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Paraaortic lymph node metastasis in patients with intra-abdominal malignancies:CT vs PET

World Journal of Gastroenterology 2009年第35期15卷 4434-4438页

作者： Mi-Jung Lee Mi jin Yun Mi-Suk Park seung Hwan Cha Myeong-jin kim Jong Doo Lee Ki Whang kim Department of Diagnostic Radiology Research Institute of Radiological Science and Institute ofGastroenterology Yonsei University College of Medicine 134Sincheon-Dong Seodaemun-Gu Seoul 120-752 South Korea Department of Nuclear medicine Yonsei University College of Medicine 134 Sincheon-Dong Seodaemun-Gu Seoul 120-752 South Korea Department of Diagnostic Radiology Yonsei University Wonju College of Medicine Wonju 220-701South Korea

AIM： To compare the diagnostic accuracy of computed tomography （CT） and positron emission tomography （PET） for the preoperative detection of paraaortic lymph node （PAN） metastasis in patients with intra- abdominal malignancies. METHODS： Sixty-six patients with intra-abdominal malignancies who underwent both CT and PET before lymphadenectomy were included in this study. Histopathologicaliy, 13 patients had metastatic PAN, while 53 had non-metastatic PAN. The CT criteria for metastasis were： short diameter ：）f 〉 8 mm, Iobular or irregular shape, and/or combined ancillary findings, including necrosis, conglomeration, vessel encasement, and infiltration. The PET criterion was positive fluorodeoxyglucose （FDG） uptake. The sensitivity, specificity, positive predictive value （PPV）, negative predictive value （NPV）, and accuracy of both modalities were compared with the pathologic findings, and the false positive and false negative cases with both CT and PET were ***： The sensitivity, specificity, PPV, NPV, and accuracy of CT were 61.5%, 84.9%, 50%, 90% and 80.3%, respectively. For PET, the percentages were 46.2%, 100%, 100%, 88.3%, and 89.4%. Additionally, there were 8 false positive CT cases （8/53, 15.1%） and zero false positive PET cases. Of the 13 metastatic PANs, there were 5 false negative CT scans （38.5%） and 7 （53.9%） false negative PET ***： For detecting PAN metastasis, CT is more sensitive than PET, while PET is more specific.

关键词： Malignancy Paraaortic lymph node Computed tomography Positron emission tomography Sensitivity Specificity

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Duodenal obstruction after successful embolization for duodenal diverticular hemorrhage: A case report

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World Journal of Gastroenterology 2009年第30期15卷 3819-3822页

作者： Yu jin Kwon Ji Hun kim seung Hyoung kim Bong Soo kim Heung Up kim Eun Kwang Choi In Ho Jeong Department of Surgery Seoul National University College of Medicine28 Yeongeon-dongSeoul 110-744South Korea Department of Surgery Ajou University School of MedicineSan-5WonchondongYeongtongguSuwon 442-749South Korea Department of radiology Jeju National University School of Medicine1753-3Ara 1-DongJeju 690-121South Korea Department of internal medicine Jeju National University School of Medicine1753-3Ara 1-DongJeju 690-121South Korea Department of surgery Jeju National University School of Medicine1753-3Ara 1-DongJeju 690-121South Korea

We present a 69-year-old woman with a duodenal obstruction after successful selective transcatheter arterial embolization (TAE) for a duodenal diverticular hemorrhage. Two weeks after TAE, the patient showed abrupt symptoms of duodenal obstruction. Resolving hematomas after successful selective transcatheter arterial embolization should be thoroughly observed because they might result in duodenal fibrotic encasement featuring inflammatory duodenal wall thickening, duodenal deformity, dysmotility, and fi nally obstruction.

关键词： Diverticulum Gastrointestinal hemorrhage Therapeutic embolization Duodenal obstruction

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Electrochemical biosensors for point-of-care testing

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Bio-Design and Manufacturing 2024年第4期7卷 548-565页

作者： jinsol kim Juho Jeong seung Hwan Ko Department of Mechanical Engineering Seoul National UniversitySeoul 08826Republic of Korea Institute of Advanced Machinery and Design(SNU-IAMD) Seoul National UniversitySeoul 08826Republic of Korea

Point-of-care testing(POCT)is the practice of diagnosing and monitoring diseases where the patient is located,as opposed to traditional treatment conducted solely in a medical laboratory or other clinical *** has been less common in the recent past due to a lack of portable medical devices capable of facilitating effective medical ***,recent growth has occurred in this field due to advances in diagnostic technologies,device miniaturization,and progress in wearable *** these developments,electrochemical sensors have attracted interest in the POCT field due to their high sensitivity,compact size,and *** are used in various applications,from disease diagnosis to health status *** this paper we explore recent advancements in electrochemical sensors,the methods of fabricating them,and the various types of sensing mechanisms that can be ***,we delve into methods for immobilizing specific biorecognition elements,including enzymes,antibodies,and aptamers,onto electrode surfaces and how these sensors are used in real-world POCT settings.

关键词： Point-of-care testing(POCT) Electrochemical sensor Enzyme Antibody Health care

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Behavior of CaO and Calcium in pure Magnesium

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Rare Metals 2006年第Z2期25卷 150-154页

作者： HA Seong-Ho LEE jin-Kyu JO Hyung-Ho JUNG seung-Boo kim Shae K. Department of Advanced Material Engineering Sungkyunkwan University 300 Chunchun-dong Jangan-gu Suwon Gyunggi-do 440-746 KoreaAdvanced Material Division Korea Institute of Industrial Technology 7-47 Songdo-dong Yeonsu-gu Incheon 406-840 Korea Advanced Material Division Korea Institute of Industrial Technology 7-47 Songdo-dong Yeonsu-gu Incheon 406-840 Korea Department of Advanced Material Engineering Sungkyunkwan University 300 Chunchun-dong Jangan-gu Suwon Gyunggi-do 440-746 Korea

Mg alloys exhibit a number of good properties such as low density, good castability and high specific strength. However, molten Mg and Mg alloys are ignited without the melt protective gases during melting and casting process due to their high reactivity. The purpose of this study is to investigate effects of Ca and CaO on pure Mg through microstructure observation, ignition test and phase analysis. With increasing Ca and CaO contents, the ignition resistance of Ca or CaO added pure Mg is increased and the grains are refined. As results of XRD and EDS, CaO is reduced to Ca in CaO added pure Mg. Mg2Ca phase is formed even in 0.1 wt.%CaO added pure Mg by reduction mechanism, while Mg2Ca phase is formed over 1.35 wt.% Ca added pure Mg.

关键词： Mg CaO ignition resistance Mg2Ca phase

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Comparison of different nutritional assessments in detecting malnutrition among gastric cancer patients

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World Journal of Gastroenterology 2010年第26期16卷 3310-3317页

作者： seung Wan Ryu In Ho kim Department of Surgery and Division of Gastrointestinal Surgery The Keimyung University School of Medicine Daegu 700-712 South Korea

AIM: To evaluate the prevalence of preoperative and postoperative malnutrition and the relationships between objective and subjective nutritional assessment of gastric cancer patients. METHODS: From October 2005 to July 2006, we studied 80 patients with no evidence of recurrent disease and no loss to follow-up after curative surgery for gastric cancer. In this group, 9 patients underwent total gastrectomy and 71 patients subtotal gastrectomy. At admission, 6 and 12 mo after surgery, the patients were assessed on the subjective global assessment (SGA), nutritional risk screening (NRS-2002), nutritional risk index (NRI) and by anthropometric measurements and laboratory data. Differences between the independent groups were assessed with the Student's t test and oneway analysis of variance. Spearman's rank correlation coefficients were calculated to evaluate the association between the scores and variables. RESULTS: The prevalence of malnutrition at admissionwas 31% by SGA and 43% by NRS-2002. At admission, the anthropometric data were lower in the malnourished groups defined by the SGA and NRS-2002 assessments, but did not differ between the groups using the NRI assessment. Body weight (BW), body mass index (BMI), triceps skin fold and midarm circumference were significantly reduced, but the total lymphocyte count, albumin, protein, cholesterol and serum iron levels did not decrease during the postoperative period. Six months after surgery, there was a good correlation between the nutritional assessment tools (SGA and NRS-2002) and the other nutritional measurement tools (BW, BMI, and anthropometric measurements). However, 12 mo after surgery, most patients who were assessed as malnourished by SGA and NRS-2002 had returned to their preoperative status, although their BW, BMI, and anthropometric measurements still indicated a malnourished status. CONCLUSION: A combination of objective and subjective assessments is needed for the early detection of the nutritional status

关键词： Gastrectomy Malnutrition Nutritional assessment Nutritional risk screening Postoperative follow up Subjective global assessment

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Long-term performance of fiber-grid-reinforced asphalt overlay pavements: A case study of Korean national highways

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Journal of Traffic and Transportation Engineering(English Edition) 2019年第4期6卷 366-382页

作者： Jong-Hoon Lee seung-Beom Baek Kang-Hoon Lee Jo-Soon kim jin-Hoon Jeong Department of Civil Engineering Inha UniversityIncheon 22212South Korea Civil&Environmental BG Doosan Engineering&ConstructionSeoul 06057South Korea Department of Infrastructure Safety Research Korea Institute of Civil Engineering and Building TechnologyGoyang-si 10223South Korea SN Construction Co. LtdDaejeon 34573South Korea

The objective of this study was to verify the effect of fiber grid reinforcement on the longterm performance of asphalt overlay pavements by performing field investigation, laboratory test, and finite element analysis. Crack, rutting, roughness, and other miscellaneous distresses of fiber-grid-reinforced overlay sections and ordinary overlay sections were compared. Pavement conditions of fiber grid overlay sections before and after the overlay were also compared. Cores were obtained from the fiber-grid-reinforced and ordinary sections to measure bonding shear strength between the intermediate and overlay *** energy, displacement after yield, and shear stiffness of the cores were also obtained by analyzing the test results. Finite element analysis was performed by using the test results to validate the effect of the fiber grid reinforcement on the long-term performance of asphalt overlay pavements. Rutting and fatigue cracking were predicted for three cases: 1) fiber grid was not used;2) glass fiber grid was used;and 3) carbon fiber grid was used. The cracking ratio of fiber-grid-reinforced sections was much smaller than that of ordinary sections. The results of field investigation, laboratory test, and finite element analysis showed that the fiber grid reinforcement improved the long-term performance of asphalt overlay pavements.

关键词： Asphalt pavement Fiber grid reinforcement Overlay pavement Finite element analysis Bonding shear strength

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Cdk2 acts upstream of mitochondrial permeability transition during paclitaxel-induced apoptosis

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Protein & Cell 2011年第7期2卷 543-553页

作者： Xiao-Xi Guo Hanna kim Yang Li Hyungshin Yim seung Ki Lee Ying-Hua jin Key Laboratory for Molecular Enzymology&Engineering of the Ministry of Education Jilin UniversityChangchun 130012China Division of Pharmaceutical Biosciences Research Institute for Pharmaceutical SciencesCollege of PharmacySeoul National UniversitySeoul 151-742Korea

Sequential activation of cyclin-dependent kinases(Cdks)controls mammalian cell *** we demonstrate that the upregulation of cyclin-dependent kinase 2(Cdk2)activity coincides with the loss of mitochondrial membrane potential(MMP)in paclitaxel-induced *** expression of the dominant negative Cdk2(Cdk2-dn)and a specific Cdk2 inhibitor,p21WAF1/CIP1,effectively suppresses the loss of MMP,the release of cytochrome c,and subsequent activation of caspase-3 in paclitaxel-treated *** forced activation of Cdk2 by overexpression of cyclin A dramatically promotes these *** further show that Cdk2 activation status does not interfere with a procedure that lies downstream of cytochrome c release induced by Bax *** findings suggest that Cdk2 kinase can regulate apoptosis at earlier stages than mitochondrial permeability transition and cytochrome c release.

关键词： apoptosis cyclin-dependent kinase 2 cytochrome c release mitochondrial membrane potential paclitaxel

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Outcome after gastrectomy in gastric cancer patients with type 2 diabetes

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World Journal of Gastroenterology 2012年第1期18卷 49-54页

作者： Jong Won kim Jae-Ho Cheong Woo jin Hyung seung-Ho Choi Sung Hoon Noh Department of Surgery Gangnam Severance Hospital Yonsei University College of Medicine Department of Surgery Severance Hospital Yonsei University College of Medicine

AIM: To evaluate the prognosis of type Ⅱ diabetes mellitus (T2DM) after gastrectomy and related factors in gastric cancer patients. METHODS: 403 gastric cancer patients with T2DM were studied, who underwent gastrectomy between May 2003 and September 2009. A review of medica records and telephone interviews was performed in this cross-sectional study. The factors included in the statistical analysis were as follows: gender, age, type of surgery, preoperative body mass index (BMI), current BMI, BMI reduction ratio, preoperative insulin or oral diabetic medicine requirement, follow-up duration, and current state of diabetes. Assessment of diabetes status after surgery was classified into four categories according to the change in hypoglycemic agents after surgery and present status of T2DM: resolution, improvement, same, and worse.(± 20.6 mo), preoperative BMI was 24.7 kg/m2 (± 3.0 kg/m2), and BMI reduction ratio was 9.8% (± 8.6%). After surgery, T2DM was cured in 58 patients (15.1%) and was improved in 117 patients (30.4%). According to the type of surgery, the BMI reduction ratio was signif icantly higher in the total gastrectomy and Roux-en-Y reconstruction group [14.2% ± 9.2% vs 9.2% ± 7.7% (Billroth Ⅱ group), P < 0.001] and signif icantly lower in the subtotal gastrectomy and Billroth Ⅰ reconstruction group [7.6% ± 8.0%, 9.2% ± 7.7% (Billroth Ⅱ group), P < 0.001]. The BMI reduction ratio, follow-up duration after surgery, type of surgery, extent of gastrectomy, and performance of duodenal bypass were signif icantly correlated to the course of T2DM (P < 0.05). The BMI reduction ratio was the most influential factor on T2DM status. In a subgroup analysis of patients with a BMI reduction ratio of 10% or less (n = 206), T2DM was cured in 15 (7.6%) patients and was improved in 57 (28.8%) patients after surgery, and only the duration of surgery was signif icantly correlated to T2DM status (P = 0.022).

关键词： Gastric cancer Diabetes mellitus Metabolic surgery Bariatric surgery

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Systematic review on the surgical treatment for T1 gallbladder cancer

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World Journal of Gastroenterology 2011年第2期17卷 174-180页

作者： seung Eun Lee jin-Young Jang Chang-Sup Lim Mee Joo Kang Sun-Whe kim Department of Surgery Chung-Ang University College of Medicine Department of Surgery Seoul National University College of Medicine

AIM:To evaluate the efficacy of simple and extended cholecystectomy for mucosa(T1a) or muscularis(T1b) gallbladder(GB) cancer. METHODS:Original studies on simple and extended cholecystectomy for T1a or T1b GB cancer were searched from MEDLINE(PubMed) ,Cochrane Library,EMBase,and CancerLit using the search terms of GB,cancer/carcinoma/tumor/neoplasm. RESULTS:Twenty-nine out of the 2312 potentially relevant publications met the eligibility *** the 1266 patients with GB cancer included in the publications,706(55.8%) and 560(44.2%) had T1a and T1b GB cancer,*** cholecystectomy for T1a and T1b GB cancer was performed in 590(83.6%) and 375(67.0%) patients,respectively(P<0.01) .In most series,the treatment of choice was simple cholecystectomy for T1a GB cancer patients with a 5-year survival rate of 100%.Lymph node metastasis was detected in 10.9% of the T1b GB cancer patients and in 1.8%of the T1a GB cancer patients,respectively(P<0.01) .Eight patients(1.1%) with T1a GB cancer and 52 patients(9.3%) with T1b GB cancer died of recurrent GB cancer(P<0.01) . CONCLUSION:Simple cholecystectomy represents the adequate treatment of T1a GB *** is no definite evidence that extended cholecystectomy is advantageous over simple cholecystectomy for T1b GB cancer.

关键词： Gallbladder Cancer Cholecystectomy Simple Extended

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Family history influences the early onset of hepatocellular carcinoma

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World Journal of Gastroenterology 2012年第21期18卷 2661-2667页

作者： Chung-Hwa Park seung-Hee Jeong Hyeon-Woo Yim jin Dong kim Si Hyun Bae Jong Young Choi seung Kew Yoon Department of Internal Medicine The Catholic University of KoreaSeoul 137-701 South Korea Department of Preventive Medicine College of Medicine The Catholic University of KoreaSeoul 137-701 South Korea Clinical Research Coordinating Center of Catholic Medical Center The Catholic University of KoreaSeoul 137-701 South Korea

AIM: To evaluate the relationship between a positive family history of primary liver cancer and hepatocellular carcinoma (HCC) development in Korean HCC patients. METHODS: We studied a total of 2242 patients diagnosed with HCC between January 1990 and July 2008, whose family history of primary liver cancer was clearly described in the medical *** family history of HCC and 2077 (92.6%) did not. The male to female ratio was 3.6:1, and the major causes of HCC were chronic hepatitis B virus (HBV) infection in 75.1%, chronic hepatitis C virus infection in 13.2% and alcohol in 3.1%. The median ages at diag- nosis in the positiveand negative-history groups were 52 years (range: 29-79 years) and 57 years (range: 18-89 years), respectively (P < 0.0001). Furthermore, among 1713 HCC patients with HBV infection, the number of patients under 45 years of age out of 136 patients with positive family history was 26 (19.1%), whereas those out of 1577 patients with negative family history was 197 (12.5%), suggesting that a positive family history may be associated with earlier development of HCC in the Korean population (P = 0.0028). CONCLUSION: More intensive surveillance maybe recommended to those with a positive family history of HCC for earlier diagnosis and proper management especially when HBV infection is present.

关键词： Liver cancer Hepatocellular carcinoma Family history Epidemiology

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