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Nano chloroquine delivery against Plasmodium berghei NK65 induced programmed cell death in spleen

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Asian Pacific Journal of Tropical Medicine 2018年第9期11卷 540-546页

作者： Satyajit Tripathy Sourav Chattopadhyay Sandeep kr.Dash Motlalepula G.Matsabisa Somenath Roy Immunology and Microbiology Laboratory Department of Human Physiology with Community HealthVidyasagar University Department of Pharmacology University of the Free State B.S.B.E.Indian Institute of Technology University of Gour Banga

Objective:To compare the protective effects of chitosan-trypolyphosphate(CS-TPP) nanoparticle conjugated chloroquine(CQ) with effect of CQ alone on the reversal of splenic damages and induction of ***:Different researches have been carried out to explore the potential role of chitosan based drug delivery system against parasitic *** successive Plasmodium berghei NK65 parasiste infection by intraperitoneal injection in Swiss mice and subsequent parasite development,the ROS generation,anti-apoptotic and pro apoptotic protein levels in spleen were *** analyze caspases,flow cytometry study was performed with annexin 桋-FITC and with PI ***:The results revealed that ROS mediated caspase 3 and 9 activation and the induction of apoptosis occurred during the parasitic ***,CS-TPP conjugated CQ was relatively better in reversing the splenic damage compared with similar effects of CQ ***:This study indicates that Plasmodium berghei NK65 induces apoptosis in the *** study further shows that CS-TPP nanoparticles conjugation with CQ have positive influence on the recovery of damaged host's system towards maintenance of normal homeostasis,and this is shown to be selective to CS-TPP conjugated CQ treated animals only.

关键词： Splenocyte Apoptosis Nano chloroquine Plasmodium berghei Chitosan

Correct Interpretation of Creep Rates: A Case Study of Cu

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Journal of Materials Science & Technology 2015年第11期31卷 1065-1068页

作者： W.Blum J.Dvoák P.král P.Eisenlohr V.Sklenika Institut für Werkstoffwissenschaften University of Erlangen-Nürnberg Institute of Physics of Materials Academy of Sciences of the Czech Republic Department of Chemical Engineering and Materials Science Michigan State University

Traditionally the deformation resistance in creep is characterized by the minimum creep rate εmin and its sensitivity to stress （stress exponent n） and temperature （activation energy Q）. Various values of constant n have been reported in the literature and interpreted in terms of specific mechanisms. The present case study of coarse-grained Cu at 573 K yields a stress exponent n = 9 for εmin. in tension and a relatively low activation energy. The evolution of the deformation resistance with strain at constant tensile creep load and comparison with creep in compression without fracture indicates that the tensile εmin. result from transition from uniform deformation to strain localization during fracture. This is confirmed by the results of creep in compression where fracture is suppressed. Both the tensile εmin, and the compressive creep rate at strains around 0.3 can be described using existing equations for quasi-stationary deformation containing the subgrain boundary misorientation θ as structure parameter. While in the latter case constant θ leads to monotonic increase of n with stress, the tensile nine-power-law results from variable θ, and has no simple meaning. The result of this case study means that uncritical interpretation of minimum tensile creep rates as stationary ones bears a high risk of systematic errors in the determination of creep parameters and identification of creep mechanisms.

关键词： Cu Creep Minimum creep rate Activation energy Stress exponent

Corrosion and mechanical properties of a novel biomedical WN43magnesium alloy prepared by spark plasma sintering

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Journal of Magnesium and Alloys 2021年第3期9卷 853-865页

作者： Michal Knapek Mária Zemková Adam Gres Eva Jablonská Frantisek Lukác Robert král Jan Bohlen Peter Minárik Charles University Faculty of Mathematics and PhysicsKe Karlovu 512116 PragueCzech Republic Nuclear Physics Institute of CAS Řež13025068ŘežCzech Republic University of Chemistry and Technology Department of Biochemistry and MicrobiologyTechnická5Prague16628 PragueCzech Republic Institute of Plasma Physics of CAS Za Slovankou 318200 PragueCzech Republic Helmholtz-Zentrum Geesthacht Magnesium Innovation Centre(MagIC)D21502 GeesthachtGermany

Alloying of Mg with rare-earth(RE)elements proved to be beneficial for their in-vitro and in-vivo *** this work,a novel WN43(Mg-4 wt%Y-3 wt%Nd)alloy with a well-defined composition was prepared,where,unlike in the commercial WE43 alloy,the possibly harmful RE mischmetal was substituted by less toxic Nd.A modern spark plasma sintering(SPS)technique was used to effectively produce WN43 samples from atomized *** temperatures of 400℃-550℃ and holding times of 3 or 10 min were used and wellcompacted final materials were successfully *** was shown that a superior combination of corrosion and mechanical properties was attained in the samples sintered at 500℃ and 550℃,while the effect of sintering time was rather *** performance of this material was exceptional within the group of Mg alloys prepared by powder metallurgy and comparable with conventionally prepared ***,it was shown that a great variety of mechanical and corrosion characteristics can be obtained by altering the SPS parameters so as to fulfill case-specific requirements typical of biomedical ***,the novel WN43 alloy prepared by SPS seems to be a particularly suitable material for biomedical use.

关键词： Magnesium Biocompatibility Powder Sintering Corrosion Rare earth element

Quality of life after curative liver resection: A single center analysis

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World Journal of Gastroenterology 2010年第19期16卷 2388-2395页

作者： Helge Bruns Kirsten krtschmer Ulf Hinz Anette Brechtel Monika Keller Markus W Büchler Peter Schemmer Department of General Surgery Ruprecht-Karls-University 69120 Heidelberg Germany Psychosomatic Medicine Section Psychooncology Ruprecht-Karls-University 69120 Heidelberg Germany

AIM: To evaluate quality of life (QoL) after curative liver resection and identify variables associated with decreased QoL. METHODS: From October 2001 to July 2004, 323 patients underwent liver resection. At 3-36 mo after discharge, 188 patients were disease free. QoL was assessed using the Short Form (SF)-12 Health Survey with mental and physical component scales (SF-12 MCS and PCS), supplemented with generic questions concerning pain and liver-specific items. RESULTS: Sixty-eight percent (128/188) returned the questionnaire, which was completed in 75% (96/128) of cases. Median SF-12 PCS and MCS were 46.7 (inter- quartile range: 34.2-53.9) and 54.1 (42.8-58.2). Fifty percent were pain free with a median symptom score of 1.75 (1.38-2.13). PCS was higher after major hepatec-tomy [57% (55/96)] compared to minor resection (P = 0.0049), which represented an improved QoL. QoL was not affected by sex but by age compared to the general German population. MCS was higher after liver surgery for metastatic disease [55.9 (47.5-58.8)] compared to primary carcinoma [49.6 (36.5-55.1)] and benign disease [49.2 (37.7-56.3)] (P = 0.0317). There was no correlation between length of postoperative period and QoL. Pain, def iciencies in everyday life and a high symptom score significantly decreased MCS and PCS. CONCLUSION: Most patients were only marginally affected even after major liver resection; however, minor complications were associated with decreased SF-12 MCS and PCS and need careful attention.

关键词： Quality of life Liver resection

Impact of antibacterial drugs on human serum paraoxonase-1(hPON1)activity:an in vitro study

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Asian Pacific Journal of Tropical Biomedicine 2014年第8期4卷 603-609页

作者： Hakan Syt Elif Duygu Kaya Skr Beydemir Department of Primary Education Faculty of EducationBayburt University69000 BayburtTurkey Department of Food Engineering Faculty of EngineeringIgdir University76000 lgdirTurkey Department of Chemistry Faculty of ScienceAtatrk University25240 ErzurumTurkey

Objective:To investigate the in vitro effects of the antihacterial drugs,mcropenem *** sodium,and cefoperazone sodium,on the activity of human serum paraoxonase ***:hPQN1 was purified from human serum using simple chromatographic *** DEAE-Sephadex anion exchange and Sephadex G-200 gel filtration ***:The three antihacterial drugs decreased in vitro hPON1 *** mechanisms meropcnem trihydrate was noncompetitive while piperacillin sodium and cefoperazone sodium were ***:Our results showed that antihacterial drugs significantly inhibit hPON1 activity,both in vitro,with rank order meropenem trihydrate piperacillin sodium cefoperazone sodium in vitro.

关键词： Paraoxonase Inhibition Meropenem trihydrate Piperacillin sodium Cefoperazone sodium

Inhibition of Cdk5 increases osteoblast differentiation and bone mass and improves fracture healing

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Bone Research 2022年第3期10卷 469-481页

作者： Mubashir Ahmad Benjamin Thilo krüger Torsten kroll Sabine Vettorazzi Ann-kristin Dorn Florian Mengele Sooyeon Lee Sayantan Nandi Dilay Yilmaz Miriam Stolz Naveen Kumar Tangudu David Carro Vázquez Johanna Pachmayr Ion Cristian Cirstea Maja Vujic Spasic Aspasia Ploubidou Anita Ignatius Jan Tuckermann Institute of Comparative Molecular Endocrinology(CME) Ulm UniversityHelmholtzstrasse 8/189081 UlmGermany Institute of Orthopedic Research and Biomechanics Ulm UniversityHelmholtzstrasse 1489081 UlmGermany Leibniz Institute on Aging–Fritz Lipmann Institute(FLI) Beutenbergstrasse 11D-07745 JenaGermany Praxisklinik für Orthopädie Unfall-und Neurochirurgie Prof.Bischoff/Dr.Spies/Dr.Mengele89231 Neu-UlmGermany Paracelsus Medizinische Privatuniverstät Institute of PharmacyStrubergasse 215020 SalzburgAustria Department of Endocrinology Ludwig Maximilians University MunichMunich 80336Germany Present address:Institute of Orthopedic Research and Biomechanics Ulm UniversityHelmholtzstrasse 1489081 UlmGermany Present address:UPMC Hillman Cancer Center Department of Pharmacology and Chemical BiologyUniversity of Pittsburgh5115 Center Avenue15232 PittsburghPAUSA Present address:TAmiRNA GmbH Leberstrasse 201110 ViennaAustria

Identification of regulators of osteoblastogenesis that can be pharmacologically targeted is a major goal in combating osteoporosis,a common disease of the elderly population. Here, unbiased kinome RNAi screening in primary murine osteoblasts identified cyclin-dependent kinase 5(Cdk5) as a suppressor of osteoblast differentiation in both murine and human preosteoblastic cells. Cdk5 knockdown by si RNA, genetic deletion using the Cre-lox P system, or inhibition with the small molecule roscovitine enhanced osteoblastogenesis in vitro. Roscovitine treatment significantly enhanced bone mass by increasing osteoblastogenesis and improved fracture healing in mice. Mechanistically, downregulation of Cdk5 expression increased Erk phosphorylation, resulting in enhanced osteoblast-specific gene expression. Notably, simultaneous Cdk5 and Erk depletion abrogated the osteoblastogenesis conferred by Cdk5 depletion alone, suggesting that Cdk5 regulates osteoblast differentiation through MAPK pathway modulation. We conclude that Cdk5 is a potential therapeutic target to treat osteoporosis and improve fracture healing.

关键词： Cdk5 healing expression

Constraining Forces Causing the Meissner Effect

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Journal of Modern Physics 2017年第8期8卷 1134-1142页

作者： Ekkehard krüger Institut für Materialwissenschaft Materialphysik Universit&auml t Stuttgart Stuttgart Germany

As shown in former papers, the nonadiabatic Heisenberg model presents a novel mechanism of Cooper pair formation which is not the result of an attractive electron-electron interaction but can be described in terms of quantum mechanical constraining forces. This mechanism operates in narrow, roughly half-filled superconducting bands of special symmetry and is evidently responsible for the formation of Cooper pairs in all superconductors. Here we consider this new mechanism within an outer magnetic field. We show that in the magnetic field the constraining forces produce Cooper pairs of non-vanishing total momentum with the consequence that an electric current flows within the superconductor. This current satisfies the London equations and, consequently, leads to the Meissner effect. This theoretical result is confirmed by the experimental observation that all superconductors, whether conventional or unconventional, exhibit the Meissner effect.

关键词： Superconductivity Meissner Effect Nonadiabatic Heisenberg Model Time Inversion in a Magnetic Field Constraining Forces

Supersonic Shock Wave with Landau Quantization in a Relativistic Degenerate Plasma

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Chinese Physics Letters 2020年第1期37卷 34-38页

作者： M.kr.Deka A.N.Dev Department of Applied Sciences Gauhati UniversityGuwahati-781014AssamIndia Center for Applied Mathematics and Computing Siksha O Anusandhan(Deemed to be University)Bh u baneswar-751030OdishaIndia

A three-dimensional(3D)BurgersJ equation adopting perturbative methodology is derived to study the evolution of a shock wave with Landau quantized magnetic field in relativistic quantum *** characteristics of a shock wave in such a plasma under the influence of magnetic quantization,relativistic parameter and degenerate electron density are studied with assistance of steady state *** magnetic field has a noteworthy control,especially on the shock wave's amplitude in the lower range of the electron density,whereas the amplitude in the higher range of the electron density reduces *** rate of increase of shock wave potential is much higher(lower)with a magnetic Held in the lower(higher)range of electron *** the relativistic factor,the shock wave's amplitude increases significantly and the rate of increase is higher(lower)for lower(higher)electron *** combined effect of the increase of relativistic factor and the magnetic field on the strength of the shock wave,results in the highest value of the wave potential in the lower range of the degenerate electron density.

关键词： density. solution. relativistic

Structural Performance Evaluation Procedure for Large Flexible Airship of HALE Stratospheric Platform Conception

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Journal of Shanghai Jiaotong university(Science) 2007年第2期12卷 293-300页

作者：陈务军肖微微 Bernd krplin Andreas KunzeInst.of Static and Dynamic for Aerospace Structures Univ.of Stuttgart Germany Space Structures Research Centre-SSRC Shanghai Jiaotong Univ. Inst.of Static and Dynamic for Aerospace Structures Univ.of StuttgartGermany

Basic loads applied on the airship envelope were *** resultant forces,the static bending moment and the dynamic bending moment were *** on classic linear elastic membrane theory,the procedures to calculate the minimum pressure were proposed for sufficient rigidity *** limit load capacity was further investigated,and the related formula were ***,the stress and internal forces analysis was carried out for cylindrical and non-cylindrical approximations of envelope hull of *** present research is very valuable to the overall preliminary design of airship and further research.

关键词：同温层飞艇平台结构评价