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Mental health and insomnia problems in healthcare workers after the COVID-19 pandemic:A multicenter cross-sectional study

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World Journal of Psychiatry 2024年第5期14卷 704-714页

作者： Wei Ding Min-Zhong Wang xian-Wei Zeng Zhen-Hua Liu Yao Meng hui-Ting Hu Yuan Zhang Yu-Guang Guan Fan-Gang Meng Jian-Guo Zhang Shu Wang Department of Public Health Liaocheng People’s HospitalLiaocheng 252000Shandong ProvinceChina Department of Neurology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021Shandong ProvinceChina Department of Neurosurgery Qilu Hospital of Shandong UniversityJinan 250012Shandong ProvinceChina Sleep Medicine Center Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021Shandong ProvinceChina Department of Neurology The First Affiliated Hospital of Shandong First Medical UniversityJinan 250014Shandong ProvinceChina Department of Neurology Heze Mudan People’s HospitalHeze 274000Shandong ProvinceChina Neonatal Center Beijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijing 100045China Department of Neurosurgery SanBo Brain HospitalCapital Medical UniversityBeijing 100093China Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China

BACKGROUND Healthcare workers(HCWs)are at increased risk of contracting coronavirus disease 2019(COVID-19)as well as worsening mental health problems and *** problems can persist for a long period,even after the ***,less is known about this *** To analyze mental health,insomnia problems,and their influencing factors in HCWs after the COVID-19 *** This multicenter cross-sectional,hospital-based study was conducted from June 1,2023 to June 30,2023,which was a half-year after the end of the COVID-19 ***-stratified population-based cluster sampling was applied at the provincial level for Chinese *** such as anxiety,depression,and insomnia were evaluated by the Generalized Anxiety Disorder-7,Patient Health Questionnaire-9,and Insomnia Severity *** influencing the symptoms were identified by multivariable logistic *** A total of 2000 participants were invited,for a response rate of 70.6%.A total of 1412 HCWs[618(43.8%)doctors,583(41.3%)nurses and 211(14.9%)nonfrontline],254(18.0%),231(16.4%),and 289(20.5%)had symptoms of anxiety,depression,and insomnia,respectively;severe symptoms were found in 58(4.1%),49(3.5%),and 111(7.9%)of the ***,female sex,and hospitalization for COVID-19 were risk factors for anxiety,depression,and insomnia symptoms;moreover,death from family or friends was a risk factor for insomnia *** the COVID-19 outbreak,most[1086(76.9%)]of the participating HCWs received psychological interventions,while nearly all[994(70.4%)]of them had received public psychological *** 102(7.2%)of the HCWs received individual counseling from *** Although the mental health and sleep problems of HCWs were relieved after the COVID-19 pandemic,they still faced challenges and greater risks than did the general *** risk factors would help in providing targeted *** addition,although a major proportion of

关键词： COVID-19 Mental health Psychological symptoms Insomnia Sleep disorders Cross-sectional study Epidemiological study

早熟陆地棉亲本遗传距离与杂种优势的相关性分析

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新疆农业科学 2011年第5期48卷 792-798页

作者：田琴孔宪辉余渝刘丽王旭文王娟邓福军新疆农垦科学院分子农业技术育种中心新疆石河子832000 新疆农垦科学院棉花研究所新疆石河子832000

【目的】为早熟陆地棉杂交亲本选配及杂种优势预测提供参考信息。【方法】将12个早熟陆地棉品种初步划分成两组亲本,田间调查17个主要性状,并进行SSR分子标记检测,对基于表现型和基因型差异的遗传距离与F1代主要性状杂种优势的相关性进... 详细信息

【目的】为早熟陆地棉杂交亲本选配及杂种优势预测提供参考信息。【方法】将12个早熟陆地棉品种初步划分成两组亲本,田间调查17个主要性状,并进行SSR分子标记检测,对基于表现型和基因型差异的遗传距离与F1代主要性状杂种优势的相关性进行分析。【结果】基于5个主成分因子得分两组亲本间的平均遗传距离为5.535,最大为9.097,最小为3.097;基于SSR扩增结果两组亲本间的平均遗传距离为4.186,最大为5.099,最小为2.646。36个组合F1代生育期、铃数、单铃重、衣分、绒长、籽棉产量和皮棉产量的平均中亲优势分别为0.367、-1.256、14.176、6.691、1.000、11.206和15.235,平均超亲优势分别为-0.966、-1.464、6.457、0.110、-2.500、7.561和10.816。基于性状主成分因子得分的遗传距离只与F1代衣分的中亲优势呈极显著正相关;基于SSR扩增结果的遗传距离与生育期的中亲优势、衣分和绒长的超亲优势呈显著负相关。【结论】早熟陆地棉的铃重和产量具有较强的杂种优势;衣分具有较强的中亲优势。亲本的遗传距离只与F1代个别性状的杂种优势具有显著相关,且与产量不是简单的线性关系。部分性状的杂种优势随遗传距离的增大而增大,但部分性状则减小。

关键词：早熟陆地棉遗传距离杂种优势相关性

“粮改饲”背景下我国肉羊养殖成本效率变动及优化路径研究

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饲料研究 2024年第12期47卷 186-192页

作者：孔慧平河南信息统计职业学院河南郑州450000

“粮改饲”政策的实施对我国肉羊养殖产业影响巨大。文章基于国内肉羊养殖成本收益的宏观统计数据,并结合2017—2022年10个典型省份实地调研数据,通过超越对数成本函数随机前沿分析方法,对比分析“粮改饲”实施前的2017年和全面落实后2... 详细信息

“粮改饲”政策的实施对我国肉羊养殖产业影响巨大。文章基于国内肉羊养殖成本收益的宏观统计数据,并结合2017—2022年10个典型省份实地调研数据,通过超越对数成本函数随机前沿分析方法,对比分析“粮改饲”实施前的2017年和全面落实后2022年各规模肉羊养殖成本效率变动情况以及影响因素,以探寻“粮改饲”背景下提升我国肉羊养殖成本效率的有效路径。结果发现:“粮改饲”政策推行后,我国肉羊养殖成本效率提升明显;养殖成本效率和养殖规模具有正相关关系,且小规模养殖的成本效率上升最明显;增加技术指导投入可稳步提高肉羊养殖成本效率;不同规模肉羊养殖成本效率的区域差异明显。研究表明,在“粮改饲”政策红利持续释放背景下,应建立肉羊养殖技术指导中心、打造差异化肉羊全产业链、实施“粮改饲”规模化养殖项目,为提高肉羊养殖的成本效率提供有益参考。

关键词： “粮改饲” 肉羊养殖成本效率随机前沿分析

Design and prototyping of the readout electronics for the transition radiation detector in the high energy cosmic radiation detection facility

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Nuclear Science and Techniques 2024年第4期35卷 189-199页

作者： Jie-Yu Zhu Yang-Zhou Su Hai-Bo Yang Fen-Hua Lu Yan Yang Xi-Wen Liu Ping Wei Shu-Cai Wan Hao-Qing Xie xian-Qin Li Cong Dai hui-Jun Hu Hong-Bang Liu Shu-Wen Tang Cheng-Xin Zhao Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China Guangxi Key Laboratory for Relativistic Astrophysics School of Physical Science and TechnologyGuangxi UniversityNanning 530004China

The high energy cosmic-radiation detection(HERD)facility is planned to launch in 2027 and scheduled to be installed on the China Space *** serves as a dark matter particle detector,a cosmic ray instrument,and an observatory for high-energy gamma rays.A transition radiation detector placed on one of its lateral sides serves dual purpose,(ⅰ)calibrating HERD's electromagnetic calorimeter in the TeV energy range,and(ⅱ)serving as an independent detector for high-energy gamma *** this paper,the prototype readout electronics design of the transition radiation detector is demonstrated,which aims to accurately measure the charge of the anodes using the SAMPA application specific integrated circuit *** electronic performance of the prototype system is evaluated in terms of noise,linearity,and *** the presented design,each electronic channel can achieve a dynamic range of 0–100 fC,the RMS noise level not exceeding 0.15 fC,and the integral nonlinearity was<0.2%.To further verify the readout electronic performance,a joint test with the detector was carried out,and the results show that the prototype system can satisfy the requirements of the detector's scientific goals.

关键词： HERD Dark matter particle detection TRD Readout electronics SAMPA Data acquisition Performance test

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新疆机采棉主要机采性状的遗传分析

西南农业学报 2015年第6期28卷 2421-2424页

作者：王娟董承光余渝孔宪辉刘丽王旭文新疆农垦科学院棉花研究所/农业部西北内陆区棉花生物学与遗传育种重点实验室新疆石河子832000

以新疆棉区2个机采性状优良且推广面积较大的机采棉品种与陆地棉遗传标准系配置组合,应用主基因-多基因联合世代分析方法对7个主要机采性状进行遗传分析。结果表明:7个机采性状在2个组合中均检测到1对主基因的存在,其中果枝始节高在2个... 详细信息

以新疆棉区2个机采性状优良且推广面积较大的机采棉品种与陆地棉遗传标准系配置组合,应用主基因-多基因联合世代分析方法对7个主要机采性状进行遗传分析。结果表明:7个机采性状在2个组合中均检测到1对主基因的存在,其中果枝始节高在2个组合中均检测到2对主基因。从主基因遗传率和多基因遗传率的分量进一步分析得出,在2个组合中均以主基因遗传为主的性状有株高、果枝始节高、单株皮棉产量、纤维比强度等;在2个组合中均以多基因遗传为主的性状有生育期性状;在2个组合中以主基因和多基因遗传并重的性状有果枝始节位和纤维长度等。同时得出生育期、纤维长度2性状的总遗传率高于其它性状。本结论为棉花适宜机采性状的主效QTL鉴定提供了理论依据。

关键词：机采棉机采性状主基因-多基因遗传分析

SSR分子标记辅助选择棉花育性恢复基因Rf_1

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新疆农业科学 2013年第4期50卷 599-602页

作者：王娟董承光孔宪辉刘丽王旭文余渝新疆农垦科学院棉花研究所/农业部西北内陆区棉花生物学与遗传育种重点实验室新疆石河子832000

【目的】借助分子手段对棉花育性恢复基因进行分子标记辅助选择。【方法】将胞质雄性不育恢复系383R与综合性状优良的早熟品系(轮回亲本)回交产生的BC3群体,利用与CMS恢复基因Rf1紧密连锁的2个EST-SSR标记进行分子检测,并展开分子标记... 详细信息

【目的】借助分子手段对棉花育性恢复基因进行分子标记辅助选择。【方法】将胞质雄性不育恢复系383R与综合性状优良的早熟品系(轮回亲本)回交产生的BC3群体,利用与CMS恢复基因Rf1紧密连锁的2个EST-SSR标记进行分子检测,并展开分子标记辅助选择。【结果】Pop1BC3中,11株标记基因型为隐性纯合型(rfrf),29株标记基因型为杂合型(Rfrf),20株标记基因型为显性纯和型(RfRf);Pop2BC3中,9株标记基因型为隐性纯合型(rfrf),33株标记基因型为杂合型(Rfrf),18株标记基因型为显性纯合型(RfRf)。【结论】隐性纯合型(rfrf)植株表明这些植株中不含有恢复基因;杂合型(Rfrf)和纯合型(RfRf)植株为快速培育含有恢复基因的早熟品系提供基础。

关键词：棉花恢复基因Rf1 EST—SSR 分子标记辅助选择

新疆早熟陆地棉籽粒发育特征研究及脂肪酸成分分析

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西南农业学报 2016年第4期29卷 765-769页

作者：刘丽余渝孔宪辉王娟王旭文华金平新疆农垦科学院棉花研究所/农业部西北内陆区棉花生物学与遗传育种重点实验室/国家棉花改良中心新疆生产建设兵团分中心新疆石河子832000 中国农业大学植物遗传育种系/杂种优势研究与利用教育部重点实验室/作物遗传改良北京市重点实验室北京100193

本研究测定了新陆早33、42号棉籽不同发育时期含水量、可溶性糖含量和油分含量的动态变化情况,并采用气相色谱法测定了9个品种（系）的脂肪酸成分及相对含量。结果表明：新陆早33、42号棉籽形态发育差异不大,新陆早33号的棉籽颜色较新陆... 详细信息

本研究测定了新陆早33、42号棉籽不同发育时期含水量、可溶性糖含量和油分含量的动态变化情况,并采用气相色谱法测定了9个品种（系）的脂肪酸成分及相对含量。结果表明：新陆早33、42号棉籽形态发育差异不大,新陆早33号的棉籽颜色较新陆早42号的稍深,籽粒也较大;棉籽发育20 DAP时的含水量较高,达82%左右;45 DPA-成熟阶段,籽粒迅速脱水至8.63%和5.12%。随着棉籽的发育,油分逐渐积累（含油量提高）,而可溶性糖含量逐渐降低。20~35 DPA是油分含量的快速增长期,也恰恰是可溶性糖的快速下降期。成熟期时,新陆早33号的含油量30.2%,高于新陆早42号的27.3%。分析不同材料脂肪酸成分可知：不同品种棉籽油所含脂肪酸成分相同,但各脂肪酸成分的相对含量差异较大,其中亚油酸含量变化范围为50.91%~57.19%,棕榈酸、油酸含量的变化范围分别为22.47%~31.17%和14.25%~17.90%;新疆早熟陆地棉间的棉籽油成分含量差异较大,说明对棉花材料的棉籽油分含量进行遗传改良具有较大的潜力。

关键词：陆地棉棉籽油分发育脂肪酸成分

Recombinant adeno-associated virus 8-mediated inhibition of microRNA let-7a ameliorates sclerosing cholangitis in a clinically relevant mouse model

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World Journal of Gastroenterology 2024年第5期30卷 471-484页

作者： hui Hua Qian-Qian Zhao Miriam Nkesichi Kalagbor Guo-Zhi Yu Man Liu Zheng-Rui Bian Bei-Bei Zhang Qian Yu Yin-Hai Xu Ren-xian Tang Kui-Yang Zheng Chao Yan Jiangsu Key Laboratory of Immunity and Metabolism Department of Pathogenic Biology and ImmunologyNational Demonstration Center for Experimental Basic Medical Science EducationLaboratory of Infection and ImmunityXuzhou Medical UniversityXuzhou 221004Jiangsu ProvinceChina Department of Laboratory Medicine The Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221002Jiangsu ProvinceChina

BACKGROUND Primary sclerosing cholangitis(PSC)is characterized by chronic inflammation and it predisposes to cholangiocarcinoma due to lack of effective treatment *** adeno-associated virus(rAAV)provides a promising platform for gene therapy on such kinds of diseases.A microRNA(miRNA)let-7a has been reported to be associated with the progress of PSC but the potential therapeutic implication of inhibition of let-7a on PSC has not been *** To investigate the therapeutic effects of inhibition of a miRNA let-7a transferred by recombinant adeno-associated virus 8(rAAV8)on a xenobiotic-induced mouse model of sclerosing *** A xenobiotic-induced mouse model of sclerosing cholangitis was induced by 0.1% 3,5-Diethoxycarbonyl-1,4-Dihydrocollidine(DDC)feeding for 2 wk or 6 wk.A single dose of rAAV8-mediated anti-let-7a-5p sponges or scramble control was injected in vivo into mice onset of DDC *** sacrifice,the liver and the serum were collected from each *** hepatobiliary injuries,hepatic inflammation and fibrosis were *** targets of let-7a-5p and downstream molecule NF-κB were detected using Western *** rAAV8-mediated anti-let-7a-5p sponges can depress the expression of let-7a-5p in mice after DDC feeding for 2 wk or 6 *** reduced expression of let-7a-5p can alleviate hepato-biliary injuries indicated by serum markers,and prevent the proliferation of cholangiocytes and biliary ***,inhibition of let-7a mediated by rAAV8 can increase the expression of potential target molecules such as suppressor of cytokine signaling 1 and Dectin1,which consequently inhibit of NF-κB-mediated hepatic *** Our study demonstrates that a rAAV8 vector designed for liver-specific inhibition of let-7a-5p can potently ameliorate symptoms in a xenobiotic-induced mouse model of sclerosing cholangitis,which provides a possible clinical translation of PSC of human.

关键词： Primary sclerosing cholangitis Recombinant adeno-associated virus 8 Let-7a-5p Therapeutic effects Inflammation

Two different mutational types of familial gastrointestinal stromal tumors:Two case reports

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World Journal of Gastrointestinal Oncology 2024年第9期16卷 4028-4036页

作者： Xiao-Ke Wang Lu-Fan Shen Xin Yang He Su Tao Wu Peng-xian Tao Hong-Ying Lv Tong-Han Yao Lin Yi Yuan-hui Gu The First School of Clinical Medical Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina School of Traditional Chinese and Western Medicine Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina Department of General Surgery Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina

BACKGROUND Gastrointestinal stromal tumors(GISTs)are the most common mesenchymal tumors of the gastrointestinal(GI)tract,and cases of GISTs tend to be of the disseminated type,with a global incidence of 10 to 15 cases/million each *** rarer familial GISTs,which often represent a population,differ in screening,diagnosis,and *** GISTs include primary familial GISTs with predominantly KIT/PDGFRA mutations and wild-type ***,whether the same genetic family has different phenotypes has not been *** SUMMARY We report two cases of rare GISTs in the same family:A male patient with the V561D mutation in exon 12 of the PDGFRA gene,who has been taking the targeted drug imatinib since undergoing surgery,and a female patient diagnosed with wild-type GIST,who has been taking imatinib for 3 years since undergoing *** favorable prognosis of these patients during the 7-year follow-up period validates the accuracy of our treatment strategy,and we have refined the entire process of diagnosis and treatment of familial GISTs in order to better manage this rare familial *** Different mutation types of familial GISTs in the same family are very rare,thus it is very important to make the correct diagnosis and treatment strategies according to the results of molecular detection for the management of familial GISTs.

关键词： Gastrointestinal stromal tumor Familial gastrointestinal stromal tumor Wild-type gastrointestinal stromal tumors PDGFRA Imatinib Treatment Case report