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Consensus on the digestive endoscopic tunnel technique

World Journal of Gastroenterology 2019年第7期25卷 744-776页

作者： Ning-Li Chai Hui-Kai Li En-Qiang Linghu Zhao-shen Li Shu-Tian Zhang Yu Bao Wei-Gang Chen Philip WY Chiu Tong Dang Wei Gong Shu-Tang Han Jian-Yu Hao Shui-Xiang He Bing Hu1 Bing Hu2.Xiao-Jun Huang Yong-Hui Huang Zhen-Dong Jin Mouen A Khashab James Lau Peng Li Rui Li De-Liang liu Hai-Feng liu Jun liu Xiao-Gang liu Zhi-Guo liu Ying-Cai Ma Gui-Yong Peng Long Rong Wei-Hong Sha Pateek Sharma Jian-Qiu sheng Shui-sheng Shi Dong Wan Seo Si-Yu Sun Gui-Qi Wang Wen Wang Qi Wu Hong Xu Mei-Dong Xu Ai-ming Yang Fang Yao Hong-Gang Yu Ping-Hong Zhou Bin Zhang Xiao-Feng Zhang Ya-Qi Zhai department of Gastroenterology and Hepatology Chinese PLA General HospitalBeijing 100853China department of Gastroenterology Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China department of Gastroenterology the First Affiliated Hospital of Xi’an Jiao Tong UniversityXi’an 710000Shaanxi ProvinceChina department of Gastroenterology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina department of Endoscopy Eastern Hepatobiliary Surgical Hospital Affiliated to Naval Medical UniversityShanghai 200438China department of Gastroenterology the Second Hospital of Lanzhou UniversityLanzhou 730030Gansu ProvinceChina department of Gastroenterology Peking University Third HospitalBeijing 100191China Division of Gastroenterology and Hepatology the Johns Hopkins University School of MedicineBaltimoreMD 21218United States department of Gastrointestinal Endoscopy Prince of Wales Hospitalthe Chinese University of Hong KongHong KongChina department of Gastroenterology the First Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina department of Gastroenterology Second Xiangya Hospital of Central South UniversityChangsha 410000Hunan ProvinceChina department of Gastroenterology Changhai HospitalNaval Medical UniversityShanghai 200433China department of Gastroenterology General Hospital of Chinese People’s Armed Police ForcesBeijing 100039China Division of Gastroenterology Union Hospital of Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022Hubei ProvinceChina department of Gastroenterology Sichuan Provincial People’s HospitalChengdu 610072Sichuan ProvinceChina department of Gastroenterology Xijing HospitalAir Force Medical UniversityXi’an 710032Shaanxi ProvinceChina department of Digestion Qinghai Provincial People’s HospitalXining 810007Qinghai ProvinceChina department of Gastroenterology Southwest HospitalArmy Medical UniversityChongqing 400038China department of Gastroenterology Peking Univ

With the digestive endoscopic tunnel technique(DETT), many diseases that previously would have been treated by surgery are now endoscopically curable by establishing a submucosal tunnel between the mucosa and muscularis propria(MP). Through the tunnel, endoscopic diagnosis or treatment is performed for lesions in the mucosa, in the MP, and even outside the gastrointestinal(GI) *** present, the tunnel technique application range covers the following:(1)Treatment of lesions originating from the mucosal layer, e.g., endoscopic submucosal tunnel dissection for oesophageal large or circular early-stage cancer or precancerosis;(2. treatment of lesions from the MP layer, per-oral endoscopic myotomy, submucosal tunnelling endoscopic resection, etc.; and(3) diagnosis and treatment of lesions outside the GI tract, such as resection of lymph nodes and benign tumour excision in the mediastinum or abdominal cavity. With the increasing number of DETTs performed worldwide, endoscopic tunnel therapeutics, which is based on DETT, has been gradually developed and optimized. However, there is not yet an expert consensus on DETT to regulate its indications, contraindications, surgical procedure, and postoperative *** International DETT Alliance signed up this consensus to standardize the procedures of DETT. In this consensus, we describe the definition, mechanism,and significance of DETT, prevention of infection and concepts of DETTassociated complications, methods to establish a submucosal tunnel, and application of DETT for lesions in the mucosa, in the MP and outside the GI tract(indications and contraindications, procedures, pre-and postoperative treatments, effectiveness, complications and treatments, and a comparison between DETT and other operations).

关键词： Digestive endoscopic tunnel technique Endoscopic submucosal tunnel dissection Per-oral endoscopic myotomy Submucosal tunnelling endoscopic resection Gastrointestinal tract

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Splitting Behaviour of Implanted MeV Au^(+)Ions in LiB_(3)O_(5)

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Chinese Physics Letters 2000年第1期17卷 40-42页

作者： WANG Ke-ming SHI Bo-rong Nelson Cue LU Fei WANG Feng-xiang XIE Zhao-xia shen Ding-yu {2. Yao-gang department of Physics Shandong UniversityJiJnan 250100 department of Physics Hong Kong University of Science and TechnologyHong Kong Laboratory of Heavy Ion Physics Peking UniversityBeijing 100871 Institute of Crystal Materials Shandong UniversityJi'nan 250100

The diffusion behaviour of 1.0 and 2.0MeV Au^(+)implanted into LiB_(3)O_(5)single crystal has been studied by the Rutherford backscattering of 2.1 MeV He *** was performed at temperatures of 600,700,and 800℃each for 30 *** results show that the diffusion behaviour is quite different in two *** LiB_(3)O_(5),the depth distribution of the 1.0MeV Au is nearly Gaussian and becomes bimodal after annealing at 800℃for 30 *** in the case of 2.0 MeV,the depth distribution of as implanted Au^(+)in LiB_(3)O_(5)has splitting *** 800℃for 30 min annealing,there is no obvious diffusion *** precise interpretation is needed.

关键词： diffusion annealing behaviour

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Mapping big brains at subcellular resolution in the era of big data in zoology

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Zoological Research 2022年第4期43卷 597-599页

作者： Yan shen Lu-Feng Ding Chao-Yu Yang Fang Xu Pak-ming Lau Guo-Qiang Bi Interdisciplinary Center for Brain Information Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research InstitutionsShenzhenGuangdong 518000China Division of Life Sciences and Medicine University of Science and Technology of ChinaHefeiAnhui 230001China Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui 230001China

Connectome-scale structural mapping is fundamental for understanding the underlying mechanisms of brain cognition and brain disease *** combining rapidly developing three-dimensional(3D)imaging techniques and big data analysis methods,researchers are working on mesoscale mapping of mammalian brains at an accelerated ***,we briefly describe existing brain-wide imaging strategies,especially our recently established primateoptimized pipeline capable of pan-brain neuronal connectivity mapping at subcellular resolution,and further discuss their vast application prospects in the big data era of zoology.

关键词： Mapping resolution mapping

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Virus load and virus shedding of SARS-CoV-2.and their impact onpatient outcomes

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World Journal of Clinical Cases 2020年第24期8卷 6252-6263页

作者： Pei-Fen Chen Xia-Xia Yu Yi-Peng liu Di Ren Min shen Bing-sheng Huang Jun-Ling Gao heng-Yang Huang {2. Wu Wei-Yan Wang Li Chen Xia Shi Zhao-Qing Wang Ying-Xia liu Lei liu Yong liu department of Respiratory Diseases Shenzhen Key Laboratory of Pathogen and ImmunityNational Clinical Research Center for Infectious DiseaseState Key Discipline of Infectious DiseasesShenzhen Third People’s HospitalThe Second Hospital Affiliated to Southern University of Science and TechnologyShenzhen 518114Guangdong ProvinceChina School of Biomedical Engineering Health Science CenterShenzhen UniversityShenzhen 518060Guangdong ProvinceChina Expert Panel of shenzhen 2.19-nCoV Pneumonia The Second People’s Hospital of ShenzhenShenzhen 518035Guangdong ProvinceChina shenzhen Key Laboratory of Pathogen and Immunity National Clinical Research Center for Infectious DiseaseState Key Discipline of Infectious DiseasesShenzhen Third People’s HospitalThe Second Hospital Affiliated to Southern University of Science and TechnologyShenzhen 518114Guangdong ProvinceChina Medical AI Laboratory School of Biomedical EngineeringHealth Science CentreShenzhen UniversityShenzhen 518060Guangdong ProvinceChina Buddhism and Science Research Laboratory Centre of Buddhist StudiesThe University of Hong KongPokfulamHong Kong 999077China ICU The Second People's Hospital of ShenzhenShenzhen 518035Guangdong ProvinceChina Expert Panel of shenzhen 2.19-nCoV Pneumonia Shenzhen HospitalSouthern Medical UniversityShenzhen 518000Guangdong ProvinceChina

BACKGROUND Understanding a virus shedding patterns in body fluids/secretions is importantto determine the samples to be used for diagnosis and to formulate infectioncontrol *** To investigate the severe acute respiratory syndrome coronavirus 2.(SARS-CoV-2.shedding patterns and its risk *** All laboratory-confirmed coronavirus disease 2.19 patients with completemedical records admitted to the shenzhen Third People’s Hospital from January2., 2.2. to March 8, 2.2. were included. Among 145 patients (54.5% males;median age, 46.1 years), three (2.1%) died. The bronco-alveolar lavage fluid(BALF) had the highest virus load compared with the other samples. The viralload peaked at admission (3.3 × 108 copies) and sharply decreased 10 d *** The viral load was associated with prolonged intensive care unit (ICU) *** in the ICU had significantly longer shedding time compared to those inthe wards (P 1). Age > 60 years [hazard ratio (HR) = 0.6;95% confidenceinterval (CI): 0.4-0.9] was an independent risk factor for SARS-CoV-2.shedding,while chloroquine (HR = 2..8;95%CI: 2.3-2.4.6) was a protective *** BALF had the highest SARS-CoV-2.load. Elderly patients had higher virus loads,which was associated with a prolonged ICU stay. Chloroquine was associatedwith shorter shedding duration and increased the chance of viral negativity.

关键词： COVID-19 Virus shedding Viral load Patient outcome china Infectious disease

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Ni基指数分布梯度熔覆层低应力多碰趋表效应

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表面技术 2017年第6期46卷 244-248页

作者：孔茗沈玲琳石世宏苏州工业职业技术学院江苏苏州215104 苏州大学激光制造技术研究所江苏苏州215021

目的研究在低应力多碰条件下,在零件表面激光熔覆制备指数分布梯度涂层的效应。方法采用网格坐标划分法,在低应力条件下通过对Ni基指数分布梯度熔覆层的0Cr18Ni9试件进行多碰试验,获取变形数据,计算获得变形率,绘制规律曲线。借助工具... 详细信息

目的研究在低应力多碰条件下,在零件表面激光熔覆制备指数分布梯度涂层的效应。方法采用网格坐标划分法,在低应力条件下通过对Ni基指数分布梯度熔覆层的0Cr18Ni9试件进行多碰试验,获取变形数据,计算获得变形率,绘制规律曲线。借助工具显微镜,获得碰撞前后组织金相图。结果采用的碰撞应力仅有115 MPa,远低于涂层材料与基体的静压缩屈服强度,但指数分布的梯度涂层发生了可测的塑性变形,第一网格层变形率最为明显,达到了18.97%,第二网格层变形率为15.03%,靠近基体的最后一个网格层的变形率为0.2.%,可以表明指数分布梯度涂层在低应力多碰后的形变具有"趋表效应"。基体的形变情况与梯度涂层的形变基本一致,从距表面6 mm处开始,涂层与基体结合处由于有瞬间激光高温熔覆,出现了应变的突变现象,宏观塑性变形增大,变形率突增到3.92.,但基体的形变总的来说也符合"趋表效应"。同时借助金相图看到的晶体滑移现象也证实了这一点。结论在低应力多碰作用后,试件表层的累积变形量最大,随着涂层深度的增加梯度减小,表明具有"趋表效应",同时抗多冲形变的能力显著增强。

关键词：指数梯度涂层多次碰撞网格坐标法变形率趋表组织金相图

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薄层色谱与表面增强拉曼散射光谱联用技术的研究进展

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光谱学与光谱分析 2021年第2期41卷 388-394页

作者：沈正东孔宪明喻倩杨占旭辽宁石油化工大学石油化工学院辽宁抚顺113001

表面增强拉曼光谱(SERS)作为一种快速、灵敏的分析技术,被广泛应用于分析化学、环境检测及食品安全等领域。在实际生活中的样品大多为混合物,直接使用SERS技术无法对复杂样品中的分析物进行准确测定。薄层色谱(TLC)分离技术具有操作简便... 详细信息

表面增强拉曼光谱(SERS)作为一种快速、灵敏的分析技术,被广泛应用于分析化学、环境检测及食品安全等领域。在实际生活中的样品大多为混合物,直接使用SERS技术无法对复杂样品中的分析物进行准确测定。薄层色谱(TLC)分离技术具有操作简便,成本低廉及分离速度快等特点,TLC作为一种高通量的分离技术在合成化学、分析化学、药物化学及食品科学等研究领域得到了广泛的应用。TLC对待测物体系进行分离后,通过碘显色或荧光对分离的斑点进行可视化处理,再结合质谱,红外光谱、荧光光谱及SERS光谱等分析技术可以对分离物质进行定性及定量分析。TLC与SERS联用技术的出现,使得SERS光谱可以应用于混合物中分析物的有效测定。TLC-SERS技术同时具备良好的分离作用和灵敏的光谱检测性能,适用于对复杂样品进行分离检测。在TLC-SERS检测过程中,样品用量少且无需使用复杂的实验设备即可实现对混合物现场快速检测。介绍了SERS的增强机理以及活性基底的制备,对TLC-SERS技术在环境污染物检测、食品安全、中草药鉴定及生物医学等方面的应用做了概括性综述。给出了TLC-SERS技术在有害物快检领域的应用实例,为TLC-SERS技术未来用于食品安全、法医鉴定及环境治理中快速检测方法建立及仪器设备研发提供参考。

关键词：薄层色谱表面增强拉曼光谱薄层色谱原位的表面增强拉曼

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王阳明从祀孔庙的史料问题

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史学集刊 2008年第6期 35-44页

作者：朱鸿林香港中文大学历史系

万历十二年王阳明获准从祀孔庙,是明代思想文化史和政治史上的大事,但却因史籍记载混淆矛盾而产生几个认知上的困难。明穆宗、神宗两朝《实录》、《万历起居注》、《国榷》等书以及当时涉事人物的奏疏等公私文字,在记述曲折的从祀过程... 详细信息

万历十二年王阳明获准从祀孔庙,是明代思想文化史和政治史上的大事,但却因史籍记载混淆矛盾而产生几个认知上的困难。明穆宗、神宗两朝《实录》、《万历起居注》、《国榷》等书以及当时涉事人物的奏疏等公私文字,在记述曲折的从祀过程时发生了问题。其实,万历十二年廷议从祀之事,主持者礼部尚书沈鲤采纳了不利于阳明的观点、意见,认为阳明所获支持甚少,因而疏请不予从祀,而阳明之终获从祀,则是由于首辅申时行特别向神宗皇帝申说请求所致。廓清各种记述上的时序淆乱,是辨正此事的关键原委,进而说明学者引用明人记述来讨论此事时,不能径以所见作为根据。

关键词：王阳明孔庙孔庙从祀真儒

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High-Throughput Computational Discovery and Intelligent Design of Two-Dimensional Functional Materials for Various Applications

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Accounts of Materials Research 2022年第6期3卷 572-583页

作者： Lei shen Jun Zhou Tong Yang ming Yang Yuan Ping Feng department of Mechanical Engineering National University of SingaporeSingapore 117575Singapore Institute of Materials Research and Engineering Agency for ScienceTechnology and Research(A*STAR)138634Singapore department of Physics National University of SingaporeSingapore 117551Singapore department of Applied Physics The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARChina

Novel technologies and new materials are in high demand for future various applications to overcome the fundamental limitations of current *** example,the nanomaterials are in high demand for the miniaturization of electric *** is one of the most viable solutions for green electric *** single-atom catalysts can provide a 100%utilization *** hold promise for applications in energy conversion and ***-dimensional(2.)materials show promising applications in various applications because they can be tailored to the specific property on which a technology is based and may be compatible with other *** the number of experimentally discovered 2. materials is growing,the speed is very slow and only a few dozen 2. materials have been synthesized or exfoliated since the discovery of ***,a novel computational technique,dubbed high-throughput computational materials design,has become a burgeoning area of materials science,which is a combination of quantum mechanical theory,materials information,and database construction with intelligent data *** new and powerful tool can greatly accelerate the discovery,design,and application of 2. materials by creating a database containing a large number of 2. materials with calculated fundamental properties and then intelligently mining(via high-throughput automation or machine learning)the database in the search for 2. materials with the desired properties for particular applications,such as energy conversion/storage,catalysis,water purification,electronics,and *** this Account,we summarize our recent progress in the emerging area of 2. materials discovery,database construction,2. functional materials design,and device development by quantum-mechanical modeling,high-throughput calculations,and machine learning inspired by the materials genome *** developed an open 2. materials database−2. materials encyclopedia(2.MatPedia;h

关键词： ferroelectric Outlook overcome

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CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen mingjun Chen mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central china Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan china academy of engineering physics MianyangSichuan china building materials academy Beijing china Center of Advanced Science and Technology Beijing china Institute of Atomic Energy Beijing china Jiliang University HangzhouZhejiang china Nuclear Instrument CO. LTDBeijing china University of Geosciences Beijing china University of Geosciences WuhanHubei china University of Mining and Technology XuzhouJiangsu china West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East china University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by china,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2.s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2.15)and the Conceptual Design Report(CDR,2.18),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2.2.-2.2.,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2.30s.

关键词： initiated exceeding precise

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脂质体模拟生物膜研究药物吸收

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高等学校化学学报 1998年第11期19卷 1730-1734页

作者：罗云敬沈含熙刘海涛孔德明南开大学化学系

应用膜模型脂质体研究了脂溶性药物水杨酸、水溶性药物维生素Ｂ６和头孢曲松钠、喹诺酮类抗菌素氟哌酸及抗癌药物阿霉素的吸收，并与细胞膜上的吸收情况作了比较．吸收曲线呈直线关系的水杨酸吸收依赖被动扩散．维生素Ｂ６的实验结果表... 详细信息

应用膜模型脂质体研究了脂溶性药物水杨酸、水溶性药物维生素Ｂ６和头孢曲松钠、喹诺酮类抗菌素氟哌酸及抗癌药物阿霉素的吸收，并与细胞膜上的吸收情况作了比较．吸收曲线呈直线关系的水杨酸吸收依赖被动扩散．维生素Ｂ６的实验结果表明吸收依赖于细胞膜上的蛋白，是一种化学过程，吸收值不呈直线关系．头孢曲松钠的吸收方式是简单的扩散过程．氟哌酸在离子作用下扩散通过脂双层．阿霉素是在细胞核内核酸的牵引力作用下跨膜吸收．

关键词：脂质体生物膜药物吸收模拟抗癌药阿霉素

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