hareesh kumar P.Anand Naval Physical and Oceanographic Laboratory KochiKeralaIndia

Spatial hydrographic data collected from August 2007 through May 2008 and the Princeton Ocean Model(POM)are utilized to explain and document the upwelling in the south eastern Arabian Sea(SEAS).The decrease in the magnitude of winds towards the coast favors local anticyclonic vorticity,resulting in the formation of cyclonic eddy and reversal of coastal *** Ekman transport due to alongshore winds,Ekman pumping due to wind stress curl,cyclonic eddy and southward West Indian Coastal Currents play different roles in the SEAS *** the offshore,wind stress curl leads to the formation of meso-scale eddies,resulting in Ekman pumping at the center and consequent *** rapid depth variation on the western side of Quilon Mount intensifies upwelling in the *** upwelling Kelvin waves generated at the equator terminates in the Bay of Bengal and do not contribute to the SEAS *** possible role of local and remote winds,especially around Sri Lanka on the upwelling dynamics of SEAS is described utilizing *** Kelvin waves generated off the coast of Sri Lanka during the active phase of the summer monsoon also contribute to the upwelling dynamics off the west coast of India.

关键词： Southeastern Arabian Sea coastal upwelling Upwelling Kelvin wave West Indian coastal currents 3-D circulation model

Numerical and experimental investigation on aluminum 6061-vgrooved stainless steel 304 explosive cladding

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Defence Technology（防务技术） 2022年第2期18卷 249-260页

作者： C.Wilson dhileep kumar S.Saravanan K.Raghukandan Department of Mechanical Engineering Annamalai UniversityAnnamalainagarTamilnadu608002India Department of Manufacturing Engineering Annamalai UniversityIndia

This study attempts to analyze the microstructure and interface behavior of aluminum 6061(Al 6061)-vgrooved stainless steel(SS304)explosive cladding by numerical and experimental *** simulation was performed by Smoothed Particle Hydrodynamics(SPH)technique,in ANSYS AUTODYN,and the results are correlated with experimental *** machining of v-grooves on the base plate transform the melted layer formed in conventional cladding(without grooves on the base plate)into a smooth undulating interface,for a similar experimental *** flyer plate and collision velocities,observed in numerical simulation,are in good agreement to the analytical *** pressure developed in the flyer plate is higher than the base plate and the maximum pressure is witnessed at the collision point irrespective of grooved base plate or *** temperature developed in the collision point of conventional explosive cladding exceeds the melting point of both the participant metals,whereas,it exceeds the melting point of aluminum alone,in case of v-grooved base plate *** shear and impact strengths of the v-grooved base plate clads are higher than the conventional clads and the fracture surfaces exhibit mixed modes of fracture.

关键词： Explosive cladding Dissimilar metals Grooves Numerical simulation Interface Strength