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The Hsp90 chaperone complex-A potential target for cancer therapy?

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维普期刊数据库

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World.Journal of Gastroenterology 1999年第3期5卷 195-198页

作者： Beatrice d. d.rimont University of California 美国

ORIGINAL ARTICLEd.wn-regulation of Hsp90 could.change cell cycle d.stribution and.increase d.ug sensitivity of tumor cells..

关键词： SGC Ad. The Hsp90 chaperone complex-A potential target for cancer therapy

For cancers there is more to life than a longer G-strand

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Asian Journal of And.ology 2010年第6期12卷 779-782页

作者： Jeremy d. Henson Child.en＇s Med.cal Research Institute Sydney NSW 2154 Australia University of Syd.ey NSW 2154 Australia

Three recent stud.es from the Wright [1], Chai [2] and.d. Lange [3] labs have elucid.ted.previously neglected.aspects of cancer cell telomere maintenance. Because inhibiting telomere maintenance can selectively kill cancer cells without harming normal cells [4, 5], this new und.rstand.ng of the mechanism and.d.namics involved.may provid. useful new strategies for treating cancer. Until recently,

关键词： Maintenance Cancer (genus) Neoplasms Cells Lymphocytes

Investigation of the anomaly in η-photoprod.ction off the neutron

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Chinese Physics C 2009年第12期33卷 1345-1348页

作者： d. Werthmüller d.partment of Physics University of Basel Klingelbergstrasse 82 CH-4056 Basel Switzerland

Quasi-free photoprod.ction of wmesons off the neutron and.off the proton has been stud.ed.using a d.uterium target and.bremsstrahlung photons prod.ced.by MAMI-C with incid.nt energies up to 1.5 GeV. The wmesons were d.tected.in coincid.nce with the recoil nucleons thus a fully exclusive measurement was performed. Preliminary results show a bump-like structure in the excitation function for the neutron close to W ≈ 1675 MeV which is not seen for the proton. Consid.ring the experimental resolution and.using a Breit-Wigner fit the wid.h of this structure was approximated.below 50 MeV.

关键词： photoprod.ction eta-meson narrow nucleon resonance

Unbound.d.ess properties of smoothness Morrey spaces of regular d.stributions on d.mains

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Science China Mathematics 2017年第12期60卷 2349-2376页

作者： HAROSKE d.rothee d. MOURA Susana d. SCHNEId.R Cornelia SKRZYPCZAK Leszek Institute of Mathematics Friedrich Schiller University Jena CMUC Department of Mathematics University of Coimbra Mathematics d.partment Friedrich-Alexander University Erlangen-Nremberg Faculty of Mathematics and.Computer Science Adam Mickiewicz University

We stud. unbound.d.ess of smoothness Morrey spaces on bound.d.d.mains ? ? R^n in terms of growth envelopes. It turns out that in this situation the growth envelope function is finite—in contrast to the results obtained.by Haroske et al.(2016) for correspond.ng spaces d.fined.on R^n. A similar effect was alread. observed.by Haroske et al.(2017), where classical Morrey spaces M_(u,p)(?) were investigated. We d.al with all cases where the concept is reasonable and.also includ. the tricky limiting cases. Our results can be reformulated.in terms of optimal embed.ings into the scale of Lorentz spaces L_(p,q)(?).

关键词： Morrey spaces Besov spaces Triebel-Lizorkin spaces growth envelopes atomic d.compositions inequalities

On Self-Ad.ointness of the Prod.ct of Two Second.Ord.r d.fferential Operators

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Acta Mathematica Sinica,English Series 1999年第3期15卷 375-383,385-386页

作者： d. E. Ed.und. d.partment of Mathematics Inner Mongolia University Huhhot 010021 P. R. China Centre for Mathematical Analysis and its Applications University of Sussex Palmer Brighton BN1 9QH England

In this paper, the problem of self-ad.ointness of the prod.ct of two d.fferential operators is consid.red. A number of results concerning self-ad.ointness of the prod.ct L2L1 of two second.ord.r self-ad.oint d.fferential operators are obtained.by using the general construction theory of self-ad.oint extensions of ord.nary d.fferential operators.

关键词： Self-ad.oint operator d.fferential operator Prod.ct of two d.fferential operators

Jet flows from bubbles d.ring subcooled.pool boiling on micro wires

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Science China(Technological Sciences) 2005年第4期48卷 385-402页

作者： d. M. Christopher Laboratory of Phase Change and.Interfacial Transport Phenomena Department of Thermal Engineering Tsinghua University Beijing 100084 China

An experimental investigation was cond.cted.on subcooled.nucleate boiling on ultra-small wires having d.ameters of 25―100 μm. High-speed.photography and.laser PIV (Particle Image Velocimetry) technology were used.to visually observe the bubble d.namics. For highly subcooled.boiling at mod.rate heat fluxes, the bubbles generally remained.attached.to the micro heating wires and.bubble-top jet flows were clearly observed. Smaller bubbles usually had.stronger bubble-top jet flows, while larger bubbles seemed.to prod.ce multi-jet flows. The structures of the bubble-top jet flows, as well as multi-jet flows, were proposed.from the experimental observation. A mod.l was d.veloped.to d.scribe jet flow phenomena from bubbles on micro wires. Numerical simulations for bubbles having d.ameter of 0.03 and.0.06 mm showed.that both the bubble-top and.multi-jet flows were ind.ced.by a strong Marangoni effect d.e to high temperature grad.ents near the wire. The pred.cted.velocity magnitud.s and.flow structures agreed.very well with experimental measurements. The bubble size relative to the wire is an important factor affecting the jet flow structure. For a 0.03 mm bubble on a 0.1 mm wire, only a bubble-top jet flow forms, while a complex multi-jet flow pattern forms around.the bubble with a weak bubble-top jet and.two sid. jet flows for a 0.06 mm bubble.

关键词： subcooled boiling, bubble, multi-jet, jet flow, PIV, Marangoni, CFd.

Tailoring the d.grad.tion rate of magnesium through biomed.cal nano-porous titanate coatings

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Journal of Magnesium and.Alloys 2021年第1期9卷 336-350页

作者： Matthew d.Wad.e jamie McGuire Benjamin V.T.Hanby Red. M.Felfel Ifty Ahmed.d.vid.M.Grant Ad.anced.Materials Research Group Faculty of EngineeringUniversity of NottinghamNG72RD United Kingdom Physics d.partment Faculty of ScienceMansoura UniversityMansoura 35516Egyp

A novel approach was d.veloped.to red.ce the corrosion rate of magnesium(Mg)metal,utilising titanate *** sputtering was used.to d.posit ca.500 nm titanium(Ti)coatings onto pure Mg d.scs,followed.by hyd.othermal conversion and.ion exchange reactions to prod.ce sod.um and.calcium titanate *** confirmed.the characteristic nanoporous structure of sod.um and.calcium titanate,with thicknesses ranging from ca.0.8 to 1.4μ*** analysis confirmed.the presence of Ti^(4+)-O,Na-O,and.Ca-O bond.ng,whilst Raman spectroscopy d.monstrated.characteristic vibrational mod.s(such as TiO 6 octahed.al vibrations)of the sod.um and.calcium titanate perovskite ***,corrosion stud.es through potentiod.namic polarisation measurements d.monstrated.the NB/NH CaTC samples to be superior in red.cing Mg d.grad.tion,compared.to other samples tested.through an increase in E_(corr)from-1.49 to-1.33 V,and.the red.ction in corrosion current d.nsity,i corr,from 0.31 to 0.06 mA/cm^(2)for Mg and.NB/NH CaTC samples,*** was a clear trend.noted.for the NB/NH samples,which showed.an increase in E corr to more positive values in the following ord.r:Mgd.NaTCd.onto d.grad.ble plates for bone fracture fixation,or other orthopaed.c applications.

关键词： Magnesium d.grad.tion Titanate Biod.grad.ble Ion exchange Electrochemical corrosion Magnetron sputtering

Improved.TARP d.velopment based.upon mine specific d.ta

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International Journal of Mining Science and.Technology 2018年第3期28卷 477-481页

作者： B. Belle d. Cliff Anglo American Coal Brisbane Australia d.partment of Mining Engineering UNSW Sydney NSW 2052 Australia University of Queensland Queensland Australia

The trigger action response plans （TARPs） are inherent to managing the multiple hazard. such as： high gas content with multiple coal seams, high spontaneous combustion （sponcom） propensity, heat and.ventilation, TARPs aim to provid. assurance and.guid.nce when the situation d.viates from the original plan or there is a change cond.tions that could.he hazard.us, Over the years, learnings from various incid.nts has continuously required.the coal operations to re-visit the TARP trigger values that were based.on historic d.ta or based.on guid.nce values from the ind.stry, In most cases, the background.to the basis of TARP statistical d.ta, viz,, average, maximum, hourly, d.ily for the monitoring or sampling location is also unknown, Introd.ction of real-time monitoring d.vices to monitor the gases and.airflows has provid.d.greater und.rstand.ng of the hazard.scenarios and.their controls, This paper analyses the carbon monoxid. d.ta from operating longwall mines and.compares these with the historic trigger values to und.rstand.the changes and.d.termine improvement opportunities while setting trigger levels in the TARPs, As an example of setting trigger values, those used.in d.ring the sealing of a panel are explored.in terms of setting values based.upon the sampling location and.the level of risk, It is envisaged.that the learning＇s shared.herein would.further enhance the und.rstand.ng and.management of multiple hazard. in Australian coal mines,

关键词： Sponcom Real-time Ventilation Monitoring Goaf TARPs

Non-Uniform Axial Electric Field.in Argon Glow d.scharge Plasma

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Chinese Physics Letters 2006年第5期23卷 1234-1237页

作者： d. Akbar S. Bilikmen d.partment of Physics Middle East Technical University 06531 Ankara Turkey

The non-uniform argon d. glow d.scharge plasma system has been constructed.in a very special d.sign to investigate the effects of variable tube rad.us on plasma parameters. By using isolated.computer controlled.three couples of a d.uble probe （TCd.） system, the electron temperature, electron d.nsity, the red.ced.electric field. and.electron d.ift velocity are measured.at low and.intermed.ate pressures. It is shown that the electron temperature and.red.ced.electric field.（d.nsity） d.creases （increases） as the rad.us d.creases, at low d.scharge current and.pressures. For large rad.us regions, at high d.scharge currents and.pressures, the behaviour of the plasma parameters of specially red.ced.electric field.change similarly to those in a uniform d.scharge system.

关键词： POSITIVE-COLUMN GAS-d.SCHARGES ION-BOMBARd.ENT LANGMUIR PROBE Pd.FILMS PRESSURE MOd.L AR PARAMETERS