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Comprehensive molecular characterization to predict immunotherapy response in advanced biliary tract cancer:a phase II trial of pembrolizumab

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Oncology Research 2025年第1期33卷 57-65页

作者： RYUL kim JOO kyung PARK MINSUK KWON MINAE AN JUNG YONG HONG JOON OH PARK SUNG HEE LIM SEUNG TAE kim Division of Hematology-Oncology Department of MedicineSamsung Medical CenterSungkyunkwan University School of MedicineSeoulKorea Division of Gastroenterology Department of MedicineSamsung Medical CenterSungkyunkwan University School of MedicineSeoulKorea Department of Hematology-Oncology Ajou University School of MedicineSuwon-siGyeonggi-doKorea Samsung Advanced Institute of Health Science and Technology Sungkyunkwan University School of MedicineSeoulKorea

Background:Immune checkpoint inhibitors(ICIs)are effective in a subset of patients with metastatic solid ***,the patients who would benefit most from ICIs in biliary tract cancer(BTC)are still *** and methods:We molecularly characterized tissues and blood from 32 patients with metastatic BTC treated with the ICI pembrolizumab as second-line ***:All patients had microsatellite stable(MSS)type *** of the 32 patients achieved partial response(PR),with an objective response rate(ORR)of 9.4%(95%confidence interval[CI],2.0–25.2)and nine showed stable disease(SD),exhibiting a disease control rate(DCR)of 37.5%(95%CI,21.1–56.3).For the 31 patients who had access to PD-1 ligand 1(PD-L1)combined positive score(CPS)testing(cut-off value≥1%),the ORR was not different between those who had PD-L1-positive(PD-L1+;1/11,9.1%)and PDL1-(2/20,10.0%)tumors(p=1.000).The tumor mutational burden(TMB)of PD-L1+BTC was comparable to that of PD-L1-BTC(p=0.630).TMB and any exonic somatic mutations were also not predictive of pembrolizumab *** analysis of blood and tumor samples demonstrated a relatively high natural killer(NK)cell proportion in the peripheral blood before pembrolizumab treatment in patients who achieved tumor ***,the tumors of these patients presented high enrichment scores for NK cells,antitumor cytokines,and Th1 signatures,and a low enrichment score for cancer-associated ***:This study shows the molecular characteristics associated with the efficacy of pembrolizumab in BTC of the MSS type.

关键词： Pembrolizumab Whole-exome sequencing Whole-transcriptome sequencing Biliary tract cancer

Early prediction of myocardial viability after acute myocardial infarction by two-dimensional speckle tracking imaging

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Journal of Geriatric Cardiology 2015年第5期12卷 474-481页

作者： Jong Shin Woo Tae-kyung Yu Woo-shik kim Kwon Sam kim Weon kim Division of Cardiology Department of lnternal Medicine Kyung Hee University Hospital Kyung Hee University Seoul South Korea

Background Identifying the transmural extent of myocardial necrosis and the degree of myocardial viability in acute myocardial infarction （AMI） is important clinically. The aim of this study was to assess myocardial viability using two-dimensional speckle tracking imaging （2D-STI） in patients with AMI. Methods 2D-STI was performed at initial presentation, three days, and six months after primary percutaneous coronary intervention （PCI） in 30 patients with AMI, who had a left anterior descending coronary artery （LAD） culprit lesion. In addition, 20 patients who had minimal stenotic lesions （〈 30% stenosis） on coronary angiography were also included in the control group. At six months dobutamine echocardiography was performed for viability assessment in seven segments of the LAD territory. According to the recovery of wall motion abnormality, segments were classified as viable or non-viable. Results A total of 131 segments were viable, and 44 were nonviable. Multivariate analysis revealed significant differences between the viable and nonviable segments in the peak systolic strain, the peak systolic strain rate at initial presentation, and peak systolic strain rate three days after primary PCI. Among these, the initial peak systolic strain rate had the highest predictive value for myocardial viability （hazard ratio： 31.22, P 〈 0.01）. Conclusions 2D-STI is feasible for assessing myocardial viability, and the peak systolic strain rate might be the most reliable predictor of myocardial viability in patients with AMI.

关键词： Acute myocardial infarction Two-dimensional speckle tracking imaging Viable myocardium

Lactic Acid Fermentation from Coffee Ground Waste Hydrolysate by Lactobacillus rhamnosus

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Journal of Renewable Materials 2019年第4期7卷 365-372页

作者： Ja-Ryong Koo Hye Min Park Se kyung kim Hyun shik Yun Department of Biological Engineering Inha UniversityIncheon 22212Korea Institute of Industrial Biotechnology Inha University Research and Business FoundationIncheon 22212Korea

Lactic acid is an important organic acid that is widely used in the food,pharmaceutical,and cosmetic *** acid was produced from coffee ground waste which contains fermentable sugars and is increasingly generated from our daily dietary *** 114 strains of Lactobacillus species,Lactobacillus rhamnosus ATCC 10863 was selected for the production of lactic acid from coffee ground *** alkali pretreatment and saccharification,cellulose and hemicellulose in coffee ground waste were converted into fermentable *** experiments were conducted at various alkali solution,concentrations,and *** pretreatment with 35 g/L of KOH at 121oC for 60 min,the highest concentration of fermentable sugars was *** optimum concentration of Viscozyme L was 2%when saccharification was proceeded at 55oC for 7 *** productivity of lactic acid fermentation was the highest(0.59 g/L/h)at 100 g of coffee ground waste(1x concentration),whereas the lactic acid concentration was the highest at 600 g of coffee ground waste(6x concentration).As the concentration of coffee ground increased,the lactic acid concentration was also increased,however,the amount was not proportional to the coffee ground waste *** this study,it was found that coffee ground waste could be used as a culture medium for Lactobacillus rhamnosus ATCC 10863 through pretreatment and saccharification for the production of lactic acid.

关键词： Coffee ground waste Lactobacillus rhamnosus lactic acid fermentable sugars saccharification alkali pretreatment

High Strength Steel Plates for Large Container Ships

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Journal of Iron and Steel Research International 2011年第S1期18卷 796-802页

作者： Chang-Sun Lee Sangho kim In-shik Suh kyung-Keun Um Ohjoon Kwon Technical Research Labs POSCOGoedong-dongNam-guPohang790-785Republic of Korea Research Institute of Industrial Science and Technology Hyoja-dongNam-guPohang790-600Republic of Korea

Heavy thickness steel plates with a good combination of strength,toughness and weldability have been demanded for building of large container *** strength steel plates with heavy gauge of EH36,EH40 and EH47 grades were developed by optimizing chemical compositions and TMCP process *** alloying elements of Ti and Nb were added to the three steel grades for enhancing the strength and toughness of base *** strength of base plates of the EH47 grade was further enhanced with the help of the increased amount of substitutional solid solutes,such as manganese,copper,nickel,or ***36 steel plates for high heat input over 550 kJ/cm were manufactured by improving thermal stability of TiN particles for better weld heat-affected zone *** stabilized TiN particles effectively suppress grain growth at weld heat-affected zone,leading to better *** steel plates showed excellent mechanical properties of base plates and welded joints.

关键词： EH36 EH40 EH47 container ship high heat input welding weldability

Compensation of image noise induced by difference in optical characteristics of array-LED chips of LED print head

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Science China(Technological Sciences) 2017年第12期60卷 1819-1830页

作者： kim Wan-Chin PARK Yong-shik kim Sung-Dae LIM Jiseok Department of Automotive Engineering Honam University Gwansan-gu Gwangju 62399 Korea Mangoslab Co. Ltd. Startupeampus 20 Pangyo-ro 289beon-gil Bundang-gu Seongnam-si Gyeonggi-do 13488 Korea S-Printing Solution Co. Ltd. (Samsung Electronics Ltd) Suwon Gyeonggi-do 443-742 Korea School of Mechanical Engineering Yeungnam University Gyeongsan Gyeongbuk 38541 Korea

There are various applied electro-optical devices, which utilize light emitting didoe(LED) chip array for applications to displays and opto-electronic sensors. In those devices, it is the one of the critical technical issues to minimize uncertain fluctuations including optical power and optical density. Due to variation in operating environment of a device, those are not corrected precisely by controlling parameters based on simple relation between parameters and resultant abovementioned ***, there is essential need to correct outputs in real-time based on correction function generated from the consideration on various operation condition. In this article, we introduce an output correction method through reporting real-time image noise reduction in the application to electro-photography with LED print head. In the technology of LED print head, as differences in optical characteristics between each LED cause vertical image noise, it should be corrected in order to obtain images that are comparable or better in quality compared to those produced by the conventional laser scanning method. Even though it seems that the method used to obtain uniform light power from each LED can solve this problem, it does not work well for high-resolution printing. Therefore, a scan method involving correction by a printed and scanned pattern is introduced through this work. The scan method is composed of correction patterns to minimize printing noise by its shape, the correction algorithm to calculate the optimized value and the printing algorithm to control gray levels in real-time precisely. We believe that the developed correction method upgrades the printing quality of the LPH printer better than commercial printers. The developed correction method can also be applied to various application areas that use an array-type light source such as display systems and lighting systems.

关键词： real-time image correction LED print head(LPH) vertical image noise electro-photography temporal correction spatial correction

MICROMECHANICS OF ROUGH SURFACE ADHESION:A HOMOGENIZED PROJECTION METHOD

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Acta Mechanica Solida Sinica 2009年第5期22卷 377-390页

作者： kyung-Suk kim Division of Engineering Brown UniversityProvidenceRI 02912USA

A quasistatic homogenized projection is made to characterize the effective cohesive zone behavior for rough-surface adhesion. In the context of the homogenized projection, the traction versus separation relation for the homogenized cohesive zone （HCZ） of a rough interface can be highly oscillatory due to instabilities during microscopic adhesion and decohesion processes. The instabilities are found to occur not only individually but also collectively among the adhesive micro-asperity contacts, leading to extensive energy dissipation. Based on the behaviors of the HCZ relations, a framework for describing instability-induced energy dissipation in rough-surface adhesion is proposed to elucidate the effect of roughness on apparent interface adhesion. Two non- dimensional parameters, α related to roughness morphology and n related to flaw distribution, are identified to be most crucial for controlling the energy dissipation. For an interface with a shallow roughness and a strong intrinsic adhesive strength, the interface adhesion can be stronger if we make it rougher （reducing α） or lower its flaw density （increasing n）. The HCZ projection method can be potentially extended and employed to bridge the apparent adhesion from intrinsic adhesion properties for engineering surfaces with multi-scale shallow roughness.

关键词： homogenized cohesive zone interface adhesion roughness effect instability energy dissipation

Maximizing biomass utilization: An integrated strategy for coproducing multiple chemicals

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Journal of Energy Chemistry 2025年第1期100卷 180-191页

作者： Byeongchan Ahn Sua Jo Jonggeol Na J.Jay Liu Young-Ju kim Wangyun Won Department of Chemical and Biological Engineering Korea University Department of Chemical Engineering (Integrated process) Kyung Hee University Department of Chemical Engineering and Materials Science Ewha Womans University Department of Chemical Engineering Pukyong National University Resources Engineering Plant Research Department Korea Institute of Geoscience and Mineral Resources

Lignocellulosic biomass is one of the viable solutions to alleviate the global warming. However, the limited utilization of biomass majorly focused on cellulose and hemicellulose restricts the economic and environmental feasibilities. To cope with this issue, we proposed an integrated process of co-producing 1,6-hexanediol（1,6-HDO） with tetrahydrofuran and adipic acid from biomass, referred to as Strategy A. To compare the impacts of lignin upgrading and feedstock, Strategy B, which co-produces tetrahydrofuran alone, and Strategy C, which is the traditional route to produce 1,6-HDO from fossil fuels, were used. Heat networks are also designed to reduce operating costs and indirect carbon emissions due to energy consumption, saving 87% and 83% of the heat and cooling requirements, respectively, in Strategy A. The market competitiveness of Strategy A was evaluated by determining the minimum selling price through techno-economic analysis, and sustainability was thoroughly investigated by quantifying the environmental impacts through both midpoint and endpoint life-cycle assessments（LCAs）.Strategy A was found to be the most favorable both economically（USRDSCHARDOLLAR3,402/ton） and environmentally（-26.9 kg CO2eq.）. This indicates that lignin valorization is not only economically but also environmentally preferred. Finally, changes in economic and environmental feasibilities depending on economic, process, and environmental parameters were investigated using sensitivity and uncertainty analyses. The results of these analyses provide valuable insight into bio-based chemical production.

关键词： Carbon capture and utilization

In situ synthesis of chemically bonded NaTi2（PO4）3/rGO 2D nanocomposite for high-rate sodium-ion batteries

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Nano Research 2016年第6期9卷 1844-1855页

作者： Ha-kyung Roh Hyun-kyung kim Myeong-Seong kim Dong-Hyun kim kyung Yoon Chung Kwang Chul Roh Kwang-Bum kim Department of Material Science & Engineering Yonsei University 50 Yonsei-ro Seodaemun-gu Seou103722 Republic of Korea Department of Materials Science and Metallurgy University of Cambridge 27 Charles Babbage Road Cambridge CB30FS UK Center for Energy Convergence Korea Institute of Science and Technology 5 Hwarang-ro 14-gil Seongbuk-gu Seou102792 Republic of Korea Energy & Environmental Division Korea Institute of Ceramic Engineering & Technology 101 Soho-ro Jinju-si Gyeongsangnam-do 52851 Republic of Korea

A phase-pure NaTi2（PO4）3/reduced graphene oxide （rGO） nanocomposite was prepared using a microwave-assisted one-pot method and subsequent heat treatment. The well-crystallized NaTi2（PO4）3 nanoparticles （30-40 nm） were uniformly precipitated on rGO templates through Ti-O-C bonds. The chemical interactions between the NaTi2（PO4）3 nanoparticles and rGO could immobilize the NaTi2（PO4）3 nanoparticles on the rGO sheets, which might be responsible for the excellent electrochemical performance of the nanocomposite. The NaTi2（PO4）B/rGO nanocomposite exhibited a specific capacity of 128.6 mA-h.g-1 approaching the theoretical value at a 0.1 C-rate with an excellent rate capability （72.9% capacity retention at 50 C-rate） and cycling performance （only 4.5% capacity loss after 1,000 cycles at a high rate of 10 C）. These properties were maintained even when the electrodes were prepared without the use of an additional conducting agent. The excellent sodium storage properties of the NaTi2（PO4）B/rGO nanocomposite could be attributed to the nano-sized NaTi2（PO4）3 particles, which significantly reduced the transport lengths for Na＋ ions, and an intimate contact between the NaTi2（PO4）3 particles and rGO due to chemical bonding.

关键词： NaTi2(PO4)dreducedgraphene oxide (rGO)nanocomposite chemical bonding energy-efficiency in situ synthesis high-rate sodium-ion batteries

A Power-Aware Branch Predictor by Accessing the BTB Selectively

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Journal of Computer Science & Technology 2005年第5期20卷 607-614页

作者： Cheol Hong kim Sung Woo Chung Chu shik Jhon Mobile System Laboratory Department of Electrical Engineering and Computer Science Seoul National University Seoul 151-742 Korea Department of Computer Science University of Virginia Charlottesville Virginia 22904 U.S.A.

Microarchitects should consider power consumption, together with accuracy, when designing a branch predictor, especially in embedded processors. This paper proposes a power-aware branch predictor, which is based on the gshare predictor, by accessing the BTB （Branch Target Buffer） selectively. To enable the selective access to the BTB, the PHT （Pattern History Table） in the proposed branch predictor is accessed one cycle earlier than the traditional PHT if the program is executed sequentially without branch instructions. As a side effect, two predictions from the PHT are obtained through one access to the PHT, resulting in more power savings. In the proposed branch predictor, if the previous instruction was not a branch and the prediction from the PHT is untaken, the BTB is not accessed to reduce power consumption. If the previous instruction was a branch, the BTB is always accessed, regardless of the prediction from the PHT, to prevent the additional delay/accuracy decrease. The proposed branch predictor reduces the power consumption with little hardware overhead, not incurring additional delay and never harming prediction accuracy. The simulation results show that the proposed branch predictor reduces the power consumption by 29-47%.

关键词： branch predictor BTB embedded processor low power design PHT