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Assessing gray matter volume in patients with idiopathic rapid eye movement sleep behavior disorder

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Neural Regeneration Research 2019年第5期14卷 868-875页

作者： Xian-Hua Han Xiu-Ming Li Wei-Jun Tang Huan Yu Ping Wu Jing-Jie Ge Jian Wang Chuan-Tao Zuo kuang-Yu shi PET Center Huashan Hospital Fudan University Department of Radiology Huashan Hospital Fudan University Department of Neurology Huashan Hospital Fudan University Department of Nuclear Medicine Technical University Munich

Idiopathic rapid eye movement sleep behavior disorder(iRBD) is often a precursor to neurodegenerative disease. However, voxel-based morphological studies evaluating structural abnormalities in the brains of iRBD patients are relatively rare. This study aimed to explore cerebral structural alterations using magnetic resonance imaging and to determine their association with clinical parameters in iRBD patients. Brain structural T1-weighted MRI scans were acquired from 19 polysomnogram-confirmed iRBD patients(male:female 16:3; mean age 66.6 ± 7.0 years) and 20 age-matched healthy controls(male:female 5:15; mean age 63.7 ± 5.9 years). Gray matter volume(GMV) data were analyzed based on Statistical Parametric Mapping 8, using a voxel-based morphometry method and two-sample t-test and multiple regression analysis. Compared with controls, iRBD patients had increased GMV in the middle temporal gyrus and cerebellar posterior lobe, but decreased GMV in the Rolandic operculum, postcentral gyrus, insular lobe, cingulate gyrus, precuneus, rectus gyrus, and superior frontal gyrus. iRBD duration was positively correlated with GMV in the precuneus, cuneus, superior parietal gyrus, postcentral gyrus, posterior cingulate gyrus, hippocampus, lingual gyrus, middle occipital gyrus, middle temporal gyrus, and cerebellum posterior lobe. Furthermore, phasic chin electromyographic activity was positively correlated with GMV in the hippocampus, precuneus, fusiform gyrus, precentral gyrus, superior frontal gyrus, cuneus, inferior parietal lobule, angular gyrus, superior parietal gyrus, paracentral lobule, and cerebellar posterior lobe. There were no significant negative correlations of brain GMV with disease duration or electromyographic activity in iRBD patients. These findings expand the spectrum of known gray matter modifications in iRBD patients and provide evidence of a correlation between brain dysfunction and clinical manifestations in such patients. The protocol was approved by the Et

关键词： nerve regeneration idiopathic rapid eye movement sleep behavior disorder synucleinopathies magnetic resonance imaging gray matter volume statistic parametric mapping voxel-based morphometry structure Parkinson’s disease neurodegenerative diseases neural regeneration

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制浆造纸工业的节能技术

中国造纸 2010年第10期29卷 56-63页

作者：邝仕均中国制浆造纸研究院北京100020

简要介绍了制浆造纸工业已经采用或有可能采用的一些节能技术。

关键词：制浆造纸工业节能技术

Interfering cellular oxidation equilibrium with Iridium（Ⅲ） prodrug

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Interfering cellular oxidation equilibrium with Iridium（Ⅲ...

“单独两孩”政策对人口出生性别比的影响效应分析

中国化学会第十四届全国生物无机化学学术会议

作者： shi kuang Liangnian Ji Hui Chao MOE Key Laboratory of Bioinorganic and Synthetic Chemistry School of Chemistry Sun Yat-Sen University

We herein report a novel iron（Ⅲ） activated, anticancer, iridium prodrug. This complex contains a m-imino catechol group which can selectively bond to, and be oxidized by, free iron（Ⅲ） inside the cell. Subsequent oxidative rearrangement releases iron（Ⅱ） and hydrolysis of the amine bond, in acidic conditions, produces an aminobipyridyl iridium complex and o-hydroxy-p-benzoquinone. This chain of reactions has a threefold effect. First iron（Ⅱ） can catalyze the decomposition of hydrogen peroxide into hydroxyl radicals. Second, benzoquinone compounds can interfere with the respiratory chain. Third, the conversion of the prodrug to the amino-iridium complex reveals a remarkable increase in luminescence. These properties, as well as the high iron（Ⅲ） content and acidity of cancer cells, make Ir-diol a highly selective and efficient theranostic agent. To the best of our knowledge, Ir-diol is the first metal-based compound that has been developed for chemotherapy using iron（Ⅲ） to enhance both selectivity and potency.

关键词： Iron Iridium Theranostics

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人口学刊 2015年第4期37卷 5-11页

作者：黄匡时中国人口与发展研究中心北京100081

如果生育控制政策会导致出生性别比升高,那么"单独两孩"等生育调整政策必然会对出生性别比升高的势头产生缓解效应。为了检验这一假设,本研究采用2014年各省(区、市)的最新数据来探讨单独两孩政策对出生性别比的影响。结果发现,单独两... 详细信息

如果生育控制政策会导致出生性别比升高,那么"单独两孩"等生育调整政策必然会对出生性别比升高的势头产生缓解效应。为了检验这一假设,本研究采用2014年各省(区、市)的最新数据来探讨单独两孩政策对出生性别比的影响。结果发现,单独两孩政策对一胎出生性别比有缓解作用,但对二胎出生性别比可能存在恶化的效应。因为单独两孩政策实际上给了有男孩偏好的单独夫妇一次选择性生育的机会,客观上恶化了二孩出生性别比。因此,治理出生性别比的关键在于改变男孩生育偏好的生育文化。

关键词：单独两孩政策出生性别比生育政策

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臭氧轻ECF漂白

中国造纸 2013年第5期32卷 50-54页

作者：邝仕均中国制浆造纸研究院北京100102

介绍了臭氧漂白的发展概况、臭氧高浓漂白和中浓漂白技术、臭氧漂白工艺运行参数和采用臭氧漂白的优点,并指出臭氧轻ECF漂白可能是应对要求日益严格的废水排放标准的首选漂白方案。

关键词：漂白臭氧漂白臭氧轻ECF

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改革开放以来北京市流动人口研究回顾与展望

北京社会科学 2008年第5期 72-79页

作者：黄匡时北京市人口研究所北京100044

改革开放30年来,北京市流动人口的规模一直并将继续扩大;并由城区、近郊区向远郊区县扩散;来京流动人口表现出较强烈的留京愿望。在此基础上,我们认为应加强对流动人口统计方法和在京流动人口社会政策建构等方面的研究,加强对在京流动... 详细信息

改革开放30年来,北京市流动人口的规模一直并将继续扩大;并由城区、近郊区向远郊区县扩散;来京流动人口表现出较强烈的留京愿望。在此基础上,我们认为应加强对流动人口统计方法和在京流动人口社会政策建构等方面的研究,加强对在京流动人口需求的调查,着重解决流动人口的就业、住房、社会保障等难题,转变管理理念和工作模式,促进在京流动人口的社会融合。

关键词：流动人口农民工外来人口暂住人口人口政策

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桉树木材性质对其硫酸盐法制浆性能的影响

中国造纸 2011年第12期30卷 51-54页

作者：邝仕均中国制浆造纸研究院北京100061

讨论了桉木的木材密度、木素含量、木素的紫丁香基和愈创木基比值(S/G)、抽提物含量、聚木糖和糖醛酸含量等重要木材性质对其硫酸盐法制浆行为的影响。

关键词：桉木硫酸盐法制浆

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2015年世界造纸工业概况

中国造纸 2017年第1期36卷 62-66页

作者：邝仕均中国制浆造纸研究院北京100102

本文对2015年全球纸和纸板、纸浆的生产及消费情况,世界范围内纸浆、废纸及各主要纸种的贸易情况进行了简要分析和介绍。

关键词：造纸生产及消费贸易

Bodipy Modifided ruthenium(Ⅱ) complexes with outstanding one and two-photon photodynamic therapeutic effect under low light dose

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Bodipy Modifided ruthenium(Ⅱ) complexes with outstanding on...