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Molecular Plant 2017年第4期10卷 652-655页

作者： Hyojin kim bong Suk kim Jung Eun Shim Sohyun Hwang Sunmo Yang Eiru kim Aniafi S. Iver-Pascuzzi2 Insuk Lee Department of Biotechnology College of Life Science and Biotechnology Yonsei University Seou1120-749 Korea Department of Botany and Plant Pathology Purdue University West Lafayette IN 47907 USA

Tomato （Solanum lycopersicum） is the second most important vegetable crop globally, with a total world production valued at over $74 billion （FAOSTAT Statistics Database, 2009）. Tomato is also an important model c... 详细信息

关键词： Genome-wide Co-functional Network Unveiling Complex Traits Tomato

The extract of the immature fruit of Poncirus trifoliata induces apoptosis in colorectal cancer cells via mitochondrial autophagy

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Food Science and Human Wellness 2020年第3期9卷 237-244页

作者： Sun-Young kim Ho-Keun Yi bong-Sik Yun Dae-Yeol Lee Pyung Han Hwang Hae-Ryong Park Min Sun kim Research Institute of Clinical Medicine of Jeonbuk National University Biomedical Research Institute of Jeonbuk National University HospitalJeonju54907South Korea Department of Oral Biochemistry Institute of Oral BioscienceSchool of DentistryJeonbuk National UniversityJeonju54907South Korea Division of Biotechnology and Advanced Institute of Environment and Bioscience Jeonbuk National UniversityIksan-si54596South Korea Department of Pediatrics Jeonbuk National University Medical SchoolJeonju54907South Korea Department of Food Science and Biotechnology Kyungnam UniversityChangwon-si51767South Korea

The immature fruits of Poncirus trifoliate are used as a medicine for the treatment of gastrointestinal disorders,inflammation,and allergies in East ***,their effect on colon cancer cells remains *** investigated the effect of the immature fruit of *** extract on colorectal *** extract of the immature fruit of *** inhibited the proliferation of CT-26 cells compared with untreated cells and it induced autophagy and apoptosis through the protein kinase B/mammalian target of rapamycin and 5'-AMP-activated protein kinase *** number of autophagic vacuoles and autophage markers increased in response to the *** later time-points,apoptosis increased dose/*** CT-26 cells pre-treated a pan-caspase inhibitor prior to *** immature fruit extract treatment,we did not find any change in pro-caspase 3 and pro-PARP ***,in cells pre-treated autphage inhibitor,SQSTM1/p62 and LC3AB,pro-caspase 3 and pro-PARP levels did not *** results indicate the molecular mechanisms that the extract of the immature fruit of *** induces apoptosis in colorectal carcinoma cells by inducing mitochondrial *** this study,we provided a draft for further investigate the use of MEPT for colorectal cancer inhibition.

关键词： Anticancer Autophagy Apoptosis Mitochondria Poncirus trifoliata

Prediction of forming limit curve for pure titanium sheet

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Transactions of Nonferrous Metals Society of China 2018年第2期28卷 319-327页

作者： Young-Suk kim bong-Hyun LEE Seung-Han YANG School of Mechanical Engineering Kyungpook National University Daegu-Gyeongbuk Center Korea Automotive Technology Institute

Commercially pure titanium（CP Ti） has been actively used in the plate heat exchanger due to its light weight, high specific strength, and excellent corrosion resistance. However, researches for the plastic deformation characteristics and press formability of the CP Ti sheet are not much in comparison with automotive steels and aluminum alloys. The mechanical properties and hardening behavior evaluated in stress-strain relation of the CP Ti sheet are clarified in relation with press formability. The flow curve denoting true stress-true strain relation for CP Ti sheet is fitted well by the kim-Tuan hardening equation rather than Voce and Swift models. The forming limit curve（FLC） of CP Ti sheet as a criterion for press formability was experimentally evaluated by punch stretching test and analytically predicted via Hora＇s modified maximum force criterion. The predicted FLC by adopting kim-Tuan hardening model and appropriate yield function shows good correlation with the experimental results of punch stretching test.

关键词： kim-Tuan hardening equation Hora modified maximum force criterion pure titanium sheet forming limit curve

Enzyme-amplified SERS immunoassay with Ag-Au bimetallic SERS hot spots

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Nano Research 2020年第12期13卷 3338-3346页

作者： Xuan-Hung Pham Eunil Hahm Tae Han kim Hyung-Mo kim Sang Hun Lee Sang Chul Lee Homan Kang Ho-Young Lee Dae Hong Jeong Hak Soo Choi bong-Hyun Jun Department of Bioscience and Biotechnology Konkuk UniversitySeoul143-701Republic of Korea Department of Nuclear Medicine Seoul National University Bundang HospitalSeongnam13620Republic of Korea Gordon Center for Medical Imaging Department of RadiologyMassachusetts General Hospital and Harvard Medical SchoolBostonMA02114USA Department of Chemistry Education Seoul National UniversitySeoul151-742Republic of Korea

Surface-enhanced Raman scattering(SERS)enables rapid detection of single molecules with high ***,quantitative and sensitive SERS analysis has been a challenge due to the lack of reliable SERS-active *** this study,we developed a quantitative SERS-based immunoassay using enzyme-guided Ag growth on Raman labeling compound(RLC)-immobilized gold nanoparticle(Au NP)-assembled silica NPs(SiO2@Au-RLC@Ag).The enzyme amplified Ag+reduction as well as Ag growth on the RLC-immobilized Au NP-assembled silica NPs(SiO2@Au-RLC),which resulted in a significant increase in SERS *** the presence of target antigens such as immunoglobulinG(IgG)or prostate-specific antigen(PSA),Ab1-Antigen-Ab2 immune complex with alkaline phosphatase triggered an enzyme-catalyzed reaction to convert 2-phospho-L-ascorbic acid(2-phospho-L-AA)to ascorbic acid(AA).As produced AA reduced Ag+to Ag,forming an Ag hot spot on the surface of SiO2@Au-RLC,which enhanced the SERS signal of SiO2@Au-RLC@Ag in a solution with a target antigen *** plasmonic immunoassay for IgG detection showed a high linearity of SERS intensity in the range of 0.6 to 9.0 ng/mL with a detection limit(LOD)of 0.09 ng/mL,while an LOD of 0.006 ng/mL was obtained for *** results indicate that the sensitivity of our novel SERS-based immunoassay is higher than that of conventional enzyme-based colorimetric immunoassays.

关键词： surface-enhanced Raman scattering(SERS)-based immunoassay Au-Ag alloy surface-enhanced Raman scattering silica template immunoglobulin G(IgG)detection

Synthesis and Gas Sensing of TiO_2 Ultrafine Powders by Precipitating

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稀有金属材料与工程 2006年第A3期35卷 163-164页

作者： Min-Hyun Seo bong-Ho Lee Jong-Won kim Gi-Hong Rue Duk-Dong Lee Jeung-Soo Huh Department of Sensor and Display Engineering Kyungpook National UniversitySangyuk-DongBukguDaegu 1370Korea Department of Materials Science and Metallurgy Kyungpook National UniversitySangyuk-DongBukguDaegu 1370Korea Department of Nano-science and Technology Kyungpook National UniversitySangyuk-DongBukguDaegu 1370Korea School of Electronic Engineering Kyungpook National UniversitySangyuk-DongBukguDaegu 1370Korea Department of Sensor and Display Engineering Kyungpook National UniversitySangyuk-DongBukguDaegu 1370Korea.Department of Nano-science and TechnologyKyungpook National UniversitySangyuk-DongBukguDaegu 1370Korea

We investigated the gas sensing characteristics of rutile and anatase TiO_2 nano-particle sensors for chemical warfare ***_2 nano-powders with rutile and anatase structure were fabricated by controlling pH value without heat treatment *** mean particle size of TiO_2 powders were below 10 ***-prepared TiO_2 powders have several advantages of nano particle size and high surface area and could be a prominent candidate for ***_2 sensors were examined with DMMP for chemical warfare agents detection.

关键词： TiO2 chemical warfare agents sensor nano-sensor pH

Variation in Summer Surface Air Temperature over Northeast Asia and Its Associated Circulation Anomalies

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Advances in Atmospheric Sciences 2016年第1期33卷 1-9页

作者： Wei CHEN Xiaowei HONG Riyu LU Aifen JIN Shizhu JIN Jae-Cheol NAM Jin-Ho SHIN Tae-Young goo Baek-Jo kim State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric Physics Chinese Academy of Sciences Beijing 100029 University of Chinese Academy of Sciences Beijing 100049 Department of Geography Yanbian University Yanji 133002 National Institute of Meteorological Research Korea Meteorological Administration deju Korea

This study investigates the interannual variation of summer surface air temperature over Northeast Asia（NEA） and its associated circulation *** leading modes for the temperature variability over NEA are obtained by EOF *** first EOF mode is characterized by a homogeneous temperature anomaly over NEA and therefore is called the NEA *** anomaly extends from southeast of Lake Baikal to Japan,with a central area in Northeast *** second EOF mode is characterized by a seesaw pattern,showing a contrasting distribution between East Asia（specifically including the Changbai Mountains in Northeast China,Korea,and Japan） and north of this *** mode is named the East Asia（EA） *** modes contribute equivalently to the temperature variability in *** two leading modes are associated with different circulation anomalies.A warm NEA mode is associated with a positive geopotential height anomaly over NEA and thus a weakened upper-tropospheric westerly *** the other hand,a warm EA mode is related to a positive height anomaly over EA and a northward displaced *** addition,the NEA mode tends to be related to the Eurasian teleconnection pattern,while the EA mode is associated with the East Asia-Pacific/PacificJapan pattern.

关键词： surface air temperature Northeast Asia East Asia circulation anomaly interannual variability

Effects of Scutellaria baicalensis on neurogenesis in the hippocampal dentate gyrus and on spatial memory of adult rats

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Neural Regeneration Research 2011年第27期6卷 2085-2093页

作者： Sun-Hwa Lee Byung-soo Ahn bong-soo Lim Seong-Kyu kim Sam-Ki kim Dae-Il Lee Sung-Rae Cho Deok-Gon kim Jae-Bok Han Byung-Il Min Department of East-West Medicine Graduate SchoolKyunghee University Department & Research Institute of Rehabilitation Medicine Yonsei University Department of Oriental Pediatrics Kyunghee Medical CenterKyunghee University Department of Physiology College of MedicineKyunghee University

We investigated the effects of ethanol extracted Scutellaria baicalensis（EESB） on spatial memory function and neurogenesis in the hippocampal dentate *** Sprague-Dawley rats were orally administered 50,100,or 200 mg/kg of EESB for 6 successive *** radial-arm maze test showed that 200 mg/kg of EESB improved the spatial memory of adult *** microscopy results showed that 100 mg/kg of EESB increased the number of bromodeoxyuridine（BrdU）-and neuron-specific nuclear protein-positive cells in the granular cell layer,and that 100 and 200 mg/kg of EESB increased the number of BrdU-/neuron-specific nuclear protein-positive cells in the sub-granular zone.200 mg/kg of EESB increased the number of BrdU-/glial fibrillary acid protein-positive cells in the subgranular *** findings indicate that EESB can effectively promote neurogenesis in the hippocampal dentate gyrus and improve spatial memory function.

关键词： Scutellaria baicalensis neurogenesis dentate gyrus hippocampus bromodeoxyuridine neuron-specific nuclear protein glial fibrillary acidic protein neural regeneration

A novel device for endoscopic submucosal dissection,the Fork knife

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World Journal of Gastroenterology 2008年第43期14卷 6726-6732页

作者： Hyun Gun kim Joo Young Cho Gene Hyun Bok Won Young Cho Wan Jung kim bong Min Ko Jin Oh kim Joon Seong Lee Moon Sung Lee Chan Sup Shim Institute for Digestive Research Digestive Disease Research CenterSoonChunHyang University College of MedicineSeoul 140-743South Korea

AIM： To introduce and evaluate the efficacy and technical aspects of endoscopic submucosal dissection （ESD） using a novel device, the Fork knife. METHODS： From March 2004 to April 2008, ESD was performed on 265 gastric lesions using a Fork knife （Endo FS）（group A） and on 72 gastric lesions using a Flexknife （group B） at a single tertiary referral center. We retrospectively compared the endoscopic characteristics of the tumors, pathological findings, and sizes of the resected specimens. We also compared the en b/oc resection rate, complete resection rate, complications, and procedure time between the two groups. RESULTS： The mean size of the resected specimens was 4.27 ± 1.26 cm in group A and 4.29 ± 1.48 cm in group B. The en b/oc resection rate was 95.8% （254/265 lesions） in group A and 93.1% （67/72） in group B. Complete ESD without tumor cell invasion of the resected margin was obtained in 81.1% （215/265） of group A and in 73.6% （53/72） of group B. The perforation rate was 0.8% （2/265） in group A and 1.4% （1/72） in group B. The mean procedure time was 59.63 ± 56.12 min in group A and 76.65 ± 70.75 min in group B （P 〈 0.05）. CONCLUSION： The Fork knife （Endo FS） is useful for clinical practice and has the advantage of reducing the procedure time.

关键词： Fork knife Novel device Endoscopic submucosal dissection Flexknife Procedure

Caenorhabditis elegans deep lipidome profiling by using integrative mass spectrometry acquisitions reveals significantly altered lipid networks

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Journal of Pharmaceutical Analysis 2022年第5期12卷 743-754页

作者： Nguyen Hoang Anh Young Cheol Yoon Young Jin Min Nguyen Phuoc Long Cheol Woon Jung Sun Jo kim Suk Won kim Eun goo Lee Daijie Wang Xiao Wang Sung Won Kwon College of Pharmacy Seoul National UniversitySeoul08826Republic of Korea School of Pharmaceutical Sciences Shandong Analysis and Test CenterQilu University of Technology(Shandong Academy of Sciences)Jinan250014China Biological Engineering Technology Innovation Center of Shandong Province Heze Branch of Qilu University of Technology(Shandong Academy of Sciences)HezeShandong274000China

Lipidomics coverage improvement is essential for functional lipid and pathway construction.A powerful approach to discovering organism lipidome is to combine various data acquisitions,such as full scan mass spectrometry(full MS),data-dependent acquisition(DDA),and data-independent acquisition(DIA).Caenorhabditis elegans(***)is a useful model for discovering toxic-induced metabolism,highthroughput drug screening,and a variety of human disease *** determine the lipidome of *** and investigate lipid disruption from the molecular level to the system biology level,we used integrative data *** methyl-tert-butyl ether method was used to extract L4 stage *** after exposure to triclosan(TCS),perfluorooctanoic acid,and nanopolystyrene(nPS).Full MS,DDA,and DIA integrations were performed to comprehensively profile the *** lipidome by Q-Exactive Plus *** annotated lipids were then analyzed using lipid ontology and pathway *** annotated up to 940 lipids from 20 lipid classes involved in various functions and *** biological investigations revealed that when *** were exposed to nPS,lipid droplets were disrupted,whereas plasma membrane-functionalized lipids were likely to be changed in the TCS treatment *** nPS treatment caused a significant disruption in lipid ***,glycerophospholipid,and ether class lipids were those primarily hindered by ***,toxicant exposure frequently involved numerous lipid-related pathways,including the phosphoinositide 3-kinase/protein kinase B *** conclusion,an integrative data acquisition strategy was used to characterize the *** lipidome,providing valuable biological insights into hypothesis generation and validation.

关键词： Caenorhabditis elegans Lipidomics Data-dependent acquisition Data-independent acquisition

A preliminary study of dietary protein requirement of juvenile marbled flounder (Pseudopleuronectes yokohamae)

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Animal Nutrition 2021年第2期7卷 548-555页

作者： Jeong-Hyeon Cho Seunghyung Lee bong-Joo Lee Sang-Woo Hur Kang-Woong kim Maeng-Hyun Son Dong-Jae Yoo Inland Fisheries Research Institute National Institute of Fisheries ScienceGapyeong12453South Korea Department of Marine Bio-materials and Aquaculture Pukyong National UniversityBusan48513South Korea Aquafeed Research Center National Institute of Fisheries SciencePohang37517South Korea Gyeongsangbuk-do Fisheries Resources Institute Yeongdeok36405South Korea Gyeongsangbuk-do Native Fish Business Center Uiseong37366South Korea

An 8-week feeding trial was conducted to determine the optimal dietary protein level for juvenile marbled *** semi-purified test diets were formulated to contain different protein levels(CP)including 42.7%,47.4%,53.3%,58.8%,and 64.5%(dry matter),named as CP42.7,CP47.4,CP53.3,CP58.8,and CP64.5,*** hundred and twenty-five juveniles(6.0±0.1 g)were randomly distributed into 15 tanks(300 L tanks),resulting in 35 fish per tank(n-3 tanks).Fish were fed the test diets 5 times per day until *** CP58.8 resulted in the highest gain in weight and the best efficiency in feed utilization among the tested protein levels(P<0.05).Fish fed the CP58.8 diet showed significantly higher whole-body protein and lipid contents than the fish that were fed the other diets(P<0.05).Fish fed the CP53.3,CP58.8,and CP64.5 diets showed a significantly higher dorsal-muscle lipid content than the fish that were fed the CP42.7 and CP47.4 diets(P<0.05).The one-slope straight broken-line regression analysis on the results of the thermal growth coefficient and feed conversion ratio indicated that the estimated optimum dietary protein level was 58.8%.Taken together,it is suggested that the dietary protein level of 58.8%is optimal for better growth and high efficiency in feed utilization for the juvenile marbled flounder.

关键词： Marbled flounder Pseudopleuronectes yokohamae Protein requirement Growth performance Proximate composition