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Elucidating regulatory processes of intense physical activity by multi-omics analysis

Military Medical Research 2024年第4期11卷 479-499页

作者： Ernesto S.Nakayasu Marina A.Gritsenko young-Mo kim Jennifer E.Kyle Kelly G.Stratton Carrie D.Nicora Nathalie Munoz Kathleen M.Navarro Daniel Claborne Yuqian Gao Karl K.Weitz Vanessa L.Paurus Kent J.Bloodsworth Kelsey A.Allen Lisa M.Bramer Fernando Montes Kathleen A.Clark Grant Tietje Justin Teeguarden Kristin E.Burnum-Johnson Biological Sciences Division Pacific Northwest National LaboratoryRichlandWA 99352USA Environmental and Molecular Sciences Division Pacific Northwest National LaboratoryRichlandWA 99352USA Centers for Disease Control and Prevention National Institute for Occupational Safety and HealthWestern States DivisionDenverCO 80204USA Computational Analytics Division Pacific Northwest National LaboratoryRichlandWA 99352USA National Security Directorate Pacific Northwest National LaboratoryRichlandWA 99352USA Los Angeles County Fire Department Los AngelesCA 90063USA Centers for Disease Control and Prevention National Institute for Occupational Safety and HealthRespiratory Health DivisionMorgantownWV 26505USA Environmental and Molecular Toxicology Oregon State UniversityCorvallisOR 97331USA

Background:Physiological and biochemical processes across tissues of the body are regulated in response to the high demands of intense physical activity in several occupations,such as firefighting,law enforcement,military,and sports.A better understanding of such processes can ultimately help improve human performance and prevent illnesses in the work ***:To study regulatory processes in intense physical activity simulating real-life conditions,we performed a multi-omics analysis of 3 biofluids(blood plasma,urine,and saliva)collected from 11 wildland firefighters before and after a 45 min,intense exercise *** profiles ***-exercise were compared by Student’s t-test followed by pathway analysis and comparison between the different omics ***:Our multi-omics analysis identified and quantified 3835 proteins,730 lipids and 182 metabolites combining the 3 different types of *** blood plasma analysis revealed signatures of tissue damage and acute repair response accompanied by enhanced carbon metabolism to meet energy *** urine analysis showed a strong,concomitant regulation of 6 out of 8 identified proteins from the renin-angiotensin system supporting increased excretion of catabolites,reabsorption of nutrients and maintenance of fluid *** saliva,we observed a decrease in 3 pro-inflammatory cytokines and an increase in 8 antimicrobial peptides.A systematic literature review identified 6 papers that support an altered susceptibility to respiratory ***:This study shows simultaneous regulatory signatures in biofluids indicative of homeostatic maintenance during intense physical activity with possible effects on increased infection susceptibility,suggesting that caution against respiratory diseases could benefit workers on highly physical demanding jobs.

关键词： Multi-omics analysis Intense exercise Human performance Biofluids Metabolism Immunity

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Tree species identity and interaction determine vertical forest structure in young planted forests measured by terrestrial laser scanning

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Forest Ecosystems 2024年第3期11卷 266-275页

作者： Mengxi Wang Lander Baeten Frieke Van Coillie kim Calders Kris Verheyen Quentin Ponette Haben Blondeel Bart Muys John Armston Hans Verbeeck Q-ForestLab Department of EnvironmentFaculty of Bioscience EngineeringGhent UniversityBelgium Forest&Nature Lab Department of EnvironmentFaculty of Bioscience EngineeringGhent UniversityBelgium Earth and Life Institute Université Catholique de Louvain(UCLouvain)Louvain-la-NeuveBelgium Department of Earth&Environmental Sciences KU LeuvenBelgium Department of Geographical Sciences University of MarylandCollege ParkMDUSA

Vertical forest structure is closely linked to multiple ecosystem characteristics,such as biodiversity,habitat,and *** tree species in planted forests has the potential to create diverse vertical forest structures due to the different physiological and morphological traits of the composing tree ***,the relative importance of species richness,species identity and species interactions for the variation in vertical forest structure remains unclear,mainly because traditional forest inventories do not observe vertical stand structure in *** laser scanning(TLS),however,allows to study vertical forest structure in an unprecedented ***,we used TLS single scan data from 126 plots across three experimental planted forests of a largescale tree diversity experiment in Belgium to study the drivers of vertical forest *** plots were 9–11years old young pure and mixed forests,characterized by four levels of tree species richness ranging from monocultures to four-species mixtures,across twenty composition *** generated vertical plant profiles from the TLS data and derived six stand structural *** mixed models were used to test the effect of species richness on structural *** a hierarchical diversity interaction modelling framework,we further assessed species identity effect and various species interaction effects on the six stand structural *** results showed that species richness did not significantly influence most of the stand structure variables,except for canopy height and foliage height *** identity on the other hand exhibited a significant impact on vertical forest structure across all *** interaction effects were observed to be site-dependent due to varying site conditions and species pools,and rapidly growing tree species tend to dominate these ***,our results highlighted the importance of considering both species identity an

关键词： TreeDivNet FORBIO Stand structural complexity Terrestrial laser scanning Vertical forest structure Tree diversity Planted forests

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Optimal Center-of-Mass Pivot Effect of Spinal Motion in Feline Galloping

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Journal of Bionic Engineering 2020年第5期17卷 970-977页

作者： young Kook kim Dongwon Yun LV R&D team Electro-technology R&D CenterLS ELECTRIC Co.LtdCheongju 28437South Korea Department of Robotics Engineering Daegu Gyeongbuk Institute of Science and Technology(DGIST)Daegu 42988South Korea

In this paper,we studied the acceleration behavior of a quadruped animal during a galloping *** the development of many quadruped robotic systems has been focused on dynamic movements,it is obvious that guidance from the dynamic behavior of quadruped animals is needed for robotics *** fulfill this demand,this paper deals with analysis of the galloping motions of a domestic cat,which is well known for its excellent acceleration performance among four-legged *** on the planar motion capture environment,the movement data of a galloping feline was acquired and the dynamic motions were estimated using a spring-mass *** particular,the effects of the position and angle of the center-of-mass of the cat,angular displacement of the spine,and angular velocity of the spine were analyzed and are discussed *** this process,it was possible to understand the dynamic movement characteristics of the cat,and to understand the relationships between,and the influences of,these *** this analysis,we provide significant data applicable to the design of joint movements in quadruped robot systems.

关键词： quadrupedalism feline galloping domestic cat center-of-mass

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Atrial natriuretic peptide signal pathway upregulated in stomach of streptozotocin-induced diabetic mice

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World Journal of Gastroenterology 2010年第1期16卷 48-55页

作者： young-Chul kim Department of Physiology Chungbuk National University College of Medicine

AIM:To investigate atrial natriuretic peptide(ANP) secretion from gastric mucosa and the relationship between the ANP/natriuretic peptide receptor type A (NPR-A)pathway and diabetic gastroparesis. METHODS:Male imprinting control region(ICR)mice (4 wk old)were divided into two groups:control mice, and streptozotocin-induced diabetic *** weeks after injection,spontaneous gastric contraction was recorded by using physiography in control and streptozotocin-induced diabetic *** ANP-positive cells in gastric mucosa and among dispersed gastric epithelial cells were detected by using immunohistochemistry and flow cytometry,*** and natriureticpeptide receptor type A(NPR-A)gene expression in gastric tissue was observed by using the reverse transcriptase polymerase chain reaction. RESULTS:The frequency of spontaneous gastric contraction was reduced from 12.9±0.8 cycles/min in the control group to 8.4±0.6 cycles/min in the diabetic mice(n=8,P<0.05).However,the amplitude of contraction was not significantly affected in the diabetic *** depletion of interstitial cells of Cajal in the gastric muscle layer was observed in the diabetic ***-positive cells were distributed in the gastric mucosal layer and the density index of ANP-positive cells was increased from 20.9±2.2 cells/field in control mice to 51.8±2.9 cells/field in diabetic mice(n=8, P<0.05).The percentage of ANP-positive cells among the dispersed gastric epithelial cells was increased from 10.0%±0.9%in the control mice to 41.2%± 1.0%in the diabetic mice(n=3,P<0.05).ANP and NPR-A genes were both expressed in mouse stomach, and the expression was significantly increased in the diabetic mice. CONCLUSION:These results suggest that the ANP/ NPR-A signaling pathway is upregulated in streptozotocin-induced diabetic mice,and contributes to the development of diabetic gastroparesis.

关键词： Diabetes mellitus Atrial natriuretic peptide Gastric mucosa Gastroparesis

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Clinical features of gastric adenoma detected within 3 years after negative screening endoscopy in Korea

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Gastroenterology Report 2023年第1期11卷 406-411页

作者： Hyun young kim Department of Internal Medicine Seoul National University Bundang HospitalSeongnam-siGyeonggi-doKorea

Background:Early detection and management of gastric adenoma are important for preventing gastric *** present study aimed to evaluate the predictors of missed gastric adenoma on screening endoscopy in Korea and identify the risk factors associated with interval precancerous gastric ***:All cases of gastric adenomas diagnosed via screening endoscopy between 2007 and 2019 were *** them,those who had undergone endoscopy within 3 years were included in the present *** gastric adenoma was defined as gastric adenoma diagnosed within 3 years after negative screening ***:In total,295 cases of gastric adenoma were *** these,95(32.2%)were missed gastric adenoma cases(mean age,60.6 years;average interval between final and index endoscopies,12.6months);the remaining 200(67.8%)were newly detected adenoma *** analysis revealed thatmale sex,endoscopist experience,observation time,and presence of gastric intestinalmetaplasia(pathologically proven)were associated with missed gastric *** analysis revealed that gastric intestinal metaplasia(odds ratio[OR],2.736;95%confidence interval[CI],1.320–5.667;P=0.007)and shorter observation time of the index screening endoscopy(B,0.011;OR,0.990;95%CI,0.986–0.993;P<0.001)were independent risk factors for missed gastric *** optimal cut-off for the observation time for detecting gastric adenoma was 3.53minutes(area under curve,0.738;95%CI,0.677–0.799;P<0.001).Conclusions:Gastric intestinal metaplasia is an indication of missed gastric ***,careful inspection of gastric mucosa with gastric intestinal metaplasia and proper observation time can lower the possibility of missing the gastric adenoma during screening.

关键词： gastric adenoma screening endoscopy gastric intestinal metaplasia observation time

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Some New Inverse-type Hilbert-Pachpatte Integral Inequalities

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Acta Mathematica Sinica,English Series 2004年第1期20卷 57-62页

作者： young Ho kim Department of Applied Mathematics Changwon National UniversityChangwon 641-773Korea

In this paper, some new generalizations of inverse type Hilbert-Pachpatte integral inequalities are proved. The results of this paper reduce to those of Pachpatte (1998, J. Math. Anal. Appl. 226, 166–179) and Zhao an... 详细信息

关键词： Hilbert’s double integral inequality H(?)lder integral inequality Jensen’s inequality Power mean inequality

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A Data Download Method from RSUs Using Fog Computing in Connected Vehicles

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Computers, Materials & Continua 2019年第5期59卷 375-387页

作者： Dae-young kim Seokhoon kim School of Information Technology Daegu Catholic UniversityGyeongsan-si 38430Republic of Korea Department of Computer Software Engineering Soonchunhyang UniversityAsan-si 31538Republic of Korea

Communication is important for providing intelligent services in connected *** must be able to communicate with different places and exchange information while *** service operation,connected vehicles frequently attempt to download large amounts of *** can request data downloading to a road side unit(RSU),which provides infrastructure for connected *** RSU is a data bottleneck in a transportation system because data traffic is concentrated on the ***,it is not appropriate for a connected vehicle to always attempt a high speed download from the *** the mobile network between a connected vehicle and an RSU has poor connection quality,the efficiency and speed of the data download from the RSU is *** problem affects the quality of the user ***,it is important for a connected vehicle to connect to an RSU with consideration of the network conditions in order to try to maximize download *** proposed method maximizes download speed from an RSU using a machine learning *** collect and learn from network data,fog computing is used.A fog server is integrated with the RSU to perform *** the algorithm recognizes that conditions are not good for mass data download,it will not attempt to download at high ***,the proposed method can improve the efficiency of high speed *** conclusion was validated using extensive computer simulations.

关键词： Connected car fog computing data download DSRC machine learning

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Network-Aided Intelligent Traffic Steering in 5G Mobile Networks

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Computers, Materials & Continua 2020年第10期65卷 243-261页

作者： Dae-young kim Seokhoon kim School of Computer Software Daegu Catholic UniversityGeyongsan38430Korea Department of Computer Software Engineering Soonchunhyang UniversityAsan31538Korea

Recently,the fifth generation(5G)of mobile networks has been deployed and various ranges of mobile services have been *** 5G mobile network supports improved mobile broadband,ultra-low latency and densely deployed massive *** allows multiple radio access technologies and interworks them for services.5G mobile systems employ traffic steering techniques to efficiently use multiple radio access ***,conventional traffic steering techniques do not consider dynamic network conditions *** this paper,we propose a network aided traffic steering technique in 5G mobile network architecture.5G mobile systems monitor network conditions and learn with network *** a machine learning algorithm such as a feed-forward neural network,it recognizes dynamic network conditions and then performs traffic *** proposed scheme controls traffic for multiple radio access according to the ratio of measured ***,it can be expected to improve traffic steering *** performance of the proposed traffic steering scheme is evaluated using extensive computer simulations.

关键词： Mobile network 5G traffic steering machine learning MEC

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Adaptive Data Transmission Method According to Wireless State in Long Range Wide Area Networks

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Computers, Materials & Continua 2020年第7期64卷 1-15页

作者： Seokhoon kim Dae-young kim Department of Computer Software Engineering Soonchunhyang UniversityAsan-si31538Korea School of Computer Software Daegu Catholic UniversityGyeongsan-si38430Korea

The Internet of Things(IoT)has enabled various intelligent services,and IoT service range has been steadily extended through long range wide area communication technologies,which enable very long distance wireless data ***-nodes are connected to a gateway with a single *** consume very low-power,using very low data rate to deliver *** long transmission time is consequently needed for each data packet transmission in long range wide area networks,data transmission should be efficiently ***,this paper proposes a multicast uplink data transmission mechanism particularly for bad network *** delay will be increased if only retransmissions are used under bad network ***,employing multicast techniques in bad network conditions can significantly increase packet delivery ***,retransmission can be reduced and hence transmission efficiency ***,the proposed method adopts multicast uplink after network condition *** predict network conditions,the proposed method uses a deep neural network *** proposed method performance was verified by comparison with uplink unicast transmission only,confirming significantly improved performance.

关键词： IoT wide area communication machine learning uplink transmission.

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Effect of carrier gas species on the microstructure and compressive deformation behaviors of ultra-strong pure copper manufactured by cold spray additive manufacturing

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Journal of Materials Science & Technology 2022年第2期97卷 264-271页

作者： young-Kyun kim Kee-Ahn Lee Department of Materials Science and Engineering Inha UniversityIncheon 22212Republic of Korea

Cold spray(CS)which has recently become a promising additive manufacturing(AM)technology,was used to fabricate ultra-strong pure *** addition,the effects of carrier gas species on the microstructural characteristics,mechanical properties and deformation mechanisms were systemically *** CSAM copper manufactured with N_(2) carrier gas reveals a heterogeneous bimodal microstructure consisting of ultra-fine grains at the particle interface and relatively coarse grains in inner *** He carrier gas,a homogeneous grain structure consisting of ultra-fine grains in most areas was *** tests showed that N_(2) and He carrier gasses enabled ultra-high yield strengths of 340 and415 MPa,*** values are comparable to severely plastic deformed copper,which has extremely low ductility and shape *** the other hand,both samples showed a strain-softening phenomenon that does not commonly occur at room *** deformation microstructures revealed that dynamic recovery(DRV)and dynamic recrystallization(DRX)phenomena were generated despite being deformed at room *** on the above findings,the overall deformation mechanisms according to the carrier gas species in the CSAM copper manufacturing process were ***,the work hardening and softening behaviors of CSAM Cu are predicted by using a constitutive equation.

关键词： Cold spray additive manufacturing Carrier gas Pure Cu Mechanical properties Deformation behavior

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