检索结果-南通市图书馆

Diabetes exacerbates inflammatory bowel disease in mice with dietinduced obesity

世界胃肠病学杂志:英文版 2023年第33期29卷 4991-5004页

作者： Kendra L Francis kimberly M Alonge Maria Cristina Pacheco Shannon J Hu Cody A Krutzsch Gregory J Morton Michael W Schwartz Jarrad M Scarlett Department of Pediatric Gastroenterology and Hepatology Seattle Children’s HospitalSeattleWA 98105United States 不详 Department of Medicinal Chemistry University of WashingtonSeattleWA 98195United States Department of Laboratory Medicine and Pathology Seattle Children's HospitalSeattleWA 98105United States

BACKGROUND The increased prevalence of inflammatory bowel disease(IBD)among patients with obesity and type 2 diabetes suggests a causal link between these diseases,potentially involving the effect of hyperglycemia to disrupt intestinal barrier *** To investigate whether the deleterious impact of diabetes on the intestinal barrier is associated with increased IBD severity in a murine model of colitis in mice with and without diet-induced *** Mice were fed chow or a high-fat diet and subsequently received streptozotocin to induce diabetic-range *** weeks later,dextran sodium sulfate was given to induce *** select experiments,a subset of diabetic mice was treated with the antidiabetic drug dapagliflozin prior to colitis *** included both clinical and histological measures of colitis activity as well as histochemical markers of colonic epithelial barrier *** In mice given a high-fat diet,but not chow-fed animals,diabetes was associated with significantly increased clinical colitis activity and histopathologic markers of disease *** was also associated with a decrease in key components that regulate colonic epithelial barrier integrity(colonic mucin layer content and epithelial tight junction proteins)in diet-induced obese *** of these effects of diabetes in diet-induced obese mice was ameliorated by restoring *** In obese mice,diabetes worsened clinical and pathologic outcomes of colitis via mechanisms that are reversible with treatment of ***-induced intestinal barrier dysfunction offers a plausible mechanism linking diabetes to increased colitis *** findings suggest that effective diabetes management may decrease the clinical severity of IBD.

关键词： Inflammatory bowel disease Type 2 diabetes Obesity Intestinal barrier Hyperglycemia Colitis in mice Tight junction proteins

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Methods for engineering therapeutic peptides

引用

Chinese Chemical Letters 2018年第7期29卷 1074-1078页

作者： Yaohao Li kimberly A.Clark Zhongping Tan Department of Chemistry and Biochemistry and BioFrontiers Institute University of Colorado

Peptides are a class of drugs that have become increasingly important and influential for the treatment of many human diseases. Compared to traditional small molecule drugs, peptides have the potential for higher target specificity and potency, along with better safety profiles. On the other hand, the complex and fragile nature of peptides poses significant challenges for their administration. Of particular concern is that they are often unstable and can be rapidly degraded by various proteases after dosing. To address these inherent problems of peptides, many different methods have been attempted. Here, we briefly review these methods, with an emphasis on the effect of each method.

关键词： Therapeutic peptides Engineering Half-life Stability Solubility Aggregation Permeability

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Emerging wearable technology applications in gastroenterology:A review of the literature

引用

World Journal of Gastroenterology 2021年第12期27卷 1149-1160页

作者： kimberly PL Chong Benjamin KP Woo College of Osteopathic Medicine Western University of Health SciencesPomonaCA 91766United States Department of Psychiatry and Biobehavioral Sciences Olive View-University of California Los Angeles Medical CenterSylmarCA 91342United States

The field of gastroenterology has recently seen a surge in wearable technology to monitor physical activity,sleep quality,pain,and even gut *** past decade has seen the emergence of wearable devices including Fitbit,Apple Watch,AbStats,and ingestible *** this review,we discuss current and future devices designed to measure sweat biomarkers,steps taken,sleep efficiency,gastric electrical activity,stomach pH,and intestinal *** also summarize several clinical studies to better understand wearable devices so that we may assess their potential benefit in improving healthcare while also weighing the challenges that must be addressed.

关键词： Wearable technology Wearables Ingestibles Smartphone Remote patient monitoring Gastroenterology

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Streamline unsupervised machine learning to survey and graph indel-based haplotypes from pan-genomes

引用

Molecular Plant 2023年第6期16卷 975-978页

作者： Bosen Zhang Haiyan Huang Laura E.Tibbs-Cortes Adam Vanous Zhiwu Zhang Karen Sanguinet kimberly A.Garland-Campbell Jianming Yu Xianran Li Department of Crop and Soil Sciences Washington State UniversityPullmanWA99164USA USDA-ARS Wheat HealthGeneticsand Quality Research UnitPullmanWA 99164USA USDA-ARS Corn Insects and Crop Genetics Research UnitAmesIA 50011USA USDA-ARS Plant Introduction ResearchAmesIA 50011USA Department of Agronomy lowa State UniversityAmesIA 50011USA

Dear Editor,Pan-genomes with high quality de novo assemblies are shifting the paradigm of biology research in genome evolution,speciation,and function annotation(Shi et al.,2023).An all-vs.-all comparison across assemblies potentially overcomes the limitation of mapping short reads to a single assembly in cataloging polymorphisms,especially large insertions and deletions(indels)contributing to phenotypic variations through altering gene structure or expression(Chen et al.,2021).

关键词： overcome shifting insertion

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

INVERSE BORN SERIES FOR SCALAR WAVES

引用

Journal of Computational Mathematics 2012年第6期30卷 601-614页

作者： kimberly Kilgore Shari Moskow John C. Schotland Department of Mathematics Drexel University Philadelphia PA 19104 USA Department of Mathematics University of Michigan Ann Arbor MI 48109 USA

We consider the inverse scattering problem for scalar waves. We analyze the conver- gence of the inverse Born series and study its use in numerical simulations for the case of a spherically-symmetric medium in two and... 详细信息

关键词： Inverse scattering.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Oncogene addiction and non-oncogene addiction in glioblastoma therapy

引用

Chinese Medical Journal 2011年第17期124卷 2565-2568页

作者： kimberly Ng Clark C. Chen Department of Radiation Oncology Dana-Farber Cancer Institute Boston MA USA Division of Neurosurgery Beth Israel Deaconess Medical Center Boston MA USA

INTRODUCTIONGlioblastoma is the most common form of primary brain tumor. The incidence of this tumor is fairly low, with 2-3 cases per 100 000 people in Europe and North America.

关键词： Oncogene addiction glioblastoma

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Non-viral causes of hepatocellular carcinoma

引用

World Journal of Gastroenterology 2010年第29期16卷 3603-3615页

作者： Wojciech Blonski David S Kotlyar kimberly A Forde Division of Gastroenterology University of Pennsylvania Department of Gastroenterology Medical University Wroclaw Department of Internal Medicine Montefi ore Medical CenterAlbert Einstein College of Medicine

Hepatocellular carcinoma(HCC) is the most common primary liver malignancy and represents an international public health concern as one of the most deadly cancers *** main etiology of HCC is chronic infection with hepatitis B and hepatitis C ***,there are other important factors that contribute to the international burden of *** these are obesity,diabetes,non-alcoholic steatohepatitis and dietary *** evidence suggests that the etiology of many cases of HCC is in fact multifactorial,encompassing infectious etiologies,comorbid conditions and environmental *** of relevant non-viral causes of HCC will aid in preventative efforts to curb the rising incidence of this disease.

关键词： Hepatocellular carcinoma Etiology Nonalcoholic steatohepatitis Obesity Diabetes Alcohol Tobacco Oral contraceptive

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The p75 neurotrophin receptor:at the crossroad of neural repair and death

引用

Neural Regeneration Research 2015年第5期10卷 721-725页

作者： Rick B.Meeker kimberly S.Williams Department of Neurology University of North Carolina Curriculum in Neurobiology University of North Carolina

The strong repair and pro-survival functions of neurotrophins at their primary receptors, TrkA, TrkB and TrkC, have made them attractive candidates for treatment of nervous system injury and disease. However, difficulties with the clinical implementation of neurotrophin therapies have prompted the search for treatments that are stable, easier to deliver and allow more precise regula- tion of neurotrophin actions. Recently, the p75 neurotrophin receptor （p75wrR） has emerged as a potential target for pharmacological control of neurotrophin activity, supported in part by stud- ies demonstrating 1） regulation of neural plasticity in the mature nervous system, 2） promotion of adult neurogenesis and 3） increased expression in neurons, macrophages, microglia, astro- cytes and/or Schwann cells in response to injury and neurodegenerative diseases. Although the receptor has no intrinsic catalytic activity it interacts with and modulates the function of TrkA, TrkB, and TrkC, as well as sortilin and the Nogo receptor. This provides substantial cellular and molecular diversity for regulation of neuron survival, neurogenesis, immune responses and pro- cesses that support neural function. Upregulation of the p75^NTR under pathological conditions places the receptor in a key position to control numerous processes necessary for nervous system recovery. Support for this possibility has come from recent studies showing that small, non-pep- tide p75^NTR ligands can selectively modify pro-survival and repair functions. While a great deal remains to be discovered about the wide ranging functions of the p75^NTR, studies summarized in this review highlight the immense potential for development of novel neuroprotective and neu- rorestorative therapies.

关键词： injury plasticity neurodegenerative disease brain therapy neuron microglia neuralprogenitor

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Do statins reduce hepatitis C RNA titers during routine clinical use?

引用

World Journal of Gastroenterology 2009年第40期15卷 5020-5027页

作者： kimberly A Forde Connie Law Rose O’Flynn David E Kaplan Philadelphia Veterans Administration Medical Center Department of Medicine Division of GastroenterologyUniversity of Pennsylvania Department of Pharmacy Philadelphia Veterans Administration Medical Center

AIM: To compare hepatitis C virus (HCV) titers in patients with chronic hepatitis C with and without exposure to 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins).METHODS: Medical records were reviewed for 6463 patients with documented HCV infection at a single center between March 2004 and September 2006. Patients with confi rmed viremia and meeting inclusion criteria were assigned to one of three groups: Group A (n = 50), dyslipidemic patients with statin usage during HCV RNA polymerase chain reaction (PCR) determination; Group B (n = 49), dyslipidemic patients with prior or future statin usage but not at the time of HCV RNA PCR determination; and Group C (n = 102), patients without statin usage during the study period. The primary analysis explored the effect of statin therapy on HCV viremia. Secondary analyses assessed class effect, dose response, and effect of other lipid-lowering therapies on HCV viral ***: Median HCV RNA titers did not signif icantly differ among the three groups (Group A: 4 550 000 IU/mL, Group B: 2 850 000 IU/mL, Group C: 3 055 000 IU/mL).For those subjects with longitudinal assessment of HCV viremia prior to and while on statins, there were no signif icant differences between pre- and post-HCV viral titers. Additionally, no differences in HCV titers were observed at any dose level of the most prescribed statin, simvastatin. However, hypertriglyceridemia independently correlated with HCV titers, and niacin exposure was associated with signif icantly lower viral titers (P < 0.05).CONCLUSION: There was no apparent effect of statins on HCV viral replication in this analysis. Further investigation is warranted to explore the possible antiviral properties of triglyceride-lowering agents and their potential role as adjuncts to standard HCV therapy.

关键词：他汀类药物临床应用 RNA 滴度肝炎 C型

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Use of Critical Ethnography to Study the PMTCT Program

引用

Advances in Infectious Diseases 2022年第1期12卷 147-158页

作者： Joyce Kamanzi Solina M. Richter Pauline Paul kimberly Jarvis Faculty of Nursing University of Alberta Edmonton Alberta Canada College of Nursing University of Saskatchewan Saskatoon SK Canada Memorial University of Newfoundland Newfoundland Canada

Background: Despite the efforts at establishing Prevention of Mother to Child Transmission (PMTCT) programs in Rwanda, there are still children who are becoming infected through mother-to-child transmission of HIV. The purpose of our research study was to explore the experiences of HIV positive women using PMTCT program to prevent HIV transmission in Rwanda. Methodology: In this study, a qualitative approach using a critical ethnographic design was used to answer to our research question and with the aim to discover the meaning, process, and context of the studied phenomenon. In this paper, we discussed ethnography, critical ethnography, and its related philosophical assumptions as well as illustrating the rational for the use of critical ethnography to study the PMTCT program. Critical ethnography ultimately will contribute to raising awareness on how we can prevent new infections among children born from HIV positive mothers who are using the PMTCT program. The findings suggested a wide range of challenging factors that are shaped by social, political, cultural, economic, ethnic, and gender values, and that directly and indirectly affect the uptake of the PMTCT program. While using the critical realist ontology, we discovered multiple truths about the challenging factors for HIV+ mothers experience to uptake the PMTCT program. We triangulated their experiences with the findings gathered from healthcare providers, PMTCT leaders and policymakers, field observation, and document analysis. No previous studies on this phenomenon used a critical lens to explore the reality behind a wide range of experiences of mothers using the PMTCT program to prevent HIV transmission in Rwanda. Conclusion: The critical nature of this inquiry contributed to the depth and breadth of knowledge related to the delivery of the PMTCT program to prevent MTCT of HIV.

关键词： Critical Ethnography HIV Nursing Knowledge PMTCT

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：