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Understanding the spectrum of non-motor symptoms in multiple sclerosis:insights from animal models

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Neural Regeneration Research 2024年第1期19卷 84-91页

作者： Poornima D.E.Weerasinghe-Mudiyanselage joong-Sun kim Taekyun Shin Changjong Moon Department of Veterinary Anatomy and Animal Behavior College of Veterinary Medicine and BK21 FOUR programChonnam National UniversityGwangjuRepublic of Korea Department of Veterinary Anatomy College of Veterinary Medicine and Veterinary Medical Research InstituteJeju National UniversityJejuRepublic of Korea

Multiple sclerosis is a chronic autoimmune disease of the central nervous system and is generally considered to be a non-traumatic,physically debilitating neurological *** addition to experiencing motor disability,patients with multiple sclerosis also experience a variety of nonmotor symptoms,including cognitive deficits,anxiety,depression,sensory impairments,and ***,the pathogenesis and treatment of such non-motor symptoms in multiple scle rosis are still under *** studies for multiple sclerosis benefit from the use of disease-appropriate animal models,including experimental autoimmune *** to understanding the pathophysiology and developing treatments for non-motor symptoms,it is critical to chara cterize the animal model in terms of its ability to replicate certain non-motor features of multiple *** such,no single animal model can mimic the entire spectrum of *** review focuses on the non-motor symptoms that have been investigated in animal models of multiple sclerosis as well as possible underlying ***,we highlighted gaps in the literature to explain the nonmotor aspects of multiple sclerosis in expe rimental animal models,which will serve as the basis for future studies.

关键词： anxiety cognitive deficit depression experimental autoimmune encephalomyelitis motor disability neurological disorder pain pathophysiology preclinical study sensory impairments

Changes in structural plasticity of hippocampal neurons in an animal model of multiple sclerosis

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Zoological Research 2024年第2期45卷 398-414页

作者： Poornima D.E.Weerasinghe-Mudiyanselage Sohi Kang joong-Sun kim Sung-Ho kim Hongbing Wang Taekyun Shin Changjong Moon Department of Veterinary Anatomy and Animal Behavior College of Veterinary Medicine and BK21 FOUR ProgramChonnam National UniversityGwangju 61186Republic of Korea Department of Anatomy and Convergence Medical Science Institute of Health SciencesCollege of MedicineGyeongsang National UniversityJinju 52727Republic of Korea Department of Physiology and Neuroscience Program Michigan State UniversityEast LansingMI 48824USA Department of Veterinary Anatomy College of Veterinary Medicine and Veterinary Medical Research InstituteJeju National UniversityJeju 63243Republic of Korea

Structural plasticity is critical for the functional diversity of neurons in the *** autoimmune encephalomyelitis(EAE)is the most commonly used model for multiple sclerosis(MS),successfully mimicking its key pathological features(inflammation,demyelination,axonal loss,and gliosis)and clinical symptoms(motor and non-motordysfunctions).Recentstudieshave demonstrated the importance of synaptic plasticity in EAE *** the present study,we investigated the features of behavioral alteration and hippocampal structural plasticity in EAE-affected mice in the early phase(11 days post-immunization,DPI)and chronic phase(28DPI).EAE-affected mice exhibited hippocampus-related behavioral dysfunction in the open field test during both early and chronic *** complexity was largely affected in the cornu ammonis 1(CA1)and CA3 apical and dentate gyrus(DG)subregions of the hippocampus during the chronic phase,while this effect was only noted in the CA1 apical subregion in the early ***,dendritic spine density was reduced in the hippocampal CA1 and CA3 apical/basal and DG subregions in the early phase of EAE,but only reduced in the DG subregion during the chronic ***,mRNA levels of proinflammatory cytokines(Il1β,Tnfα,and Ifnγ)and glial cell markers(Gfap and Cd68)were significantly increased,whereas the expression of activity-regulated cytoskeletonassociated protein(ARC)was reduced during the chronic ***,exposure to the aforementioned cytokines in primary cultures of hippocampal neurons reduced dendritic complexity and ARC *** cultures of hippocampal neurons also showed significantly reduced extracellular signal-regulated kinase(ERK)phosphorylation upon treatment with proinflammatory ***,these results suggest that autoimmune neuroinflammation alters structural plasticity in the hippocampus,possibly through the ERK-ARC pathway,indicating that this alteration may be associated with hi

关键词： Activity-regulated cytoskeleton-associated protein Anxiety-like behavior Experimental autoimmune encephalomyelitis Hippocampal dysfunction Neuroinflammation

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丙烯酸酯压敏胶的紫外光固化研究(英文)

丙烯酸酯压敏胶的紫外光固化研究(英文)

汽车底涂用聚酯涂料的固化及其表面性能(英文)

'2010北京国际粘接技术研讨会

作者： LEE yong-ju PARK ji-won kim hyun-joong Lab.of Adhesion ＆ Bio-Composites Program in Environmental Materials ScienceSeoul National UniversitySeoul 151-921S.Korea

＜正＞*** Pressure-sensitive adhesives（PSAs） are viscoelastic materials which adhere to substrates on the application of slight pressure over short periods of *** term"pressure sensitive"（or sometimes self-adhesive） is used to designate a distinct category of *** are used for many *** are used for masking tapes,medical tape,labels,and packaging[1,2].

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汽车底涂用聚酯涂料的固化及其表面性能(英文)

Highly Elastic,Bioresorbable Polymeric Materials for Stretchable,Transient Electronic Systems

'2010北京国际粘接技术研讨会

作者： PARK cho-hee HWANG hyeon-deuk MOON je-ik kim hyun-joong NOH seung man NAM joon hyun Lab.of Adhesion and Bio-Composites Program in Environmental Materials ScienceSeoul National UniversitySeoul 151-921S.Korea

＜正＞*** Various physical properties are required for automotive *** fulfilling these properties, automotive coatings are made up multi-layers hence coating system is very *** automotive coating process is consisted of electro-deposition,primer,base coat,and clear coat. Car body forming,welding,assembling and phosphate pretreatment are accomplished in order

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Nano-Micro Letters 2024年第6期16卷 1-13页

作者： Jeong‑Woong Shin Dong‑Je kim Tae‑Min Jang Won Bae Han joong Hoon Lee Gwan‑Jin Ko Seung Min Yang Kaveti Rajaram Sungkeun Han Heeseok Kang Jun Hyeon Lim Chan‑Hwi Eom Amay J.Bandodkar Hanul Min Suk‑Won Hwang KU‑KIST Graduate School of Converging Science and Technology Korea University145 Anam‑roSeongbuk‑guSeoul 02841Republic of Korea SK Hynix 2091Gyeongchung‑daeroBubal‑eupIcheon‑siGyeonggi‑do 17336Republic of Korea Hanwha Systems Co. Ltd.188Pangyoyeok‑roBundang‑guSeongnam‑siGyeonggi‑do 13524Republic of Korea Department of Electrical and Computer Engineering North Carolina State UniversityRaleighNC 27606USA Center for Advanced Self‑Powered Systems of Integrated Sensors and Technologies(ASSIST) North Carolina State UniversityRaleighNC 27606USA Department of Integrative Energy Engineering Korea University145 Anam‑roSeongbuk‑guSeoul 02841Republic of Korea Biomaterials Research Center Korea Institute of Science and Technology(KIST)5 Hwarang‑ro 14‑gilSeongbuk‑guSeoul 02792Republic of Korea Semiconductor R&D Center Samsung Electronics Co.Ltd.Hwaseong‑siGyeonggi‑do 18448Republic of Korea Center for Advanced Biomolecular Recognition Biomedical Research DivisionKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea

Substrates or encapsulants in soft and stretchable formats are key components for transient,bioresorbable electronic systems;however,elastomeric polymers with desired mechanical and biochemical properties are very limited compared to nontransient ***,we introduce a bioresorbable elastomer,poly(glycolide-co-ε-caprolactone)(PGCL),that contains excellent material properties including high elongation-at-break(<1300%),resilience and toughness,and tunable dissolution *** of PGCLs as polymer matrices,in combination with conducing polymers,yields stretchable,conductive composites for degradable interconnects,sensors,and actuators,which can reliably function under external *** of device components with wireless modules demonstrates elastic,transient electronic suture system with on-demand drug delivery for rapid recovery of postsurgical wounds in soft,time-dynamic tissues.

关键词： Biodegradable elastomer Conductive polymer composites Biomedical device Transient electronics

黄土高原4种高糖黑麦草在不同刈割方式下的营养价值评价

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草地学报 2024年

作者：邹敏成慧宁娇李腾飞谢凯丽 Eun joong kim Nigel Scollan 常生华侯扶江草种创新与草地农业生态系统全国重点实验室兰州大学农业农村部草牧业创新重点实验室兰州大学草地农业科技学院 Department of Animal Science， Kyungpook National University Institute of Biological， Environmental and Rural Sciences， Aberystwyth University

为探究刈割方式对高糖黑麦草营养价值的影响，在黄土高原种植了‘AberStar’‘AberMagic’‘AberAvon’和‘Premium’4种高糖黑麦草（High sugar ryegrass，HSR），并进行了动态取样，研究多次刈割和一次刈割两种刈割方式对其产量、营... 详细信息

为探究刈割方式对高糖黑麦草营养价值的影响，在黄土高原种植了‘AberStar’‘AberMagic’‘AberAvon’和‘Premium’4种高糖黑麦草（High sugar ryegrass，HSR），并进行了动态取样，研究多次刈割和一次刈割两种刈割方式对其产量、营养品质动态和稳定性的影响，并完成了综合评价。结果表明，在牧草的生长过程中，4个品种多次刈割的产量均高于一次刈割，但产量稳定性低于一次刈割5.38%～23.91%。多次刈割的粗蛋白含量稳定性显著高于一次刈割（P<0.05），可溶性碳水化合物稳定性最低为31.77%～45.20%。4个品种的再生速度和再生强度呈先升后降趋势，多次刈割的再生速度和再生强度分别高于一次刈割18.12%～105.21%和18.41%～92.63%，并在108 d时达到最高。多次刈割的食物当量显著高于一次刈割（P<0.05）。在所有处理组合中，‘AberStar’品种进行多次刈割产量和品质表现最佳。本研究确定了高产优质的高糖黑麦草品种及其刈割方式，将为黄土高原地区高糖黑麦草的栽培管理措施提供科学依据。

关键词：高糖黑麦草黄土高原营养品质产草量

Measurements of Formaldehyde and TVOC Emission from Paints and Coating Materials using Small Chamber Method for Building Composites

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Journal of Wuhan University of Technology(Materials Science) 2012年第1期27卷 120-125页

作者： Jin-A kim Sumin kim hyun-joong kim Janghoo SEO National Instrumentation Center for Environmental Management Seoul National University Seoul 151-921 Republic of Korea Laboratory of Adhesion & Bio-Composites Program in Environmental Materials Science Seoul National University Seoul 151-921 Republic of Korea Building Environment & Materials Lab School of Architecture Soongsil University Seoul 156-743 Republic of Korea School of Architecture Chosun University Gwangju 507-759 Korea

An optimal test method for paint is proposed; additionally, the Field and Laboratory Emission Cell （FLEC） method used in Europe is applied as a substitute for the 20 L small chamber method. The emission factors of total volatile organic compounds （TVOC） and formaldehyde from oil-based paint, emulsion paint, and water-dispersion paint with a coating weight of 300 g/m2, cured for 24/48 hours, were measured using the 20 L small chamber method. The emission rate of TVOC and formaldehyde from all paints began to stabilize after approximately 7 days after 24/48 hours of curing even though Korean standards stipulate that paint should be measured and analyzed after the third day of application. The emission factor of TVOC and formaldehyde from oil-based, emulsion, and water-dispersion paints were also measured using the FLEC method. There was good correlation between the 20 L small chamber method and the FLEC method for oil-based, emulsion, and water-dispersion paint emissions. With the FLEC method, using paints prepared under identical conditions, the emission rate was stable 24 hours after installation of samples because the air flow rate of FLEC is much higher than that of a 20 L small chamber, and the relative cell volume of FLEC is much smaller than that of a 20 L small chamber.

关键词： formaldehyde TVOC paints coating materials FLEC

Optimal rotor wear design in hypotrochoidal gear pump using genetic algorithm

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Journal of Central South University 2011年第3期18卷 718-725页

作者： KWON Soon-man kim Chang-hyun SHIN joong-ho Department of Mechanical Design and Manufacturing Engineering Changwon National University

The wear rate between the rotors of a hypotrochoidal gear pump is *** the knowledge of shape design on the rotors,the contact stresses without hydrodynamic effect between the rotor teeth were evaluated through the calculation of the Hertzian contact *** on the above results and the sliding velocity between the rotors,a genetic algorithm (GA) was used as an optimization technique forminimizing the wear rate proportional factor (WRPF).The result shows that the wear rate or the WRPF can be reduced considerably,*** 12.8%,throughout the optimization using GA.

关键词： gerotor hypotrochoidal gear pump Hertzian contact stress wear rate proportional factor genetic algorithm

Generation of Discrete Bicubic G^1 B-Spline Ship Hullform Surfaces from a Given Curve Notwork Using Virtual Iso-Parametric Curves

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Journal of Computer Science & Technology 2006年第2期21卷 265-271页

作者： joong-hyun Rhim Doo-Yeoun Cho Kyu-Yeul Lee Tao-Wan kim EzGragh Co.Ltd.Seoul 135-080 Koren Department of Naval Architecture & Ocean Engincering Seoul National UniversitySeoul 151-744Korea Department of Naval Architecture & Ocean Engincering and Research Institute of Macine Systems Engineering Seoul National University Seoul 151-744Korea

We propose a method that automatically generates discrete bicubic G^1 continuous B-spline surfaces that interpolate the curve network of a ship ***,the curves in the network are classified into two types;boundary curves and ＂reference curves＂,The boundary curves correspond to a set of rectangular（or triangular）topological type that can be representes with tensot-product （or degenerate）B-spline surface ***,in the interior of the patches,surface fitting points and cross boundary derivatives are estimated from the reference curves by constructing ＂virtual＂isoparametric ***,a discrete G^1 continuous B-spline surface is gencrated by a surface fitting *** smooth ship hullform surfaces generated from curve networks corresponding to actual ship hullforms demonstrate the quality of the method.

关键词： curve netowork interpotation discrete G^1 continuous B-spline surface,iso-parametric curve,ship hullform