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人参细胞悬浮培养法生产皂甙

中国现代应用药学 1985年第1期 35-39页

作者： t.Furuya t.Yoshikawa Y.Orihara h.Oda 孙昌高

引言人参根在中国和日本是名贵的药物,被认为具有滋补和强壮的作用。许多研究者已作了人参皂甙和皂甙元的化学和药理方面的研究,并肯定了人参皂甙中人参皂甙 Rb1和 Rg1是最有效的成份。关于从人参愈伤组织中分离人参萜二醇、人参萜三醇... 详细信息

引言人参根在中国和日本是名贵的药物,被认为具有滋补和强壮的作用。许多研究者已作了人参皂甙和皂甙元的化学和药理方面的研究,并肯定了人参皂甙中人参皂甙 Rb1和 Rg1是最有效的成份。关于从人参愈伤组织中分离人参萜二醇、人参萜三醇、齐墩果酸、人参皂甙 Rb1和 Rg1,植物生长素对生长和皂甙产量的影响,以及在人参愈伤组织培养中,生物合成

关键词：悬浮培养鲜重光照继代培养幼根 Rb 甲醇一元醇人参根创伤组织愈伤组织

Structural Resistance of SRC Column-Steel Beam Joint Developed for Innovative Construction of Buildings

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Structural Resistance of SRC Column-Steel Beam Joint Develop...

第六届国际低合金高强度钢会议

作者： Seo Soo-yeon Yun hyun-Do kim Seung-hun (Dept.of Architectural Engineering Chungju National UniversityChungjuKorea Dept.of Architectural Engineering Chungnam National UniversityDaejeonKorea Dept.of Architectural Engineering Hanbat National UniversityDaejeonKorea

＜正＞this paper presents an experimental study investigating factors influencing the effective width of steel reinforced concrete（SRC）column-steel beam joints of building in order to calculate its resisting *** 1/2 scaled interior SRC column-steel beam joint specimens were made with considering parameters such as beam flange width, beam depth and SRC column *** directional increasing moment was applied to the joint by acting forces to each ends of beam and the structural behavior of joint was *** previous design method suggested by Deierlein was reviewed and a modified equation was proposed from the analysis of test *** result indicated that the equation to calculate the effective width in Deierlein’s design method didn’t consider effectively the influence caused by the variation of beam depth so that a modified equation was suggested and the validation of it was confirmed in this paper.

关键词： SRC column-steel beam joint effective width flange width beam depth

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岩石学报 2016年第10期32卷 3123-3138页

作者：金正男韩龙渊赵磊李秋立金石山朝鲜国家科学院地质研究所平壤3812100 中国科学院地质与地球物理研究所岩石圈演化国家重点实验室北京100029

朝鲜半岛北侧的狼林地块是中朝克拉通的重要组成部分,狼林地块具有与辽南地块以及辽吉活动带类似的早前寒武纪岩石组成、变质和变形特征。我们在分布有稀土矿的朝鲜定州-铁山一带(狼林地块西北部),采集了与稀土矿密切相关的碱性岩(粗粒... 详细信息

朝鲜半岛北侧的狼林地块是中朝克拉通的重要组成部分,狼林地块具有与辽南地块以及辽吉活动带类似的早前寒武纪岩石组成、变质和变形特征。我们在分布有稀土矿的朝鲜定州-铁山一带(狼林地块西北部),采集了与稀土矿密切相关的碱性岩(粗粒正长岩和萤石化霓辉正长岩)和花岗岩(似斑状花岗岩)样品。岩石样品的岩相学观察表明,定州与铁山地区的碱性岩和花岗岩并不显示明显的岩浆期之后的热液蚀变特征。SIMS锆石U-Pb定年结果显示粗粒正长岩的岩浆结晶年龄为1865±6Ma,萤石化霓辉正长岩的岩浆结晶年龄为1868±8Ma,铁山地区的四件似斑状花岗岩的年龄结果分别为1871±13 Ma、1866±8 Ma、1872±6 Ma和1873±7 Ma,这些年龄值一方面代表了岩浆活动时代,另一方面可能也代表了朝鲜定州和铁山稀土矿的成矿时代。狼林地块的这些碱性岩与花岗岩的时代与华北克拉通辽吉活动带以及狼林地块其它地区的高级变质作用同期,并且在辽南地块,也有类似碱性岩的报道。综合现有的证据表明,辽吉活动带、辽南地块以及狼林地块在古元古代可能属于同一个大型构造带,并且这个构造带(或者构造带的一部分)当时处于伸展的构造背景。通过全面对比野外观测结果、岩石的岩相结构、岩浆结晶时代可知,朝鲜定州和铁山一带的稀土矿与中朝克拉通的世界级稀土矿——白云鄂博,在岩石组合、稀土矿物组成、岩石蚀变特征、成矿时代等方面存在较大的区别。关于这一稀土矿的具体稀土矿物组成、矿床成因以及储量等众多问题,未来还需要进行大量的工作。

关键词：朝鲜北部狼林地块碱性岩似斑状花岗岩稀土矿

Sugarcane bagasse amendment mitigates nutrient leaching from a mineral soil under tropical conditions

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Pedosphere 2022年第6期32卷 876-883页

作者： Nan XU Jehangir h.BhADhA Abul RABBANY Stewart SWANSON James MMCCRAY Yuncong LI Sarah LStRAUSS Rao MYLAVARAPU horticultural Sciences Department University of FloridaGainesville FL 32611(USA) Everglades Research and Education Center University of FloridaBelle Glade FL 33430(USA) Department of Soil Waterand Ecosystem SciencesUniversity of FloridaGainesville FL 32611(USA) Institute of Food and Agricultural Sciences(IFAS)Extension University of FloridaLaBelle FL 33935(USA) Agronomy Department University of FloridaBelle Glade FL 33430(USA) Department of Soil Waterand Ecosystem SciencesUniversity of FloridaHomestead FL 33031(USA) Department of Soil Waterand Ecosystem SciencesUniversity of FloridaImmokalee FL 34142(USA)

Large quantities of organic by-products are generated by the sugarcane industry during sugar extraction *** by-products may be used as soil amendments to improve soil quality,as nutrient leaching is common in mineral soils of Florida in USA due to their sandy texture and frequent rain events.A soil column study was designed to evaluate the effects of bagasse application at 85 t ha^(-1) of fresh bagasse,170 t ha^(-1) of fresh bagasse,and 170 t ha^(-1) of fresh bagasse+nitrogen(N)on the leaching potential of carbon(C),N,phosphorus(P),and potassium(K).Bagasse was incorporated within the topsoil(0-15 cm)in outdoor soil columns exposed to natural conditions,with periodical irrigation during the *** approximately 57 weeks,the distributions of C,N,P,and K were evaluated at three soil depths(i.e.,0-15,15-30,and 30-53 cm)within the soil *** organic C(tOC),N,and P in leachates decreased significantly from the soils amended with bagasse compared with the control with no bagasse and no *** on K content changes in the columns,bagasse could also be utilized as a potential source of K for ***,application of bagasse as a soil amendment might be an effective way to sustainably reutilize organic by-products while reducing concerns regarding major nutrients entering groundwater *** results of this study could assist in developing nutrient management plans of using sugarcane bagasse as a potential soil amendment in mineral soils.

关键词： nutrient leaching potential nutrient loss pore volume sandy soil soil amendment soil column sugarcane by-product

X100/X120管线钢焊接接头强韧化研究进展

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电焊机 2013年第4期43卷 1-7页

作者：栗卓新马司鸣 hEE Jin-kim 北京工业大学材料科学与工程学院北京100124 韩国工业技术研究院高级熔焊研究组

围绕X100/X120管线钢焊接接头组织的强韧化,从合金元素、热影响区的脆化软化、hIC敏感性以及焊接工艺等方面综述了国内外X100/X120管线钢最新研究进展及其应用前景。X100/X120焊材主要以Mn-Mo-Ni为合金系,焊缝金属为贝氏体和马氏体组织... 详细信息

围绕X100/X120管线钢焊接接头组织的强韧化,从合金元素、热影响区的脆化软化、hIC敏感性以及焊接工艺等方面综述了国内外X100/X120管线钢最新研究进展及其应用前景。X100/X120焊材主要以Mn-Mo-Ni为合金系,焊缝金属为贝氏体和马氏体组织,以板条贝氏体及马氏体为强化相;粒状贝氏体、少量针状铁素体为韧化相。热影响区依靠高熔点氧化夹杂物在1 400℃下仍可有效钉扎原奥氏体晶粒,起到细化晶粒的作用,抑制热影响区的软化和脆化。调整合金化过程,减少焊缝中含Al、S的非金属夹杂物,并控制其形貌可降低X100/X120管线钢焊缝hIC敏感性。

关键词： X100 X120 焊接材料超低碳贝氏体

雄猫穆尔的生活观暨乐队指挥克赖斯勒的传记片段

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hDAC inhibitors overcome immunotherapy resistance in B-cell lymphoma

2016年

作者： (德)E.t.A霍夫曼

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Protein & Cell 2020年第7期11卷 472-482页

作者： Xiaoguang Wang Brittany C.Waschke Rachel A Woolaver Samantha M.Y.Chen Zhangguo Chen Jing h.Wang Department of Immunology and Microbiology University of Colorado Anschutz Medical CampusSchool of Medicine12800 E.19th AveMail Stop 8333AuroraCO 80045USA

Immunotherapy has been applied successully to treat B-cell lymphomas in preclinical models or clinical ***,immunotherapy resistance is a major challenge for B-cell lymphoma *** overcome this issue,combinatorlal therapeutic strategies have been pursued to achieve a better efficacy for treating B-cell *** of such strategies is to combine immunotherapy with histone deacetylase(hDAC)*** inhibitors can potentially increase tumor immunogenicity,promote antitumor immune respon-ses,or reverse immunosuppressive tumor ***,the combination of hDAC inhibitors and immunotherapy has drawn much attention in current cancer ***,not all hDAC inhibitors are created equal and their net effects are highly dependent on the specific inhibitors used and the hDACs they ***,we suggest that optimal treatment effh-cacy requires personalized design and rational combination based on prognostic biomarkers and unique profiles of hDAC ***,we discuss the possible mechanisms by which B-cell lymphomas acquire immunotherapy resistance and the effects of hDAC inhibitors on tumor cells and immune cells that could help overcome immunotherapy resistance.

关键词： cancer immunotherapy hDAC inhibitor B-cell lymphomas anti-PD1 resistance tumor immunogenicity

Matrix metalloproteinase-9 contributes to parenchymal hemorrhage and necrosis in the remnant liver after extended hepatectomy in mice

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World Journal of Gastroenterology 2012年第19期18卷 2320-2333页

作者： Norifumi Ohashi tomohide hori Florence Chen Sura Jermanus Christopher B Eckman Akimasa Nakao Shinji Uemoto Justin h Nguyen Gastroenterological Surgery Nagoya University Graduate School of MedicineNagoyaAichi 466-8550Japan Divisions of hepato-Pancreato-Biliary Transplant and Pediatric SurgeryDepartment of SurgeryKyoto University Graduate School of MedicineKyoto 606-8507Japan Department of Neuroscience Mayo ClinicJacksonvilleFL 32224United States Division of transplant Surgery Department of TransplantationMayo ClinicJacksonvilleFL 32224United States

AIM： to investigate the effect of matrix metallopro- teinase-9 （MMP-9） on the remnant liver after massivehepatectomy in the mouse.MEthODS： Age-matched, C57BL/6 wild-type （Wt）, MMP-9（-/-）, and tissue inhibitors of metalloprotein- ases （tIMP）-1（-/-） mice were used. the mice received 80%-partial hepatectomy （Ph）. Samples were obtained at 6 h after 80%-Ph, and we used histology, immuno- histochemical staining, western blotting analysis and zymography to investigate the effect of Ph on MMP-9. the role of MMP-9 after Ph was investigated using a monoclonal antibody and MMP inhibitor.RESULtS： We examined the remnant liver 6 h after 80%-Ph and found that MMP-9 deficiency attenuated the formation of hemorrhage and necrosis. there were significantly fewer and smaller hemorrhagic and ne- crotic lesions in MMP-9（-/-） remnant livers compared with Wt and tIMP-1（-/-） livers （P 〈 0.01）, with no dif- ference between Wt and tIMP-1（-/-） mice. Serum ala- nine aminotransaminase levels were significantly lower in MMP-9（-/-） mice compared with those in tIMP-I（-/-） mice （Wt： 476± 83 IU/L, MMP-9（-/-）： 392 ± 30 IU/L, tIMP-I（-/-）： 673 ± 73 IU/L, P 〈 0.01）. Western blot- ting and gelatin zymography demonstrated a lack of MMP-9 expression and activity in MMP-9（-/-） mice, which was in contrast to Wt and tIMP-1（-/-） mice. No change in MMP-2 expression was observed in any of the study groups. Similar to MMP-9（-/-） mice, when Wt mice were treated with MMP-9 monoclonal antibody or the synthetic inhibitor GM6001, hemorrhagic and necrotic lesions were significantly smaller and fewer than in control mice （P 〈 0.05）. these results suggest that MMP-9 plays an important role in the development of parenchymal hemorrhage and necrosis in the small remnant liver.CONCLUSION： Successful MMP-9 inhibition attenuates the formation of hemorrhage and necrosis and mightbe a potential therapy to ameliorate liver injury after massive hepatectomy.

关键词： Matrix metalloproteinase Liver remnant hepatectomy Liver failure Necrosis

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芽尖培养繁殖马铃薯 Ⅱ芽尖的发根

园艺与种苗 1982年第3期 40-41页

作者： P.B.Goodwin Y.C.kim t.Adisarwanto 饶湖生

前文(Goodwin 等,1980)已描述了马铃薯芽尖培养的快速繁殖法。本文将叙述能进行田间试验的有效幼芽发根方法。材料和方法Pontiac Exton 和 Kennebec 等几个马铃薯品种按前述方法做芽尖培养之后,将15～25毫

关键词：发根混合土幼芽芽尖培养马铃薯土豆茄属