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FK506 contributes to peripheral nerve regeneration by inhibiting neuroinflammatory responses and promoting neuron survival

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Neural Regeneration Research 2025年第7期20卷 2108-2115页

作者： Yuhui kou zongxue Jin Yusong Yuan Bo Ma Wenyong Xie Na Han Department of Trauma and Orthopedics Peking University People’s HospitalBeijingChina National Center for Trauma Medicine Peking University People’s HospitalBeijingChina Key Laboratory of Trauma and Neural Regeneration(Peking University) Ministry of EducationBeijingChina Trauma Medicine Center Peking University People’s HospitalBeijingChina Department of Orthopedics China-Japan Friendship HospitalBeijingChina

FK506(Tacrolimus)is a systemic immunosuppressant approved by the *** and Drug ***506 has been shown to promote peripheral nerve regeneration,however,its precise mechanism of action and its pathways remain *** this study,we established a rat model of sciatic nerve injury and found that FK506 improved the morphology of the injured sciatic nerve,increased the numbers of motor and sensory neurons,reduced inflammatory responses,markedly improved the conduction function of the injured nerve,and promoted motor function *** findings suggest that FK506 promotes peripheral nerve structure recovery and functional regeneration by reducing the intensity of inflammation after neuronal injury and increasing the number of surviving neurons.

关键词： FK506 inflammation motor neurons nerve regeneration neuron peripheral nerve injury sensory neurons

16.48% Efficient solution-processed CIGS solar cells with crystal growth and defects engineering enabled by Ag doping strategy

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Journal of Energy Chemistry 2025年第1期100卷 59-65页

作者： Mengyu Xu Shaocong Yan Ting Liang Jia Jia Shengjie Yuan Dongxing kou Zhengji Zhou Wenhui Zhou Yafang Qi Yuena Meng Litao Han Sixin Wu Key Laboratory for Special Functional Materials of MOE National & Local Joint Engineering Research Centre for High-efficiency Display and Lighting Technology School of Nanoscience and Materials Engineering Henan University

Solution-processed Cu（In,Ga）Se2（CIGS） solar cells suffer from serious carrier recombination and power conversion efficiency（PCE） loss because of the poor film properties and easy formation of ***, we propose Ag&Se co-selenization strategy to enhance the crystallization and passivate harmful defects of the CIGS films. The formation of Ag-Se phase during the selenization process enables the formation of large grains and suppresses the deep level defects. It is found that Ag doping can enlarge the depletion region width, lower the Urbach energy and prolong the carrier lifetime. As a result, a champion solution-processed CIGS solar cell presents a high efficiency of 16.48% with the highly improved opencircuit voltage（VOC） of 662 m V and fill factor（FF） of 75.8%. This work provides an efficient strategy to prepare high quality solution-processed CIGS films for high-performance CIGS solar cells.

关键词： Cell engineering

High-performance sandwiched hybrid solid electrolytes by coating polymer layers for all-solid-state lithium-ion batteries

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Rare Metals 2021年第11期40卷 3175-3184页

作者： Zhi-Yan kou Yan Lu Chang miao Jie-Qiong Li Cheng-Jin Liu Wei Xiao College of Chemistry and Environmental Engineering Yangtze UniversityJingzhou 434023China School of Mechanical MaterialsMechatronic and Biomedical EngineeringAustralian Institute for Innovative MaterialsInstitute for Superconducting and Electronic MaterialsUniversity of WollongongWollongongNSW 2522Australia

Poly(vinylidenefluoride-co-hexafluoropropylene)(P(VDF-HFP))/Li_(1.3)Al_(0.3)Ti_(1.7)(PO_(4))_(3)(LATP)/P(VDFHFP) sandwiched hybrid solid electrolytes were precisely tailored and successfully fabricated to assemble into allsolid-state lithium-ion batteries,which were systematically evaluated on microstructure,morphology,thermal stability and electrochemical *** sandwiched hybrid solid electrolytes can achieve intimate contact with cathode and anode electrodes to present an excellent interfacial ***,the sandwiched hybrid solid electrolytes possess flexible surface,wide electrochemical working window of 4.7 V,high ionic conductivity of 0.763 mS·cm^(-1) and high thermal stability of 460℃,which may contribute to realizing the practical application in all-solid-state lithium-ion *** assembled cells with the hybrid solid electrolytes can quickly stabilize at a specific discharge capacity of 145.4 mAh·g^(-1) at 0.1 C after only 5 cycles and present admirable rate *** addition,morphology characterizations of the sandwiched hybrid solid electrolytes after long-term cycles show a relatively integrated structure coating with a compact LATP *** investigations afford a promising strategy that the sandwiched hybrid solid electrolytes can overcome the mechanical limitations of the interface between electrodes and inorganic solid electrolytes to provide favorable properties for all-solid-state lithium-ion batteries.

关键词： Sandwiched hybrid solid electrolytes Li_(1.3)Al_(0.3)Ti_(1.7)(PO_(4))_(3) Polymer layer All-solid-state lithium-ion batteries

Pollution characteristics of ambient PM_(2.5)-bound PAHs and NPAHs in a typical winter time period in Taiyuan

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Chinese Chemical Letters 2014年第5期25卷 663-666页

作者： Rui-Jin Li Xiao-Jing kou Hong Geng Chuan Dong zong-Wei Cai Institute of Environmental Science Shanxi University State Key Laboratory of Environmental and Biological Analysis Department of ChemistryHong Kong Baptist University

The pollution characteristics of ambient fine particulate matter（PM2.5） containing polycyclic aromatic hydrocarbons（PAHs） and nitrated PAHs（NPAHs） in samples collected during a typical winter time period in Taiyuan of China were *** obtained results revealed that the mean mass concentrations of PM2.5,SPAHs（sum of 16 PAHs） and SNPAHs（sum of 3 NPAHs） on PM2.5were161.4 mg/m3,119.8 ng/m3and 0.446 ng/m3,*** ratios of PAHs and NPAHs implied that coal consumption might be the main source of the *** measured PM2.5mass concentrations,BaP equivalent toxicity（28.632 ng/m3） and individual carcinogenicity index（3.14 10 5） were much higher than those of the recommended safety standards.

关键词： PM2.5 PAHs NPAHs Taiyuan

Partial organic substitution weakens the negative effect of chemical fertilizer on soil micro-food webs

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Journal of Integrative Agriculture 2022年第10期21卷 3037-3050页

作者： LIU Han-wen ZHANG Xiao-ke ZHANG Gui-zong kou Xin-chang LIANG Wen-ju Institute of Applied Ecology Chinese Academy of SciencesShenyang 110016P.R.China University of Chinese Academy of Sciences Beijing 100049P.R.China School of Geographical Science Northeast Normal UniversityChangchun 130024P.R.China

Soil biotic communities play vital roles in enhancing soil nutrient cycling and soil ***-term excessive nitrogen(N)application is disadvantageous to the stability of soil food webs and affects arable soil health and sustainable *** organic substitution is essential to improve soil health and alleviate the disadvantages of excessive chemical ***,the biological effects of various organic amendments on soil micro-food webs are poorly *** order to explore the effects of various organic amendments including stover,biochar and manure on soil micro-food webs(microbial and nematode communities),a field plot experiment with maize having five treatments viz.,100%urea(100%N),70%urea(70%N),70%urea plus stover(Stover),70%urea plus cattle manure(Manure)and 70%urea plus biochar(Biochar)was *** treatment increased the carbon(C)to N use efficiency of soil microbes,which contributed to the retention of soil C,while Biochar treatment elevated soil organic C(SOC)and soil p ***,Biochar treatment mitigated the negative effects of soil acidification on the soil micro-food web and reduced the abundance of plant ***,the biological effect of organic amendments was distinguished from chemical fertilization(100%N and 70%N)through principal co-ordinates *** relationships among soil properties,microbial and nematode biomass in the 100%N treatment were diminished in treatments where chemical fertilizer was *** bottom-up effects on soil food webs were observed in organic substitution *** conclusion,organic amendments improved soil fertility by regulating soil microbial and nematode communities in the cropland ecosystem,alleviated the negative effects of chemical fertilizer on the micro-food webs and controlled the trophic cascades among soil biota.

关键词： microbial community nematode community soil micro-food webs organic substitution chemical fertilizer soil health

Evolution of microstructure in reheated coarse-grained zone of G115 novel martensitic heat-resistant steel

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Journal of Iron and Steel Research International 2022年第2期29卷 327-338页

作者： Zhong-yi Chen Zheng-zong Chen Dong-xu kou Yong-qing Li Yong-lin Ma Yi-ming Li School of Material and Metallurgy Inner Mongolia University of Science and TechnologyBaotou014010Inner MongoliaChina Institute for Special Steels China Iron and Steel Research InstituteBeijing100081China Technology Center Inner Mongolia North Heavy Industry Group Co.Ltd.Baotou014010Inner MongoliaChina Key Laboratory of Advanced Metals and Materials of Inner Mongolia of Materials and Metallurgy School Inner Mongolia University of Science and TechnologyBaotou014010Inner MongoliaChina

Based on the thermal simulation method,a systematical analysis was conducted on the effect of welding peak temperature and the cooling time that takes place from 800 to 500℃ on microstructure,precipitates,substructure and microhardness of the reheated coarse-grained heat-affected zone(CGHAZ)of G115 novel martensitic heat-resistant *** revealed from the results,the microstructure of un-altered CGHAZ(UACGHAZ)and supercritically CGHAZ(SCCGHAZ)was lath martensite,and structural heredity *** reheated CGHAZ(IRCGHAZ)exhibited martensite and over-tempered martensite,and subcritical CGHAZ(SCGHAZ)displayed martensite and under-tempered *** austenite in UACGHAZ and SCCGHAZ was transformed with the diffusion mechanism during the first thermal cycle,but with the non-diffusion mechanism during the second thermal *** this reason,A_(c1) and A_(c3) during the second thermal cycle were significantly lower than those during the first thermal cycle,and A_(c1) and A_(c3) were reduced by nearly 14 and 44℃,*** the content and stability of the austenite alloy during the second thermal cycle of IRCGHAZ were lower than those during the first thermal cycle,M_(s) increased by nearly 30℃.There were considerable precipitates in the over-tempered region of IRCGHAZ,and the Laves phase was contained,which was not conducive to high-temperature creep ***,the dislocation density and the number of sub-grains in the region were lower,resulting in a sharp decrease in the microhardness,and it was the weak area in the reheated CGHAZ.

关键词： Heat-resistant steel G115 steel Reheated coarse-grained heat-affected zone Microstructure evolution Precipitate

Cascade degradation and electrocatalytic upcycling of waste poly(ethylene terephthalate)to valued products

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Nano Research 2025年第1期18卷 76-93页

作者： Xin Li Zirui Jiang zongkui kou John Wang Shiyou Zheng School of Materials and Chemistry University of Shanghai for Science and TechnologyShanghai 200093China School of Materials Science and Engineering Wuhan University of TechnologyWuhan 430070China Department of Materials Science and Engineering National University of SingaporeSingapore 117574Singapore

The global annual production of poly(ethylene terephthalate)(PET)has reached 82 million tons,yet only a small fraction(less than 20%)is *** ultra-slow degradation rate of PET results in the accumulation of PET waste in the environment,causing serious plastic pollution and posing severe challenges to *** response,great efforts have been directed toward developing a cascade degradation and electrocatalytic upcycling strategy,which serves as a“waste-towealth”*** strategy involves electro-reforming PEThydrolyzed intermediates or using PET pyrolyzed products as electrocatalysts to generate high-value *** review provides an overview of the state-of-the-art strategies for the“degradation-electrocatalytic upcycling(De-eUp)”of PET ***,an introduction to the strategy is provided,categorizing it into two main frameworks:“pyrolysis-electrocatalytic upcycling”and“hydrolysis-electrocatalytic upcycling”.The section on“pyrolysis-electrocatalytic upcycling”delves into the degradation methods for designing derived carbon nanomaterials and their utilization as high-performance ***“hydrolysis-electrocatalytic upcycling”section discusses recent advancements in electro-reforming of PET hydrolyzed intermediates for the production of C_(1) and C_(2) *** review concludes by examining the challenges and future prospects in developing an efficient and economical PET upcycling *** is anticipated that this review will stimulate further progress in plastic waste valorization.

关键词： poly(ethylene terephthalate)waste electrocatalytic upcycling pyrolysis hydrolysis ethylene glycol oxidation reaction

Prognostic implications of ferroptosis-associated gene signature in colon adenocarcinoma

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World Journal of Clinical Cases 2021年第29期9卷 8671-8693页

作者： Yan-Dong miao Zhi-Yong kou Jiang-Tao Wang Deng-Hai Mi The First Clinical Medical College Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Oncology The First Affiliated Hospital of Kunming Medical UniversityKunming 650000Yunnan ProvinceChina Dean’s Office Gansu Academy of Traditional Chinese MedicineLanzhou 730000Gansu ProvinceChina

BACKGROUND Colon adenocarcinoma(COAD)is one of the most common and fatal malignant tumors,which increases the difficulty of prognostic ***,new biomarkers for the diagnosis and prognosis of COAD should be *** is a recently identified programmed cell death process that has the characteristics of iron-dependent lipid peroxide ***,the predictive value of ferroptosis-related genes(FRGs)for COAD still needs to be further *** To identify some critical FRGs and construct a COAD patient prognostic signature for clinical *** The Cancer Genome Atlas database(TCGA)and Gene Expression Omnibus databases were the data sources for mRNA expression and corresponding COAD patient clinical *** expressed FRGs were recognized using R and Perl *** constructed a multi-FRG signature of the TCGA-COAD cohort by performing a univariate Cox regression and least absolute shrinkage and selection operator Cox regression *** patients from the Gene Expression Omnibus cohort were utilized for *** Our research showed that most of the FRGs(85%)were differentially expressed between the corresponding adjacent normal tissues and cancer tissues in the TCGA-COAD *** FRGs were related to overall survival(OS)in the univariate Cox analysis(all P1,P<0.01).The predictive capacity of the model was verified by a receiver operating characteristic curve *** addition,a nomogram based on the expression of five hub FRGs and risk score can precisely predict the OS of individual COAD cancer p

关键词： Colon adenocarcinoma Ferroptosis Immune status Prognosis Overall survival

Nondeterministic Probabilistic Petri Net -- A New Method to Study Qualitative and Quantitative Behaviors of System

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Journal of Computer Science & Technology 2013年第1期28卷 203-216页

作者： Yang Liu Huai-kou miao Hong-Wei Zeng Yan Ma Pan Liu School of Computer Engineering and Science Shanghai University Shanghai 200072 China School of Information Science and Technology Taishan University Taian 271021 China State Key Laboratory of Novel Software Technology Nanjing University Nanjing 210093 China

There are many variants of Petri net at present, and some of them can be used to model system with both function and performance specification, such as stochastic Petri net, generalized stochastic Petri net and probabilistic Petri net. In this paper, we utilize extended Petri net to address the issue of modeling and verifying system with probability and nondeterminism besides function aspects. Using probabilistic Petri net as reference, we propose a new mixed model NPPN （Nondeterministic Probabilistic Petri Net） system, which can model and verify systems with qualitative and quantitative behaviours. Then we develop a kind of process algebra for NPPN system to interpret its algebraic semantics, and an action- based PCTL （Probabilistic Computation Tree Logic） to interpret its logical semantics. Afterwards we present the rules for compositional operation of NPPN system based on NPPN system process algebra, and the model checking algorithm based on the action-based PCTL. In order to put the NPPN system into practice, we develop a friendly and visual tool for modeling, analyzing, simulating, and verifying NPPN system using action-based PCTL. The usefulness and effectiveness of the NPPN system are illustrated by modeling and model checking an elaborate model of travel arrangements workflow.

关键词： nondeterminism probabilistic Petri net model checking action-based probabilistic computation tree logic