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不同年龄小儿支气管哮喘临床特征及其并发呼吸道感染的危险因素分析

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现代生物医学进展 2024年第8期24卷 1525-1529页

作者：寇晓辉杨晓林李娟赵扬扬陈欢欢河南科技大学附属黄河医院儿科二区河南三门峡472000

目的:探讨不同年龄小儿支气管哮喘临床特征及其并发呼吸道感染的危险因素。方法:选取我院2018年1月到2023年1月收治的256例支气管哮喘患儿进行研究,依照患儿年龄进行分组,将年龄0.05),低龄组患儿喘息、气促、咳嗽症状发生率和疾病严重... 详细信息

目的:探讨不同年龄小儿支气管哮喘临床特征及其并发呼吸道感染的危险因素。方法:选取我院2018年1月到2023年1月收治的256例支气管哮喘患儿进行研究,依照患儿年龄进行分组,将年龄0.05),低龄组患儿喘息、气促、咳嗽症状发生率和疾病严重程度为重度的比率明显高于高龄组(P0.05),低龄组患儿牛奶、霉菌、花草过敏率低于高龄组,低龄组患儿动物皮毛、户尘螨或粉尘螨过敏率高于高龄组(P0.05),呼吸道感染组与非呼吸道感染组患儿年龄、每半年发作次数、发病季节、静脉应用糖皮质激素、血清总Ig E、EOS计数水平对比差异显著(P<0.05);logistic回归分析结果表明:每半年发作次数≥3次、发病季节为秋冬季、静脉应用糖皮质激素、血清总Ig E<100IU/mL、EOS计数≥0.52×10^(9)/L为小儿支气管哮喘并发呼吸道感染的独立危险因素(P<0.05)。结论:不同年龄小儿支气管哮喘临床症状、病情严重程度、过敏原分布情况具有一定差异,且每半年发作次数≥3次、发病季节为秋冬季、静脉应用糖皮质激素、血清总Ig E<100IU/mL、EOS计数≥0.52×10^(9)/L为小儿支气管哮喘并发呼吸道感染的独立危险因素,针对此类患儿在哮喘急性发作期需采取相关措施预防呼吸道感染的发生。

关键词：支气管哮喘临床症状呼吸道感染危险因素

Carbon Catabolite Repressor UvCreA is Required for Development and Pathogenicity in Ustilaginoidea virens

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Rice science 2024年第2期31卷 203-214,I0029-I0031页

作者： XIE Shuwei SHI Huanbin WEN hui LIU Zhiquan QIU Jiehua JIANG Nan kou Yanjun State Key Laboratory of Rice Biology and Breeding China National Rice Research InstituteHangzhou 311400China

The rice false smut disease, caused by Ustilaginoidea virens, has emerged as a significantglobal threat to rice production. The mechanism of carbon catabolite repression plays a crucial role in theefficient utilization of carbon nutrients and enzyme regulation in the presence of complex nutritionalconditions. Although significant progress has been made in understanding carbon catabolite repression infungi such as Aspergillus nidulans and Magnaporthe oryzae, its role in U. virens remains unclear. Toaddress this knowledge gap, we identified UvCreA, a pivotal component of carbon catabolite repression,in U. virens. Our investigation revealed that UvCreA localized to the nucleus. Deletion of UvCreA resultedin decreased growth and pathogenicity in U. virens. Through RNA-seq analysis, it was found that theknockout of UvCreA led to the up-regulation of 514 genes and down-regulation of 640 genes. Moreover,UvCreA was found to be involved in the transcriptional regulation of pathogenic genes and genesassociated with carbon metabolism in U. virens. In summary, our findings indicated that UvCreA isimportant in fungal development, virulence, and the utilization of carbon sources through transcriptionalregulation, thus making it a critical element of carbon catabolite repression.

关键词： Ustilaginoidea virens virulence carbon catabolite repression Oryza sativa rice false smut

Tissue engineering for the repair of peripheral nerve injury

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Neural Regeneration Research 2019年第1期14卷 51-58页

作者： Pei-Xun Zhang Na Han Yu-hui kou Qing-Tang Zhu Xiao-Lin Liu Da-Ping Quan Jian-Guo Chen Bao-Guo Jiang Peking University People's Hospital The First Affiliated Hospital of Sun Yat-sen University School of Life Science Peking University

Peripheral nerve injury is a common clinical problem and affects the quality of life of patients. Traditional restoration methods are not satisfactory. Researchers increasingly focus on the field of tissue engineering. The three key points in establishing a tissue engineering material are the biological scaffold material, the seed cells and various growth factors. Understanding the type of nerve injury, the construction of scaffold and the process of repair are necessary to solve peripheral nerve injury and promote its regeneration. This review describes the categories of peripheral nerve injury, fundamental research of peripheral nervous tissue engineering and clinical research on peripheral nerve scaffold material, and paves a way for related research and the use of conduits in clinical practice.

关键词： nerve regeneration scaffold biomaterial stem cells nerve growth factor peripheral nerve injury peripheral nerve repair tissue engineering neural regeneration

Intraoperative single administration of neutrophil peptide 1 accelerates the early functional recovery of peripheral nerves after crush injury

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Neural Regeneration Research 2020年第11期15卷 2108-2115页

作者： Yu-Song Yuan Su-Ping Niu Fei Yu Ya-Jun Zhang Na Han Hao Lu Xiao-Feng Yin Hai-Lin Xu Yu-hui kou Department of Trauma and Orthopedics Peking University People’s HospitalPeking UniversityBeijingChina Key Laboratory of Trauma and Neural Regeneration(Peking University) Ministry of EducationBeijingChina Office of Academic Research Peking University People’s HospitalBeijingChina National and Local Joint Engineering Research Center of Orthopaedic Biomaterials Department of Bone&Joint SurgeryPeking University Shenzhen HospitalShenzhenGuangdong ProvinceChina National Center for Trauma Medicine BeijingChina Diabetic Foot Treatment Center Peking University People’s HospitalPeking UniversityBeijingChina

Neutrophil peptide 1 belongs to a family of peptides involved in innate immunity. Continuous intramuscular injection of neutrophil peptide 1 can promote the regeneration of peripheral nerves, but clinical application in this manner is not convenient. To this end, the effects of a single intraoperative administration of neutrophil peptide 1 on peripheral nerve regeneration were experimentally observed. A rat model of sciatic nerve crush injury was established using the clamp method. After model establishment, a normal saline group and a neutrophil peptide 1 group were injected with a single dose of normal saline or 10 μg/mL neutrophil peptide 1, respectively. A sham group, without sciatic nerve crush was also prepared as a control. Sciatic nerve function tests, neuroelectrophysiological tests, and hematoxylin-eosin staining showed that the nerve conduction velocity, sciatic functional index, and tibialis anterior muscle fiber cross-sectional area were better in the neutrophil peptide 1 group than in the normal saline group at 4 weeks after surgery. At 4 and 8 weeks after surgery, there were no differences in the wet weight of the tibialis anterior muscle between the neutrophil peptide 1 and saline groups. Histological staining of the sciatic nerve showed no significant differences in the number of myelinated nerve fibers or the axon cross-sectional area between the neutrophil peptide 1 and normal saline groups. The above data confirmed that a single dose of neutrophil peptide 1 during surgery can promote the recovery of neurological function 4 weeks after sciatic nerve injury. All the experiments were approved by the Medical Ethics Committee of Peking University People's Hospital, China(approval No. 2015-50) on December 9, 2015.

关键词： crush injury defensin 1 gait analysis intraoperative administration nerve conduction velocity nervous system neutrophil peptide 1 peripheral nerve injury peripheral nerve regeneration sciatic nerve tibialis anterior muscle trauma

一种设计实用分子铁磁体的有效构件——普鲁士蓝类配合物

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无机化学学报 1999年第2期15卷 141-150页

作者：寇会忠廖代正南开大学化学系

合成常温下的分子铁磁体是化学家研究的新领域。普鲁士蓝类分子铁磁体是目前最有望用于实际的一类体系。我们拟就该类配合物的设计、合成及磁性特点作一展望性评述。

关键词：分子铁磁体杂化型普鲁士蓝铁磁体配合物

Autologous transplantation with fewer fibers repairs large peripheral nerve defects

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Neural Regeneration Research 2017年第12期12卷 2077-2083页

作者： Jiu-xu Deng Dian-yin Zhang Ming Li Jian Weng Yu-hui kou Pei-xun Zhang Na Han Bo Chen Xiao-feng Yin Bao-guo Jiang Department of Orthopedics and Trauma Peking University People's Hospital Beijing China

Peripheral nerve injury is a serious disease and its repair is challenging. A cable-style autologous graft is the gold standard for repairing long peripheral nerve defects; however, ensuring that the minimum number of transplanted nerve attains maximum therapeutic effect remains poorly understood. In this study, a rat model of common peroneal nerve defect was established by resecting a 10-mm long right common peroneal nerve. Rats receiving transplantation of the common peroneal nerve in situ were designated as the in situ graft group. Ipsilateral sural nerves（10–30 mm long） were resected to establish the one sural nerve graft group, two sural nerves cable-style nerve graft group and three sural nerves cable-style nerve graft group. Each bundle of the peroneal nerve was 10 mm long. To reduce the barrier effect due to invasion by surrounding tissue and connective-tissue overgrowth between neural stumps, small gap sleeve suture was used in both proximal and distal terminals to allow repair of the injured common peroneal nerve. At three months postoperatively, recovery of nerve function and morphology was observed using osmium tetroxide staining and functional detection. The results showed that the number of regenerated nerve fibers, common peroneal nerve function index, motor nerve conduction velocity, recovery of myodynamia, and wet weight ratios of tibialis anterior muscle were not significantly different among the one sural nerve graft group, two sural nerves cable-style nerve graft group, and three sural nerves cable-style nerve graft group. These data suggest that the repair effect achieved using one sural nerve graft with a lower number of nerve fibers is the same as that achieved using the two sural nerves cable-style nerve graft and three sural nerves cable-style nerve graft. This indicates that according to the ‘multiple amplification＇ phenomenon, one small nerve graft can provide a good therapeutic effect for a large peripheral nerve defect.

关键词： nerve regeneration peripheral nerve injury peripheral nerve defect autologous nerve graft functional recovery nerve conductionvelocity sural nerve common peroneal nerve sleeve bridging suture neural regeneration

Territory maximization hypothesis during peripheral nerve regeneration

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Neural Regeneration Research 2018年第2期13卷 230-231页

作者： jiu-xu deng jian weng yu-hui kou pei-xun zhang yan-hua wang na han bao-guo jiang xiao-feng yin department of orthopedics and trauma peking university people's hospitalBeijingChina

Territory awareness refers to the notion that an organism lives in a territory, considers this territory its own, and prevents entry of other organisms. Generally, an organism maximizes its territory for best survival... 详细信息

关键词： Territory maximization hypothesis during peripheral nerve regeneration

Manipulating guest-responsive spin transition to achieve switchable fluorescence in a Hofmann-type framework

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Science China Chemistry 2024年第10期67卷 3339-3346页

作者： Xue-Ru Wu Shu-Qi Wu Zhi-Kun Liu Ming-Xing Chen Jun Tao Osamu Sato hui-Zhong kou Engineering Research Center of Advanced Rare Earth Materials(Ministry of Education) Department of ChemistryTsinghua UniversityBeijing 100084China Institute for Materials Chemistry and Engineering&IRCCS Kyushu University744 MotookaNishi-kuFukuoka 819-0395Japan Key Laboratory of Cluster Science of Ministry of Education School of Chemistry and Chemical EngineeringLiangxiang CampusBeijing Institute of TechnologyBeijing 102488China Analytical Instrumentation Center College of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China

The change of fluorescence emission manipulated by spin state transition attracts considerable attention owing to its potential applications in magneto-optical switching ***,we report two two-dimensional(2D)Hofmann-type spin crossover(SCO)metal-organic frameworks(MOFs)[Fe^(Ⅱ)(PNI)_(2){Ag^(Ⅰ)(CN)_(2)}_(2)]·CHCl_(3)(3Ag·CHCl_(3))and[FeⅡ(PNI)_(2){AuⅠ(CN)_(2)}_(2)]·CHCl_(3)(3Au·CHCl_(3))based on the fluorescent ligand N-(4-pyridylmethyl)-1,8-naphthalimide(PNI).Both complexes exhibit interesting SCO behaviors switched by guest solvent molecules,namely three-step transitions for the solvated complexes and complete onestep hysteretic SCO for the desolvated ones,verified by temperature-dependent magnetic susceptibility measurements,Mossbauer spectra,structural analyses,and differential scanning calorimetry ***,temperature-dependent fluorescence spectra exhibit double peaks(monomer and excimer emission)with both emission peaks change consistent with the change in SCO properties during the solvent molecule *** this study,we integrated guest-responsive SCO behavior into MOFs to manipulate the multistability of spin state and fluorescence switching,providing a rational strategy for the development of stimuli-responsive multifunctional materials.

关键词： spin crossover fluorescence multifunctional materials metal-organic frameworks Hofmann-type

Synthesis of thiol-functionalized TiO_2 nanocomposite and photocatalytic degradation for PAH under visible light irradiation

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Chinese Chemical Letters 2009年第11期20卷 1366-1370页

作者： Long Liu Jia hui kou Da Meng Guo Jing Yang Hong Lin Liu Hong Xia Yu Sheng Chu Ke Ren Jiang Ying Wang Zhi Gang Zou Eco-materials and Renewable Energy Research Center (ERERC) National Laboratory of Solid State Microstructures Nanjing University Nanjing 210093 China School of Chemistry and Chemical Engineering Nanjing University Nanjing 210093 China School of Environment Nanjing University Nanjing 210093 China

In this paper, a thiol-functionalized nanophotocatalyst MPTES/TiO2 was first synthesized by one-pot method using P123 as a template. X-ray diffraction confirms the complete anatase crystalline of thiol-functionalized TiO2, N2 adsorption-desorption isotherm demonstrated that these materials possess high surface area and mesoporous structure. The results of XPS show that MPTES has been successfully polymerized in mesoporous structured TiO2. The photodegradation of phenanthrene （PHE） was investigated under visible light irradiation （λ 〉 420 nm） to evaluate the photocatalytic activity of these materials. Based the experiment results of GC-Mass analysis, a possible mechanism was proposed.

关键词： Thiol-functionalized TiO2 Photocatalysis Degradation