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Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan Huang Yi-De Zhang Jie Chen Hai-Di Fan Wan Wang Bin Wang Ju-yun Ma Peng-Peng Li Hai-Wei Pu Xin-Yian Guo Jian-Gang Shen Su-Hua qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late stroke.Indeed,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain tissue.Our previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently unclear.To simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic stroke.We found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous acid.Further,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid hydrazide.Our results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/reoxygenation.However,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and astrocytes.This suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion injury.Lower levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-catenin.By transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear translocation.Altogether,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

Tube Model Predictive Control Based Cyber-attack-resilient Optimal Voltage Control Strategy in Wind Farms

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CSEE Journal of Power and Energy Systems 2024年第2期10卷 530-538页

作者： Zhenming Li Minghao Wang yunfeng Yan Donglian qi Zhao Xu Jianliang Zhang Zezhou Wang College of Electrical Electronic Engineering Zhejiang UniversityHangzhou 310058China Department of Electrical Engineering The Hong Kong Polytechnic UniversityKowloonHong KongChina Haiyan power supply company of State Grid Zhejiang Electric Power Co. LtdHangzhouChina

Optimal voltage controls have been widely applied in wind farms to maintain voltage stability of power grids.In order to achieve optimal voltage operation,authentic grid information is widely needed in the sensing and actuating processes.However,this may induce system vulnerable to malicious cyber-attacks.To this end,a tube model predictive control-based cyber-attack-resilient optimal voltage control method is proposed to achieve voltage stability against malicious cyber-attacks.The proposed method consists of two cascaded model predictive controllers(MPC),which outperform other peer control methods in effective alleviation of adverse effects from cyber-attacks on actuators and sensors of the system.Finally,efficiency of the proposed method is evaluated in sensor and actuator cyber-attack cases based on a modified IEEE 14 buses system and IEEE 118 buses system.Index Terms-Attack-resilient control,optimal voltage control,tube-based model predictive control,wind farm-connected power system.

关键词： Attack-resilient control optimal voltage control tube-based model predictive control wind farm-connected power system

High dimensional proteomic mapping of bone marrow immune characteristics in immune thrombocytopenia

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Science China Life Sciences 2024年第8期 1635-1647页

作者： Feng-qi Liu qing-Yuan Qu Ying Lei qi Chen Yu-Xiu Chen Meng-Lin Li Xue-Yan Sun Ye-Jun Wu qiu-Sha Huang Hai-Xia Fu Yuan kong Yue-Ying Li qian-Fei Wang Xiao-Jun Huang Xiao-Hui Zhang Peking University People's Hospital Peking University Institute of Hematology Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation National Clinical Research Center for Hematologic Disease Collaborative Innovation Centre of Hematology Peking University CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for Bioinformation University of Chinese Academy of Sciences Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesPeking University State Key Laboratory of Natural and Biomimetic Drugs Peking University

To investigate the role of co-stimulatory and co-inhibitory molecules on immune tolerance in immune thrombocytopenia(ITP),this study mapped the immune cell heterogeneity in the bone marrow of ITP at the single-cell level using Cytometry by Time of Flight(Cy TOF).Thirty-six patients with ITP and nine healthy volunteers were enrolled in the study.As soluble immunomodulatory molecules,more s CD25 and s Galectin-9 were detected in ITP patients.On the cell surface,co-stimulatory molecules like ICOS and HVEM were observed to be upregulated in mainly central memory and effector T cells.In contrast,co-inhibitory molecules such as CTLA-4 were significantly reduced in Th1and Th17 cell subsets.Taking a platelet count of 30×109L-1as the cutoff value,ITP patients with high and low platelet counts showed different T cell immune profiles.Antigen-presenting cells such as monocytes and B cells may regulate the activation of T cells through CTLA-4/CD86 and HVEM/BTLA interactions,respectively,and participate in the pathogenesis of ITP.In conclusion,the proteomic and soluble molecular profiles brought insight into the interaction and modulation of immune cells in the bone marrow of ITP.They may offer novel targets to develop personalized immunotherapies.

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基于第一性原理的Si/SiC、Al/SiC界面成键特性和结合强度对比研究

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原子与分子物理学报 2024年第5期41卷 159-168页

作者：肖鹏胡启耀邓昀麒南昌航空大学航空制造工程学院南昌330063

采用半固态搅拌铸造法制备AlSi7-SiC复合材料,并利用真空压铸工艺实现了其近净成形,结合第一性原理计算方法研究了共晶Si对SiC颗粒和基体界面结合强度的影响.结果显示,在AlSi7-SiC复合材料中,发现较为严重的共晶Si偏析现象,当SiC颗粒同... 详细信息

采用半固态搅拌铸造法制备AlSi7-SiC复合材料,并利用真空压铸工艺实现了其近净成形,结合第一性原理计算方法研究了共晶Si对SiC颗粒和基体界面结合强度的影响.结果显示,在AlSi7-SiC复合材料中,发现较为严重的共晶Si偏析现象,当SiC颗粒同时处于共晶Si和α-Al边界时,形成了少量的共晶Si夹杂、被大量共晶Si包裹、完全被共晶Si包裹三种典型的界面.第一性原理计算结果显示,在C端和Si端的Si/SiC界面中,弛豫后topSi 1配位方式具有最大的粘附功,与Al/SiC界面相比,Si/SiC界面具有更高的结合强度.Si偏析相提高了界面处的电荷密度,因而具有更好的界面结构稳定性.

关键词： SiC-Al基复合材料元素偏析第一性原理界面性能

Perioperative outcomes of transvaginal specimen extraction laparoscopic total gastrectomy and conventional laparoscopicassisted total gastrectomy

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1527-1536页

作者： Zhi-Cao Zhang Wen-Sheng Wang Jiang-Hong Chen Yuan-Hang Ma qi-Fa Luo yun-Bo Li Yang Yang Dan Ma Department of General Surgery Xinqiao Hospital of Army Medical UniversityChongqing 400037China

BACKGROUND Natural orifice specimen extraction surgery(NOSES)has emerged as a promising alternative compared to conventional laparoscopic-assisted total gastrectomy(LATG)for treating gastric cancer(GC).However,evidence regarding the efficacy and safety of NOSES for GC surgery is limited.This study aimed to compare the safety and feasibility,in addition to postoperative complications of NOSES and LATG.METHODS Dual circular staplers were used in Roux-en-Y digestive tract reconstruction for transvaginal specimen extraction LATG,and its outcomes were compared with LATG in a cohort of 51 GC patients with tumor size≤5 cm.The study was conducted from May 2018 to September 2020,and patients were categorized into the NOSES group(n=22)and LATG group(n=29).Perioperative parameters were compared and analyzed,including patient and tumor characteristics,postoperative outcomes,and anastomosis-related complications,postoperative hospital stay,the length of abdominal incision,difference in tumor type,postoperative complications,and postoperative survival.RESULTS Postoperative exhaust time,operation duration,mean postoperative hospital stay,length of abdominal incision,number of specific staplers used,and Brief Illness Perception Questionnaire score were significant in both groups(P<0.01).In the NOSES group,the postoperative time to first flatus,mean postoperative hospital stay,and length of abdominal incision were significantly shorter than those in the LATG group.Patients in the NOSES group had faster postoperative recovery,and achieved abdominal minimally invasive incision that met aesthetic requirements.There were no significant differences in gender,age,tumor type,postoperative complications,and postoperative survival between the two groups.CONCLUSION The application of dual circular staplers in Roux-en-Y digestive tract reconstruction combined with NOSES gastrectomy is safe and convenient.This approach offers better short-term outcomes compared to LATG,while long-term survival rates are comparable to those of conventional la

关键词： Gastric cancer Circular stapler Natural orifice specimen extraction surgery Laparoscopic-assisted total gastrectomy

FDX1 as a novel biomarker and treatment target for stomach adenocarcinoma

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1803-1824页

作者： Xian-Ze Xie Lei Zuo Wei Huang qiao-Mei Fan Ya-yun Weng Wen-Dong Yao Jia-Li Jiang Jia-qi Jin Department of Pharmacy The First Affiliated Hospital of Zhejiang Chinese Medical University(Zhejiang Provincial Hospital of Chinese Medicine)Hangzhou 310018Zhejiang ProvinceChina Anhui Province Huainan City Shou County Agricultural Machinery Affairs Management Center Huainan 232200Anhui ProvinceChina

BACKGROUND Stomach adenocarcinoma(STAD)is one of the main reasons for cancer-related deaths worldwide.This investigation aimed to define the connection between STAD and Cuproptosis-related genes(CRGs).Cuproptosis is a newly identified form of mitochondrial cell death triggered by copper.AIM To explore the identification of potential biomarkers for STAD disease based on cuproptosis.METHODS A predictive model using Gene Ontology(GO),Least Absolute Shrinkage and Selection Operator(LASSO),Kyoto Encyclopedia of Genes and Genomes(KEGG),Gene Set Variation Analysis(GSVA),and Gene Set Enrichment Analysis analyzed gene interconnections,focusing on 3 copper-related genes and their expression in The Cancer Genome Atlas-STAD.Networks for mRNA-miRNA and mRNA-transcription factor interactions were constructed.The prognostic significance of CRG scores was evaluated using time-receiver operating characteristic,Kaplan-Meier curves,and COX regression analysis.Validation was conducted with datasets GSE26942,GSE54129,and GSE66229.Expression of copper-related differ-entially expressed genes was also analyzed in various human tissues and gastric cancer subpopulations using the human protein atlas.RESULTS Three significant genes(FDX1,LIAS,MTF1)were identified and selected via LASSO analysis to predict and classify individuals with STAD into high and low CRG score subgroups.These genes were down-regulated in both risk categories.GO and KEGG analyses highlighted their involvement mainly in the electron transport chain.After validating their differential expression,FDX1 emerged as the most accurate diagnostic marker for gastric cancer.Additionally,the RCircos package localized FDX1 on chromosome 11.CONCLUSION Our study revealed that FDX1 could be a potential biomarker and treatment target for gastric malignancy,providing new ideas for further scientific research.

关键词： Stomach adenocarcinoma disease Copper death FDX1 prognostic biomarkers Cuproptosis-related genes

Prediction of Renal Function by Urinary Lead and Cadmium - Based on Classification Decision Tree and Logistic Regression Model

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Biomedical and Environmental Sciences 2024年第3期37卷 331-335页

作者： LI Yang WANG qing Yao TIAN qing Hua AN qi YANG Yu Tong ZHANG Jia Chen LI Shuang Jing ZHOU Han LIANG yun Fen SHEN Wei Tong MU Li Na LEI Li Jian Department of Epidemiology School of Public HealthShanxi Medical UniversityTaiyuan 030001ShanxiChina Department of Epidemiology School of Public HealthShanxi Key Laboratory of Environmental Health Impairment and PreventionNHC Key Laboratory of PneumoconiosisMOE Key Laboratory of Coal Environmental Pathogenicity and PreventionShanxi Medical UniversityTaiyuan 030001ShanxiChina Department of Epidemiology and Environmental Health School of Public Health and Health ProfessionsThe State University of New York at BuffaloBuffaloNYUSA.

It is estimated that chronic kidney disease(CKD)will be the fifth leading cause of death in the world by 2040[1].Early recognition and intervention for kidney damage are essential.Estimated glomerular filtration rate(eGFR)can be calculated by measuring blood creatinine to evaluate glomerular function,and urinary N-acetyl-β-δ-glucosaminidase(UNAG)level is generally recognized as a marker of renal tubular injury.Exposure to lead(Pb)and cadmium(Cd)can damage renal function,leading to a decrease in eGFR and an increase in UNAG[2].Both Pb and Cd are easily accumulated in the body and then slowly released by the kidneys and excreted.So,urinary Pb(UPb)and Cd(UCd)levels can be used as biomarkers of exposure[3,4].

关键词： urinary damage slowly

弹簧地基上大直径单桩海上风机的一阶自振频率

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计算力学学报 2024年第2期41卷 383-389页

作者：余云燕许蓉孔嘉乐兰州交通大学土木工程学院兰州730070

自振频率是海上风机前期动力设计的主要难点之一,计算精度要求极高,而桩-土相互作用对自振频率影响显著。目前,针对桩-土相互作用普遍采用弹簧地基简化模型,为对比分析不同弹簧地基简化模型的准确性和精度,本文采用回传射线矩阵法,建立... 详细信息

自振频率是海上风机前期动力设计的主要难点之一,计算精度要求极高,而桩-土相互作用对自振频率影响显著。目前,针对桩-土相互作用普遍采用弹簧地基简化模型,为对比分析不同弹簧地基简化模型的准确性和精度,本文采用回传射线矩阵法,建立固定端、单弹簧、双弹簧和三弹簧这4种地基简化模型,基于Bernoulli-Euler梁理论和Timoshenko梁理论,求解风机系统的自振频率,并与风机基频实测值作对比,进一步分析三弹簧简化地基模型中地基旋转刚度、地基耦合刚度和地基水平刚度对风机系统基频的影响。研究结果表明,桩-土相互作用不可忽略,三弹簧地基简化模型计算风机系统基频精度最高;地基刚度对风机系统基频的敏感性次序为,地基耦合刚度>地基旋转刚度>地基水平刚度;当地基旋转(水平)刚度较小时,地基耦合刚度与地基旋转(水平)刚度的耦合效应对风机系统的基频影响较大;地基耦合刚度与地基旋转刚度的耦合效应对风机系统基频的影响程度大于地基耦合刚度与地基水平刚度的耦合效应。

关键词：海上风机弹簧地基自振频率回传射线矩阵法单桩基础

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异质虹膜识别研究综述

计算机科学 2024年第6期51卷 186-197页

作者：孔佳琳张琪王财勇中国人民公安大学信息网络安全学院北京100038 北京建筑大学电气与信息工程学院北京100044

虹膜图像采集环境和设备的不同导致虹膜注册和识别样本差异较大,给传统的虹膜识别技术带来了挑战。异质虹膜识别问题已成为学术界和工业界关注的焦点。文中从不同层级、样本差异性以及单源和多源3个角度对现有的异质虹膜识别方法进行了... 详细信息

虹膜图像采集环境和设备的不同导致虹膜注册和识别样本差异较大,给传统的虹膜识别技术带来了挑战。异质虹膜识别问题已成为学术界和工业界关注的焦点。文中从不同层级、样本差异性以及单源和多源3个角度对现有的异质虹膜识别方法进行了分类和综述,总结了目前异质虹膜识别的最新进展。按照跨质量、跨设备和跨光谱的分类对现有的异质虹膜数据集进行综述,并总结概述虹膜识别评价指标,以便研究人员更好地评估和验证算法的性能。最后,从环境鲁棒性、数据异质性建模和多模态融合3个方向,对未来异质虹膜识别研究的发展方向进行了展望。

关键词：虹膜识别异质图像生物特征深度学习