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Increased intestinal macromolecular permeability and urine nitrite excretion associated with liver cirrhosis with ascites

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World Journal of Gastroenterology 2008年第24期14卷 3884-3890页

作者： Soong Lee seung-Cheol Son Moon-Jong Han Woo-jin kim Soo-Hyun kim Hye-Ran kim Woo-Kyu Jeon Ki-Hong Park Myung-Geun Shin Department of Internal Medicine College of MedicineSeonam University and Seonam University Hospital Department of Laboratory Medicine Chonnam National University Medical School and Chonnam National University Hwasun Hospital Brain Korea 21 Project Center for Biomedical Human Resources at Chonnam National University Medical School Department of Internal Medicine Kangbuk Samsung HospitalSungkyunkwan University School of Medicine Korea Polymer Testing & Research Institute Ltd.

AIM： To determine intestinal permeability, the serum tumor necrosis factor （TNF）-α level and urine nitric oxide （NO） metabolites are altered in liver cirrhosis （LC） with or without ascites. METHODS： Fifty-three patients with LC and 26 healthy control subjects were enrolled in the study. The intestinal permeability value is expressed as the percentage of polyethylene glycol （PEG） 400 and 3350 retrieval in 8-h urine samples as determined by high performance liquid chromatography. Serum TNF-α concentrations and urine NO metabolites were determined using an enzyme-linked immunosorbent assay （ELISA） and Greiss reaction method, respectively. RESULTS： The intestinal permeability index wassignificantly higher in patients with LC with ascites than in healthy control subjects or patients with LC without ascites （0.88 ± 0.12 vs 0.52 ± 0.05 or 0.53 ± 0.03, P 〈 0.05） and correlated with urine nitrite excretion （r = 0.98）. Interestingly, the serum TNF-α concentration was significantly higher in LC without ascites than in control subjects or in LC with ascites （198.9 ± 55.8 pg/mL vs 40.9 ± 12.3 pg/mL or 32.1 ± 13.3 pg/mL, P 〈 0.05）. Urine nitrite excretion was significantly higher in LC with ascites than in the control subjects or in LC without ascites（ 1170.9± 28.7 μmol/L vs 903.1 ± 55.1 μmol/L or 956.7 ± 47.7 μmol/L, P 〈 0.05）. COMCLUSIOM： Increased intestinal macromolecular permeability and NO is probably of importance in the pathophysiology and progression of LC with ascites, but the serum TNF-α concentration was not related to LC with ascites.

关键词： Intestinal permeability Tumor necrosisfactor-R Nitric oxide Liver cirrhosis Ascites

Environmental Sound Event Detection in Wireless Acoustic Sensor Networks for Home Telemonitoring

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China Communications 2017年第9期14卷 1-10页

作者： Hyoung-Gook kim jin Young kim The Dept. of Electronics Convergence Engineering Kwangwoon University The Dept. of Electronics and Computer Engineering Chonnam National University

In this paper, we present an approach to improve the accuracy of environmental sound event detection in a wireless acoustic sensor network for home monitoring. Wireless acoustic sensor nodes can capture sounds in the home and simultaneously deliver them to a sink node for sound event detection. The proposed approach is mainly composed of three modules, including signal estimation, reliable sensor channel selection, and sound event detection. During signal estimation, lost packets are recovered to improve the signal quality. Next, reliable channels are selected using a multi-channel cross-correlation coefficient to improve the computational efficiency for distant sound event detection without sacrificing performance. Finally, the signals of the selected two channels are used for environmental sound event detection based on bidirectional gated recurrent neural networks using two-channel audio features. Experiments show that the proposed approach achieves superior performances compared to the baseline.

关键词： sound event detection wirelesssensor network gated recurrent neural net-work multichannel audio

Adhesion and Suction Functions of the Tip Region of a Nectar-drinking Butterfly Proboscis

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Journal of Bionic Engineering 2017年第4期14卷 600-606页

作者： seung Chul Lee Jun Ho kim Sang Joon Lee Department of Mechanical Engineering Pohang University of Science and Technology Pohang 37673 Gyeongbuk Republic of Korea Center for Biofluid and Biomimic Research Pohang University of Science and Technology Pohang 37673 Gyeongbuk Republic of Korea

In this study, we investigated the dynamic functions of the tip region of the butterfly proboscis through which liquid is sucked during liquid feeding. The microstructures and flow patterns in the tip region of the proboscis were in vivo analyzed. The tip region can be divided into two functional sections： namely adhesion and suction sections. The liquid adheres to the adhesion section during liquid suction. Although the tip region has numerous slits connected to food canal of the proboscis, liquid is mainly sucked through the suction section, which section is submerged in the fluid pulled by the adhesion section and then successfully imbibes liquid. To check the dynamic functions of the tip region, we fabricated a suction tip model having adhesion and suction parts. The in vitro model experiments show that the hydrophilicity of the adhesion part and the existence of the suction inlet improve the liquid uptake driven by a suction pump. This study may provide insights for the biomimetic design of nectar-feeding butterflies.

关键词： butterfly proboscis nectar-feeding strategy suction

Effects of a Building’s Density on Flow in Urban Areas

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Advances in Atmospheric Sciences 2009年第1期26卷 45-56页

作者： Jae-jin kim Do-Yong kim Department of Environmental Atmospheric Sciences Pukyong National University Busan Korea Center for Atmosphere Science and Earthquake Research Korea Meteorological Administration Busan Korea

The effects of a building＇s density on urban flows are investigated using a CFD model with the RNG k - ε turbulence closure scheme. Twenty-seven cases with different building＇s density parameters （e.g., building and street-canyon aspect ratios） are numerically simulated. As the building＇s density parameters vary, different flow regimes appear. When the street canyon is relatively narrow and high, two counterrotating vortices in the vertical direction are generated. The wind speed along streets is mainly affected by the building＇s length. However, it is very difficult to find or generalize the characteristics of the street-canyon flows in terms of a single building＇s density parameter. This is because the complicated flow patterns appear due to the variation of the vortex structure and vortex number. Volume-averaged vorticity magnitude is a very good indicator to reflect the flow characteristics despite the strong dependency of flows on the variation of the building＇s density parameters. Multi-linear regression shows that the volume-averaged vorticity magnitude is a strong function of the building＇s length and the street-canyon width. The increase in the building＇s length decreases the vorticity of the street-canyon flow, while, the increase in the street- canyon width increases the vorticity.

关键词： urban flow characteristics building's density parameter volume-averaged vorticity CFD model

Secure Sharing Scheme of Sensitive Data in the Precision Medicine System

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Computers, Materials & Continua 2020年第9期64卷 1527-1553页

作者： Deukhun kim Heejin kim jin Kwak ISAA Lab. Department of Computer EngineeringAjou UniversitySuwon16499Korea Korea Orphan&Essential Drug Center Seoul04523Korea Department of Cyber Security Ajou UniversitySuwon16499Korea

Numerous industries,especially the medical industry,are likely to exhibit significant developments in the *** since the announcement of the precision medicine initiative by the United States in 2015,interest in the field has considerably *** techniques of precision medicine are employed to provide optimal treatment and medical services to patients,in addition to the prevention and management of diseases via the collection and analysis of big data related to their individual genetic characteristics,occupation,living environment,and dietary *** this involves the accumulation and utilization of sensitive information,such as patient history,DNA,and personal details,its implementation is difficult if the data are inaccurate,exposed,or forged,and there is also a concern for privacy,as massive amount of data are collected;hence,ensuring the security of information is ***,it is necessary to develop methods of securely sharing sensitive data for the establishment of a precision medicine *** authentication and data sharing scheme is presented in this study on the basis of an analysis of sensitive *** proposed scheme securely shares sensitive data of each entity in the precision medicine system according to its architecture and data flow.

关键词： Precision medicine sensitive data keyless signature infrastructure data sharing

Surgical treatment outcomes of primary hepatic sarcomas: A singlecenter experience

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World Journal of Hepatology 2021年第5期13卷 584-594页

作者： Sang jin kim jinsoo Rhu Jong Man kim Gyu seung Choi Jae-Won Joh Department of Surgery Korea University College of MedicineSeoulRepublic of KoreaDivision of Hepatobiliopancreas and Transplant SurgeryKorea University Ansan HospitalAnsan 15355South Korea Department of Surgery Samsung Medical CenterSeoul 06351South Korea

BACKGROUND Primary hepatic sarcoma is a rare tumor originated from mesenchymal *** are various pathologic types of primary hepatic sarcoma and the treatment outcome of this tumor was usually *** hepatocellular carcinoma,outcome of primary hepatic sarcoma is not well-known due to it’s ***,with development of medical technology,surgical treatment may lead to better *** To investigate the surgical outcomes of primary hepatic sarcoma,we gathered and analyzed the cases of a single *** From August 2001 to September 2016,a total of nine patients were surgically treated for primary hepatic sarcoma after exclusion of cases with open and closure,early loss to follow-up and sarcomatoid hepatocellular carcinoma and sarcomatoid cholangiocellular *** characteristics,tumor characteristics such as tumor pathology,size and number,surgical and adjuvant treatments were *** recurrence,and patient survival were analyzed with retrospective *** The enrolled participants included five patients with angiosarcoma and four patients with undifferentiated *** patients experienced tumor recurrence at a median of 52 post-operative *** two patients survived and the 5-year survival rate was 29.6%.One patient with angiosarcoma who received central hepatectomy for primary tumor and received radiofrequency ablation for recurrent tumor still lives for 11 *** patient with undifferentiated sarcoma received *** for primary tumor followed by chemotherapy and radiation therapy still lives around 30 mo even though she got additional operation for recurrent *** patients who received living donor liver transplantation due to angiosarcoma *** adjuvant therapy was associated with survival gain(P=0.002).CONCLUSION Patients with primary hepatic sarcoma may gain survival benefit with surgical resection followed by adjuvant therapy,even though the outcome remains relatively poor

关键词： Liver Angiosarcoma Undifferentiated sarcoma Operation Survival Recurrence

Human neural stem cells promote proliferation of endogenous neural stem cells and enhance angiogenesis in ischemic rat brain

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Neural Regeneration Research 2016年第2期11卷 298-304页

作者： Sun Ryu seung-Hoon Lee seung U.kim Byung-Woo Yoon Department of Neurology and Clinical Research Institute Seoul National University Hospital Seoul National University Medical Research Center Seoul National University Medical Research Institute Chung-Ang University School of Medicine Department of Neurology UBC Hospital University of British Columbia

Transplantation of human neural stem cells into the dentate gyrus or ventricle of rodents has been reportedly to enhance neurogenesis. In this study, we examined endogenous stem cell proliferation and angiogenesis in the ischemic rat brain after the transplantation of human neural stem cells. Focal cerebral ischemia in the rat brain was induced by middle cerebral artery occlusion. Human neural stem cells were transplanted into the subventricular zone. The behavioral performance of human neural stem cells-treated ischemic rats was significantly improved and cerebral infarct volumes were reduced compared to those in untreated animals. Numerous transplanted human neural stem cells were alive and preferentially localized to the ipsilateral ischemic hemisphere. Furthermore, 5-bromo-2′-deoxyuridine-labeled endogenous neural stem cells were observed in the subventricular zone and hippocampus, where they differentiated into cells immunoreactive for the neural markers doublecortin, neuronal nuclear antigen Neu N, and astrocyte marker glial fibrillary acidic protein in human neural stem cells-treated rats, but not in the untreated ischemic animals. The number of 5-bromo-2′-deoxyuridine-positive ？ anti-von Willebrand factor-positive proliferating endothelial cells was higher in the ischemic boundary zone of human neural stem cells-treated rats than in controls. Finally, transplantation of human neural stem cells in the brains of rats with focal cerebral ischemia promoted the proliferation of endogenous neural stem cells and their differentiation into mature neural-like cells, and enhanced angiogenesis. This study provides valuable insights into the effect of human neural stem cell transplantation on focal cerebral ischemia, which can be applied to the development of an effective therapy for stroke.

关键词： nerve regeneration focal cerebral ischemia middle cerebral artery occlusion human neural stem cells transplantation differentiation infarct size behavioral analysis endogenous neurogenesis angiogenesis rats neural regeneration

Feasibility of wear reduction for soft nanostructured thin film through enhanced elastic recoverability and contact stress relief

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Friction 2023年第7期11卷 1292-1306页

作者： Kuk-jin SEO Hyun-Joon kim Dae-Eun kim Department of Mechanical Engineering Yonsei UniversitySeoul 03722Republic of Korea Department of Precision Mechanical Engineering Kyungpook National UniversitySangju 37224Republic of Korea Department of Advanced Science and Technology Convergence Kyungpook National UniversitySangju 37224Republic of Korea

This work shows that a soft,thin film comprising randomly aligned carbon nanotubes(CNTs)can reduce surface wear more effectively than a homogeneous thin film because of enhanced elastic recoverability and contact stress relief originating from its mesh *** investigate the wear characteristics of the mesh structure compared to those of the homogeneous thin film,multi-walled CNTs(MWCNTs)and diamond-like carbon(DLC)thin films were prepared to conduct nanoscale tribological experiments using the atomic force microscopy(AFM).The MWCNT thin film showed unmeasurably low wear compared with the DLC thin film under a certain range of normal *** demonstrate the wear reduction mechanism of the MWCNT thin film,its indentation and frictional behaviors were *** indentation behavior of the MWCNT thin film revealed repetitive elastic deformation with a wide strain range and a significantly lower elastic modulus than that of the DLC thin *** permanent deformation of the MWCNT thin film was observed through frictional experiments under relatively high normal load *** results are expected to provide insights into the design of highly wear-resistant surfaces using nanostructures.

关键词： carbon nanotube(CNT) thin film wear friction elastic recovery

Anti-inflammatory effects of natural volatile organic compounds from Pinus koraiensis and Larix kaempferi in mouse model

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The Journal of Biomedical Research 2019年第5期33卷 343-350页

作者： Changhwan Ahn Jae-Woo kim Mi-jin Park seung Ryul kim Sung-Suk Lee Eui-Bae Jeung Laboratory of Veterinary Biochemistry and Molecular Biology Veterinary Medical Center and College of Veterinary MedicineChungbuk National UniversityCheongjuChungbuk 28644Republic of Korea Division of Wood Chemistry&Microbiology Department of Forest ProductsNational Institute of Forest ScienceSeoul 02455Republic of Korea Laboratory of Biochemistry School of MedicineChungbuk National UniversityCheongjuChungbuk 28644Republic of Korea.

Natural volatile organic compounds(VOCs) extracted from conifers such as P. koraiensis and L. kaempferi have long been studied for their anti-oxidant, anti-proliferative, and anti-inflammatory effects. To evaluate the anti-inflammatory effects of VOCs from P. koraiensis and L. kaempferi, lipopolysaccharide(LPS) was administered to generate a mouse model for inflammation by the nasal route to the lungs and intraperitoneally to the whole body. VOCs of P. koraiensis and L. kaempferi were exposed to the mice by standardized wood panels with closed system. Increased levels of serum IgE and PGE2 were observed after exposure to dexamethasone and VOCs. We further determined the expression levels of inflammatory cytokine mRNA in the LPS-induced inflammation model by the reverse transcription quantitative polymerase chain reaction. Furthermore, the levels of cyclooxygenase-2, tumor necrosis factor-α, interleukin-1β, and interleukin-13 were determined in peripheral blood mononuclear cells. Those inflammatory cytokines and the key enzyme for inflammation cyclooxygenase-2 expression in PBMCs were strongly reversed by dexamethasone and VOCs. Lung tissues after nasal LPS exposure showed increased cytokine mRNA expressions which were suppressed by treatment with dexamethasone and VOCs. Furthermore, the damage induced by LPS was attenuated by dexamethasone and VOCs. In conclusion, the results from the present study indicate that VOCs of P. koraiensis and L. kaempferi have a therapeutic potential in the treatment or prevention of local and systemic inflammation due to their immunosuppressive effects.

关键词： Pinus koraiensis Larix kaempferi inflammation cytokine lungs