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Prognostic significance of preoperative and postoperative CK19 and CEA m RNA levels in peripheral blood of patients with gastric cardia cancer

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World Journal of Gastroenterology 2017年第8期23卷 1424-1433页

作者： Yu-Feng qiao Chuan-Gui Chen jie Yue Ming-Quan ma Zhao ma Zhen-Tao Yu Department of Esophageal Cancer Tianjin Medical University Cancer Institute and HospitalKey Laboratory of Cancer Prevention and Therapy of Tianjin CityTianjin 300060China

AIM To evaluate the clinical and prognostic significance of preoperative and postoperative cytokeratin 19(CK19) and carcinoembryonic antigen(CEA) m RNA levels in peripheral blood of patients with gastric cardia cancer(GCC).METHODS We detected the preoperative and postoperative mR NA levels of CK19 and CEA in peripheral blood of 129 GCC patients by using reverse transcription-polymerase chain reaction and evaluated their clinical and prognostic significance by univariate Kaplan-Meier survival analysis and multivariate Cox proportional hazard analysis. A new prognostic model which stratified patients into three different risk groups was established based on the independent prognostic *** Elevated preoperative and postoperative CK19 and CEA mR NA levels in peripheral blood of GCC patients were associated with lymph node metastasis. Univariate analysis showed that tumor size, histological grade, depth of tumor invasion, lymph node metastasis, preoperative CK19 m RNA, and preoperative and postoperative CEA m RNA levels were correlated with the prognosis of GCC patients. The multivariate analysis showed that lymph node status(P = 0.018), preoperative CK19(P = 0.035) and CEA(P = 0.011) m RNA levels were independent prognostic factors for overall survival(OS). The 5-year OS rates for the low-, intermediate-, and high-risk groups were 48.3%, 22.6%, and 4.6%, respectively(P may be regarded as promising biomarkers for predicting lymph node metastasis and poor prognosis in patients with GCC. This new prognostic model may help us identify the subpopulations of GCC patients with the highest risk.

关键词： Gastric cardia cancer Cytokeratin 19 Carcinoembryonic antigen Clinicopathological factor Prognosis

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Histone H3 lysine 27 trimethylation suppresses jasmonate biosynthesis and signaling to affect male fertility under high temperature in cotton

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Plant Communications 2023年第6期4卷 96-112页

作者： Yanlong Li Miao Chen Aamir Hamid Khan Yizan ma Xin He Jing Yang Rui Zhang Huanhuan ma Chunyang Zuo Yawei Li jie kong maojun Wang Longfu Zhu Xianlong Zhang ling Min National Key Laboratory of Crop Genetic Improvement&Hubei Hongshan Laboratory Huazhong Agricultural UniversityWuhan 430070HubeiChina Institute of Economic Crops Xinjiang Academy of Agricultural SciencesUrumqi 830091XinjiangChina

High-temperature(HT)stress causes male sterility in crops,thus decreasing *** explore the possible contribution of histone modifications to male fertility under HT conditions,we defined the histone methylation landscape for the marks histone H3 lysine 27 trimethylation(H3K27me3)and histone H3 lysine 4 trimethylation(H3K4me3)by chromatin immunoprecipitation sequencing(ChIP-seq)in two differing upland cotton(Gossypium hirsutum)*** observed a global disruption in H3K4me3 and H3K27me3 modifications,especially H3K27me3,in cotton anthers subjected to *** affected the bivalent H3K4me3–H3K27me3 modification more than either monovalent *** determined that removal of H3K27me3 at the promoters of jasmonate-related genes increased their expression,maintaining male fertility under HT in the HT-tolerant variety at the anther dehiscence *** jasmonate homeostasis or signaling resulted in an anther indehiscence phenotype under *** suppression of H3K27me3 deposition increased jasmonic acid contents and maintained male fertility under *** summary,our study provides new insights into the regulation of male fertility by histone modifications under HT and suggests a potential strategy for improving cotton HT tolerance.

关键词： high temperature H3K27me3 H3K4me3 cotton anther jasmonate

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Durable Ru Nanocrystal with HfO_(2)Modification for Acidic Overall Water Splitting

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Nano-Micro Letters 2024年第9期16卷 462-477页

作者： Xiangkai kong jie Xu Zhicheng Ju Changle Chen School of materials and Physics China University of Mining and TechnologyXuzhou 221116JiangsuPeople’s Republic of China Anhui Province Key Laboratory of Pollutant Sensitive materials and Environmental Remediation Huaibei Normal UniversityHuaibei 235000AnhuiPeople’s Republic of China School of Chemistry and materials Science University of Science and Technology of ChinaHefei 230026AnhuiPeople’s Republic of China School of Chemistry and Chemical Engineering Nanjing UniversityNanjing 210023JiangsuPeople’s Republic of China

Durable and efficient bi-functional catalyst,that is capable of both oxygen evolution reaction and hydrogen evolution reaction under acidic condition,are highly desired for the commercialization of proton exchange membrane water ***,we report a robust L-Ru/HfO_(2)heterostructure constructed via confining crystalline Ru nanodomains by HfO_(2)*** assembled with a proton exchange membrane,the bi-functional L-Ru/HfO_(2)catalyst-based electrolyzer presents a voltage of 1.57 and 1.67 V to reach 100 and 300 ma cm^(-2)current density,prevailing most of previously reported Ru-based materials as well as commercial Pt/C||RuO_(2)*** is revealed that the synergistic effect of HfO_(2)modification and small crystalline domain formation significantly alleviates the over-oxidation of *** importantly,this synergistic effect facilitates a dual-site oxide path during the oxygen evolution procedure via optimization of the binding configurations of oxygenated *** a result,the Ru active sites maintain the metallic state along with reduced energy barrier for the rate-determining step(^(*)O→^(*)OOH).Both of water adsorption and dissociation(Volmer step)are strengthened,while a moderate hydrogen binding is achieved to accelerate the hydrogen desorption procedure(Tafel step).Consequently,the activity and stability of acidic overall water splitting are simultaneously enhanced.

关键词： Ruthenium Hafnium dioxide Oxygen evolution catalysis Anti-oxidation

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Kinetics and mechanism of mercuration of N-(substituted benzylidene)-4-toluidines

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Chinese Journal of Chemistry 1993年第6期11卷 554-559页

作者： Yang-jie Wu Kui-ling Ding Ya-Li kong Zheng-Yan Yu Department of Chemistry Zhengzhou University Zhengzhou Henan 450052

In order to investigate the mechanism of mercuration reaction of substituted ben- zylideneanilines, kinetic measurements of these reactions at different temperatures (40-60℃) in methanol-l,4-dioxane (1/1, V/V) were carried out and Hammett ρ value for C-phenyl substituents of-0.61 for the N-(substituted benzylidene)-4-toluidine series was obtained. Thermodynamic parameters E_a, △S~≠ were obtained for the reaction of different. N-(substituted benzylidene)-4- toluidines. It was found that this ortho-mercuration was brought about by an internal cyclometal- lation process involving the imino-moiety.

关键词： Kinetics and mechanism of mercuration of N substituted benzylidene

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Synergistic Lewis acid-base sites of ultrathin porous Co_(3)O_(4)nanosheets with enhanced peroxidase-like activity

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Nano Research 2021年第10期14卷 3514-3522页

作者： Wenhui Lu Ming Yuan Jing Chen Jiaxin Zhang lingshuai kong Zhenyu Feng Xicheng ma jie Su Jinhua Zhan Key Laboratory of Colloid and Interface Chemistry Ministry of EducationSchool of Chemistry and Chemical EngineeringState Key Laboratory of Crystal MaterialsShandong UniversityJinan 250100China

Surface Lewis acid-base sites in crystal structure may influence the physicochemical properties and the catalytic performances in *** the synergistic effect mechanism of Co_(3)O_(4)nanozymes towards substances(3,3’,5,5’-tetramethylbenzidine(TMB)and hydrogen peroxide(H2O2))induced by surface Lewis acid-base sites is important to enhance the efficiency for peroxidase-like ***,ultrathin porous Co_(3)O_(4)nanosheets with abundant Lewis acid-base sites were prepared by sodium borohydride(NaBH4)reduction treatment,which exhibited high-efficiency peroxidase-like activity compared with original Co_(3)O_(4)*** Lewis acid-base sites for ultrathin porous Co_(3)O_(4)nanosheets nanozyme were owing to the coordination unsaturation of Co ions and the formation of defect *** porous Co_(3)O_(4)nanosheets had 18.26-fold higher catalytic efficiency(1.27×10^(-2)s^(-1)·mM^(-1))than that of original Co_(3)O_(4)(6.95×10^(-4)s^(-1)·mM^(-1))in oxidizing TMB *** synergistic effect of surface acid and base sites can enhance the interfacial electron transfer process of Co_(3)O_(4)nanosheets,which can be a favor of absorption substrates and the generation of reactive intermediates such as ***,the limit of detection of hydroquinol was 0.58μM for ultrathin porous Co_(3)O_(4)nanosheets,965-fold lower than original Co_(3)O_(4)(560μM).Besides,the linear range of ultrathin porous Co_(3)O_(4)nanosheets was widely with the concentration of 5.0-1,000μ*** detection of hydroquinol by agarose-based hydrogel membrane was provided based on excellent peroxidase-like *** study provided insights into designing high-performance nanozymes for peroxidase-like catalysis via a strategy of solid surface acid-base sites engineering.

关键词： cobalt oxide nanozyme Lewis acid-base sites peroxidase-like colorimetric sensor hydroquinol

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3D simulation of image-defined complex internal features using the numerical manifold method

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Science China(Technological Sciences) 2024年第4期67卷 1023-1039页

作者： WU jie ma GuoWei School of Civil and Transportation Engineering Hebei University of TechnologyTianjin 300401China Tianjin Key Laboratory for Prefabricated Building and Intelligent Construction Tianjin 300401China

The numerical simulation of internal features,such as inclusions and voids,is important to analyze their impact on the performance of composite ***,the complex geometries of internal features and the induced continuous-discontinuous(C-D)deformation fields are challenges to their numerical *** this study,a 3D approach using a simple mesh to simulate irregular internal geometries is developed for the first *** the help of a developed voxel crack model,image models that are efficient when recording complex geometries are directly imported into the *** reconstructions,which are usually labor-intensive,are excluded from this ***,using image models as the geometric input,image processing techniques are applied to detect material interfaces and develop contact ***,the C-D deformations of the complex internal features are directly calculated based on the numerical manifold *** accuracy and convergence of the developed3D approach are examined based on multiple *** 3D C-D simulation of sandstones with naturally formed complex microfeatures demonstrates the capability of the developed approach.

关键词： 3D continuous-discontinuous simulation image-based simulation complex internal features numerical manifold method voxel crack model structured mesh

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Modeling the Water-Flushing Properties of the Yangtze Estuary and Adjacent Waters

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Journal of Ocean University of China 2019年第1期18卷 93-107页

作者： YANG jie kong Jun TAO Jianfeng College of Harbour Coastal and Offshore Engineering Hohai University Department of Civil and Environmental Engineering National University of Singapore State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering Hohai University

As a multi-branch estuary system, the Yangtze Estuary presents distinctive characteristics of hydrodynamic processes through co-action among river runoff, tides, wind-waves, and gravitational circulation. To study the pathways of flushing water along all of the estuary's branches and analyze their differences, especially those due to the influence of seawater intrusion and discharge variations, a free surface flow modeling suite TELEmaC-maSCARET involving passive tracers was applied to the Yangtze Estuary and the adjacent waters. The open boundary conditions were provided by the Nao.99 b model(matsumoto et al., 2000), which was calibrated using observed velocity and salinity data obtained in march 2002. The water age, which was used as the diagnostic tool to study the flushing efficiency of the water body across the estuary, was solved by additional advection-diffusion-reaction equations implemented in the TELEmaC modeling system. The transport properties were investigated under different river discharge scenarios, which represented seasonal impacts; aspects relating to the influence of tide, surface wind stress, and density-induced circulation on age were also investigated. Model results showed that river runoff is one of the dominant factors influencing the spatial distribution of the mean age, while tidal force is another important factor. The horizontal freshwater age distribution demonstrated similarity compared with the salinity distribution; the vertical age distribution resembled the stratification pattern of salinity in all branches where stratification persists. An experimental numerical simulation of tracing saltwater age from the lower reaches of the estuary was conducted, and implicated the connectivity with transport processes of freshwater from upstream. Additionally, a particle tracking algorithm was used to analyze the dynamic characteristics of the four passages. The South Passage and South Channel were found to be significant as main water flow pa

关键词： water age seawater intrusion the Yangtze Estuary numerical modeling particle tracking algorithm

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What are carbon nanotubes' roles in anti-tumor therapies?

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Science China Chemistry 2010年第11期53卷 2250-2256页

作者： HaiYan Xu jie Meng Hua kong Institute of Basic Medical Sciences Chinese Academy of Medical Sciences & Peking Union Medical College Beijing China

Since their discovery,carbon nanotubes(CNTs) have become one of the most promising nanomaterials in many industrial and biomedical *** to their unique physicochemical properties,CNTs have been proposed and actively exploited as multipurpose innovative carriers for cancer *** aim of this article is to provide an overview of the status of applications,advantages,and up-to-date research and development of carbon nanotubes in cancer therapy with an emphasis on drug delivery,photothermal therapy,gene therapy,RNAi,and immune *** addition,the issues of risk and safety of CNTs in cancer nanotechnology are discussed briefly.

关键词： carbon nanotubes tumor therapy delivery immune

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Recent advances of MXene as promising catalysts for electrochemical nitrogen reduction reaction

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Chinese Chemical Letters 2020年第4期31卷 953-960页

作者： jie Sun Wenhan kong Zhaoyong Jin Yaqian Han Liangyu ma Xiaoteng Ding Yusheng Niu Yuanhong Xu College of materials Science and Engineering College of Life SciencesQingdao UniversityQingdao 266071China

Electrochemical reduction of N2,as an eco-friendly alternative,not only allows the use of protons in water as a source of hydrogen under mild conditions but also can be driven by renewable electric *** major challenge is to identify high-efficiency *** is a new class of 2D transition metal carbides,nitrides,and carbonitrides that have received significant attention in *** investigations on MXene in electrocatalytic nitrogen fixation are rapidly proceeding,and some breakthroughs have emerged ve ry recently due to MXenes’satisfacto ry catalytic ***,the recent progress concerning the MXene-based catalysts for electrochemical N2 reduction reaction(NRR)is *** regards to giving guidelines for exploring more efficient MXene-based catalysts for the NRR,the fabrication and surface modification of MXene are ***,the shortcomings and challenges of current research are summarized and the future research directions are prospected.

关键词： Nitrogen reduction reaction Electrocatalysis MXene Nanomaterials Two-dimensional nanomaterials

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Determination of neutron-skin thickness using configurational information entropy

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Nuclear Science and Techniques 2022年第1期33卷 60-66页

作者： Chun-Wang ma Yi-Pu Liu Hui-ling Wei jie Pu Kai-Xuan Cheng Yu-Ting Wang School of Physics Henan Normal UniversityXinxiang 453007China Key Laboratory Optoelectronic Sensing Integrated Application of Henan Province Henan Normal UniversityXinxiang 453007China

Configurational information entropy(CIE)theory was employed to determine the neutron-skin thickness of neutron-rich calcium *** nuclear density distributions and fragment cross sections in 350 MeV/u ^(40-60)Ca+^(9)Be projectile fragmentation reactions were calculated using a modified statistical abrasion-ablation *** quantities were determined from the nuclear density,isotopic,mass,and charge *** linear correlations between the CIE determined using the isotopic,mass,and charge distributions and the neutron-skin thickness of the projectile nucleus show that CIE provides new methods to extract the neutron-skin thickness of neutron-rich nuclei.

关键词： Neutron-skin thickness Configurational information entropy Cross section distribution Projectile fragmentation

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