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从天而降的大冰期

新发现 2020年第4期 76-85页

作者： helene gelot 黄雅琴(编译) 不详

大约4.6亿年前,地球经历了次大冰期——巧合的是,次前所未有的生命大灭绝同时在海洋中上演。近来有研究显示,那个漫漫长冬可能是小行星相撞连锁反应的产物。大碰撞嘭!4.66亿年前,在火星和木星之间的小行星带上,有两顺小行星发生了碰撞。

关键词：小行星带连锁反应大冰期碰撞海洋木星火星

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彼得·卒姆托的建筑美学:一种朴素的精致

缤纷 2009年第12期 102-105页

作者：葛丽丽 helene Binet

彼得·卒姆托(Peter Zumthor),瑞士建筑师,65岁,获得了今年普立兹克建筑奖。这是当今建筑界的最高荣誉。或许,对于非建筑领域的人来说,这个名字是陌生的,远不及扎哈、赫尔佐格、安德鲁等明星建筑师的知名度。的确,在西方的"明星"建筑师... 详细信息

彼得·卒姆托(Peter Zumthor),瑞士建筑师,65岁,获得了今年普立兹克建筑奖。这是当今建筑界的最高荣誉。或许,对于非建筑领域的人来说,这个名字是陌生的,远不及扎哈、赫尔佐格、安德鲁等明星建筑师的知名度。的确,在西方的"明星"建筑师当中,卒姆托算是个独特的人物。生为金牛座的他性格内敛,作风低调,一直与主流保持距离。

关键词：建筑美学建筑奖赫尔佐格扎哈彼得当今建筑普利兹柯布西耶艺术博物馆普立

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查令十字街84号

疯狂英语（新悦读） 2018年第4期 22-25页

作者： helene Hanff 陈建铭

伦敦有很多奇妙的地址,比如会破案的贝克街221B、有魔法的国王十字车站9？站台,以及卖旧书的查令十字街84号.这本被奉为“爱书之人必读”的书信体小说其实是美国小说家海莲·汉芙的亲身经历-她在报纸上看到一家二手书店的广告,兴冲冲地... 详细信息

伦敦有很多奇妙的地址,比如会破案的贝克街221B、有魔法的国王十字车站9？站台,以及卖旧书的查令十字街84号.这本被奉为“爱书之人必读”的书信体小说其实是美国小说家海莲·汉芙的亲身经历-她在报纸上看到一家二手书店的广告,兴冲冲地给对方写信咨询,很快便收到店主弗兰克的恳切回复,由此开启了一段长达20年的书信交心。

关键词：书信体小说二手书店亲身经历小说家弗兰克海莲

Racial Demographics in an Urban Movement Disorders Clinic

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Advances in Parkinson's Disease 2017年第3期6卷 86-92页

作者： Chantale O. Branson Luke Quehl Raymond James Janice Weinberg Anna D. Hohler Marie-helene Saint-Hilaire Department of Neurology Boston University Medical Center Boston MA USA Boston University School of Medicine Boston MA USA Boston University School of Public Health Boston MA USA

Objective: To assess the prevalence of Parkinson’s disease (PD) among African- Americans compared to non-Hispanic Whites in a tertiary urban Movement Disorders center. Background: Contributing factors in the prevalence of Parkinson’s disease (PD) based on race may improve health disparities in the United States. According to the largest study analyzing prevalence and incidence of PD among Medicare beneficiaries, the ratio of African-Americans (AA) to Caucasians in the general Medicare population is 9%, while the prevalence ratio of PD among AA compared to Caucasians is approximately 5%. Methods: We performed a retrospective analysis of African-American patients with PD in the movement disorders database at Boston Medical Center, which is the largest safety net hospital in New England. The demographics of the patients seen in the general neurology clinic are 30.57% AA and 38.06% non-Hispanic Caucasian. Results: The Movement disorders database included 488 patients, 327 of whom had PD. Of these, 287 were Caucasians and 18 were of African descent. Based on our clinic population the expected PD case ratio among AA compared to Caucasians was approximately 49%. The actual race ratio in patients of African descent compared to Caucasian was 6%, which was substantially lower than expected at Boston Medical Center. Conclusion: The demographics of the PD patients in our movement disorders clinic do not reflect the population at Boston Medical Center, or the demographics of our neurology clinic as a whole.

关键词： Racial Demographics Urban Movement Disorders Clinic

Evaluation of the Effects of Corticosteroids on Histamine Release by ex Vivo Cutaneous Microdialysis

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Journal of Cosmetics, Dermatological Sciences and Applications 2013年第3期3卷 228-233页

作者： Carol Courderot-Masuyer Sophie Robin helene Tauzin Sylvain Harbon Sophie Mac-Mary Alexandre Guichard Patrice Muret Philippe Humbert Bioexigence SARL Espace Lafayette8 rue Alfred de VignyBesanconFrance Plastic Surgery 9 rue KleinSaint Vincent ClinicBesanconFrance Skinexigence SAS immeuble Bioparc2 rue du Dr Paul MilleretBesanconFrance Research and Clinicl Center on the Tegument(CERT Clinical Investigation Center(CIC BT506) Department of DermatologyBesancon University HospitalBesanconFrance Laboratory of Clinical and Toxicology Pharmacology Jean Minjoz University HospitalBesanconFrance University of Franche-Comte Inserm U1098SFR FED 4234 IBCTBesanconFrance

The purpose of the study was to evaluate the effects of corticosteroids on histamine release and to compare their potency with the MacKenzie classification based on their vasoconstrictor effects. Thanks to ex Vivo cutaneous microdialysis, we studied histamine-induced release over a period of time on excised abdominal skin from women. Eight corticosteroids were topically applied with occlusive dressing onto the skin, above probes, before anti-IgE injection. Histamine levels were assessed by an EIA method. In order to compare the different corticosteroids, AUC was calculated allowing an estimation of the amount of released histamine for 60 min of ex vivo cutaneous microdialysis. Diflucortolone 0.1% and micronized betamethasone dipropionate 0.05% are considered as corticosteroids with high potency in MacKenzie classification. Betamethasone dipropionate associated with propylene glycol 0.05%, belongs to a stronger class in Mackenzie classification. Our results showed that the decrease in histamine release was more important with difluocortolone than with both of these corticosteroids. Therefore there was no correlation between the vasoconstrictor potency of topical corticosteroids and their ability to inhibit histamine release.

关键词： MacKenzie Test Corticosteroids ex Vivo Cutaneous Microdialysis Histamine