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Gastric cancer occurring in a patient with Plummer-Vinson syndrome: A case report

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World Journal of Gastroenterology 2005年第44期11卷 7048-7050页

作者： Ki-Han kim Min-Chan kim Ghap-joong Jung Department of Surgery

Plummer-Vinson syndrome (sideropenic dysphagia) is characterized by dysphagia due to an upper esophageal or hypopharyngeal web in patients with chronic iron deficiency anemia. The main cause of dysphagia is the presence of the web in the cervical esophagus,and abnormal motility of the pharynx or esophagus is also found to play a significant role in this *** syndrome is thought to be precancerous because squamous cell carcinoma of hypopharynx, oral cavity or esophagus takes place in 10% of those patients suffering from this malady, but it is even more unusual that Plummer-Vinson syndrome should be accompanied by gastric cancer. We have reported here a case of a43-year-old woman with Plummer-Vinson syndrome who developed stomach cancer and recovered after a radical total gastrectomy with D2 nodal dissection.

关键词： Plummer-Vinson syndrome Gastric cancer Esophageal web

Evaluation of the Twentieth Century Reanalysis Dataset in Describing East Asian Winter Monsoon Variability

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Advances in Atmospheric Sciences 2013年第6期30卷 1645-1652页

作者：张自银郭文利龚道溢 Seong-joong kim Beijing Meteorological Bureau State Key Laboratory of Earth Surface Processes and Resource Ecology Beijing Normal University Korea Polar Research Institute

The Twentieth Century Reanalysis （20thCR） dataset released in 2010 covers the period 1871-2010 and is one of the longest reanalysis datasets available worldwide. Using ERA-40, ERA-Interim and NCEP-NCAR reanalysis data, as well as HadSLP2 data and meteorological temperature records over eastern China, the performances of 20thCR in reproducing the spatial patterns and temporal variability of the East Asian winter monsoon （EAWM） are examined. Results indicate that 20thCR data：（1） can accurately reproduce the most typical configuration patterns of all sub-factors differences in the main circulation fields over East Asia involved in the EAWM system, albeit with some in comparison to ERA-40 reanalysis data; （2） is reliable and stable in describing the temporal variability of EAWM since the 1930s; and （3） can describe the high-frequency variability of EAWM better than the low-frequency fluctuations, especially in the early period. In conclusion, caution should be taken when using 20thCR data to study interdecadal variabilities or long-term trends of the EAWM, especially prior to the 1930s.

关键词： Twentieth Century Reanalysis dataset East Asian winter monsoon Siberian High eastern China

Hepatic cyst misdiagnosed as a gastric submucosal tumor:A case report

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World Journal of Gastroenterology 2008年第19期14卷 3092-3094页

作者： joong-Min Park Jin kim Ho-Il kim Chong-Suk kim Department of Surgery Korea University College of Medicine

We describe here a case of 51-year-old woman with a symptomatic hepatic cyst that was misdiagnosed as a gastric submucosal tumor (SMT) with endoscopic ultrasound (EUS) and CT scan. The patient presented with an epigastric pain for two months. On endoscopy, a submucosal tumor was found on the cardia of the stomach. Based on EUS and abdominal CT scan, the lesion was diagnosed as a gastric duplication cyst or a gastrointestinal stromal tumor (GIST). The operative plan was laparoscopic wedge resection for the GIST of the gastric cardia. A cystic mass arising from the left lateral segment of the liver was found at the laparoscopic examination. There was no abnormal finding at the gastric cardia. She was treated by laparoscopic hepatic wedge resection including the hepatic cyst using an endoscopic linear stapler.

关键词： Hepatic cyst Submucosal tumor Stomach

Embolization of pancreatic arteriovenous malformation:A case report

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World Journal of Clinical Cases 2020年第8期8卷 1471-1476页

作者： So Yeon Yoon Gyeong Sik Jeon Shin Jae Lee Dae joong kim Chang Il Kwon Mi hyun Park Department of Radiology CHA Bundang Medical CenterCollege of MedicineCHA UniversitySeongnam-si 13496Gyeonggi-doSouth Korea Department of Radiology Research Institute of Radiological ScienceYongin Severance HospitalYonsei University College of MedicineYongin-si 17046South Korea Department of Internal Medicine Digestive Disease CenterCHA Bundang Medical CenterCollege of MedicineCHA UniversitySeongnam-si 13496Gyeonggi-doSouth Korea Department of Radiology Dankook University HospitalChungcheongnam-do 31116South Korea

BACKGROUND Pancreatic arteriovenous malformation(AVM)is a rare disease with a number of different reported treatment methods,but there are as yet no established or definite treatments for the *** SUMMARY A 43-year-old man visited the hospital due to periumbilical *** patient underwent imaging study and laboratory testing for evaluation of *** AVM associated with pancreatitis was suspected on computed tomography and magnetic resonance *** patient was diagnosed with pancreatic AVM with pancreatitis on imaging study and *** arterial embolization with various embolic materials was ***-up computed tomography scan revealed progressive regression of AVM and improvement of *** two-year follow-up,the patient showed no recurrence of symptom or *** Transcatheter arterial embolization can be considered an effective treatment modality for selective cases of pancreatic AVM.

关键词： Pancreas Arteriovenous malformation Pancreatitis Pancreatic pseudocyst Embolization Therapeutic Case report

Worldwide experiences of endoscopic submucosal dissection:Not just Eastern acrobatics

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World Journal of Gastroenterology 2011年第21期17卷 2611-2617页

作者： Kwang Bum Cho Won joong Jeon Jae J kim Division of Gastroenterology Department of Internal MedicineKeimyung University School of Medicine Department of Internal Medicine Cheju Halla General Hospital Department of Medicine Samsung Medical CenterSungkyunkwan University School of Medicine

The high incidence of gastric cancer has led to the initiation of cancer screening *** a result,the number of early gastric cancer cases has increased and consequentially,the cancer mortality rate has ***,the development of minimally invasive endoscopic treatment has been introduced for these early *** submucosal dissection(ESD) is now recognized as one of the preferred treatment modalities for premalignant gastrointestinal epithelial lesions and early gastric cancer without lymph node *** review the results of ESD including experiences in Japan and Korea,as well as western countries.

关键词： Experiences Endoscopic submucosal dissection

Temporal profiles of synaptic plasticity-related signals in adult mouse hippocampus with methotrexate treatment

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Neural Regeneration Research 2012年第21期7卷 1651-1658页

作者： Miyoung Yang Juhwan kim Sung-Ho kim joong-Sun kim Taekyun Shin Changjong Moon Department of Veterinary Anatomy College of Veterinary Medicine and Animal Medical Institute Chonnam National University Department of Experimental Radiation Research Center Dongnam Institute of Radiological & Medical Sciences (DIRAMS) Department of Veterinary Anatomy College of Veterinary Medicine Jeju National University

Methotrexate, which is used to treat many malignancies and autoimmune diseases, affects brain functions including hippocampal-dependent memory function. However, the precise mechanisms underlying methotrexate-induced hippocampal dysfunction are poorly understood. To evaluate temporal changes in synaptic plasticity-related signals, the expression and activity of N-methyI-D-aspartic acid receptor 1, calcium/calmodulin-dependent protein kinase II, extracellular signal-regulated kinase 1/2, cAMP responsive element-binding protein, glutamate receptor 1, brain-derived neurotrophic factor, and glial cell line-derived neurotrophic factor were examined in the hippocampi of adult C57BL/6 mice after methotrexate （40 mg/kg） intraperitoneal injection. Western blot analysis showed biphasic changes in synaptic plasticity-related signals in adult hippocampi following methotrexate treatment. N-methyI-D-aspartic acid receptor 1, calcium/calmodulin-dependent protein kinase II, and glutamate receptor 1 were acutely activated during the early phase （1 day post-injection）, while extracellular signal-regulated kinase 1/2 and cAMP responsive element-binding protein activation showed biphasic increases during the eady （1 day post-injection） and late phases （7-14 days post-injection）. Brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor expression increased significantly during the late phase （7-14 days post-injection）. Therefore, methotrexate treatment affects synaptic plasticity-related signals in the adult mouse hippocampus, suggesting that changes in synaptic plasticity-related signals may be associated with neuronal survival and plasticity-related cellular remodeling.

关键词： hippocampus methotrexate neurotrophic factor synaptic plasticity-related signal neuralregeneration

Stable Zn Metal Anodes with Limited Zn-Doping in MgF_(2) Interphase for Fast and Uniformly Ionic Flux

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Nano-Micro Letters 2022年第3期14卷 169-183页

作者： Ji Young kim Guicheng Liu Ryanda Enggar Anugrah Ardhi Jihun Park Hansung kim joong Kee Lee Energy Storage Research Center Korea Institute of Science and TechnologyHwarang‑ro 14‑gil 5Seongbuk‑guSeoul 02792Republic of Korea Department of Chemical and Biomolecular Engineering Yonsei University50 Yonsei‑roSeodaemun‑guSeoul 03722Republic of Korea Department of Physics Dongguk UniversitySeoul 04620Republic of Korea APC Technology 10868 Gangbyeonyeok‑ro‑4‑gilGwangjin‑guSeoul 05116Republic of Korea Department of Energy and Environmental Engineering KIST SchoolKorea University of Science and TechnologyHwarang‑ro 14‑gil 5Seongbuk‑guSeoul 02792Republic of Korea

The practical applications of aqueous Zn metal batteries are currently restricted by the inherent drawbacks of Zn such as the hydrogen evolution reaction,sluggish kinetics,and dendrite *** address these problems,herein,a limitedly Zn-doped MgF_(2)interphase comprising an upper region of pure,porous MgF_(2)and a lower region of gradient Zn-doped MgF_(2)is achieved via radio frequency sputtering *** porous MgF_(2)region is a polar insulator whose high corrosion resistance facilitates the de-solvation of the solvated Zn ions and suppression of hydrogen evolution,resulting in Zn metal electrodes with a low interfacial *** Zn-doped MgF_(2)region facilitates fast transfer kinetics and homogeneous deposition of Zn ions owing to the interfacial polarization between the Zn dopant and MgF_(2)matrix,and the high concentration of the Zn dopant on the surface of the metal substrate as fine ***,a symmetric cell incorporating the proposed Zn metal exhibits low overpotentials of~27.2 and~99.7 mV without Zn dendrites over 250 to 8000 cycles at current densities of 1.0 and 10.0 mA cm−2,*** developed Zn/MnO2 full cell exhibits superior capacity retentions of 97.5%and 84.0%with average Coulombic efficiencies of 99.96%after 1000 and 3000 cycles,respectively.

关键词： Zinc metal battery MgF_(2)layer Limited zinc doping Ion-transfer kinetic Deposition guidance

Ni Single Atoms and Ni Phosphate Clusters Synergistically Triggered Surface-Functionalized MoS_(2)Nanosheets for High-performance Freshwater and Seawater Electrolysis

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Energy & Environmental Materials 2022年第4期5卷 1340-1349页

作者： Min Sung kim Duy Thanh Tran Thanh Hai Nguyen Van An Dinh Nam Hoon kim joong Hee Lee Department of Nano Convergence Engineering Jeonbuk National UniversityJeonju 54896Republic of Korea Department of Precision Engineering Graduate School of EngineeringOsaka University2-1Yamada-okaSuita 565-0871Japan Carbon Composite Research Center Department of Polymer-Nanoscience and TechnologyJeonbuk National UniversityJeonju 54896Republic of Korea

Two-dimensional metal dichalcogenides have been evidenced as potential electrocatalysts for hydrogen evolution reaction(HER);however,their application is limited by a poor oxygen evolution reaction(OER)activity due to insufficient number/types of multi-integrated active *** this study,we report a novel bifunctional catalyst developed by simultaneous engineering of single nickel atoms(Ni_(SA)) and nickel phosphate clusters(Ni_(Pi)) to synergistically trigger surface-functionalized MoS_(2) nanosheets(NSs)resulting in high reactivities for both HER and *** Ni_(SA)-Ni_(Pi)/MoS_(2)NSs material exhibits a fairly Pt-like HER behavior with an overpotential of 94.0 mV and a small OER overpotential of 314.0 mV to reach 10 mA cm^(-2) in freshwater containing 1.0 M *** results of the catalyst are well supported by theoretical study,which reveals the significant modulation of electronic structure and enrichment of electroactive site number/types with their reasonably adjusted free adsorption *** evaluating practicability,the Ni_(SA)-Ni_(Pi)/MoS_(2)NSs-based electrolyzer delivers effective operation voltage of 1.62,1.52,and 1.66 V at 10 mA cm^(-2) and superior long-term stability as compared to Pt/C//RuO_(2) system in freshwater,mimic seawater,and natural seawater,*** present study indicates that the catalyst is a promising candidate for the practical production of green hydrogen via water electrolysis.

关键词： bifunctional electrocatalyst freshwater and seawater electrolysis nickel phosphate clusters nickel single atoms surface-functionalized-MoS_(2)nanosheets

Induction of clusterin Expression by Neuronal Cell Death in Zebrafish

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Journal of Genetics and Genomics 2014年第11期41卷 583-589页

作者： Yun-Mi Jeong Tae-Eun Jin Jung-Hwa Choi Mi-Sun Lee hyun-Taek kim Kyu-Seok Hwang Doo-Sang Park hyun-Woo Oh joong-Kook Choi Vladimir Korzh Melitta Schachner Kwan-Hee You Cheol-Hee kim Department of Biology Chungnam National University Korea Research Institute of Bioscience and Biotechnology Department of Biochemistry College of MedicineChungbuk National University Institute of Molecular and Cell Biology Agency for ScienceTechnology and Research Keck Center for Collaborative Neuroscience and Department of Cell Biology and Neuroscience Rutgers University Center for Neuroscience Shantou University Medical College

Clusterin, a protein associated with multiple functions, is expressed in a wide variety of mammalian tissues. Although clusterin is known to be involved in neurodegenerative diseases, ageing, and tumorigenesis, a detailed analysis of the consequences of gain- or loss-of- function approaches has yet to be performed to understand the underlying mechanisms of clusterin functions. Since clusterin levels change in neurological diseases, it is likely that clusterin contributes to cell death and degeneration in general. Zebrafish was investigated as a model system to study human diseases. During development, zebrafish clusterin was expressed in the notochord and nervous system. Embryonic overexpression of clusterin by mRNA microinjection did not affect axis formation, whereas its knock-down by anti-sense morpholino treatment resulted in neuronal cell death. To analyze the function of clusterin in neurodegeneration, a transgenic zebrafish was investigated, in which nitroreductase expression is regulated under the control of a neuron-specifc huC promoter which is active between the stages of early neuronal precursors and mature neurons. Nitroreductase turns metronidazole into a cytotoxic agent that induces cell death within 12 h. After metronidazole treatment, transgenic zebrafish showed neuron-specific cell death. Interestingly, we also observed a dramatic induction of clusterin expression in the brain and spinal cord in these fish, suggesting a direct or indirect role of clusterin in neuronal cell death and thus, more generally, in neurodegeneration.

关键词： Clusterin Neuronal cell death Neurodegeneration Zebrafish