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Suspected Close Contacts as the Pilot Indicator of the Growth Trend of Confirmed Population During the COVID-19 Pandemic: A Simulation Approach

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Infectious Microbes & Diseases 2020年第2期2卷 35-41页

作者： Sisi Huang Anding Zhu Yan wang Yancong Xu Lu Li dexing kong School of Mathematical Sciences Zhejiang UniversityHangzhou 310027China School of Management Engineering Zhejiang Gongshang UniversityHangzhou 310018China School of Mathematical Sciences Chongqing Normal UniversityChongqing 401331China department of mathematics Hangzhou Normal UniversityHangzhou 311121China College of Basic Medical Sciences Zhejiang Chinese Medical UniversityHangzhou 310053China

Regarding to the actual situation of the new coronavirus disease 2019 epidemic,social factors should be taken into account and the increasing growth trend of confirmed populations needs to be explained.A proper model needs to be established,not only to simulate the epidemic,but also to evaluate the future epidemic situation and find a pilot indicator for the *** original susceptible-infectious-recover model is modified into the susceptible-infectious-quarantine-confirm-recover combined with social factors(SIDCRL)model,which combines the natural transmission with social factors such as external interventions and *** numerical simulation method is used to imitate the change curve of the cumulative number of the confirmed cases and the number of cured ***,we investigate the relationship between the suspected close contacts(SCC)and the final outcome of the growth trend of confirmed cases with a simulation *** article selects four representative countries,that is,china,South Korea,Italy,and the United States,and gives separate numerical *** simulation results of the model fit the actual situation of the epidemic development and reasonable predictions are *** addition,it is analyzed that the increasing number of SCC contributes to the epidemic outbreak and the prediction of the United States based on the population of the SCC highlights the importance of external intervention and active prevention *** simulation of the model verifies its reliability and stresses that observable variable SCC can be taken as a pilot indicator of the coronavirus disease 2019 pandemic.

关键词： COVID-19 SIR model social factors numerical simulation suspected close contacts confirmed case temporary hospital

Application of computer-aided diagnosis of congenital heart disease in four-chamber view of fetal heart basic screening

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Chinese Medical Journal 2022年第24期135卷 3010-3012页

作者： Fangfei Su Xiaoqian Zhang Jijing Han Jingjing wang Lu Li dexing kong Qingqing Wu department of Ultrasound Beijing Obstetrics and Gynecology HospitalCapital Medical UniversityBeijing 100026China School of Mathematical Sciences Zhejiang UniversityHangzhouZhejiang 310058China department of Obstetrics&Gynecology The Chinese University of Hong KongHong KongChina

To the Editor:Congenital heart disease(CHD)is the most common severe congenital malformation which threatens the health of the fetus and the primary factor of intrauterine *** detection of severe CHD could reduce the neonatal mortality and *** detection rate ranges between 25.0%and 59.7%in the prenatal ultrasonographic examination.^([1])We need to identify new strategies to improve detection rates of CHD ***-learning(DL)-based computer-aided diagnosis(CAD)has been highly and rapidly developed in recent years.

关键词： diagnosis congenital fetal

多种非高斯分布模型扩散加权成像对大鼠肝脏缺血再灌注模型的评价价值

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中华放射学杂志 2019年第1期53卷 63-68页

作者：张思影尧林鹏洪源汪启东孔德兴周华陈峰浙江大学医学院附属第一医院放射科杭州310003 浙江大学数学科学学院杭州310003

目的探讨联合多种非高斯分布模型DWI评价大鼠肝脏缺血再灌注损伤(HIRI)模型的价值。方法SD大鼠42只,采用随机数字表法分为7组,每组6只,分别为HIRI后6h、12h、1d、3.、7d、14d组和对照组。实验组行肝右叶门静脉和肝动脉结扎3.后再灌注,... 详细信息

目的探讨联合多种非高斯分布模型DWI评价大鼠肝脏缺血再灌注损伤(HIRI)模型的价值。方法SD大鼠42只,采用随机数字表法分为7组,每组6只,分别为HIRI后6h、12h、1d、3.、7d、14d组和对照组。实验组行肝右叶门静脉和肝动脉结扎3.后再灌注,分别在HIRI后6h、12h、1d、3.、7d、14d进行MRI扫描(T1WI、T2WI、低b值DWI以及超高b值DWI),对照组行假手术后行MRI扫描。根据单指数模型、双指数模型、三指数模型、拉伸指数模型的DWI以及扩散峰度成像得出多个参数,并观察各时间点其动态变化,参数包括标准ADC值(ADCs)、纯扩散系数(D)、伪扩散系数(D*)、灌注分数(f)、超高ADC值(ADCu)、扩散分布指数(DDC)、扩散异质性指数(α)、平均扩散系数(MD)及平均峰度系数(MK)。所有大鼠在MRI扫描结束后于肝右叶取材,行HE染色观察病理表现。应用单因素方差分析比较多组之间各参数(ADCs、D、D^*、f、ADCu、α、DDC、MD、MK)差异。结果所有大鼠均顺利完成了MRI检查及病理检查。术后6h开始大鼠肝右叶T1WI呈稍低信号,T2WI呈高信号。肝右叶病变区域在术后1周明显变小,术后2周基本消失,低b值DWI以及超高b值DWI表现与T2WI基本一致。HIRI后6h、12h、1d、3.、7d、14d组和对照组间的各参数的差异均有统计学意义(P均12h组、1d组、3.组分别与HIRI后6h组、7d组、14d组、对照组组间ADCs差异有统计学意义(P12h组、1d组、3.组、7d组分别与HIRI后14d组、对照组组间D、D^*、f、ADCu、α、DDC、MK差异有统计学意义(P1d组、3.组分别与HIRI后6h组、12h组、7d组、14d组、对照组组间D差异有统计学意义(P12h组、1d组、3.组分别与HIRI后7d组、14d组、对照组组间f差异有统计学意义(P12h组与HIRI后14d组、对照组组间MD差异有统计学意义(P1d组与HIRI后14d组组间MD差异有统计学意义(P<0.05)。结论多种非高斯分布模型DWI评价大鼠HIRI模型优于常规DWI。

关键词：肝脏缺血再灌注损伤非高斯分布模型多b值磁共振成像

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环磷酰胺与环孢素联用致卡波西肉瘤

药物不良反应杂志 2022年第8期24卷 441-443页

作者：唐冯一孔玮束庆葛卫红彭宇竹王红中国药科大学南京鼓楼医院药学部南京210008 南京大学医学院附属鼓楼医院风湿免疫科南京210008 南京大学医学院附属鼓楼医院药学部南京210008 南京市卫生健康委员会南京210008

1例62岁女性系统性血管炎患者长期应用糖皮质激素和环磷酰胺治疗,因病情控制不佳加用环孢素。应用环孢素4个月余,患者右下肢出现暗红色皮疹,行病变皮肤组织活检,病理和免疫组织化学检查结果提示卡波西肉瘤。患者血淋巴细胞亚群计数未见... 详细信息

1例62岁女性系统性血管炎患者长期应用糖皮质激素和环磷酰胺治疗,因病情控制不佳加用环孢素。应用环孢素4个月余,患者右下肢出现暗红色皮疹,行病变皮肤组织活检,病理和免疫组织化学检查结果提示卡波西肉瘤。患者血淋巴细胞亚群计数未见异常,不支持免疫缺陷性疾病,考虑与免疫抑制药物作用过强有关。将环磷酰胺和环孢素改为雷公藤多苷,糖皮质激素减量,7 d后患者皮疹好转;2个月余后,患者右下肢皮疹消退,皮肤平整、无肿胀。

关键词：肉瘤,卡波西免疫抑制剂环磷酰胺环孢素