检索结果-南通市图书馆

Clinicopathological Features and Long-Term Prognostic Role of Human Epidermal Growth Factor Receptor-2 Low Expression in Chinese Patients with Early Breast Cancer:A Single-Institution Study

在线全文

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2024年第5期37卷 457-470页

作者： kong Zi Qing LIU Li Qun HUANG De Qin WANG Yu Tong LI Jing Jie ZHANG Zheng WANG Xi Xi LIU Chuan ling ZHANG Ya Di SHAO Jia Kang ZHU Yi Min CHEN Yi Meng LIU Mei ZHAO Wei Hong Medical School of Chinese PLA Beijing 100853China Department of Medical Oncology the First Medical CenterGeneral Hospital of the Chinese People’s Liberation ArmyBeijing 100853China Nankai University School of Medicine Tianjin 300071China Department of Medical Oncology the Fifth Medical CenterGeneral Hospital of the Chinese People’s Liberation ArmyBeijing 100039China Department of Medical Oncology Xi'an Jiaotong UniversityXi’an 710061ShaanxiChina Department of Pathology the Sixth Medical CenterGeneral Hospital of the Chinese People’s Liberation ArmyBeijing 100037China

Objective This study aimed to comprehensively analyze and compare the clinicopathological features and prognosis of Chinese patients with human epidermal growth factor receptor 2(HER2)-low early breast cancer(BC)and HER2-IHC0 *** Patients diagnosed with HER2-negative BC(N=999)at our institution between January2011 and December 2015 formed our study *** characteristics,association between estrogen receptor(ER)expression and HER2-low,and evolution of HER2 immunohistochemical(IHC)score were ***-Meier method and log-rank test were used to compare the long-term survival outcomes(5-year follow-up)between the HER2-IHC0 and HER2-low *** HER2-low BC group tended to demonstrate high expression of ER and more progesterone receptor(PgR)positivity than HER2-IHC0 BC group(P<0.001).The rate of HER2-low status increased with increasing ER expression levels(Mantel-Haenszelχ^(2)test,P<0.001,Pearson’s R=0.159,P<0.001).Survival analysis revealed a significantly longer overall survival(OS)in HER2-low BC group than in HER2-IHC0 group(P=0.007)in the whole cohort and the hormone receptor(HR)-negative *** were no significant differences between the two groups in terms of disease-free survival(DFS).The discordance rate of HER2 IHC scores between primary and metastatic sites was 36.84%.Conclusion HER2-low BC may not be regarded as a unique BC group in this population-based study due to similar clinicopathological features and prognostic roles.

关键词： HER2 HER2-low Breast cancer Estrogen receptor Trastuzumab deruxtecan

Experimental study on workability and permeability of sandy soils conditioned with thickened foam

在线全文

学校读者我要写书评

暂无评论

Journal of Rock Mechanics and Geotechnical Engineering 2024年第2期16卷 532-544页

作者： Zhiyao Feng Shuying Wang Tongming Qu Xiangcou Zheng Fanlin ling School of Civil Engineering Central South UniversityChangsha410075China Tunnel and Underground Engineering Research Center Central South UniversityChangsha410075China Department of Civil and Environmental Engineering The Hong Kong University of Science and TechnologyClearwater BayKowloon999077Hong KongChina Geo-Engineering Section Delft University of TechnologyDelft999025Netherlands

Water spewing and muck plugging often occur during earth pressure balance(EPB)shield machines tunnelling in water-rich sandy strata,even though the conventional foam has been employed to condition sandy *** this study,a novel thickened foaming agent suitable for EPB shield tunnelling in water-rich sandy strata is *** contrast to conventional foam-conditioned sands,the thickened foam-conditioned sand has a low permeability due to the consistent filling of soil pores with the thickened foam,and the initial permeability coefficient decreases by approximately two orders of *** also exhibits a suitable workability,which is attributed to the enhanced capability of the thickened foam to condition sandy *** addition,the effect of concentration on the stability of the foam is explained by the Gibbs-Marangoni effect,and conditioning mechanisms for the thickened foam on sands are discussed from the evolution of foam bubbles.

关键词： Earth pressure balance(EPB)shield Thickened foam Foam-conditioned sand Permeability Workability

Simultaneous guidance of electromagnetic and elastic waves via glide symmetry phoxonic crystal waveguides

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics B 2024年第3期33卷 363-368页

作者：雷林霖何灵娟廖清华刘文兴于天宝 School of Physics and Materials Science Nanchang UniversityNanchang 330031China

A phoxonic crystal waveguide with the glide symmetry is designed,in which both electromagnetic and elastic waves can propagate along the glide plane at the same *** to the glide symmetry,the bands of the phoxonic crystal super-cell degenerate in pairs at the boundary of the Brillouin *** is the so-called band-sticking effect and it causes the appearance of gapless *** adjusting the magnitude of the glide dislocation the edge bandgaps,the bandgap of the guided-modes at the boundary of the Brillouin zone,can be further *** photonic and phononic guided-modes can then possess only one mode for a certain frequency with relatively low group velocities,achieving single-mode guided-bands with relatively flat dispersion *** addition,there exists acousto-optic interaction in the cavity constructed by the glide *** proposed waveguide has potential applications in the design of novel optomechanical devices.

关键词： phoxonic crystals glide symmetry waveguide acousto-optic interaction

Precise Planar-Twisted Molecular Engineering to Construct Semiconducting Polymers with Balanced Absorption and Quantum Yield for Efficient Phototheranostics

在线全文

学校读者我要写书评

暂无评论

Research 2024年第2期2023卷 227-238页

作者： Xiang Su Zhirong bao Wei Xie Deliang Wang Ting Han Dong Wang Ben Zhong Tang Center for AIE Research Shenzhen Key Laboratory of Polymer Science and TechnologyGuangdong Research Center for Interfacial Engineering of Functional MaterialsCollege of Materials Science and EngineeringShenzhen UniversityShenzhen 518060China School of Biomedical and Pharmaceutical Sciences Guangdong University of TechnologyGuangzhou 510006China Department of Radiation and Medical Oncology Hubei Key Laboratory of Tumor Biological BehaviorsHubei Cancer Clinical Study CenterZhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Materials Chemistry Huzhou UniversityHuzhou 313000China School of Science and Engineering Shenzhen Institute of Aggregate Science and TechnologyThe Chinese University of Hong KongShenzhenGuangdong 518172China

Semiconducting polymers(SPs)have shown great feasibility as candidates for near-infrared-II(NIR-Ⅱ)fluorescence imaging-navigated photothermal therapy due to their strong light-harvesting ability and flexible ***,the fluorescence signal of traditional SPs tends to quench in their aggregate states owing to the strongπ-πstacking,which can lead to the radiative decay pathway shutting *** address this issue,aggregation-induced emission effect has been used as a rational tactic to boost the aggregate-state fluorescence of NIR-Ⅱ*** this contribution,we developed a precise molecular engineering tactic based on the block copolymerizations that integrate planar and twisted segments into one conjugated polymer backbone,providing great flexibility in tuning the photophysical properties and photothermal conversion capacity of *** monomers featured with twisted and planar architectures,respectively,were tactfully incorporated via a ternary copolymerization approach to produce a series of new *** optimal copolymer(SP2)synchronously shows desirable absorption ability and good NIR-Ⅱquantum yield on the premise of maintaining typical aggregation-induced emission characteristics,resulting in balanced NIR-Ⅱfluorescence brightness and photothermal ***-dispersible nanoparticles fabricated from the optimal SP2 show efficient photothermal therapeutic effects both in vitro and in *** in vivo investigation reveals the distinguished NIR-Ⅱfluorescence imaging performance of SP2 nanoparticles and their photothermal ablation toward tumor with prominent tumor accumulation ability and excellent biocompatibility.

关键词： property conducting twisted

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

促进因子对阿舒假囊酵母合成核黄素的影响

江西农业大学学报 2010年第2期32卷 363-367页

作者：刘志文黄林孔令宝程新涂晓嵘李昆太江西农业大学生物科学与工程学院江西南昌330045 南昌市发酵应用技术重点实验室江西南昌330045

研究在发酵培养基中添加不同促进因子(玉米浆、酵母膏和豆油)对阿舒假囊酵母合成核黄素的影响。试验结果表明:添加10g/L玉米浆是最促进阿舒假囊酵母菌体生长和核黄素合成的最适质量浓度;40g/L酵母膏分别在0h补加20g/L,24h和48h各补加10g... 详细信息

研究在发酵培养基中添加不同促进因子(玉米浆、酵母膏和豆油)对阿舒假囊酵母合成核黄素的影响。试验结果表明:添加10g/L玉米浆是最促进阿舒假囊酵母菌体生长和核黄素合成的最适质量浓度;40g/L酵母膏分别在0h补加20g/L,24h和48h各补加10g/L,其核黄素产量达到1587.37mg/L,比在0h1次添加40g/L酵母膏的产量提高了21.07%;在发酵培养基中添加2～5g/L豆油,对核黄素的合成均有促进作用。

关键词：阿舒假囊酵母核黄素生物合成促进因子

Fe-Mn-Al-C系奥氏体基低密度钢使役性能研究进展

在线全文

学校读者我要写书评

暂无评论

机械工程学报 2024年第8期60卷 34-47页

作者：孔玲王玉辉杨浩坤彭艳燕山大学国家冷轧板带装备及工艺工程技术研究中心秦皇岛066004 香港生产力促进局智能制造部中国香港999077

双碳战略催生轻量化材料和技术的蓬勃发展。作为最重要的结构材料之一,钢铁材料在国民经济发展中扮演重要角色。Fe-Mn-Al-C系钢具备优异的轻量化特征、耐腐蚀性、机械强度(抗拉强度600~2000 MPa)和塑性(伸长率30%~100%)匹配,引起国内外... 详细信息

双碳战略催生轻量化材料和技术的蓬勃发展。作为最重要的结构材料之一,钢铁材料在国民经济发展中扮演重要角色。Fe-Mn-Al-C系钢具备优异的轻量化特征、耐腐蚀性、机械强度(抗拉强度600~2000 MPa)和塑性(伸长率30%~100%)匹配,引起国内外极大关注。其中,奥氏体基低密度钢在综合性能和加工方面具有显著优势,是汽车、交通、军事等领域结构件极具潜力的轻量化先进钢铁材料。对近年来国内外发表的Fe-Mn-Al-C系低密度钢典型使役性能进行总结和分析,着重聚焦其作为结构件应用中的“基本力学性能、加工成形性能和重要服役性能”等方面,综述Fe-Mn-Al-C系奥氏体基低密度钢使役过程中的力学行为、变形特征以及冲击、疲劳和腐蚀等使役评价,归纳阻碍该类钢作为结构件工业应用仍需突破的科学与技术问题,提出未来提高奥氏体基Fe-Mn-Al-C系低密度钢使役性能的重点方向和研究路径,以期为奥氏体基低密度钢作为结构件应用研究提供参考。

关键词：奥氏体基低密度钢 Fe-Mn-Al-C 力学性能成形性能服役性能

PRaG 3.0 therapy for human epidermal growth factor receptor 2-positive metastatic pancreatic ductal adenocarcinoma:A case report

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第9期30卷 1237-1249页

作者： Yue-Hong kong Mei-ling Xu Jun-Jun Zhang Guang-Qiang Chen Zhi-Hui Hong Hong Zhang Xiao-Xiao Dai Yi-Fu Ma Xiang-Rong Zhao Chen-Yang Zhang Rong-Zheng Chen Peng-Fei Xing Li-Yuan Zhang Center for Cancer Diagnosis and Treatment The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Radiotherapy&Oncology The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Institution of Radiotherapy&Oncology Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Radiology The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Nuclear Medicine The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Clinical Laboratory The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Pathology The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina

BACKGROUND Pancreatic ductal adenocarcinoma(PDAC)is a highly fatal disease with limited effective treatment especially after first-line *** human epidermal growth factor receptor 2(HER-2)immunohistochemistry(IHC)positive is associated with more aggressive clinical behavior and shorter overall survival in *** SUMMARY We present a case of multiple metastatic PDAC with IHC mismatch repair proficient but HER-2 IHC weakly positive at diagnosis that didn’t have tumor regression after first-line nab-paclitaxel plus gemcitabine and PD-1 inhibitor treatment.A novel combination therapy PRaG 3.0 of RC48(HER2-antibody-drug conjugate),radio-therapy,PD-1 inhibitor,granulocyte-macrophage colony-stimulating factor and interleukin-2 was then applied as second-line therapy and the patient had confirmed good partial response with progress-free-survival of 6.5 months and overall survival of 14.2 *** had not developed any grade 2 or above treatment-related adverse events at any *** of peripheral CD8^(+) Temra and CD4^(+) Temra were increased during first two activation cycles of PRaG 3.0 treatment containing radiotherapy but deceased to the baseline during the maintenance cycles containing no *** PRaG 3.0 might be a novel strategy for HER2-positive metastatic PDAC patients who failed from previous first-line approach and even PD-1 immunotherapy but needs more data in prospective trials.

关键词： Pancreatic ductal adenocarcinoma PRaG 3.0 therapy Human epidermal growth factor receptor 2 Novel combination therapy Case report

Glutamine transporters as effective targets in digestive system malignant tumor treatment

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Oncology Research 2024年第10期32卷 1661-1671页

作者： FEI CHU KAI TONG XIANG GU MEI bao YANFEN CHEN BIN WANG YANHUA SHAO ling WEI School of Chinese Materia Medica Guangdong Pharmaceutical UniversityGuangzhou510006China Department of Pharmacy Tianjin Medical University General HospitalTianjin300070China

Glutamine is one of the most abundant non-essential amino acids in human plasma and plays a crucial role in many biological processes of the human *** cells take up a large amount of glutamine to meet their rapid proliferation requirements,which is supported by the upregulation of glutamine *** inhibition of glutamine transporters effectively inhibits cell growth and proliferation in *** all cancers,digestive system malignant tumors(DSMTs)have the highest incidence and mortality rates,and the current therapeutic strategies for DSMTs are mainly surgical resection and *** to the relatively low survival rate and severe side effects associated with DSMTs treatment,new treatment strategies are urgently *** article summarizes the glutamine transporters involved in DSMTs and describes their role in ***,glutamine transportertarget drugs are discussed,providing theoretical guidance for the further development of drugs DSMTs treatment.

关键词： Glutamine transporter Targeted therapy Inhibitors Cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

全球史视域下唐代“长安-天山廊道”的形成

中南民族大学学报（人文社会科学版） 2024年第1期44卷 51-61,183页

作者：黄达远孔令昊西安外国语大学丝绸之路与欧亚文明研究中心陕西西安710100 中央民族大学历史文化学院北京100081

通过对“关中-七河”沿线跨区域交流的讨论,探讨唐代“长安-天山廊道”形成与贯通原因,从全球史的视角出发,超越了近代早期“欧洲中心观”下的民族国家史学范式以及“农耕-游牧”对立的二元观。研究指出,认识唐朝与中亚的关系,要从“中... 详细信息

通过对“关中-七河”沿线跨区域交流的讨论,探讨唐代“长安-天山廊道”形成与贯通原因,从全球史的视角出发,超越了近代早期“欧洲中心观”下的民族国家史学范式以及“农耕-游牧”对立的二元观。研究指出,认识唐朝与中亚的关系,要从“中原-游牧-绿洲(粟特)”地缘关系中发掘城镇带的形成机制及其对走廊的支撑作用,由此重新认识和丰富“中国与周边”作为区域命运共同体的历史内涵。

关键词：唐代“长安-天山廊道” 跨区域交流新北道 “外族盛衰之连环性”