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Science China Chemistry 2012年第5期55卷 850-853页

作者： TAGAYA Akihiro LOU LiPing IDE Yoko koike yasuhiro OKAMOTO Yoshiyuki Keio Photonics Research Institute Keio University E-building Shin-Kawasaki Town Campus 7-1 Shin-Kawasaki Saiwai-ku Kawasaki 212-0032 Japan Faculty of Science and Technology Keio University 3-14-1 Hiyoshi Kohoku-ku Yokohama 223-8522 Japan Polymer Research Institute Polytechnic Institute of NYU 6 MetroTech Center Brooklyn New York 11201 USA

Copolymers of N-pentafluorophenyl maleimide (PFPMI) with methyl methacrylate (MMA) were synthesized by a free radical initiator, such as AIBN. The refractive indexes of the copolymers remained nearly constant (1.4970 at 532 nm) regardless of the polymer composition. These copolymers also showed high thermal stability. The orientational and photoelastic birefringence of the copolymers obtained were measured. Since both of the orientational and photoelastic birefringences of PMMA are negative whereas poly(PFPMI) exhibits positive, thus we have obtained nearly zero orientational and photoelastic birefringence polymers when the ratios of MMA/PFPMI were 91.8/8.2 and 97.0/3.0 mol%, respectively. Based on the experimental data, the ratios of MMA/PFPMI for zero birefringence were determined to be 88.9/11.1 and 93.8/6.2 mol% for orientational and photoelastic birefringence, respectively. The Tgs of corresponding copolymers were estimated to be 128 and 122 ℃.

关键词： N-pentafluorophenyl maleimide copolymers orientational birefringence photoelastic birefringence

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低损耗高带宽渐变型折射率塑料光纤

电线电缆 1993年第2期 24-26页

作者： yasuhiro koike 葛宜妹

首次研制成功的一种低损耗和高带宽的渐变型折射率(GI)塑料光纤,在652nm波长处的传输损耗为134dB/km,其带宽则大于数百门HZ·km。

关键词：塑料光纤制造光纤

Chemotherapy as a component of multimodal therapy for gastric carcinoma

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World Journal of Gastroenterology 2006年第13期12卷 2000-2005页

作者： yasuhiro Kodera Michitaka Fujiwara Masahiko koike Akimasa Nakao Department of Surgery Ⅱ Nagoya University Graduate School of Medicine 65Tsurumai-choShowa-kuNagoyaAichi 466-8550Japan

Prognosis of locally advanced gastric cancer remains poor, and several multimodality strategies involving surgery, chemotherapy, and radiation have been tested in clinical trials. Phase Ⅲ trial testing the benefit of postoperative adjuvant chemotherapy over treatment with surgery alone have revealed little impact on survival, with the exception of some small trials in Western nations. A large trial from the United States exploring postoperative chemoradiation was the first major success in this category. Results from Japanese trials suggest that moderate chemotherapy with oral fluoropyrimidines may be effective against less-advanced （T2-stage） cancer, although another confirmative trial is needed to prove this point. Investigators have recently turned to neoadjuvant chemotherapy, and some promising results have been reported from phase Ⅱ trials using active drug combinations. In 2005, a large phase Ⅲ trial testing preand postoperative chemotherapy has proven its survival benefit for resectable gastric cancer. Since the rate of pathologic complete response is considered to affect treatment results of this strategy, neoadjuvant chemoradiation that further increases the incidence of pathologic complete response could be a breakthrough, and phase Ⅲ studies testing this strategy may be warranted in the near future.

关键词： Surgery Radiation Anticancer drug Adjuvant chemotherapy Neoadjuvant chemotherapy

Microbiota in the stomach and application of probiotics to gastroduodenal diseases

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World Journal of Gastroenterology 2022年第47期28卷 6702-6715页

作者： yasuhiro Koga Japanese Society for Probiotic Science Isehara 259-1143Japan

The stomach is a hostile environment for most microbes because strong gastric acid kills indigenous ***,the mass of indigenous microbes detected by traditional culturing method in a highly acidic stomach is reported to be very ***,in a stomach with less acidity due to atrophic changes of the gastric mucosa,the number of live gastric microbiota dramatically increases and their composition changes.A probiotic is defined as a live microorganism that,when administered in adequate amounts,confers a health benefit on the *** administration of probiotics to the stomach has thus far been considered impractical,mainly due to the strong acidity in the *** identification of candidate probiotic strains with sufficient resistance to acidity and the ability to achieve close proximity to the gastric mucosa could enable the application of probiotics to the *** utilization of probiotics alone for Helicobacter pylori(***)infection significantly improves gastric mucosal inflammation and decreases the density of *** on the mucosa,although complete eradication of *** has not yet been *** use of probiotics in combination with antimicrobial agents significantly increases the *** eradication rate,especially when the *** strains are resistant to antimicrobial *** *** has been considered the most important pathogenic bacterium for the development of gastric cancer,bacteria other than *** are also suggested to be causative pathogens that promote the development of gastric cancer,even after the eradication of *** *** Gram-negative bacteria in the stomach with weak acidity accompanying atrophic gastritis may perpetuate gastric mucosal inflammation and accelerate carcinogenic progression,even after *** *** restore the acidity in this stomach environment and may therefore prevent the development of gastric cancer by termination of Gram-negative ba

关键词： Stomach Microbiota Probiotics Helicobacter pylori Post-eradication gastric cancers Functional dyspepsia

Centrifuge model test on earthquake-induced differential settlement of foundation on cohesive ground

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Science China(Technological Sciences) 2009年第7期52卷 2138-2146页

作者： SHAMOTO yasuhiro HOTTA Hiroyuki MOE Key Laboratory of Soft Soils and Geoenvironmental Engineering Zhejiang University Hangzhou 310058 China Insititute of Technology Shimizu Corporation Tokyo 135-8530 Japan

Dynamic centrifuge model test was conducted to study the earthquake-induced differential settlement of foundation on cohesive ground, and the influence of asymmetry of building was investigated. During the experiment, the overconsolidated kaolin clay ground with a three-dimensional asymmetrical structure model was shaken by a basically balanced input motion, and bender elements were used to measure shear wave velocities of model ground to reveal the soil fabric evolution during and after shaking. The test results show that, the total seismic settlement of foundation is composed of instantaneous and long-term post-earthquake settlements, and most of the differential settlement occurs immediately after the earthquake while the post-earthquake settlement is relatively uniform despite its large amplitude. The asymmetry of building affects the settlement behavior considerably. Compared with 1-or 2-dimensional structures, more evident differential settlement occurs under threedimensional asymmetrical building during shaking, which accounts for one-half of the total seismic settlements and results in complex spatial tilting effects of foundation.

关键词： soft clay centrifuge model test shaking table earthquake-induced differential settlement bender elements

Perioperative management of distal pancreatectomy

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World Journal of Gastroenterology 2015年第11期21卷 3166-3169页

作者： yasuhiro Fujino Department of Surgery Hyogo Cancer Center

Recent advances in surgical techniques and perioperative management have markedly reduced operative morbidity after distal pancreatectomy(DP).However,some questions remain regarding the protocol for the perioperative management of DP,in particular,with regard to the development of pancreatic fistula(PF).A review of DP was therefore conducted in order to standardize the management of patients for a favorable ***,operative technique and perioperative management emerged as two critical factors contributing to favorable outcome in DP *** for the operative method,surgical and closure techniques exhibited differences in *** DP generally yields more favorable perioperative outcomes compared to open DP,and is applicable for benign tumors and some ductal carcinomas of the *** DP is also available for safe pancreatic *** bloc celiac axis resection offers a high R0 resection rate and potentially allows for some local control in the case of advanced pancreatic *** resection,staple closure was not found to reduce the rate of PF when compared to hand-sewn *** addition,ultrasonic dissection devices,fibrin glue sealing,and staple closure with mesh reinforcement were shown to significantly reduce PF,although there was some bias in these *** perioperative management,both preoperative and postoperative treatment affected ***,preoperative endoscopic pancreatic stenting may be an effective prophylactic measure against fistula development following DP in selected ***,in postoperative management,a multifactorial approach including prophylactic antibiotics improved high surgical site infection rates following complex hepato-pancreatobiliary ***,although conflicting results have been reported,somatostatin analogues should be administered selectively to patients considered to have a high risk for ***,careful drain management also facilitates a favorable outcome in

关键词： Distal pancreatectomy Pancreatic fistula Periopera

Novel diagnostics for aggravating pancreatic fistulas at the acute phase after pancreatectomy

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World Journal of Gastroenterology 2014年第26期20卷 8535-8544页

作者： Mitsuro Ka Tsutomu Fujii Hideki Takami Masaya Suenaga Yoshikuni Inokawa Suguru Yamada Daisuke Kobayashi Chie Tanaka Hiroyuki Sugimoto Masahiko koike Shuji Nomoto Michitaka Fujiwara yasuhiro Kodera Department of Gastroenterological Surgery (Surgery Ⅱ) Nagoya University Graduate School of Medicine

AIM: To identify sensitive predictors of clinically relevant postoperative pancreatic fistula (POPF) at the acute phase after pancreatectomy.

关键词： Pancreatectomy Pancreatic fistula Prediction Inflammatory marker C-reactive protein

Ghost Imaging with Deep Learning for Position Mapping of Weakly Scattered Light Source

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Nanomanufacturing and Metrology 2021年第1期4卷 37-45页

作者： yasuhiro Mizutani Shoma Kataoka Tsutomu Uenohara yasuhiro Takaya Department of Mechanical Engineering Osaka UniversityOsaka 565-0871Japan

We propose ghost imaging(GI)with deep learning to improve detection ***,which uses an illumination light with random patterns and a single-pixel detector,is correlation-based and thus suitable for detecting weak ***,its detection time is too long for practical *** overcome this problem,we applied a convolutional neural network that was constructed based on a classification of the causes of ghost image degradation.A feasibility experiment showed that when using a digital mirror device projector and a photodiode,the proposed method improved the quality of ghost images.

关键词： Inspection Metrology Defect mapping Ghost imaging Single-pixel imaging Deep learning Weak light imaging

Probing CO on a rutile TiO_(2)(110)surface using atomic force microscopy and Kelvin probe force microscopy

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Nano Research 2022年第3期15卷 1909-1915页

作者： Yuuki Adachi yasuhiro Sugawara Yan Jun Li Department of Applied Physics Osaka University2-1 YamadaokaSuitaOsaka 565-0871Japan

Probing CO at a specific site on a metal oxide surface is essential for characterizing various applications such as CO oxidation,hydrogenation,and water–gas shift ***,we use atomic force microscopy and Kelvin probe force microscopy to probe the CO on a rutile TiO_(2)(110)*** results indicate that CO can be manipulated along the Ti row by the repulsive lateral force of“pushing”***,the joint combination of precise manipulation and the distance dependence of local contact potential difference allow us to resolve the interatomic dipole moment and charge state of CO at atomic ***,we found that the negatively charged CO with the dipole moment of negative pole down on the rutile TiO_(2)(110)*** results suppose that both the charge state as well as the on-surface dipole interaction are very effective for CO reaction on rutile TiO_(2)(110)surface.

关键词： CO rutile TiO_(2) dipole moment charge state atomic force microscopy Kelvin probe force microscopy

Splenectomy in living donor liver transplantation and risk factors of portal vein thrombosis

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Hepatobiliary & Pancreatic Diseases International 2019年第4期18卷 337-342页

作者： Nobuhiko Kurata yasuhiro Ogura Satoshi Ogiso Yasuharu Onishi Hideya Kamei yasuhiro Kodera Department of Transplantation and Endocrine Surgery(Surgery II) Nagoya University Graduate School of MedicineNagoyaJapan Department of Transplantation Surgery Nagoya University Hospital65 Tsurumai-choShowa-kuNagoya 466-8560Japan Department of Gastroenterological Surgery(Surgery II) Nagoya University Graduate School of MedicineNagoyaJapan

Background:Graft inflow modulation(GIM)during adult-to-adult living donor liver transplantation(LDLT)is a common strategy to avoid small-for-size syndrome,and some transplant surgeons attempt small size graft strategy with frequent GIM procedures,which are mostly performed by splenectomy,in ***,splenectomy can cause serious complications such as portal vein thrombosis and overwhelming postsplenectomy ***:Forty-eight adult-to-adult LDLT recipients were enrolled in this study and retrospectively *** applied the graft selection criteria,which routinely fulfill graft-to-recipient weight ratio≥0.8%,and consider GIM as a backup strategy for high portal venous pressure(PVP).Results:In our current strategy of LDLT,splenectomy was performed mostly due to hepatitis C and splenic arterial aneurysms,but splenectomy for GIM was intended to only one patient(2.1%).The final PVP values≤20 mmHg were achieved in all recipients,and no significant difference was observed in patient survival or postoperative clinical course based on whether splenectomy was performed or ***,6 of 18 patients with splenectomy(33.3%)developed postsplenectomy portal vein thrombosis(PVT),while none of the 30 patients without splenectomy developed PVT after *** was identified as a risk factor of PVT in this study(P<0.001).Our study revealed that a lower final PVP could be risk factor of postsplenectomy ***:Using sufficient size grafts was one of the direct solutions to control PVP,and allowed GIM to be reserved as a backup *** should be avoided as much as possible during LDLT because splenectomy was found to be a definite risk factor of *** splenectomy cases with a lower final PVP,a close follow-up is required for early detection and treatment of PVT.

关键词： Living donor liver transplantation Splenectomy Portal venous pressure Graft-to-recipient weight ratio Portal vein thrombosis