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Effect of amitriptyline on gastrointestinal function and brain-gut peptides: A double-blind trial

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World Journal of Gastroenterology 2013年第26期19卷 4214-4220页

作者： Wei Huang Shu-man Jiang Lin Jia le-Qing You Yao-Xing Huang Yan-Mei Gong Gui-Qin Wang Department of Gastroenterology Guangzhou First People's Hospital Guangzhou Medical University Department of Radiology Guangzhou First People's Hospital Guangzhou Medical University Department of Statistics Guangzhou First People's Hospital Guangzhou Medical University

AIM: To study the effects of low-dose amitriptyline (AMT) on gastrointestinal function and brain-gut peptides in healthy Chinese volunteers. METHODS: This was a double-blind, randomised, placebo-controlled, two-period cross-over trial. Twentyeight healthy volunteers were randomised and administered 1-wk treatments of AMT (12.5 mg tid) or placebo. Before and during the final two days of treatment, gastric emptying, proximal gastric accommodation and visceral sensitivity were measured by drinkingultrasonography test; the orocecal transit time (OCTT) was measured by lactulose hydrogen breath test, and fasting blood was collected. Plasma levels of ghrelin, motilin and neuropeptide Y (NPY) were measured by enzyme-linked immunosorbent assay ***: AMT slowed the OCTT (109.2 ± 29.68 min vs 96.61 ± 23.9 min, P = 0.004) but did not affect liquid gastric emptying and had no effect on proximal gastric accommodation. AMT resulted in decreases in the visual analogue scale (VAS) for difficulty in drinking 600 and 800 mL of water (3.57 ± 0.94 vs 2.98 ± 0.85, 5.57 ± 0.82 vs 4.57 ± 0.98, P level (442.87 ± 176.79 pg/mL vs 526.87 ± 158.44 pg/mL, P = 0.04) and the neuropeptide-Y level (890.15 ± 131.46 pg/mL vs 965.64 ± 165.63 pg/mL, P = 0.03), whereas it had no effect on the MTL level. CONCLUSION: Low-dose AMT could slow OCTT, make the stomach less sensitive and increase the plasma levels of ghrelin and NPY. Thus, we recommend the use of low-dose AMT for functional gastrointestinal disorders.

关键词： Amitriptyline Orocecal transit time Visceral hypersensitivity Gastric emptying Brain-gut peptides

An idiopathic hypogonadotropic hypogonadism patient with metabolic disorder and diabetes： case report

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Asian Journal of Andrology 2015年第2期17卷 341-342页

作者： man-Na Zhang Bin Su Chun-Hua Qian le Bu Xiao-Yun Cheng Wen-Jun Li Shen Qu Department of Endocrinology and Metabolism Shanghai Tenth People's HospitalTongji University School of Medicine 301 Middle Yanchang RoadShanghai 200072 China.

Dear Editor, Congenital idiopathic hypogonadotropic hypogonadism （CIHH） is a rare congenital disorder characterized by delayed or absent sexual maturation and infertility associated with inappropriately low gonadotropin and sex steroid levels. We report a 34-year-old patient with CIHH accompanying with metabolic syndrome （MS） and diabetes.

关键词： @@

Electrodeposition of rare refractory metals in low-temperature ionic liquids

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Rare Metals 2024年第10期43卷 4921-4933页

作者： Lin-Lin Wang Han-Dong Jiao Rui Yuan le-Yang Li man-Peng Lin Rui-Yang Sun Jiu-San Xiao Shu-Qiang Jiao Institute of Advanced Structure Technology Beijing Institute of TechnologyBeijing 100081China State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China

Rare refractory metals(RRMs)play a significant role in fundamental industries,including electronics,chemical industry,machinery,etc.,and future advanced fields,such as aerospace and ***,the traditional production processes of RRMs based on high-temperature thermal reduction cannot meet the requirements of low-energy *** dilemma could be addressed efficiently by using a low-temperature electrodeposition strategy in ionic liquids(ILs).This review summarizes a panoramic view of the latest developments on the electrodeposition of RRMs in ILs after a brief review on the current industrial production methods of *** on this,the electrochemical mechanism occurring at the cathode during the electrodeposition process of RRMs in different electrolytes and under different conditions is thoroughly discussed,because it is crucial for the successful production of pure *** addition,this review not only analyses the main challenges that hinder the industrial application of the electrodeposition of RRMs in ILs,but also proposes corresponding *** hope this review can provide a valuable guidance for the fundamental research and industrial development of lowtemperature electrodeposition of RRMs.

关键词： Rare refractory metals Ionic liquids Electrodeposition Production process

Endogenous ceramide phosphoethanolamine modulates circadian rhythm via neural-glial coupling in Drosophila

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National Science Review 2022年第12期9卷 104-123页

作者： Xiupeng Chen Jie Li Zhongbao Gao Yang Yang Wenqing kuang Yue Dong Gek Huey Chua Xiahe Huang Binhua Jiang He Tian Yingchun Wang Xun Huang Yan Li Sin man Lam Guanghou Shui State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental Biology Chinese Academy of Sciences University of Chinese Academy of Sciences State Key Laboratory of Brain and Cognitive Science Institute of Biophysics Chinese Academy of Sciences Lipid ALL Technologies Company Limited

While endogenous lipids are known to exhibit rhythmic oscillations,less is known about how specific lipids modulate circadian *** a series of loss-of-function and gain-of-function experiments on cer amide phosphoethanolamine(CPE) synthase of Drosophila,we demonstrated that pan-glial-specific deficiency in membrane CPE,the structural analog of mammalian sphingomyelin(SM),leads to arrhythmic locomotor behavior and shortens lifespan,while the reverse is true for increasing *** proteomics uncovered dysregulated synaptic glutamate utilization and transport in CPE-deficient *** extensive genetic screen was conducted to verify the role of differentially expressed proteins in circadian *** locomotion under cpes1mutant background was rescued only by restoring endogenous CPE or SM through expressing their respective *** results underscore the essential role of CPE in maintaining synaptic glutamate homeostasis and modulating circadian behavior in *** findings suggest that region-specific elevations of functional membrane lipids can benefit circadian regulation.

关键词： ceramide phosphoethanolamine sphingomyelin circadian longevity glutamate homeostasis

Photoexcitation dynamics and energy engineering in supramolecular doping of organic conjugated molecules

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Light(Science & Applications) 2023年第2期12卷 183-193页

作者： Xiang An Chuanxin Wei Lubing Bai Jun Zhou le Wang Yamin Han Lili Sun Jinyi Lin Heyuan Liu Jiewei Lil man Xu Haifeng Ling Linghai Xie Wei Huang Key Laboratory of Flexible Electronics(KLOFE)&Institute of Advanced Materials(IAM) Nanjing Tech University(NanjingTech)30 South Puzhu RoadNanjing 211816China State Key Laboratory of Organic Electronics and Information Displays&Institute of Advanced Materials(IAM) Nanjing University of Posts&Telecommunications9 Wenyuan RoadNanjing 210023China College of Science and Institute of New Energy China University of Petroleum(East China)Qingdao 266580China Shaanxi Institute of Flexible Electronics(SIFE) Northwestern Polytechnical University(NPU)127 West Youyi RoadXi'an 710072 ShaanxiChina

Doping and blending strategies are crucial means to precisely control the excited states and energy level in conjugated molecular ***,effective models and platforms are rarely proposed to systematically explore the effects of the formation of trapped doped centers on heterogeneous structures,energy level and ultrafast photophysical ***,for deeply understanding the impact of molecular doping in film energy levels and photoexcitation dynamics,we set a supramolecular N-B coordination composed by the conjugated molecules of pyridine functionalized diarylfluorene(host material),named as ODPF-Phpy and ODPF-(Phpy)2,and the molecule of tris(perfluorophenyl)borane(BCF)(guest material).The generation of the molecular-level coordination bond increased the binding energy of N atoms and tuned the band-gap,leading to a new fluorescent emission center with longer excitation wavelength and emission *** intermolecular Forster resonance energy transfer(FRET)in blending flms make it present inconsistent fluorescent behaviors compared to that in *** charge transfer(CT)state of N-B coordinated compounds and the changed dielectric constant of blending films resulted in a large PL spectra red-shift with the increased dopant ratio,causing a wide-tunable fluorescent *** excited state behaviors of two compounds in blending system was further investigated by the transient absorption(TA)***,we found supramolecular coordination blending can effectively improve the films'photoluminescence quantum yield(PLQY)and *** believe this exploration in the internal coordination mechanisms would deepen the insights about doped semiconductors and is helpful in developing novel high-efficient fluorescent systems.

关键词： spectroscopy. solution. excitation

Revolution of vitamin E production by starting from microbial fermented farnesene to isophytol

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The Innovation 2022年第3期3卷 73-79页

作者： Ziling Ye Bin Shi Yanglei Huang Tian Ma Zilei Xiang Ben Hu Zhaolin kuang man Huang Xiaoying Lin Zhu Tian Zixin Deng Kun Shen Tiangang Liu Key Laboratory of Combinatorial Biosynthesis and Drug Discovery Ministry of Education and School of Pharmaceutical SciencesWuhan UniversityWuhan 430071China J1 Biotech Co. Ltd.Wuhan 430075China

Vitamin E is one of the most widely used *** the classical commercial synthesis of vitamin E(a-tocopherol),the chemical synthesis of isophytol is the key technical ***,we establish a new process for isophytol synthesis from microbial fermented *** achieve an efficient pathway for farnesene production,Saccharomyces cerevisiae was selected as the host ***,b-farnesene synthase genes from different sources were screened,and through protein engineering and system metabolic engineering.

关键词： strain synthesis starting

Boundless love:a German Professor Uli Schwarz in China

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Protein & Cell 2024年第8期15卷 553-558页

作者： le Kang State Key Laboratory of Integrated management of Pest Insects and Rodents Institute of ZoologyChinese Academy of SciencesBeijing 100101China

More than 20 years ago,an old German man embarked on a quest to explore the suburbs of Shanghai and the villages of jiangsu Province in search of antique Chinese *** was not a mere antique collector or aficionado of ancient furmiture,but a German scientist motivated by his profound love of Chinese *** name was Uli Schwarz(Fig.1),a distinguished German scientist who had dedicated the majority of his life to promoting cross-cultural scientific exchanges,an effort that left an indelible mark on the landscape of research collaborations between China and Germany.

关键词： Schwarz German landscape

Early colon cancer within a diverticulum treated by magnifying chromoendoscopy and laparoscopy

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World Journal of Gastroenterology 2010年第12期16卷 1545-1547页

作者： kuang I Fu Yukihiro Hamahata Yasunobu Tsujinaka Department of Coloproctology Tokatsu-Tsujinaka Hospital Department of Gastroenterology Juntendo University Nerima Hospital

We report a unique case of intramucosal carcinoma in a tubulovillous adenoma arising from a single *** mucosal resection(EMR)was carried out successfully and completely with the assistance of laparoscopy.A 71-year-old man was admitted to our hospital because of melena and *** colonoscopy showed diverticulosis in the right-sided ***,endoscopy could not exactly detect the bleeding site.A flat elevated polyp was found within a single diverticulum located in the descending colon and diagnosed as an intramucosal carcinoma,as magnifying chromoendoscopy revealed a type Ⅳ pit *** his diverticular bleeding repeated,a rightsided hemicolectomy was decided for treatment,the polyp within the diverticulum was also completely removed by EMR with the assistance of *** a colonic perforation was detected immediately after EMR,the perforation was closed with endoclips intraluminally and also repaired laparoscopically from the serosal ***,the resected lesion was an intramucosal well-differentiated adenocarcinoma and the surgical margin was free of tumor.

关键词： Early colon cancer Diverticulum Magnifying chromoendoscopy Endoscopic mucosal resection Laparoscopy

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论庄子的生死观

河北大学学报（哲学社会科学版） 2016年第6期41卷 122-127页

作者：况晓慢首都师范大学文学院北京100089 河北大学教务处河北保定071002

以"生死一体"与"安之若命"两个截然相反的命题为出发点,探索庄子对待生死的态度。庄子在"无为而为"的自觉意识中将生命历程的个体体验塑造成一个中心圆的世界,生和死是起点和终点的重合,死生成为一体。安之若命是生命得以延续、实现生... 详细信息

以"生死一体"与"安之若命"两个截然相反的命题为出发点,探索庄子对待生死的态度。庄子在"无为而为"的自觉意识中将生命历程的个体体验塑造成一个中心圆的世界,生和死是起点和终点的重合,死生成为一体。安之若命是生命得以延续、实现生命之自然价值的无可奈何之举,其最终目的是突破生死而得"道",超越自我达到无待,实现逍遥的精神价值。

关键词：生死命自然逍遥