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Usefulness of liver infiltrating CD86-positive mononuclear cells for diagnosis of autoimmune hepatitis

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World Journal of Gastroenterology 2006年第16期12卷 2523-2529页

作者： kazutaka kurokohchi tsutomu Masaki takashi Himoto Akihiro Deguchi Seiji Nakai Asahiro Morishita Hirohito Yoneyama Yasuhiko kimura Seishiro Watanabe Shigeki kuriyama third Department of Internal Medicine Kagawa University School of Medicine1750-1 IkenobeMiki-choKita-gunKagawa 761-0793Japan

AIM： Although the pathogenic mechanism underlying autoimmune hepatitis （AIH） remains unclear, the immune system is thought to be critical for the progression of the disease. Cellular immune responses may be linked to the hepatocellular damage in AIH. Recently, much attention has been focused on the critical functions of costimulatory molecules expressed on mononuclear cells in the generation of effective t cell-mediated immune responses. Analysis of costimulatory molecule expressed on mononuclear cells from the patients with AIH may give us insight into the pathogenic mechanism of hepatocellular damage in AIH. MEtHODS： Peripheral blood mononuclear cells （PBMC） were taken from the patients with AIH （34 cases） and healthy controls （25 cases）. Uver infiltrating mononuclear cells （LIMCs） were taken from the patients with AIH （18 cases）, the patient with chronic hepatitis C （CH-C）（13 cases） and the patients with fatty liver （2 cases）. Using flow cytometry, the cells were analyzed for the expression of costimulatory molecules, such as CD80, CD86, and CD152 （CtLA-4）. the results were compared with clinical data such as the level of gammaglobulin, histological grade, presence or absence of corticosteroids administration and the response to corticosteroids. RESULtS： the levels of CD80＋, CD86＋ and CD152＋ PBMC were significantly reduced in the patients with AIH as compared with healthy controls. By contrast, those cells were significantly higher in LIMC than in PBMC of the patients with AIH. Especially, the level of CD86＋ LIMC showed a marked increase irrespective of the degree of disease activity in the patients with AIH,although CD86＋ cells were rarely present in PBMC. the levels of CD86＋ cells were present in significantly higher frequency in patients with AIH than in the patients with CH-C. Furthermore, the patients with AIH with high levels of CD86＋ LIMC showed good responses to corticosteroids, whereas 2 cases of AIH with low levels of CD86＋ LIMC did not respond well. C

关键词： Autoimmune hepatitis Costimulatory molecule CD86 molecule Peripheral blood mononuclear cells Liver infiltrating mononuclear cells Flow cytometry

Clinical Presentation and Outcome in Patients of over 75 Years Old with Malignant Lymphoma—Clinical Presentation and Outcome in Elderly Lymphoma Patients

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International Journal of Clinical Medicine 2011年第3期2卷 246-253页

作者： Noriyasu Fukushima Fukushima Itamura Chisako Urata Mariko tanaka takashi Hisatomi Yasushi kubota Eisaburo Sueoka Shinya kimura 不详

We analyzed the relationship between the clinical characteristics, comorbidity, average relative dose intensity (aRDI) and outcome in patients of over 75 years old with malignant lymphoma. Of the 98 patients studied, the mean age was 79.9 years, and 68 patients (69.4%) had B-cell lymphomas, corresponding to mainly diffuse large B-cell lymphoma. the 5-year overall survival rate was 32.2% in 97 malignant lymphoma patients. t/Nk subtype, poor performance status (PS) and high-intermediate/high international prognostic index (IPI) were found to be predictive of significantly poorer overall survival, as is the case in young patients. Correlation between comorbidity index and survival rate was not observed. We also analyzed the aRDI of cyclophosphamide and pirarubicin for 64/97 patients. the proportion of patients receiving ≤84% of the planned DI during five cycles gradually increased. Most patients could not maintain aRDI ≥85%. However, overall survival was not significantly different between patients with aRDI ≥0.85 and those with aRDI ≤0.84. In conclusion, the prognoses of very elderly patients with malignant lymphoma were not so poor when they were appropriately treated with modification of the applied dose and the duration of chemotherapy according to their status.

关键词： Malignant Lymphoma Elderly Comorbidity Relative Dose Intensity

10例淋巴细胞药物刺激试验呈阳性的非细胞毒性药物诱导的肺炎病例的临床研究

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中华结核和呼吸杂志 1997年第Z1期20卷 77-77页

作者： Yoneyama H Yano t kimura M Okimoto N Matsushima t 刘兴荣(译) DepartmentofInternalMedicine KawasakiMedicalSchoolKawasakeHospital2—1—80NakasangeOkayamaCityJapan DepartmentofInternalMedicine KawasakiMedicalSchoolKawasakeHospit—80NakasangeOkayamaCityJapan DepartmentofInternalMedicine KawasakiMedicalSchoolKawasakeHospital0NakasangeOkayamaCityJapan

Adjacent Segment Disease after Long Spinal Fusion Ending at L5 for Adult Spinal Deformity: A Retrospective Cohort Study

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Open Journal of Orthopedics 2022年第6期12卷 268-276页

作者： Ryota kimura Michio Hongo Eiji Abe takahi kobayashi kazuma kikuchi Hayato kinoshita Yuji kasukawa Daisuke kudo Naohisa Miyakoshi Department of Orthopedic Surgery Akita University Graduate School of Medicine Akita Japan Department of Orthopedic Surgery Akita Kousei Medical Center Akita Japan

Study Design: this is a retrospective cohort study using data from the adult spinal deformity (ASD) database of a single institution. Purpose: to investigate the incidence of proximal junctional failure and distal junctional failure (DJF) after ASD surgery with a lower instrumented vertebra (LIV) at L5. Overview of Literature: Spinopelvic fixation from the lower thoracic vertebra to the pelvis is the current gold standard treatment for ASD. However, the LIV at L5 is acceptable in some cases. Methods: Fifty-six patients who underwent corrective surgery for ASD with LIV at L5 were included. the upper instrumented vertebra (UIV) was t7 in one patient, t9 in 14, t10 in three, t11 in four, t12 in eight, L1 in 10, and L2 in 16. Regarding clinical parameters, age, sex, curve types of Scoliosis Research Society-Schwab classification, number of levels fused, follow-up period, hip bone mallow density, revision surgery rate, and radiographic measurements were compared between the t (UIV: t7 - 10) and tL (UIV: t11 - L2) groups. Results: the revision surgery rate was 19.6% overall. In the t and tL groups, it was 27.8%, and 15.8%, respectively (p = 0.305). the rate of DJF in the t group (33.3%) was significantly higher than in the tL group (5.3%). the rate of proximal junctional kyphosis in the t group (55.6%) was higher than in the tL group (28.9%), with no significant difference. the mean global alignment, sagittal vertical axis, and C7 plumb line-central sacral vertical line were not different between both groups. Conclusions: ASD surgery with LIV set at L5 and UIV set at the thoracic vertebrae (t7 - t10) has a risk of adjacent segment disease.

关键词： Adjacent Segment Disease Adult Spinal Deformity Spinal Long Fusion L5 Distal Junctional Failure Proximal Junctional Failure

形变双奇核^(186)Au的高自旋态能级结构

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中国科学：物理学、力学、天文学 2012年第10期42卷 1062-1075页

作者：李仕成张玉虎周小红石跃柳敏良方永得王建国高丙水许甫荣 OSHIMA M tOH Y kOIZUMI M OSA A kimura A HAtSUkAWA Y HAYAkAWA H SHIZUMA t kAtAkURA J MAtSUDA M MORIkAWA t SUGAWARA M kUSAkARI H 中国科学院近代物理研究所兰州730000 中国科学院研究生院北京100049 北京大学物理学院核物理与核技术国家重点实验室北京100871 Japan Atomic Energy Agency Tokai-MuraIbaraki 319-1195Japan Department of Physics Kyushu UniversityFukuoka 812-81Japan Chiba Institute of technology NarashinoChiba 275-0023Japan Chiba University Inage-kuChiba 263-8512Japan

利用重离融合蒸发反应和在束γ谱学验方法,研究了双奇核186Au的高旋态能级结构.扩展了186Au核基于πh9/2i13/2和πi13/2i13/22-准粒组态的转动带能级纲图,并重新指认了两条转动带的能级旋值,发现两条转动带在低旋区均出现旋称反转.... 详细信息

利用重离融合蒸发反应和在束γ谱学验方法,研究了双奇核186Au的高旋态能级结构.扩展了186Au核基于πh9/2i13/2和πi13/2i13/22-准粒组态的转动带能级纲图,并重新指认了两条转动带的能级旋值,发现两条转动带在低旋区均出现旋称反转.系统地分析了Au同位素双奇核πh9/2i13/2,πi13/2i1/3和πh-111/2-νi-1312转动带的旋称劈裂特征.本工对186Au核πh-111/-2νi-132/2j(j=p3/2,f5/2)转动带(17+)态之上能级结构了修改.根据验提取的准粒顺排角动量以及对Au双奇核带结构的系统性比较和分析,别出了一条组态为πh-111/-2νi-1322h-19/2的扁椭球转动带.

关键词：高旋态能级间隔系统性旋称反转准粒顺排

Ras相关基因在非小细胞肺癌中的异常甲基化研究

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中华结核和呼吸杂志 2010年第1期33卷 32-32页

作者：陈虹 Suzuki M Nakamura Y Ohira M Ando S Iida t Nakajima t Nakagawara A kimura H 重庆医科大学附属第一医院呼吸内科 400016

基因启动子中CpG岛的异常甲基化常导致抑癌基因表达沉默，已被证实在众多肿瘤的发生中扮演重要角色。Ras相关区域家族1A基因（RASSF1A）作为新型抑癌基因，已被发现在肺癌和多种恶性肿瘤中具有较高的甲基化率和表达缺失。然而Ras蛋白特... 详细信息

基因启动子中CpG岛的异常甲基化常导致抑癌基因表达沉默，已被证实在众多肿瘤的发生中扮演重要角色。Ras相关区域家族1A基因（RASSF1A）作为新型抑癌基因，已被发现在肺癌和多种恶性肿瘤中具有较高的甲基化率和表达缺失。然而Ras蛋白特异性的鸟苷酸释放因子2（RASGRF2）仅有报道在胰腺癌细胞株中存在高频率甲基化和表达缺失。

关键词：异常甲基化非小细胞肺癌 Ras蛋白相关基因抑癌基因表达胰腺癌细胞株表达缺失恶性肿瘤

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多普勒超声心动图估测的收缩压评估肺高血压

中华高血压杂志 2019年第12期27卷 1219-1219页

作者： Sawada N kawata t Daimon M Nakao t Hatano M Maki H kimura k Hirokawa M Ishiwata J Xu B Yatomi Y komuro I 刘青(译) 刘莉(审校) 不详

Int Heart J,2019,60(4):836-844.肺高血压定义为右心导管检查(right heart catheterization,RHC)评估的静息时平均肺动脉压≥25 mm Hg(1 mm Hg=0.133 kPa)。多普勒超声心电图推导的肺动脉收缩压(Doppler echocardiography-derived pulmonary arterial systolic pressure,sPAPECHO)或三尖瓣反流压力梯度(tricuspid regurgitation pressure gradient,tRPG)广泛用于筛查肺高血压。

关键词：肺高血压多普勒超声心动图收缩压

采用高导热碳化硅蜂窝结构的先进非旁通废热回收系统的开发

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汽车与新动力 2020年第3期3卷 66-70页

作者： [日]t.SAkUMA [日]M.YOSHIHARA [日]t.kAWAGUCHI [日]t.HAMADA [日]H.MIZUNO [日]D.kimura 孙丹红(译) 田永海(译) 不详

废热回收(EHR)系统是改善燃油经济性和车内舒适性的有效且充满吸引力的方法之一,对于冬季的混合动力汽车尤为如此。多数传统旁通系统的热执行器都含有旁通管和旁通阀,从而导致EHR系统的体积和质量都较大。在有效改善EHR系统废热回收性... 详细信息

废热回收(EHR)系统是改善燃油经济性和车内舒适性的有效且充满吸引力的方法之一,对于冬季的混合动力汽车尤为如此。多数传统旁通系统的热执行器都含有旁通管和旁通阀,从而导致EHR系统的体积和质量都较大。在有效改善EHR系统废热回收性能的同时,必须使系统的尺寸和质量最小化。非旁通系统回收来自废气的热量,对其废热回收性能进行设置,以确保在高发动机负荷下不超过散热器的冷却能力,从而防止整车动力系统过热。对于非旁通系统来说,在高发动机负荷或高冷却液温度条件下,减少回收热量及在低发动机负荷或低冷却液温度条件下增加回收热量是必不可少的。提出了一种能取代原有旁通阀机构的先进非旁通EHR系统,该系统采用的是能根据冷却液温度或发动机负荷自动限制回收热量的双层冷却液通道结构,可实现发动机预热阶段的有效废热回收及高发动机负荷或高冷却液温度条件下的有效散热。介绍了该先进非旁通EHR系统的基本结构。试验结果表明,该系统在冷起动阶段具有良好的废热回收性能,在发动机高负荷下具有良好的散热性能。

关键词：废热回收非旁通蜂窝结构碳化硅

用于光生成反应的低温液体氢/氘靶系统的研制

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原子能科学技术 2010年第7期44卷 873-875页

作者：韩运成王铁山 B.Beckford 藤井隆穗二川健太桥本治神田浩树金田雅司川崎泰斗木村千草前田和茂奥山皓兰州大学核科学与技术学院甘肃兰州730000 日本东北大学物理学院

为研究光生成带电π介子和中性k介子,研制了1套液体氢/氘靶系统,用于日本东北大学核科学实验室的中性k介子谱仪实验系统。这套靶系统的设计目标是使生成产额最大化、本底最小化及操作安全易行。经实验检验,该套液体氢/氘靶系统的几何安... 详细信息

为研究光生成带电π介子和中性k介子,研制了1套液体氢/氘靶系统,用于日本东北大学核科学实验室的中性k介子谱仪实验系统。这套靶系统的设计目标是使生成产额最大化、本底最小化及操作安全易行。经实验检验,该套液体氢/氘靶系统的几何安置误差约为1.1mm,靶的有效核子个数不确定度约为0.63%。靶系统在液体状态连续稳定工作可超过3周。靶系统的良好运行完全达到了预先设计目标。

关键词：中性k介子氢/氘靶系统设计目标