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BIOCELL 2017年第2期41卷 33-40页

作者： SARA SOLTANIAN HELIA RIAHIRAD ATHAREH PABARJA MOHAMMAD REZA KARIMZADEH kolsoum saeidi Department of Biology Faculty of ScienceShahid Bahonar University of KermanKermanIran Department of Medical Genetics Afzalipour School of MedicineKerman University of Medical SciencesKermanIran Student Research Committee Kerman University of Medical SciencesKermanIran Department of Medical Genetics Kerman University of Medical SciencesKermanIran

Cancer stem cells(CSCs)are a small subpopulation of cancer cells whose resistance to chemotherapy and radiotherapy plays a pivotal role in treatment failure,tumor recurrence and ***,the ability of many phytochemicals in targeting of CSCs has been *** is a plant phytoestrogen that was recognized as a useful agent for targeting cancer cells by apoptosis induction,cell cycle arrest and inhibition of angiogenesis,migration,and invasion of cancer *** this study,we compared the effect of docetaxel as a common breast cancer chemotherapy drug and kaempferol on MCF-7 breast *** showed that both docetaxel and kaempferol caused a dose-dependent reduction in cell *** 123 dye staining and flow cytometry analysis revealed that after docetaxel and kaempferol treatment,SP cells proportion of MCF-7 decreased to 11.83±2.2% and 3±0.25% respectively relative to proportion of untreated control cells(23±3.2%).Moreover,real time PCR results showed that kaempferol treatment of MCF-7 was more effective than docetaxel in down-regulating the CSC-associated markers(***4,nanog,abcb1 and aldh1a1).Taken together,these results indicate that kaempferol is an effective anti-CSCs agent,therefore it may be a therapeutic strategy for eradicating breast cancer through the elimination of CSCs.

关键词： Breast cancer Cancer stem like cells Kaempferol Docetaxel

A methodology for damage evaluation of underground tunnels subjected to static loading using numerical modeling

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第6期16卷 1993-2005页

作者： Shahriyar Heidarzadeh Ali saeidi Rock Mechanics Engineer AtkinsRéalisMontrealQuebecCanada Department of Applied Sciences Universitédu QuébecàChicoutimiChicoutimiQuebecCanada

We have proposed a methodology to assess the robustness of underground tunnels against potential *** involves developing vulnerability functions for various qualities of rock mass and static loading *** account for these variations,we utilized a Monte Carlo Simulation(MCS)technique coupled with the finite difference code FLAC^(3D),to conduct two thousand seven hundred numerical simulations of a horseshoe tunnel located within a rock mass with different geological strength index system(GSIs)and subjected to different states of static *** quantify the severity of damage within the rock mass,we selected one stress-based(brittle shear ratio(BSR))and one strain-based failure criterion(plastic damage index(PDI)).Based on these criteria,we then developed fragility ***,we used mathematical approximation techniques to produce vulnerability functions that relate the probabilities of various damage states to loading intensities for different quality classes of blocky rock *** results indicated that the fragility curves we obtained could accurately depict the evolution of the inner and outer shell damage around the ***,we have provided engineers with a tool that can predict levels of damages associated with different failure mechanisms based on variations in rock mass quality and in situ stress *** method is a numerically developed,multi-variate approach that can aid engineers in making informed decisions about the robustness of underground tunnels.

关键词： Fragility curves Underground tunnels Vulnerability functions Brittle damage FLAC3D Numerical modeling

Evaluation of the effect of geometrical parameters on stope probability of failure in the open stoping method using numerical modeling

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International Journal of Mining Science and Technology 2019年第3期29卷 399-408页

作者： Shahriyar Heidarzadeh Ali saeidi Alain Rouleau Department of Applied Sciences University of Quebec at Chicoutimi

Stress-induced failure is among the most common causes of instability in Canadian deep underground *** stoping is the most widely practiced underground excavation method in these mines,and creates large stopes which are subjected to stress-induced *** probability of failure(POF)depends on many factors,of which the geometry of an open stope is especially *** this study,a methodology is proposed to assess the effect of stope geometrical parameters on the POF,using numerical *** ranges for each input parameter are defined according to previous surveys on open stope geometry in a number of Canadian underground mines.A Monte-Carlo simulation technique is combined with the finite difference code FLAC3D,to generate model realizations containing stopes with different geometrical *** probability of failure(POF)for different categories of stope geometry,is calculated by considering two modes of failure;relaxation-related gravity driven(tensile)failure and rock mass brittle *** individual and interactive effects of stope geometrical parameters on the POF,are analyzed using a general multi-level factorial ***,mathematical optimization techniques are employed to estimate the most stable stope conditions,by determining the optimal ranges for each stope’s geometrical parameter.

关键词： Stope stability Stope geometrical parameters Probability of failure General factorial design Numerical modeling Sublevel open stoping

A Review on Applications of Integrated Terahertz Systems

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China Communications 2021年第5期18卷 175-201页

作者： Xuyang Lu Suresh Venkatesh Hooman saeidi University of Michigan–Shanghai Jiao Tong University Joint Institute Shanghai Jiao Tong UniversityShanghai 200240China Department of Electrical and Computer Engineering Princeton UniversityPrincetonNJ 08540USA

A review on Terahertz end-to-end systems with an emphasis on integrated approaches is *** major catalogs of THz integrated systems,including THz communication systems,THz imaging systems,THz radars,and THz spectroscopy systems,are reviewed in this *** performance of integrated systems is compared with non-integrated solutions,followed by a discussion on the trend in future research avenues and applications.

关键词： terahertz integrated circuit imaging communication spectroscopy on-chip antenna CMOS wireless transceivers phased array MIMO

Efficient oxidative deprotection of trimethylsilyl,tetrahydropyranyl and methoxymethyl ethers under solvent-free conditions

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Chinese Chemical Letters 2008年第6期19卷 676-680页

作者： Farhad Shirini Saeideh saeidi Department of Chemistry College of ScienceUniversity of GuilanRasht 41335Islamic Republic of Iran

A mild, efficient and fast method for direct oxidation of trimethylsilyl, tetrahydropyranyl and methoxymethyl ethers to their corresponding carbonyl compounds using trinitratocerium（Ⅳ） bromate （TNCB） supported on... 详细信息

关键词： Oxidative deprotection Trinitratocerium(Ⅳ) bromate Trimethylsilyl ethers Tetrahydropyranyl ethers Methoxymethyl ethers

This study has been supported by the Programme of Introducing Talents of Discipline to Universities(D21025),the National Natural Science Foundation of China(U20B6005-05),and the National Key R&D Program of China(2019YFC0312300).

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Petroleum 2021年第4期7卷 364-384页

作者： Bjørn Kvamme Navid saeidi Hyzenenergy 26701 Quail CreekLaguna HillsCA92656USA Strategic Carbon LLC 20 Ladd St.Suite 200PortsmouthNH 03801USA State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum UniversityXindu Road No.8Chengdu610500China

The global amount of energy contained in natural gas hydrates is huge,maybe as much as twice all known conventional fossil fuel *** the worldwide distribution of conventional fossil fuels,hydrocarbons trapped in water as hydrate is also available in countries with limited conventional hydrocarbon *** development towards lower global emissions of greenhouse gases requires new strategies for the use of hydrocarbons,whether they are available as conventional resources,or in the form of natural gas *** this work we outline some possible strategies of utilizing hydrocarbon energy resources in a clean and environmentally friendly *** use of carbon dioxide for producing hydrates is not *** from several experimental studies are *** this work we shed more light on thermodynamic limitations and the need for additives in order to make the approach technically *** thermodynamic analysis we show that up to 20 mol per cent N2 is feasible in a CO2/N2 injection gas based on ability to form a new hydrate with free pore water and the released enthalpy needed to dissociate in situ CH4 *** is also needed in order to keep the injection gas front free of blocking hydrate *** alcohols like methanol and ethanol have surfactant *** is demonstrated that even 10 wt%ethanol in liquid pore water still makes it feasible to create a new hydrate from injection gas containing 20 mol per cent *** of other components than CH4 in the hydrate are also *** in practical cases with a well-defined source of CO2 it is also important to investigate impact of other components like for instance H2S on the stability of injection gas hydrate,as well as changes in enthalpy of hydrate *** key element of this work is the conversion of produced hydrocarbons over to hydrogen and carbon dioxide using steam *** technology for this is very old and in daily use.

关键词： Hydrate Non-equilibrium Thermodynamics Kinetics

Determination of uncertainties of geomechanical parameters of metamorphic rocks using petrographic analyses

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第2期16卷 345-364页

作者： Behzad Dastjerdy Ali saeidi Shahriyar Heidarzadeh Department of Applied Sciences University of Quebec at ChicoutimiSaguenayQCCanada SNC-Lavalin MontrealCanada

Geomechanical parameters of intact metamorphic rocks determined from laboratory testing remain highly uncertain because of the great intrinsic variability associated with the degrees of *** aim of this paper is to develop a proper methodology to analyze the uncertainties of geomechanical characteristics by focusing on three domains,*** treatment process,schistosity angle,and ***,the variabilities of the geomechanical laboratory data of Westwood Mine(Quebec,Canada)were examined statistically by applying different data treatment techniques,through which the most suitable outlier methods were selected for each parameter using multiple decision-making criteria and engineering *** indicated that some methods exhibited better performance in identifying the possible outliers,although several others were unsuccessful because of their limitation in large sample *** well-known boxplot method might not be the best outlier method for most geomechanical parameters because its calculated confidence range was not acceptable according to engineering ***,several approaches,including adjusted boxplot,2MADe,and 2SD,worked very well in the detection of true ***,the statistical tests indicate that the best-fitting probability distribution function for geomechanical intact parameters might not be the normal distribution,unlike what is assumed in most geomechanical ***,the negative effects of schistosity angle on the uniaxial compressive strength(UCS)variabilities were reduced by excluding the samples within a specific angle range where the UCS data present the highest ***,a petrographic analysis was conducted to assess the associated uncertainties such that a logical link was found between the dispersion and the variabilities of hard and soft minerals.

关键词： Intact rock parameters Natural variabilities Outlier detection methods Uncertainties Westwood mine Mineralogy

Integrated Intelligent Electromagnetic Radiator Design for Future THz Communication:A Review

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Chinese Journal of Electronics 2022年第3期31卷 499-515页

作者： LU Xuyang Venkatesh Suresh saeidi Hooman Sengupta Kaushik UM-SJTU Joint Institute Shanghai Jiao Tong University Electrical and Computer Engineering Princeton University

Advances in 6 G communication changes how machines and humans interact. The blossom of new applications demands significantly higher data bandwidth while preserving the mobility and sustainability of electronic wireless communication systems. It also demands an integrable system that allows convenient interactions between communication units and signal processing units.A review of CMOS-based THz communication system solutions is presented, with a focus on novel systematic EM-circuit co-design philosophy. This review starts with a review of THz power generation, followed by the discussion of THz localization and THz beamforming for efficient high-throughput communication.

关键词： submillimetre wave generation efficient high-throughput communication THz power generation THz localization integrable system integrated intelligent electromagnetic radiator design electronic wireless communication systems sustainability 6G communication communication system solutions future THz communication signal processing units mobility 6G mobile communication CMOS integrated circuits THz beamforming integrated circuit design array signal processing communication units CMOS systematic EM-circuit co-design philosophy

A method to determine relevant geomechanical parameters for evaluating the hydraulic erodibility of rock

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Journal of Rock Mechanics and Geotechnical Engineering 2019年第5期11卷 1004-1018页

作者： Lamine Boumaiza Ali saeidi Marco Quirion Département des Sciences appliquées Universitédu QuébecàChicoutimiChicoutimiG7H 2B1Canada Expertise en barrages Direction Barrages et infrastructuresHydro-QuébecMontréalH2Z 1A4Canada

Among the methods used for evaluating the potential hydraulic erodibility of rock,the most common methods are those based on the correlation between the force of flowing water and the capacity of a rock to resist erosion,such as Annandale’s and Pells’*** capacity of a rock to resist erosion is evaluated based on erodibility indices that are determined from specific geomechanical parameters of a rock *** indices include unconfined compressive strength(UCS)of rock,rock block size,joint shear strength,a block’s shape and orientation relative to the direction of flow,joint openings,and the nature of the surface to be potentially ***,it is difficult to determine the relevant geomechanical parameters for evaluating the hydraulic erodibility of *** assessment of eroded unlined spillways of dams has shown that the capacity of a rock to resist erosion is not accurately *** more than 100 case studies,we develop a method to determine the relevant geomechanical parameters for evaluating the hydraulic erodibility of rock in unlined *** UCS of rock is found not to be a relevant parameter for evaluating the hydraulic erodibility of *** the other hand,we find that the use of three-dimensional(3D)block volume measurements,instead of the block size factor used in Annandale’s method,improves the rock block size ***,the parameter representing the effect of a rock block’s shape and orientation relative to the direction of flow,as considered in Pells’method,is more accurate than the parameter adopted by Annandale’s method.

关键词： Rock mass Hydraulic erodibility Geomechanical parameters Rock block size Annandale’s method Pells’method Kirsten’s index Erosion level

Determining relative block structure rating for rock erodibility evaluation in the case of non-orthogonal joint sets

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Journal of Rock Mechanics and Geotechnical Engineering 2019年第1期11卷 72-87页

作者： Lamine Boumaiza Ali saeidi Marco Quirion Department of Applied Saences University of Quebec at Chicoutimi Hydro-Quebec

The most commonly used method for assessing the hydraulic erodibility of rock is Annandale's *** method is based on a correlation between the erosive force of flowing water and the capacity of rock resistance. This capacity is evaluated using Kirsten's index, which was initially developed to evaluate the excavatability of earth materials. For rocky material, this index is determined according to certain geomechanical factors related to intact rock and rock mass, such as compressive strength of intact rock, rock block size, discontinuity shear strength and relative block structure. To quantify the relative block structure, Kirsten(1982) developed a mathematical expression that accounts for the shape and orientation of the blocks relative to the direction of flow. Kirsten's initial concept for assessing the relative block structure considers that the geological formation is mainly fractured by two joint sets forming an orthogonally fractured system. An adjusted concept is proposed to determine the relative block structure when the fractured system is non-orthogonal where the angle between the planes of the two joint sets is greater or less than 90°. An analysis of the proposed relative block structure rating shows that considering a non-orthogonally fractured system has a significant effect on Kirsten's index and, as a consequence, on the assessment of the hydraulic erodibility of rock.

关键词： Fractured rock Dip angle Dip direction Joint spacing Relative block structure Hydraulic erodibility of rock Annandale’s method Kirsten’s index