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World Journal of Gastroenterology 2005年第20期11卷 3091-3098页

作者： km fock EK Teo TL Ang TS Chua TM Ng YL Tan Division of Gastroenterology Department of Medicine Changi General Hospital Singapore

AIM：Gastro-esophageal reflux disease (GERD) is becoming increasingly common in Asia. Data on the efficacy of proton pump inhibitors in patients with non-erosive GERD (NERD)in Asia is lacking. This double-blind study compared the efficacy and safety of rabeprazole with esomeprazole in relief of symptoms in patients with ***: One hundred and thirty-four patients with reflux symptoms of NERD and normal endoscopy were randomized to receive rabeprazole 10 mg or esomeprazole 20 mg once daily for 4 wk. Symptoms were recorded in a diary and changes in severity of symptoms ***: At 4 wk of treatment, rabeprazole 10 mg and esomeprazole 20 mg were comparable with regards to the primary endpoint of time to achieve 24-h symptomfree interval for heartburn 8.5 d vs9 d and regurgitation 6 d vs 7.5 d. Rabeprazole and esomeprazole were also similarly efficacious in term of patient's global evaluation with 96% of patients on rabeprazole and 87.9% of patients on esomeprazole, reporting that symptoms improved(P=NS). Satisfactory relief of day- and night-time symptoms was achieved in 98% of patients receiving rabeprazole and 81.4% of patients receiving esomeprazole. Adverse events were comparable in both groups (P = NS).CONCLUSION: Rabeprazole 10 mg has a similar efficacy and safety profile in Asians with NERD as esomeprazole 20 mg. Further study is necessary to investigate whether the small differences between the two drugs seen in this study are related to the improved pharmacodynamicpro perties of rabeprazole. Both drugs were well tolerated.

关键词：食管逆流疾病亚洲城市居民质子泵雷贝拉唑药物治疗

胃食管反流病处置流程的亚太共识中关于难治性胃食管反流病和巴雷特食管的内容更新

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中华胃食管反流病电子杂志 2016年第3期3卷 97-109页

作者：王强王一凡杜植鹏译张伟仇明 fock km 上海市第二军医大学附属长征医院普外三科上海市200003 不详

大多数胃食管反流病（ gastroesophageal reflux disease , GERD）属于非糜烂性胃食管反流病（NERD）,其余则为糜烂性胃食管反流病,其严重程度不同,并发症多样,包括巴雷特食管（Barrett esophagus,BE）、食道狭窄和食道腺癌,所幸在亚太... 详细信息

大多数胃食管反流病（ gastroesophageal reflux disease , GERD）属于非糜烂性胃食管反流病（NERD）,其余则为糜烂性胃食管反流病,其严重程度不同,并发症多样,包括巴雷特食管（Barrett esophagus,BE）、食道狭窄和食道腺癌,所幸在亚太地区,这些并发症并不多见甚至罕见. 一般认为在2004 年前,亚洲人种与西方相比, GERD 并不常见. 但在2004年胃食管反流病处置流程的亚太共识中,发现在亚洲,这种疾病呈增长趋势,因此针对该地区对GERD诊断和处置措施的相关文献进行回顾复习. 随后,第二部共识也因GERD非典型的胃肠道外表现越来越多,而内镜和手术干预措施也越来越普及而发表. 目前,认为有必要对GERD处置流程进行第三次文献复习以阐明质子泵抑制剂（ proton pump inhibitors,PPI）难治性GERD相关问题,回顾关于BE诊断的方法并对其筛查和随访中的价值提出新的推荐等级.

关键词：难治性胃食管反流病巴雷特食管处置流程非糜烂性胃食管反流病 esophagus GERD 质子泵抑制剂文献复习

Multi-species probiotics enhance survival,growth,intestinal microbiota and disease resistance of rohu(Labeo rohita)larvae

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Water Biology and Security 2024年第1期3卷 71-79页

作者： Zannatul Ferdous Md Kabir Hossain Md Hadiuzzaman SMRafiquzzaman km Abdul Halim Tanvir Rahman Md Ali Reza Faruk Zulhisyam Abdul Kari Md Shahjahan Laboratory of Fish Ecophysiology Department of Fisheries ManagementBangladesh Agricultural UniversityMymensingh2202Bangladesh Department of Aquaculture Bangladesh Agricultural UniversityMymensingh2202Bangladesh Department of Fisheries Matshoy BhabanDhakaBangladesh Department of Fisheries Biology&Aquatic Environment Bangabandhu Sheikh Mujibur Rahman Agricultural UniversityGazipur1706Bangladesh Department of Agricultural Sciences Faculty of Agro-Based IndustryUniversiti Malaysia KelantanJeli Campus17600JeliKelantanMalaysia

Multi-strain probiotics provide the most dependable approaches to improve health,immune response,and disease resistance in farmed *** the present study,we examined the effects of multi-species probiotics on the survival,growth,immune response,and disease resistance of rohu(Labeo rohita)*** hatched larvae from the day of first feeding(average weight of 0.003 g)were reared with multi-species probiotics having a combination of Bacillus subtilis(109 colony forming units(cfu)/mL)and Lactobacillus spp.(Lactobacillus plantarum,Lactobacillus buchneri-1011 cfu/mL)in water containing doses of 0(control-C),0.5 mL/L(treatment 1-T1),and 1.0 mL/L(treatment 2-T2)in triplicates for 90 *** the experiment,a challenge test was performed to assess the fish's resistance to pathogenic Aeromonas *** higher survival was recorded in larvae of treated groups(87%in T2 and 79%in T1)compared to the control(62%).Significantly higher growth performance(weight gain and specific growth rate—SGR)was shown by the probiotic-treated larval groups compared to the *** supplementation resulted in significantly higher counts of total viable colony(TVC)and lactic acid bacteria(LAB)in the *** immunological parameters(mucosal fold fattening,goblet cell abundance,expansion of lamina propria and enterocytes)of the gut were significantly better in probiotic-treated *** liver of treated fish showed irregular shape nuclei turning into regular shape and reducing spaces between the hepatic ***-treated fish had the highest post-challenge survival rate(90%)against *** *** erythrocytes of challenged fish treated with probiotics had significantly lower frequencies of various nuclear and cellular *** findings suggest that multi-species probiotic supplements could improve the survival,growth,health status,and immune response of rohu in the early stages of its development.

关键词： Aquaculture Disease resistance Immunity Labeo rohita Probiotics

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亚太地区炎症性肠病处理共识意见(一)

胃肠病学 2006年第4期11卷 233-238页

作者：欧阳钦 Rakesh Tandon KL Goh 潘国宗 km fock Claudio Fiocchi SK Lam 萧树东张虎梁红亮王玉芳中国成都四川大学华西医院消化内科 610041 印度新德里肝肾和消化系疾病Pushpawati Singhania研究所胃肠科马来西亚吉隆坡马来亚大学医学院内科中国北京协和医院消化内科新加坡Changi总医院胃肠科美国俄亥俄州克里夫兰临床医院胃肠病学和肝病学科中国香港大学医学院皇家玛丽医院中国上海交通大学医学院仁济医院上海市消化疾病研究所

虽然目前亚太地区尚无炎症性肠病(IBD)的大规模流行病学资料,但一系列研究显示其发病率和患病率呈上升趋势,与西方国家相比仍呈滞后现象,溃疡性结肠炎(UC)的发病率仍较克罗恩病(CD)高。除地域差异外,在一些多民族国家中,IBD尚可见种族... 详细信息

虽然目前亚太地区尚无炎症性肠病(IBD)的大规模流行病学资料,但一系列研究显示其发病率和患病率呈上升趋势,与西方国家相比仍呈滞后现象,溃疡性结肠炎(UC)的发病率仍较克罗恩病(CD)高。除地域差异外,在一些多民族国家中,IBD尚可见种族差异。亚太地区IBD的遗传背景有异于西方国家,如据报道该地区CD患者未检出NOD2/CARD15变异。一般而言,该地区IBD患者的临床过程似不如西方国家严重。亚太地区IBD的诊断存在一些特殊问题。如缺乏IBD诊断金标准,存在多种小肠结肠炎,与IBD临床表现相似,使鉴别诊断特别困难。迄今为止,亚太地区IBD的诊断标准多采用西方国家的诊断标准。诊断必须逐步排除非IBD的小肠结肠炎,确诊应有典型的组织学表现,某些患者需借助随访和诊断性治疗才能确诊。进一步研究IBD发病机制将有助于开发更好的诊断标记物。亚太地区IBD的治疗亦存在特殊问题。由于诊断困难,IBD患者常未能及时接受适当的药物治疗,但该地区仍广泛采用药物治疗方案。结合西方指南和本地经验可制定类似的处理原则,以利诱导缓解和维持缓解。提倡逐级使用基于病变范围、活动性和严重度的阶梯式治疗方案,对不同病例采用综合性、个体化的方法。随着对IBD发病机制和亚太地区IBD独特性的深入理解,合理、实用的药物治疗指南和应用生物制剂治疗将改善该地区IBD的治疗前景。

关键词：亚太地区炎症性肠病共识意见药物治疗方案诊断金标准诊断性治疗阶梯式治疗方案西方国家小肠结肠炎流行病学资料

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亚太地区炎症性肠病处理共识意见(二)

胃肠病学 2006年第5期11卷 301-305页

作者：欧阳钦 Rakesh Tandon KL Goh 潘国宗 km fock Claudio Fiocchi SK Lam 萧树东张虎（翻译）梁红亮（翻译）王玉芳（翻译）欧阳钦（审校）四川大学华西医院消化内科 610041 印度新德里肝肾和消化系疾病Pushpawati Singhania研究所胃肠科马来西亚吉隆坡马来亚大学医学院内科北京协和医院消化内科新加坡Changi总医院胃肠科美国俄亥俄州克里夫兰临床医院胃肠病学和肝病学科香港大学医学院皇家玛丽医院上海交通大学医学院附属仁济医院上海市消化疾病研究所不详

三、IBD治疗的亚太观点通过Medline检索过去15年内亚太地区发表的IBD治疗文献发现,虽然可检索到该地区有关IBD的先进治疗手段,但缺乏富有实践经验的临床治疗研究文献[38～41].在亚太地区IBD工作组(APWPIBD)会议上就IBD的治疗提出了下列... 详细信息

三、IBD治疗的亚太观点通过Medline检索过去15年内亚太地区发表的IBD治疗文献发现,虽然可检索到该地区有关IBD的先进治疗手段,但缺乏富有实践经验的临床治疗研究文献[38～41].在亚太地区IBD工作组(APWPIBD)会议上就IBD的治疗提出了下列问题,并基于文献回顾和专家经验达成如下共识意见.

关键词：亚太地区共识意见炎症性肠病 Medline检索治疗手段研究文献 IBD 临床治疗实践经验专家经验

世界胃肠病学组织(WGO-OMGE)临床指南——发展中国家幽门螺杆菌感染

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胃肠病学 2007年第1期12卷 40-52页

作者： Hunt RH Xiao SD Megraud F Leon-Barua R Bazzoli F Van der Merwe S vaz Coelho LG fock km Fedail S Cohen H Malfertheiner P Vakil N Hamid S Goh KL Wong BC Krabshuis JH 杜颖丛衍群戴宁

我非常高兴向大家推荐这份发展中国家幽门螺杆菌（***）临床指南。该指南的编译是由数位在该领域具有丰富临床经验的世界知名专家共同完成的。

关键词：幽门螺杆菌感染发展中国家临床指南胃肠病学世界组织临床经验

Metabolomic profiles in a green alga (Raphidocelis subcapitata) following erythromycin treatment: ABC transporters and energy metabolism

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Journal of Environmental Sciences 2023年第2期124卷 591-601页

作者： Jiezhang Mo Zhihua Ma Shiwei Yan Napo km Cheung Fangshe Yang Xiunan Yao Jiahua Guo Shaanxi Key Laboratory of Earth Surface System and Environmental Carrying Capacity College of Urban and Environmental SciencesNorthwest UniversityXi’an 710127China State Key Laboratory of Marine Pollution and Department of Chemistry City University of Hong KongKowloonHong KongChina

A recent study showed that erythromycin(ERY)exposure caused hormesis in a model alga(Raphidocelis subcapitata)where the growth was promoted at an environmentally realistic concentration(4μg/L)but inhibited at two higher concentrations(80 and 120μg/L),associated with opposite actions of certain signaling pathways(e.g.,xenobiotic metabolism,DNA replication).However,these transcriptional alterations remain to be investigated and verified at the metabolomic *** study uncovered metabolomic profiles and detailed toxic mechanisms of ERY in *** using *** analysis showed that metabolomic pathways including ABC transporters,fatty acid biosynthesis and purine metabolism were associated with growth promotion in algae treated with 4μg/L *** overcompensation was possibly activated by the low level of ERY in algae where more resources were reallocated to efficiently restore the temporary impairments,ultimately leading to the outperformance of *** contrast,algal growth inhibition in the 80 and 120μg/L ERY treatments was likely attributed to the dysfunction of metabolomic pathways related to ABC transporters,energy metabolism and metabolism of *** from binding of ERY to the 50S subunit of ribosomes to inhibit protein translation as in bacteria,the data presented here indicate that inhibition of protein translation and growth performance of algae by ERY may also result from the suppression of amino acid biosynthesis and aminoacyl-tRNA *** study provides novel insights into the dose-dependent toxicity of ERY on ***.

关键词： Hormesis Metabolome ABC transporters DNA replication Microalgae Macrolide antibiotic

为波士顿非洲裔居民提供食品以帮助未经治疗的高血压成人终止高血压试验的基本原理和设计

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中华高血压杂志(中英文) 2024年第1期32卷 100-100页

作者： Turkson-Ocran RN Cluett JL Fitzpatrick SL Kraemer km Mc Manus K Mukamal KJ Davis RB Elborki M Ferro K Ismail N Laura AE Larbi KF Castilla-Ojo N Grobman B Seager R Hines AL Miller ER Crews DC Juraschek SP 刘青

不健康的膳食是影响非洲裔成年人高血压差异的重要因素。终止高血压膳食疗法(dietary approaches to stop hypertension,DASH)的膳食模式可以降低血压,但食品荒漠的城市居民难以接触到DASH模式的食品,这是主要的障碍。方法:为波士顿非...

不健康的膳食是影响非洲裔成年人高血压差异的重要因素。终止高血压膳食疗法(dietary approaches to stop hypertension,DASH)的膳食模式可以降低血压,但食品荒漠的城市居民难以接触到DASH模式的食品,这是主要的障碍。方法:为波士顿非洲裔居民提供食品以帮助未经治疗的高血压成人终止高血压(Go Feshr,GF)研究是解决预防高血压的社会决定因素(addressing social determinants to prevent hypertension,RESTORE)网络的五个项目之一。

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Main factors influencing the expulsion of oil derived from coal

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Chinese Science Bulletin 1997年第22期42卷 1905-1908页

作者： Zhao, CY Cheng, km China Natl Petr Corp Res Inst Petr Explorat & Dev Beijing 100083 Peoples R China

THE expulsion of hydrocarbons from coal is controlled by two main factors. The first is theproperties inherited from coal itself and contains two implications. One is original potential ofhydrocarbon generation from c... 详细信息

关键词： oil derived from coal expulsion pore surface chemistry.

Effective antimicrobial therapies of urinary tract infections among children in low-and middle-income countries:A systematic review

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Pediatric Investigation 2023年第2期7卷 102-110页

作者： Rifat Ara Sarker Mohammad Nasrullah Zarrin Tasnim Sadia Afrin Mohammad Delwer Hossain Hawlader km Saif-Ur-Rahman Infectious Disease Division icddrbDhakaBangladesh Maternal and Child Health Division icddrbDhakaBangladesh Public Health Professional Development Society(PPDS) DhakaBangladesh Health System and Population Studies Division icddrbDhakaBangladesh Department of Public Health North South UniversityDhakaBangladesh Evidence Synthesis Ireland and Cochrane Ireland University of GalwayGalwayIreland College of Medicine Nursing and Health SciencesUniversity of GalwayGalwayIreland

Importance:Urinary tract infection(UTI)is one of the most common infections encountered in infancy and *** the emerging problem of antibiotic resistance in recent years,the use of antibiotics for better management of UTIs is ***:This study aims to explore the efficacy and adverse effects of the available antimicrobial agents that are used in pediatric UTIs in low-and middle-income countries(LMICs).Methods:Five electronic databases were searched to identify relevant *** reviewers independently performed screening,data extraction,and quality assessment of the available *** controlled trials providing antimicrobial interventions in both male and female participants within the age range of 3 months to 17 years in LMICs were ***:Six randomized controlled trials from 13 LMICs were included in this review(four trials explored the efficacy).Due to high heterogeneity across the studies,a meta-analysis was not *** than attrition and reporting bias,the risk of bias was moderate to high due to poor study *** differences in the efficacy and adverse events of different antimicrobials were not found to be statistically ***:This review indicates the necessity for additional clinical trials on children from LMICs with more significant sample numbers,adequate intervention periods,and study design.

关键词： Antimicrobial agents Children Efficacy LMICs Urinary tract infection